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Proteomic Analysis of Seminal Plasma from Normal Volunteers and Post-Vasectomy Patients Identifies over 2000 Proteins and Candidate Biomarkers of the Urogenital System

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    Proteomic Analysis of Seminal Plasma from Normal Volunteers and Post-Vasectomy Patients Identifies over 2000 Proteins and Candidate Biomarkers of the Urogenital System
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    † ‡ †Samuel Lunenfeld Research Institute, Department of Pathology and Laboratory Medicine and ‡Department of Surgery (Division of Urology), Mount Sinai Hospital, Toronto, ON, Canada M5T 3L9
    ⊥ §Department of Clinical Biochemistry, University Health Network, ∥Department of Laboratory Medicine and Pathobiology, and ⊥Department of Surgery, University of Toronto, Toronto, ON, Canada M5G 1L5
    *To whom correspondence should be addressed. Tel: 416-586-6367. Fax: 416-586-4776. E-mail, [email protected]
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    Journal of Proteome Research

    Cite this: J. Proteome Res. 2011, 10, 3, 941–953
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    https://doi.org/10.1021/pr100745u
    Published December 10, 2010
    Copyright © 2010 American Chemical Society
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    Abstract

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    Seminal plasma is a fluid that originates from the testis, epididymis,prostate, and seminal vesicles, and hence, proteomic studies may identify potential markers of infertility and other diseases of the genito-urinary tract. We profiled the proteomes of pooled seminal plasma from fertile Control and post-vasectomy (PV) men. PV seminal plasma samples are void of proteins originating from the testis and the epididymis due to ligation of the vas deferens, and hence, comparative analysis of Control and PV data sets allows for identification of proteins originating from these tissues. Utilizing offline MudPIT and high-resolution mass spectrometry, we were able to identify over 2000 proteins in Control and PV pools each and over 2300 proteins all together. With semiquantitative analysis using spectral counting, we catalogued 32 proteins unique to Control, 49 at lower abundance in PV, 3 unique to PV, and 25 at higher abundance in PV. We believe that proteins unique to Control or at lower abundance in PV have their origin in the testis and the epididymis. Public databases have confirmed that many of these proteins originate from the testis and epididymis and are linked to the reproductive tract. These proteins may serve as candidate biomarkers for future studies of infertility and urogenital diseases.

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    Supplementary Tables 1, 2, 3, 4, 5, 6, 7 and supplementary Scaffold files “Control_SP.sfd”, “PV_SP.sfd”, and “Control-PV_SP.sfd”. This material is available free of charge via the Internet at http://pubs.acs.org.

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    46. Fengli Wang, Weina Yang, Sijin Ouyang, Shuiqiao Yuan. The Vehicle Determines the Destination: The Significance of Seminal Plasma Factors for Male Fertility. International Journal of Molecular Sciences 2020, 21 (22) , 8499. https://doi.org/10.3390/ijms21228499
    47. Naina Kumar, Namit Kant Singh. “Emerging role of Novel Seminal Plasma Bio-markers in Male Infertility: A Review”. European Journal of Obstetrics & Gynecology and Reproductive Biology 2020, 253 , 170-179. https://doi.org/10.1016/j.ejogrb.2020.08.015
