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Variability, Heritability and Environmental Determinants of Human Plasma N-Glycome

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Department of Biochemistry and Molecular Biology, University of Zagreb, Faculty of Pharmacy and Biochemistry, Zagreb, Croatia, Andrija Štampar School of Public Health, University of Zagreb Medical School, Zagreb, Croatia, Croatian Centre for Global Health, University of Split Medical School, Split, and Institute for Clinical Medical Research, University Hospital “Sestre Milosrdnice”, Zagreb, Croatia, Public Health Sciences, University of Edinburgh, Edinburgh EH8 9AG, United Kingdom, MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, United Kingdom, Dublin-Oxford Glycobiology Laboratory, NIBRT, Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland, and Genos d.o.o., Trg Ljudevita Gaja 6, 31000 Osijek, Croatia
* To whom correspondence should be addressed. Dr. Gordan Lauc, Department of Biochemistry and Molecular Biology, University of Zagreb, Faculty of Pharmacy and Biochemistry, A. Kovačića 1, 10 000 Zagreb, Croatia. Fax, +385 1 639 4400; e-mail, [email protected]
†University of Zagreb.
‡University of Zagreb Medical School.
§University of Split Medical School.
∥University of Edinburgh.
⊥Western General Hospital.
#University College Dublin.
∇Genos d.o.o.
Cite this: J. Proteome Res. 2009, 8, 2, 694–701
Publication Date (Web):November 26, 2008
Copyright © 2008 American Chemical Society

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    Abstract Image

    Plasma glycans were analyzed in 1008 individuals to evaluate variability and heritability, as well as the main environmental determinants that affect glycan structures. By combining HPLC analysis of fluorescently labeled glycans with sialidase digestion, glycans were separated into 33 chromatographic peaks and quantified. A high level of variability was observed with the median ratio of minimal to maximal values of 6.17 and significant age- and gender-specific differences. Heritability estimates for individual glycans varied widely, ranging from very low to very high. Glycome-wide environmental determinants were also detected with statistically significant effects of different variables including diet, smoking and cholesterol levels.

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    50. Jasminka Krištić, Sodbo Zh. Sharapov, Yurii S. Aulchenko. Quantitative Genetics of Human Protein N-Glycosylation. 2021, 151-171.
    51. Rossella Indellicato, Marco Trinchera. Epigenetic Regulation of Glycosylation. 2021, 173-186.
    52. Fabio Dall’Olio, Nadia Malagolini. Immunoglobulin G Glycosylation Changes in Aging and Other Inflammatory Conditions. 2021, 303-340.
    53. Kaitlyn A. Lagattuta, Peter A. Nigrovic. Estrogen-Driven Changes in Immunoglobulin G Fc Glycosylation. 2021, 341-361.
    54. M. Muenchhoff, A. W. Chung, J. Roider, Anne-Sophie Dugast, Simone Richardson, Henrik Kløverpris, Alasdair Leslie, Thumbi Ndung’u, Penny Moore, Galit Alter, Philip J. R. Goulder, . Distinct Immunoglobulin Fc Glycosylation Patterns Are Associated with Disease Nonprogression and Broadly Neutralizing Antibody Responses in Children with HIV Infection. mSphere 2020, 5 (6)
    55. L.R. Ruhaak, C.M. Cobbaert. Quantifying apolipoprotein(a) in the era of proteoforms and precision medicine. Clinica Chimica Acta 2020, 511 , 260-268.
    56. Qingqing Wu, Yao Yang, Dongni Xie, Shuang Li, Yunfei Liu, Linjing Shu, Gang Fu, Yamei Xu, Ping Ji. The sialylation profile of IgG determines the efficiency of antibody directed osteogenic differentiation of iMSCs by modulating local immune responses and osteoclastogenesis. Acta Biomaterialia 2020, 114 , 221-232.
    57. Yuka Kishimoto, Fuka Okada, Tomohiro Maesako, Sachio Yamamoto, Mitsuhiro Kinoshita, Takao Hayakawa, Shigeo Suzuki. Analysis of 2-aminopyridine labeled glycans by dual-mode online solid phase extraction for hydrophilic interaction and reversed-phase liquid chromatography. Journal of Chromatography A 2020, 1625 , 461194.
