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Download Hi-Res ImageDownload to MS-PowerPointCite This:J. Proteome Res. 2012, 11, 6, 3449-3457
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Metabolic Fate of Tea Polyphenols in Humans

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† School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China
‡ Department of Nutrition, University of North Carolina at Greensboro, North Carolina Research Campus, Kannapolis, North Carolina 28081, United States
§ X-omics Center for Metabolic Disease and Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai 200233, China
∥ Department of Bioinformatics, University of North Carolina at Charlotte, North Carolina 28223, United States
⊥ Key Laboratory of Drug Targeting and Drug Delivery Systems, Ministry of Education, West China School of Pharmacy, Sichuan University, Sichuan 610041, China
*E-mail: [email protected]. Phone: 704-250-5803. Fax: 704-250-5809.
Cite this: J. Proteome Res. 2012, 11, 6, 3449–3457
Publication Date (Web):May 7, 2012
https://doi.org/10.1021/pr300318m
Copyright © 2012 American Chemical Society
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Abstract

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Polyphenols, a ubiquitous group of secondary plant metabolites sharing at least one aromatic ring structure with one or more hydroxyl groups, represent a large group of natural antioxidants abundant in fruits, vegetables, and beverages, such as grape juice, wine, and tea, and are widely considered to contribute to health benefits in humans. However, little is yet known concerning their bioactive forms in vivo and the mechanisms by which they may alter our metabolome, which ultimately contribute toward disease prevention. Here we report a study to determine the metabolic fate of polyphenolic components in a Chinese tea (Pu-erh) in human subjects using a metabonomic profiling approach coupled with multivariate and univariate statistical analysis. Urine samples were collected at 0 h, 1 h, 3 h, 6 h, 9 h, 12 h, and 24 h within the first 24 h and once a day during a 6 week period including a 2 week baseline phase, a 2 week daily Pu-erh tea ingestion phase, and a 2 week “wash-out” phase, and they were analyzed by gas chromatography mass spectrometry and liquid chromatography mass spectrometry. The dynamic concentration profile of bioavailable plant molecules (due to in vivo absorption and the hepatic and gut bacterial metabolism) and the human metabolic response profile were measured and correlated with each other. This study demonstrates that the metabonomic strategy will enable us to integrate the overwhelming amount of metabolic end points as a systems' response to the absorption, metabolism, and disposition of a multicomponent botanical intervention system, leading to a direct elucidation of their mechanisms of action.

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Supplementary methods; information including standard meals, body weight, blood pressure, and bedtime and morning time of participants; identified bioavailable pu-erh tea components; metabolites produced in vivo after pu-erh tea intake; altered endogenous metabolites intervened by pu-erh tea ingestion; differential metabolites detected from the metabonome after Pu-erh tea intake (postdose) as compared to predose metabonome; representative base peak intensity (BPI) chromatograms of pu-erh tea and urine at different time points derived from UPLC-QTOFMS analysis; representative total ion current (TIC) chromatograms of pu-erh tea and urine at different time points derived from GC-TOFMS analysis; PCA scores plot obtained from human urine samples at different time points; OPLS-DA scores plots and S-plots of metabonomic comparison among the groups of 24 h, 2 week, and 2 week wash-out after pu-erh tea intake based on the spectral data of (A) UPLC-QTOFMS analysis and (B) GC-TOFMS analysis. This material is available free of charge via the Internet at http://pubs.acs.org.

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