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Metabolomics of Fecal Extracts Detects Altered Metabolic Activity of Gut Microbiota in Ulcerative Colitis and Irritable Bowel Syndrome
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    Metabolomics of Fecal Extracts Detects Altered Metabolic Activity of Gut Microbiota in Ulcerative Colitis and Irritable Bowel Syndrome
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    Institute of Food Research, Norwich Research Park, Norwich NR4 7UA, United Kingdom
    The Ipswich Hospital NHS Trust, Heath Road, Ipswich IP4 5PD, United Kingdom
    § Norfolk and Norwich University Hospital, Colney Lane, Norwich NR4 7UY, United Kingdom
    E-mail: [email protected]. Telephone: +44 1603 255280. Fax: +44 1603 507723.
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    Journal of Proteome Research

    Cite this: J. Proteome Res. 2011, 10, 9, 4208–4218
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    https://doi.org/10.1021/pr2003598
    Published July 18, 2011
    Copyright © 2011 American Chemical Society

    Abstract

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    1H NMR spectroscopy of aqueous fecal extracts has been used to investigate differences in metabolic activity of gut microbiota in patients with ulcerative colitis (UC) (n = 13), irritable bowel syndrome (IBS) (n = 10), and healthy controls (C) (n = 22). Up to four samples per individual were collected over 2 years giving a total of 124 samples. Multivariate discriminant analysis, based on NMR data from all three groups, was able to predict UC and C group membership with good sensitivity and specificity; classification of IBS samples was less successful and could not be used for diagnosis. Trends were detected toward increased taurine and cadaverine levels in UC with increased bile acid and decreased branched chain fatty acids in IBS relative to controls; changes in short chain fatty acids and amino acids were not significant. Previous PCR-denaturing gradient gel electrophoresis (PCR-DGGE) analysis of the same fecal material had shown alterations of the gut microbiota when comparing UC and IBS groups with controls. Hierarchical cluster analysis showed that DGGE profiles from the same individual were stable over time, but NMR spectra were more variable; canonical correlation analysis of NMR and DGGE data partly separated the three groups and revealed a correlation between the gut microbiota profile and metabolite composition.

    Copyright © 2011 American Chemical Society

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    28. Xuan Ju, Zhenliang Jiang, Jiayin Ma, Dong Yang. Changes in Fecal Short-Chain Fatty Acids in IBS Patients and Effects of Different Interventions: A Systematic Review and Meta-Analysis. Nutrients 2024, 16 (11) , 1727. https://doi.org/10.3390/nu16111727
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    64. Justin X. Boeckman, Sarah Sprayberry, Abby M. Korn, Jan S. Suchodolski, Chad Paulk, Kenneth Genovese, Raquel R. Rech, Paula R. Giaretta, Anna K. Blick, Todd Callaway, Jason J. Gill. Effect of chronic and acute enterotoxigenic E. coli challenge on growth performance, intestinal inflammation, microbiome, and metabolome of weaned piglets. Scientific Reports 2022, 12 (1) https://doi.org/10.1038/s41598-022-08446-z
    65. Luiza Holst, Cristina Iribarren, Maria Sapnara, Otto Savolainen, Hans Törnblom, Yvonne Wettergren, Hans Strid, Magnus Simrén, Maria K. Magnusson, Lena Öhman. Fecal Luminal Factors from Patients with Gastrointestinal Diseases Alter Gene Expression Profiles in Caco-2 Cells and Colonoids. International Journal of Molecular Sciences 2022, 23 (24) , 15505. https://doi.org/10.3390/ijms232415505