    58. Jodie L Abrahams, Ghazaleh Taherzadeh, Gabor Jarvas, Andras Guttman, Yaoqi Zhou, Matthew P Campbell. Recent advances in glycoinformatic platforms for glycomics and glycoproteomics. Current Opinion in Structural Biology 2020, 62 , 56-69.
    59. Gordan Lauc, Alemka Markotić, Ivan Gornik, Dragan Primorac. Fighting COVID-19 with water. Journal of Global Health 2020, 10 (1)
    60. Alessandro Quaranta, Maya Spasova, Elena Passarini, Isabella Karlsson, Lorena Ndreu, Gunnar Thorsén, Leopold L. Ilag. N -Glycosylation profiling of intact target proteins by high-resolution mass spectrometry (MS) and glycan analysis using ion mobility-MS/MS. The Analyst 2020, 145 (5) , 1737-1748.
    61. Mendy M Welsink-Karssies, Sacha Ferdinandusse, Gert J Geurtsen, Carla E M Hollak, Hidde H Huidekoper, Mirian C H Janssen, Janneke G Langendonk, Johanna H van der Lee, Roisin O’Flaherty, Kim J Oostrom, Stefan D Roosendaal, M Estela Rubio-Gozalbo, Radka Saldova, Eileen P Treacy, Fred M Vaz, Maaike C de Vries, Marc Engelen, Annet M Bosch. Deep phenotyping classical galactosemia: clinical outcomes and biochemical markers. Brain Communications 2020, 2 (1)
    62. Guinevere S. M. Lageveen-Kammeijer, Noortje de Haan, Pablo Mohaupt, Sander Wagt, Mike Filius, Jan Nouta, David Falck, Manfred Wuhrer. Highly sensitive CE-ESI-MS analysis of N-glycans from complex biological samples. Nature Communications 2019, 10 (1)
    63. Jiaonan Liu, Mamatyusupu Dolikun, Jerko Štambuk, Irena Trbojević-Akmačić, Jie Zhang, Jinxia Zhang, Hao Wang, Xiaoni Meng, Genadij Razdorov, Desmond Menon, Deqiang Zheng, Lijuan Wu, Youxin Wang, Manshu Song, Gordan Lauc, Wei Wang. Glycomics for Type 2 Diabetes Biomarker Discovery: Promise of Immunoglobulin G Subclass-Specific Fragment Crystallizable N-glycosylation in the Uyghur Population. OMICS: A Journal of Integrative Biology 2019, 23 (12) , 640-648.
    64. Viktoria Dotz, Manfred Wuhrer. N ‐glycome signatures in human plasma: associations with physiology and major diseases. FEBS Letters 2019, 593 (21) , 2966-2976.
    65. Ngoc Nguyen Lunde, Tatjana Bosnjak, Rigmor Solberg, Harald Thidemann Johansen. Mammalian legumain – A lysosomal cysteine protease with extracellular functions?. Biochimie 2019, 166 , 77-83.
    66. Róisín O'Flaherty, Mohankumar Muniyappa, Ian Walsh, Henning Stöckmann, Mark Hilliard, Richard Hutson, Radka Saldova, Pauline M. Rudd. A Robust and Versatile Automated Glycoanalytical Technology for Serum Antibodies and Acute Phase Proteins: Ovarian Cancer Case Study. Molecular & Cellular Proteomics 2019, 18 (11) , 2191-2206.
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    69. Najda Rudman, Olga Gornik, Gordan Lauc. Altered N‐glycosylation profiles as potential biomarkers and drug targets in diabetes. FEBS Letters 2019, 593 (13) , 1598-1615.
    70. Andrew R. Ednie, Austin R. Parrish, Martha J. Sonner, Eric S. Bennett. Reduced hybrid/complex N-glycosylation disrupts cardiac electrical signaling and calcium handling in a model of dilated cardiomyopathy. Journal of Molecular and Cellular Cardiology 2019, 132 , 13-23.
    71. Freja Scheys, Kristof De Schutter, Ying Shen, Na Yu, Nicolas Smargiasso, Edwin De Pauw, Els J.M. Van Damme, Guy Smagghe. The N-glycome of the hemipteran pest insect Nilaparvata lugens reveals unexpected sex differences. Insect Biochemistry and Molecular Biology 2019, 107 , 39-45.
