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Autoantibody Signature in Human Ductal Pancreatic Adenocarcinoma

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Download Hi-Res ImageDownload to MS-PowerPointCite This:J. Proteome Res. 2007, 6, 10, 4025-4031
    Article

    Autoantibody Signature in Human Ductal Pancreatic Adenocarcinoma
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    Center for Experimental Research and Medical Studies (CeRMS) and University of Turin, San Giovanni Battista Hospital, Turin, Italy, Department of Medicine and Experimental Oncology, University of Turin, Turin, Italy, Department of Gastro-Hepatology, Department of Gastroenterology, and Centro Oncologico Ematologico Subalpino (COES), San Giovanni Battista Hospital, Turin, Italy, Department of Internal Medicine, Gastroenterology Unit, San Luigi Gonzaga Hospital, Orbassano, Italy, Laboratories of Immunology and Medical Oncology, Regina Elena National Cancer Institute, Rome, Italy, Proteome Biochemistry, San Raffaele Scientific Institute, Milan, Italy, and CNR-Institute of Science of Food Production (ISPA), Bioindustry Park Canavese, Colleretto Giacosa, Italy
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    Journal of Proteome Research

    Cite this: J. Proteome Res. 2007, 6, 10, 4025–4031
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    https://doi.org/10.1021/pr070281a
    Published September 8, 2007
    Copyright © 2007 American Chemical Society
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    Abstract

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    Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy characterized by rapid progression, invasiveness, and resistance to treatment. It is the fourth leading cause of cancer death with a 2% 5-year survival rate. Biomarkers for its early detection are lacking. This study was designed to use a proteomics-based approach as a means of identifying antigens that elicit a humoral response in PDAC patients. Antibodies against PDAC-associated antigens are useful for early cancer diagnosis and therapy. Proteins from PDAC cell lines were separated by 2-DE, and the serum IgG reactivity of 70 PDAC patients, 40 healthy subjects (HS), 30 non-PDAC tumor patients, and 15 chronic pancreatitis (CP) patients was tested by Western blot analysis. Spots specifically recognized by PDAC sera and revealed by mass spectrometry corresponded to metabolic enzymes or cytoskeletal proteins. Most were up-regulated in PDAC tissues. Thus, it seems that metabolic enzymes and cytoskeletal proteins are specific targets of the humoral response during PDAC. The results of further studies of these serological-defined antigens could be of diagnostic and therapeutic significance in PDAC.

    Keywords: pancreatic ductal adenocarcinoma • autoantibody • tumor associated antigen • mass spectrometry • two-dimensional electrophoresis

    Copyright © 2007 American Chemical Society

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    †

     CeRMS.

    ‡

     Department of Medicine and Experimental Oncology.

    §

     COES.

    ‖

     Department of Gastro-Hepatology.

    ⊥

     Department of Gastroenterology.

    £

     Department of Internal Medicine.

    ¢

     Laboratory of Immunology.

    ×

     Laboratory of Medical Oncology.

    #

     Proteome Biochemistry.

    ¥

     ISPA-CNR.

    *

     To whom correspondence should be addressed. Prof. Francesco Novelli, Ph.D., Center for Experimental Research and Clinical Studies (CeRMS), San Giovanni Battista Hospital, Via Cherasco 15, 10126 Turin, Italy. Telephone, (+39) 011-6334463; Fax, (+39) 011-6336887; E-mail, [email protected].

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    This article is cited by 63 publications.

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    Journal of Proteome Research

    Cite this: J. Proteome Res. 2007, 6, 10, 4025–4031
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    https://doi.org/10.1021/pr070281a
    Published September 8, 2007
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