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Dysregulation of Retinoid Transporters Expression in Body Fluids of Schizophrenia Patients
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    Dysregulation of Retinoid Transporters Expression in Body Fluids of Schizophrenia Patients
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    Bio-X Life Science Research Center, Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai 200030, China, Institutes for Nutritional Sciences, Shanghai Institute of Biological Sciences, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200031, China, Shanghai Institute of Mental Health, 600 South Wan Ping Road, Shanghai, China
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    Journal of Proteome Research

    Cite this: J. Proteome Res. 2006, 5, 11, 3213–3216
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    https://doi.org/10.1021/pr060176l
    Published September 27, 2006
    Copyright © 2006 American Chemical Society

    Abstract

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    This study aims to find the biomarkers or associated proteins in body fluids of schizophrenia patients so that we can further understand the etiology of schizophrenia. We applied proteomic technologies combining two-dimensional electrophoresis with Coomassie blue staining and mass spectrometry and identifyed a procedure for the clinical screening of disease-influenced body fluid proteins in two sets of samples, plasma from 19 schizophrenia patients and cerebrospinal fluid (CSF) from 35 drug-treated schizophrenic patients and 36 healthy controls. The expression of transthyretin (TTR) tetramer increased significantly in plasma of schizophrenic patients after a valid 2 months in-hospital antipsychotic treatment. Conversely, the expression of the TTR tetramer and apolipoprotein E (ApoE) was down-regulated by up to 1.68 and 3.62 times, respectively, in the CSF of schizophrenia patients compared to that of normal controls, which has not been reported previously. Considering that the TTR tetramer and ApoE are both retinoid transporters, retinoid dysfunction might be involved in the pathology of schizophrenia.

    Keywords: Transthyretin • Retinoid Transporter • Schizophrenia • Plasma • Cerebrospinal Fluid

    Copyright © 2006 American Chemical Society

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     Shanghai Jiao Tong University.

     Chinese Academy of Sciences.

    #

     These two authors contributed equally.

    §

     Shanghai Institute of Mental Health.

    *

     Address correspondence to Dr. Lin He, Shanghai Jiao Tong University, Bio-X Life Science Research Center, Hao Ran Building, 1954 Huashan Road, Shanghai 200030, China; or Institute for Nutritional Sciences, SIBS, Chinese Academy of Sciences, 294 Taiyuan Road, Shanghai 200031, China. E-mail:  [email protected]. Tel/fax:  86-21-62822491.

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    Journal of Proteome Research

    Cite this: J. Proteome Res. 2006, 5, 11, 3213–3216
    Click to copy citationCitation copied!
    https://doi.org/10.1021/pr060176l
    Published September 27, 2006
    Copyright © 2006 American Chemical Society

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