    72. Sodbo Zh Sharapov, Yakov A Tsepilov, Lucija Klaric, Massimo Mangino, Gaurav Thareja, Alexandra S Shadrina, Mirna Simurina, Concetta Dagostino, Julia Dmitrieva, Marija Vilaj, Frano Vuckovic, Tamara Pavic, Jerko Stambuk, Irena Trbojevic-Akmacic, Jasminka Kristic, Jelena Simunovic, Ana Momcilovic, Harry Campbell, Margaret Doherty, Malcolm G Dunlop, Susan M Farrington, Maja Pucic-Bakovic, Christian Gieger, Massimo Allegri, Edouard Louis, Michel Georges, Karsten Suhre, Tim Spector, Frances M K Williams, Gordan Lauc, Yurii S Aulchenko. Defining the genetic control of human blood plasma N-glycome using genome-wide association study. Human Molecular Genetics 2019, 3
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    74. M. Vilaj, I. Gudelj, I. Trbojević-Akmačić, G. Lauc, M. Pezer. IgG Glycans as a Biomarker of Biological Age. 2019, 81-99.
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    78. Ivan Gudelj, Gordan Lauc, Marija Pezer. Immunoglobulin G glycosylation in aging and diseases. Cellular Immunology 2018, 333 , 65-79.
    79. Irena Trbojević-Akmačić, Frano Vučković, Marija Vilaj, Andrea Skelin, Lennart C. Karssen, Jasminka Krištić, Julija Jurić, Ana Momčilović, Jelena Šimunović, Massimo Mangino, Manuela De Gregori, Maurizio Marchesini, Concetta Dagostino, Jerko Štambuk, Mislav Novokmet, Richard Rauck, Yurii S. Aulchenko, Dragan Primorac, Leonardo Kapural, Klaas Buyse, Dieter Mesotten, Frances M.K. Williams, Jan van Zundert, Massimo Allegri, Gordan Lauc. Plasma N-glycome composition associates with chronic low back pain. Biochimica et Biophysica Acta (BBA) - General Subjects 2018, 1862 (10) , 2124-2133.
    80. Surya Kumari Vadrevu, Irena Trbojevic-Akmacic, Andrew V Kossenkov, Florent Colomb, Leila B Giron, Alitzel Anzurez, Kenneth Lynn, Karam Mounzer, Alan L Landay, Robert C Kaplan, Emmanouil Papasavvas, Luis J Montaner, Gordan Lauc, Mohamed Abdel-Mohsen. Frontline Science: Plasma and immunoglobulin G galactosylation associate with HIV persistence during antiretroviral therapy. Journal of Leukocyte Biology 2018, 104 (3) , 461-471.
    81. Tereza Dědová, Detlef Grunow, Kai Kappert, Dagmar Flach, Rudolf Tauber, Véronique Blanchard, . The effect of blood sampling and preanalytical processing on human N-glycome. PLOS ONE 2018, 13 (7) , e0200507.
    82. Si Liu, Liming Cheng, Yang Fu, Bi-Feng Liu, Xin Liu. Characterization of IgG N-glycome profile in colorectal cancer progression by MALDI-TOF-MS. Journal of Proteomics 2018, 181 , 225-237.
    83. Davide Alocci, Marie Ghraichy, Elena Barletta, Alessandra Gastaldello, Julien Mariethoz, Frederique Lisacek. Understanding the glycome: an interactive view of glycosylation from glycocompositions to glycoepitopes. Glycobiology 2018, 28 (6) , 349-362.
    84. Domenico Tehran, Marco Pirazzini. Novel Botulinum Neurotoxins: Exploring Underneath the Iceberg Tip. Toxins 2018, 10 (5) , 190.
    85. Sakari Joenvaara, Mayank Saraswat, Pentti Kuusela, Shruti Saraswat, Rahul Agarwal, Johanna Kaartinen, Asko Järvinen, Risto Renkonen, . Quantitative N-glycoproteomics reveals altered glycosylation levels of various plasma proteins in bloodstream infected patients. PLOS ONE 2018, 13 (3) , e0195006.