    66. Diego Taladrid, Irene Zorraquín‐Peña, Natalia Molinero, Mariana Silva, Noemi Manceñido, Ramón Pajares, Begoña Bartolomé, M. Victoria Moreno‐Arribas. Polyphenols and Ulcerative Colitis: An Exploratory Study of the Effects of Red Wine Consumption on Gut and Oral Microbiome in Active‐Phase Patients. Molecular Nutrition & Food Research 2022, 66 (21) https://doi.org/10.1002/mnfr.202101073
    67. Wenwen Zhang, Yifang Cui, Zihan Liu, Shaoping Wang, Ailin Yang, Xiulian Li, Jiayu Zhang. Astragalus membranaceus ultrafine powder alleviates hyperuricemia by regulating the gut microbiome and reversing bile acid and adrenal hormone biosynthesis dysregulation. Arabian Journal of Chemistry 2022, 15 (9) , 103970. https://doi.org/10.1016/j.arabjc.2022.103970
    68. Pandi He, Leilei Yu, Fengwei Tian, Hao Zhang, Wei Chen, Qixiao Zhai. Dietary Patterns and Gut Microbiota: The Crucial Actors in Inflammatory Bowel Disease. Advances in Nutrition 2022, 13 (5) , 1628-1651. https://doi.org/10.1093/advances/nmac029
    69. Benjamin Churcheward, Maxime Millet, Audrey Bihouée, Guillaume Fertin, Samuel Chaffron, . MAGNETO: An Automated Workflow for Genome-Resolved Metagenomics. mSystems 2022, 7 (4) https://doi.org/10.1128/msystems.00432-22
    70. Cui Cao, Linlin Wang, Chunqing Ai, Guiping Gong, Zhongfu Wang, Linjuan Huang, Shuang Song, Beiwei Zhu. Impact of Lycium barbarum arabinogalactan on the fecal metabolome in a DSS-induced chronic colitis mouse model. Food & Function 2022, 13 (16) , 8703-8716. https://doi.org/10.1039/D2FO01283A
    71. Todor T. Koev, Hannah C. Harris, Sara Kiamehr, Yaroslav Z. Khimyak, Frederick J. Warren. Starch hydrogels as targeted colonic drug delivery vehicles. Carbohydrate Polymers 2022, 289 , 119413. https://doi.org/10.1016/j.carbpol.2022.119413
    72. Amira Metwaly, Sandra Reitmeier, Dirk Haller. Microbiome risk profiles as biomarkers for inflammatory and metabolic disorders. Nature Reviews Gastroenterology & Hepatology 2022, 19 (6) , 383-397. https://doi.org/10.1038/s41575-022-00581-2
    73. Kamyar Khoshnevisan, Maryam Chehrehgosha, Melissa Conant, Amir Mohammad Meftah, Hadi Baharifar, Hanieh-Sadat Ejtahed, Pooneh Angoorani, Morteza Gholami, Farshad Sharifi, Hassan Maleki, Bagher Larijani, Mohammad Reza Khorramizadeh. Interactive relationship between Trp metabolites and gut microbiota: The impact on human pathology of disease. Journal of Applied Microbiology 2022, 132 (6) , 4186-4207. https://doi.org/10.1111/jam.15533
    74. Fangjia Hao, Jiamin Zhu, Ning Zhang, Peng He, Qiandan Miao, Yumin Liu, Yu Gao, Xijian Liu, Guoying Deng, Zhong Zhang, Meiqing Feng, Linjing Zhao. Association between gut microbiome and metabolome in mice suffering from acute carbapenem-resistant Escherichia coli infection. Journal of Pharmaceutical and Biomedical Analysis 2022, 215 , 114770. https://doi.org/10.1016/j.jpba.2022.114770
    75. Leon Deutsch, Tadej Debevec, Gregoire P. Millet, Damjan Osredkar, Simona Opara, Robert Šket, Boštjan Murovec, Minca Mramor, Janez Plavec, Blaz Stres. Urine and Fecal 1H-NMR Metabolomes Differ Significantly between Pre-Term and Full-Term Born Physically Fit Healthy Adult Males. Metabolites 2022, 12 (6) , 536. https://doi.org/10.3390/metabo12060536
    76. Li Yang, Zhao Xiang, Jinmei Zou, Yu Zhang, Yuanpiao Ni, Jing Yang. Comprehensive Analysis of the Relationships Between the Gut Microbiota and Fecal Metabolome in Individuals With Primary Sjogren’s Syndrome by 16S rRNA Sequencing and LC–MS-Based Metabolomics. Frontiers in Immunology 2022, 13 https://doi.org/10.3389/fimmu.2022.874021
