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Variability, Heritability and Environmental Determinants of Human Plasma N-Glycome

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Department of Biochemistry and Molecular Biology, University of Zagreb, Faculty of Pharmacy and Biochemistry, Zagreb, Croatia, Andrija Štampar School of Public Health, University of Zagreb Medical School, Zagreb, Croatia, Croatian Centre for Global Health, University of Split Medical School, Split, and Institute for Clinical Medical Research, University Hospital “Sestre Milosrdnice”, Zagreb, Croatia, Public Health Sciences, University of Edinburgh, Edinburgh EH8 9AG, United Kingdom, MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, United Kingdom, Dublin-Oxford Glycobiology Laboratory, NIBRT, Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland, and Genos d.o.o., Trg Ljudevita Gaja 6, 31000 Osijek, Croatia
* To whom correspondence should be addressed. Dr. Gordan Lauc, Department of Biochemistry and Molecular Biology, University of Zagreb, Faculty of Pharmacy and Biochemistry, A. Kovačića 1, 10 000 Zagreb, Croatia. Fax, +385 1 639 4400; e-mail, [email protected]
†University of Zagreb.
‡University of Zagreb Medical School.
§University of Split Medical School.
∥University of Edinburgh.
⊥Western General Hospital.
#University College Dublin.
∇Genos d.o.o.
Cite this: J. Proteome Res. 2009, 8, 2, 694–701
Publication Date (Web):November 26, 2008
https://doi.org/10.1021/pr800737u
Copyright © 2008 American Chemical Society

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    Abstract

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    Plasma glycans were analyzed in 1008 individuals to evaluate variability and heritability, as well as the main environmental determinants that affect glycan structures. By combining HPLC analysis of fluorescently labeled glycans with sialidase digestion, glycans were separated into 33 chromatographic peaks and quantified. A high level of variability was observed with the median ratio of minimal to maximal values of 6.17 and significant age- and gender-specific differences. Heritability estimates for individual glycans varied widely, ranging from very low to very high. Glycome-wide environmental determinants were also detected with statistically significant effects of different variables including diet, smoking and cholesterol levels.

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