    48. Luz Candenas, Rosanna Chianese. Exosome Composition and Seminal Plasma Proteome: A Promising Source of Biomarkers of Male Infertility. International Journal of Molecular Sciences 2020, 21 (19) , 7022. https://doi.org/10.3390/ijms21197022
    49. Rossella Cannarella, Federica Barbagallo, Andrea Crafa, Sandro La Vignera, Rosita A. Condorelli, Aldo E. Calogero. Seminal Plasma Transcriptome and Proteome: Towards a Molecular Approach in the Diagnosis of Idiopathic Male Infertility. International Journal of Molecular Sciences 2020, 21 (19) , 7308. https://doi.org/10.3390/ijms21197308
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    52. Marc Llavanera, Yentel Mateo-Otero, Sergi Bonet, Isabel Barranco, Beatriz Fernández-Fuertes, Marc Yeste. The triple role of glutathione S-transferases in mammalian male fertility. Cellular and Molecular Life Sciences 2020, 77 (12) , 2331-2342. https://doi.org/10.1007/s00018-019-03405-w
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    66. Zahra Kanannejad, Behrouz Gharesi-Fard. Difference in the seminal plasma protein expression in unexplained infertile men with successful and unsuccessful in vitro fertilisation outcome. Andrologia 2019, 51 (1) , e13158. https://doi.org/10.1111/and.13158
    67. Ping Li, Hao Du, Xin Mei Qiao, Zhi Gang Liu, Qiong Zhou, Qi Wei Wei. Protein profile of Dabry’s sturgeon (Acipenser dabryanus) spermatozoa and relationship to sperm quality. Animal Reproduction Science 2019, 201 , 1-11. https://doi.org/10.1016/j.anireprosci.2018.12.002
    68. Manesh Kumar Panner Selvam, Ashok Agarwal. Proteomic and Metabolomic Profile of Semen and Seminal Plasma in Varicocele. 2019, 73-85. https://doi.org/10.1007/978-3-319-79102-9_6
    69. Manesh Kumar Panner Selvam, Saradha Baskaran, Ashok Agarwal. Proteomics of reproduction: Prospects and perspectives. 2019, 217-243. https://doi.org/10.1016/bs.acc.2019.04.005
    70. Cristina Pérez-Patiño, Inmaculada Parrilla, Junwei Li, Isabel Barranco, Emilio A. Martínez, Heriberto Rodriguez-Martínez, Jordi Roca. The Proteome of Pig Spermatozoa Is Remodeled During Ejaculation. Molecular & Cellular Proteomics 2019, 18 (1) , 41-50. https://doi.org/10.1074/mcp.RA118.000840
    71. Mariana Camargo, Paula Intasqui, Ricardo Pimenta Bertolla. Understanding the seminal plasma proteome and its role in male fertility. Basic and Clinical Andrology 2018, 28 (1) https://doi.org/10.1186/s12610-018-0071-5
    72. Jane-Fang Yu, Yu-Hua Lai, Tse-En Wang, Yu-Syuan Wei, Yu-Jia Chang, Sheng-Hsiang Li, Shih-Chien Chin, Radhika Joshi, Hui-Wen Chang, Pei-Shiue Tsai. The effects of type I collagenase on the degelification of chimpanzee (Pan troglodytes) semen plug and sperm quality. BMC Veterinary Research 2018, 14 (1) https://doi.org/10.1186/s12917-018-1389-0
    73. Gayatri Mohanty, Luna Samanta. Redox regulation & sperm function. Indian Journal of Medical Research 2018, 148 (Suppl 1) , S84-S91. https://doi.org/10.4103/ijmr.IJMR_242_18
    74. Xin Liu, Wenting Wang, Peng Zhu, Jiahui Wang, Yanwei Wang, Xuebo Wang, Juan Liu, Ning Li, Xiong Wang, Chunhua Lin, Fujun Liu. In-depth quantitative proteome analysis of seminal plasma from men with oligoasthenozoospermia and normozoospermia. Reproductive BioMedicine Online 2018, 37 (4) , 467-479. https://doi.org/10.1016/j.rbmo.2018.06.025
    75. Xavier Druart, Simon de Graaf. Seminal plasma proteomes and sperm fertility. Animal Reproduction Science 2018, 194 , 33-40. https://doi.org/10.1016/j.anireprosci.2018.04.061