    77. Jasmijn Z Jagt, Eduard A Struys, Ibrahim Ayada, Abdellatif Bakkali, Erwin E W Jansen, Jürgen Claesen, Johan E van Limbergen, Marc A Benninga, Nanne K H de Boer, Tim G J de Meij. Fecal Amino Acid Analysis in Newly Diagnosed Pediatric Inflammatory Bowel Disease: A Multicenter Case-Control Study. Inflammatory Bowel Diseases 2022, 28 (5) , 755-763. https://doi.org/10.1093/ibd/izab256
    78. Xuemei Jia, Yunxiao Gao, Liran Liu, Yuxi Guo, Jie Wang, Hongyu Ma, Runyuan Zhao, Bolin Li, Yao Du, Qian Yang, . Artemisinin Alleviates Intestinal Inflammation and Metabolic Disturbance in Ulcerative Colitis Rats Induced by DSS. Evidence-Based Complementary and Alternative Medicine 2022, 2022 , 1-13. https://doi.org/10.1155/2022/6211215
    79. Ian D. Young, Sergey A. Nepogodiev, Ian M. Black, Gwenaelle Le Gall, Alexandra Wittmann, Dimitrios Latousakis, Triinu Visnapuu, Parastoo Azadi, Robert A. Field, Nathalie Juge, Norihito Kawasaki. Lipopolysaccharide associated with β-2,6 fructan mediates TLR4-dependent immunomodulatory activity in vitro. Carbohydrate Polymers 2022, 277 , 118606. https://doi.org/10.1016/j.carbpol.2021.118606
    80. Elizabeth C. Plunk, Weston S. Chambers, Sean M. Richards. System biology. 2022, 3-25. https://doi.org/10.1016/B978-0-323-85062-9.00001-5
    81. M.D. Smirnova, O.N. Svirida, Z.N. Blankova, F.T. Ageev. Atherosclerosis and depression. Obvious and non-obvious relationships. Part II. Kardiologicheskii vestnik 2022, 17 (1) , 14. https://doi.org/10.17116/Cardiobulletin20221701114
    82. Juraj Piestansky, Dominika Olesova, Michaela Matuskova, Ivana Cizmarova, Petra Chalova, Jaroslav Galba, Petra Majerova, Peter Mikus, Andrej Kovac. Amino acids in inflammatory bowel diseases: Modern diagnostic tools and methodologies. 2022, 139-213. https://doi.org/10.1016/bs.acc.2021.07.003
    83. Anna V. Glyakina, Constantine D. Pavlov, Julia V. Sopova, Raul R. Gainetdinov, Elena I. Leonova, Oxana V. Galzitskaya. Search for Structural Basis of Interactions of Biogenic Amines with Human TAAR1 and TAAR6 Receptors. International Journal of Molecular Sciences 2022, 23 (1) , 209. https://doi.org/10.3390/ijms23010209
    84. Maritza Ashton Sirven, Vinicius Paula Venancio, Smriti Shankar, Cory Klemashevich, Maria Joselyn Castellón-Chicas, Chuo Fang, Susanne U. Mertens-Talcott, Stephen T. Talcott. Ulcerative colitis results in differential metabolism of cranberry polyphenols by the colon microbiome in vitro. Food & Function 2021, 12 (24) , 12751-12764. https://doi.org/10.1039/D1FO03047G
    85. Jinhee Kim, Iyshwarya Balasubramanian, Sheila Bandyopadhyay, Ian Nadler, Rajbir Singh, Danielle Harlan, Amanda Bumber, Yuling He, Lee J. Kerkhof, Nan Gao, Xiaoyang Su, Ronaldo P. Ferraris. Lactobacillus rhamnosus GG modifies the metabolome of pathobionts in gnotobiotic mice. BMC Microbiology 2021, 21 (1) https://doi.org/10.1186/s12866-021-02178-2
    86. Sina Marsilio, Betty Chow, Steve L. Hill, Mark R. Ackermann, J. Scot Estep, Benjamin Sarawichitr, Rachel Pilla, Jonathan A. Lidbury, Joerg M. Steiner, Jan S. Suchodolski. Untargeted metabolomic analysis in cats with naturally occurring inflammatory bowel disease and alimentary small cell lymphoma. Scientific Reports 2021, 11 (1) https://doi.org/10.1038/s41598-021-88707-5
    87. Asmita Madatali Abuwani, Shweta Priyadarshini Dash, Raja Ganesan, Kaviyarasi Renu, Balachandar Vellingiri, Sabariswaran Kandasamy, Sundara Rajan C.R., Abilash Valsala Gopalakrishnan. Gut microbiome and metabolic response in non-alcoholic fatty liver disease. Clinica Chimica Acta 2021, 523 , 304-314. https://doi.org/10.1016/j.cca.2021.10.014
    88. Namrata Iyer, Sinéad C. Corr. Gut Microbial Metabolite-Mediated Regulation of the Intestinal Barrier in the Pathogenesis of Inflammatory Bowel Disease. Nutrients 2021, 13 (12) , 4259. https://doi.org/10.3390/nu13124259
