Dysregulation of Retinoid Transporters Expression in Body Fluids of Schizophrenia PatientsClick to copy article linkArticle link copied!
Abstract

This study aims to find the biomarkers or associated proteins in body fluids of schizophrenia patients so that we can further understand the etiology of schizophrenia. We applied proteomic technologies combining two-dimensional electrophoresis with Coomassie blue staining and mass spectrometry and identifyed a procedure for the clinical screening of disease-influenced body fluid proteins in two sets of samples, plasma from 19 schizophrenia patients and cerebrospinal fluid (CSF) from 35 drug-treated schizophrenic patients and 36 healthy controls. The expression of transthyretin (TTR) tetramer increased significantly in plasma of schizophrenic patients after a valid 2 months in-hospital antipsychotic treatment. Conversely, the expression of the TTR tetramer and apolipoprotein E (ApoE) was down-regulated by up to 1.68 and 3.62 times, respectively, in the CSF of schizophrenia patients compared to that of normal controls, which has not been reported previously. Considering that the TTR tetramer and ApoE are both retinoid transporters, retinoid dysfunction might be involved in the pathology of schizophrenia.
Keywords: Transthyretin • Retinoid Transporter • Schizophrenia • Plasma • Cerebrospinal Fluid
†
Shanghai Jiao Tong University.
‡
Chinese Academy of Sciences.
#
These two authors contributed equally.
§
Shanghai Institute of Mental Health.
*
Address correspondence to Dr. Lin He, Shanghai Jiao Tong University, Bio-X Life Science Research Center, Hao Ran Building, 1954 Huashan Road, Shanghai 200030, China; or Institute for Nutritional Sciences, SIBS, Chinese Academy of Sciences, 294 Taiyuan Road, Shanghai 200031, China. E-mail: [email protected]. Tel/fax: 86-21-62822491.
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