    76. R Singh, GS Sengar, U Singh, R Deb, V Junghare, S Hazra, S Kumar, S Tyagi, AK Das, TV Raja, A Kumar. Functional proteomic analysis of crossbred (Holstein Friesian × Sahiwal) bull spermatozoa. Reproduction in Domestic Animals 2018, 53 (3) , 588-608. https://doi.org/10.1111/rda.13146
    77. Laura Bianchi, Chiara Carnemolla, Viola Viviani, Claudia Landi, Valentina Pavone, Alice Luddi, Paola Piomboni, Luca Bini. Soluble protein fraction of human seminal plasma. Journal of Proteomics 2018, 174 , 85-100. https://doi.org/10.1016/j.jprot.2017.12.015
    78. Manesh Kumar Panner Selvam, Ashok Agarwal. Update on the proteomics of male infertility: A systematic review. Arab Journal of Urology 2018, 16 (1) , 103-112. https://doi.org/10.1016/j.aju.2017.11.016
    79. Samantha E. T. Larkin, Benjamin Abbott, Michael D. Brown, Thomas R. Jackson, Noel W. Clarke, Paul A. Townsend. Proteomics in Prostate Cancer Research. 2018, 213-236. https://doi.org/10.1007/978-3-319-64096-9_14
    80. Dimitrios Korbakis, Christina Schiza, Davor Brinc, Antoninus Soosaipillai, Theano D. Karakosta, Christine Légaré, Robert Sullivan, Brendan Mullen, Keith Jarvi, Eleftherios P. Diamandis, Andrei P. Drabovich. Preclinical evaluation of a TEX101 protein ELISA test for the differential diagnosis of male infertility. BMC Medicine 2017, 15 (1) https://doi.org/10.1186/s12916-017-0817-5
    81. Amilcar Flores-Morales, Diego Iglesias-Gato. Quantitative Mass Spectrometry-Based Proteomic Profiling for Precision Medicine in Prostate Cancer. Frontiers in Oncology 2017, 7 https://doi.org/10.3389/fonc.2017.00267
    82. J. de la Torre, P. Sánchez-Martín, J. Gosálvez, F. Crespo. Equivalent seminal characteristics in human and stallion at first and second ejaculated fractions. Andrologia 2017, 49 (8) , e12708. https://doi.org/10.1111/and.12708
    83. M. Słowińska, J. Nynca, G.J. Arnold, T. Fröhlich, J. Jankowski, K. Kozłowski, A. Mostek, A. Ciereszko. Proteomic identification of turkey (Meleagris gallopavo) seminal plasma proteins ,. Poultry Science 2017, 96 (9) , 3422-3435. https://doi.org/10.3382/ps/pex132
    84. C. Yang, W.‐b. Guo, W.‐s. Zhang, J. Bian, J.‐k. Yang, Q.‐z. Zhou, M.‐k. Chen, W. Peng, T. Qi, C.‐y. Wang, C.‐d. Liu. Comprehensive proteomics analysis of exosomes derived from human seminal plasma. Andrology 2017, 5 (5) , 1007-1015. https://doi.org/10.1111/andr.12412
    85. Annice Aquino-Cortez, Breno Queiroz Pinheiro, David Baruc Cruvinel Lima, Herlon Victor Rodrigues Silva, Antônio Cavalcante Mota-Filho, Jorge André Matias Martins, Paula Rodriguez-Villamil, Arlindo Alencar Moura, Lúcia Daniel Machado Silva. Proteomic characterization of canine seminal plasma. Theriogenology 2017, 95 , 178-186. https://doi.org/10.1016/j.theriogenology.2017.03.016
    86. Robert Sullivan, Clémence Belleannée. Role of the Epididymis in Sperm Maturation. 2017, 73-87. https://doi.org/10.1017/9781316411124.007
    87. Susan S. Suarez, Mariana F. Wolfner. Seminal Plasma Plays Important Roles in Fertility. 2017, 88-108. https://doi.org/10.1017/9781316411124.008
    88. . The Use of Sperm Proteomics in the Assisted Reproduction Laboratory. 2017, 233-244. https://doi.org/10.1201/9781315151632-19
    89. Jochen Neuhaus, Eric Schiffer, Ferdinando Mannello, Lars-Christian Horn, Roman Ganzer, Jens-Uwe Stolzenburg. Protease Expression Levels in Prostate Cancer Tissue Can Explain Prostate Cancer-Associated Seminal Biomarkers—An Explorative Concept Study. International Journal of Molecular Sciences 2017, 18 (5) , 976. https://doi.org/10.3390/ijms18050976