    89. Laila Aldars-García, Javier P. Gisbert, María Chaparro. Metabolomics Insights into Inflammatory Bowel Disease: A Comprehensive Review. Pharmaceuticals 2021, 14 (11) , 1190. https://doi.org/10.3390/ph14111190
    90. Wanfeng Wu, Yihang Sun, Ning Luo, Cheng Cheng, Chengting Jiang, Qingping Yu, Shaowu Cheng, Jinwen Ge. Integrated 16S rRNA Gene Sequencing and LC-MS Analysis Revealed the Interplay Between Gut Microbiota and Plasma Metabolites in Rats With Ischemic Stroke. Journal of Molecular Neuroscience 2021, 71 (10) , 2095-2106. https://doi.org/10.1007/s12031-021-01828-4
    91. Lina Zhou, Di Yu, Sijia Zheng, Runze Ouyang, Yuting Wang, Guowang Xu. Gut microbiota-related metabolome analysis based on chromatography-mass spectrometry. TrAC Trends in Analytical Chemistry 2021, 143 , 116375. https://doi.org/10.1016/j.trac.2021.116375
    92. Eliška Ivanovová, Barbora Piskláková, Jaroslava Friedecká, Ondřej Krystyník, David Friedecký, David Karásek. Plasma Short-Chain Fatty Acids and Their Derivatives in Women with Gestational Diabetes Mellitus. Separations 2021, 8 (10) , 188. https://doi.org/10.3390/separations8100188
    93. Na Li, Shukai Zhan, Zhenyi Tian, Caiguang Liu, Zonglin Xie, Shenghong Zhang, Minhu Chen, Zhirong Zeng, Xiaojun Zhuang. Alterations in Bile Acid Metabolism Associated With Inflammatory Bowel Disease. Inflammatory Bowel Diseases 2021, 27 (9) , 1525-1540. https://doi.org/10.1093/ibd/izaa342
    94. Alesia Walker, Philippe Schmitt-Kopplin. The role of fecal sulfur metabolome in inflammatory bowel diseases. International Journal of Medical Microbiology 2021, 311 (5) , 151513. https://doi.org/10.1016/j.ijmm.2021.151513
    95. Kate Gallagher, Alexandra Catesson, Julian L Griffin, Elaine Holmes, Horace R T Williams. Metabolomic Analysis in Inflammatory Bowel Disease: A Systematic Review. Journal of Crohn's and Colitis 2021, 15 (5) , 813-826. https://doi.org/10.1093/ecco-jcc/jjaa227
    96. Hyo Shin Yoon, Chung Hwan Cho, Myeong Sik Yun, Sung Jae Jang, Hyun Ju You, Jun-hyeong Kim, Dohyun Han, Kwang Hyun Cha, Sung Hyun Moon, Kiuk Lee, Yeon-Ji Kim, Sung-Joon Lee, Tae-Wook Nam, GwangPyo Ko. Akkermansia muciniphila secretes a glucagon-like peptide-1-inducing protein that improves glucose homeostasis and ameliorates metabolic disease in mice. Nature Microbiology 2021, 6 (5) , 563-573. https://doi.org/10.1038/s41564-021-00880-5
    97. Alessia Vignoli, Emanuela Risi, Amelia McCartney, Ilenia Migliaccio, Erica Moretti, Luca Malorni, Claudio Luchinat, Laura Biganzoli, Leonardo Tenori. Precision Oncology via NMR-Based Metabolomics: A Review on Breast Cancer. International Journal of Molecular Sciences 2021, 22 (9) , 4687. https://doi.org/10.3390/ijms22094687
    98. Wenjing Yang, Yingzi Cong. Gut microbiota-derived metabolites in the regulation of host immune responses and immune-related inflammatory diseases. Cellular & Molecular Immunology 2021, 18 (4) , 866-877. https://doi.org/10.1038/s41423-021-00661-4
    99. Yu Yu, Wenjing Yang, Anthony J. Bilotta, Xiaojing Zhao, Yingzi Cong, Yanqing Li. L‐lactate promotes intestinal epithelial cell migration to inhibit colitis. The FASEB Journal 2021, 35 (4) https://doi.org/10.1096/fj.202100095R
    100. M Effenberger, S Reider, S Waschina, C Bronowski, B Enrich, T E Adolph, R Koch, A R Moschen, P Rosenstiel, K Aden, H Tilg. Microbial Butyrate Synthesis Indicates Therapeutic Efficacy of Azathioprine in IBD Patients. Journal of Crohn's and Colitis 2021, 15 (1) , 88-98. https://doi.org/10.1093/ecco-jcc/jjaa152
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