    90. Karl Smith, Byrne, Jose Maria Castaño, Maria Dolores Chirlaque, Hans Lilja, Antonio Agudo, Eva Ardanaz, Miguel Rodríguez-Barranco, Heiner Boeing, Rudolf Kaaks, Kay-Tee Khaw, Nerea Larrañaga, Carmen Navarro, Anja Olsen, Kim Overvad, Aurora Perez-Cornago, Sabine Rohrmann, Maria José Sánchez, Anne Tjønneland, Konstantinos K. Tsilidis, Mattias Johansson, Elio Riboli, Timothy J. Key, Ruth C. Travis. Vasectomy and Prostate Cancer Risk in the European Prospective Investigation Into Cancer and Nutrition (EPIC). Journal of Clinical Oncology 2017, 35 (12) , 1297-1303. https://doi.org/10.1200/JCO.2016.70.0062
    91. Cristiana Pistol Tanase, Elena Codrici, Ionela Daniela Popescu, Simona Mihai, Ana-Maria Enciu, Laura Georgiana Necula, Adrian Preda, Gener Ismail, Radu Albulescu. Prostate cancer proteomics: Current trends and future perspectives for biomarker discovery. Oncotarget 2017, 8 (11) , 18497-18512. https://doi.org/10.18632/oncotarget.14501
    92. Mohammad Atikuzzaman, Libia Sanz, Davinia Pla, Manuel Alvarez-Rodriguez, Marie Rubér, Dominic Wright, Juan J. Calvete, Heriberto Rodriguez-Martinez. Selection for higher fertility reflects in the seminal fluid proteome of modern domestic chicken. Comparative Biochemistry and Physiology Part D: Genomics and Proteomics 2017, 21 , 27-40. https://doi.org/10.1016/j.cbd.2016.10.006
    93. Ashima Sinha, Savita Yadav. Proteomics of Male Infertility. 2017, 317-345. https://doi.org/10.1007/978-981-10-4017-7_18
    94. Mariana Pereira Antoniassi, Paula Intasqui, Mariana Camargo, Daniel Suslik Zylbersztejn, Valdemir Melechco Carvalho, Karina H. M. Cardozo, Ricardo Pimenta Bertolla. Analysis of the functional aspects and seminal plasma proteomic profile of sperm from smokers. BJU International 2016, 118 (5) , 814-822. https://doi.org/10.1111/bju.13539
    95. Kenneth J. DeLay, Wayne J.G. Hellstrom. Semen proteome alterations in the smoking male: a non‐generalizable study. BJU International 2016, 118 (5) , 673-674. https://doi.org/10.1111/bju.13551
    96. Y.R. Montanholi, A.B.P. Fontoura, M. Diel de Amorim, R.A. Foster, T. Chenier, S.P. Miller. Seminal plasma protein concentrations vary with feed efficiency and fertility-related measures in young beef bulls. Reproductive Biology 2016, 16 (2) , 147-156. https://doi.org/10.1016/j.repbio.2016.04.002
    97. Jun Fu, Rongyan Yao, Yanyun Luo, Dantong Yang, Yang Cao, Yi Qiu, Wei Song, Shiying Miao, Yiqun Gu, Linfang Wang. Anti-GAPDHS antibodies: a biomarker of immune infertility. Cell and Tissue Research 2016, 364 (1) , 199-207. https://doi.org/10.1007/s00441-016-2361-6
    98. Paula Intasqui, Mariana Camargo, Mariana Pereira Antoniassi, Agnaldo Pereira Cedenho, Valdemir Melechco Carvalho, Karina Helena Morais Cardozo, Daniel Suslik Zylbersztejn, Ricardo Pimenta Bertolla. Association between the seminal plasma proteome and sperm functional traits. Fertility and Sterility 2016, 105 (3) , 617-628. https://doi.org/10.1016/j.fertnstert.2015.11.005
    99. Jared M. Bieniek, Kirk C. Lo. Recent advances in understanding & managing male infertility. F1000Research 2016, 5 , 2756. https://doi.org/10.12688/f1000research.9375.1
    100. Paolo Iadarola, Marco Fumagalli, Anna Maria Bardoni, Roberta Salvini, Simona Viglio. Recent applications of CE‐ and HPLC‐MS in the analysis of human fluids. ELECTROPHORESIS 2016, 37 (1) , 212-230. https://doi.org/10.1002/elps.201500272
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    Cite this: J. Proteome Res. 2011, 10, 3, 941–953
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