    86. Fabio Dall’Olio. Glycobiology of Aging. 2018, 505-526.
    87. Ran Wang, Yufei Liu, Chang Wang, Henghui Li, Xin Liu, Liming Cheng, Yanhong Zhou. Comparison of the methods for profiling N -glycans—hepatocellular carcinoma serum glycomics study. RSC Advances 2018, 8 (46) , 26116-26123.
    88. Isabella Karlsson, Lorena Ndreu, Alessandro Quaranta, Gunnar Thorsén. Glycosylation patterns of selected proteins in individual serum and cerebrospinal fluid samples. Journal of Pharmaceutical and Biomedical Analysis 2017, 145 , 431-439.
    89. Ngoc Nguyen Lunde, Mads Haugland Haugen, Kristina Broe Bodin Larsen, Ingrid Damgaard, Solveig J. Pettersen, Roya Kasem, Wioletta Rut, Marcin Drag, Marcin Poreba, Harald Thidemann Johansen, Rigmor Solberg. Glycosylation is important for legumain localization and processing to active forms but not for cystatin E/M inhibitory functions. Biochimie 2017, 139 , 27-37.
    90. Daniela Monti, Rita Ostan, Vincenzo Borelli, Gastone Castellani, Claudio Franceschi. Inflammaging and human longevity in the omics era. Mechanisms of Ageing and Development 2017, 165 , 129-138.
    91. Qing Gao, Mamatyusupu Dolikun, Jerko Štambuk, Hao Wang, Feifei Zhao, Nizam Yiliham, Youxin Wang, Irena Trbojević-Akmačić, Jie Zhang, Honghong Fang, Yang Sun, Hongli Peng, Zhongyao Zhao, Di Liu, Jiaonan Liu, Qihuan Li, Qi Sun, Lijuan Wu, Gordan Lauc, Wei Wang, Manshu Song. Immunoglobulin G N -Glycans as Potential Postgenomic Biomarkers for Hypertension in the Kazakh Population. OMICS: A Journal of Integrative Biology 2017, 21 (7) , 380-389.
    92. Toma Keser, Frano Vučković, Clara Barrios, Jonas Zierer, Annika Wahl, Akintunde O Akinkuolie, Jerko Štambuk, Natali Nakić, Tamara Pavić, Josipa Periša, Samia Mora, Christian Gieger, Cristina Menni, Tim D Spector, Olga Gornik, Gordan Lauc. Effects of statins on the immunoglobulin G glycome. Biochimica et Biophysica Acta (BBA) - General Subjects 2017, 1861 (5) , 1152-1158.
    93. Madeleine F. Jennewein, Galit Alter. The Immunoregulatory Roles of Antibody Glycosylation. Trends in Immunology 2017, 38 (5) , 358-372.
    94. Alyce C Russell, Mirna Šimurina, Monique T Garcia, Mislav Novokmet, Youxin Wang, Igor Rudan, Harry Campbell, Gordan Lauc, Meghan G Thomas, Wei Wang. The N-glycosylation of immunoglobulin G as a novel biomarker of Parkinson's disease. Glycobiology 2017, 27 (5) , 501-510.
    95. Marco Pirazzini, Ornella Rossetto, Roberto Eleopra, Cesare Montecucco, . Botulinum Neurotoxins: Biology, Pharmacology, and Toxicology. Pharmacological Reviews 2017, 69 (2) , 200-235.
    96. Aleksandra Fucic, Vedrana Guszak, Toma Keser, Jasenka Wagner, Emilja Juretić, Davor Plavec, Ranko Stojković, Olga Gornik, Gordan Lauc. Micronucleus, cell-free DNA, and plasma glycan composition in the newborns of healthy and diabetic mothers. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 2017, 815 , 6-15.
    97. Karli R. Reiding, L. Renee Ruhaak, Hae-Won Uh, Said el Bouhaddani, Erik B. van den Akker, Rosina Plomp, Liam A. McDonnell, Jeanine J. Houwing-Duistermaat, P. Eline Slagboom, Marian Beekman, Manfred Wuhrer. Human Plasma N-glycosylation as Analyzed by Matrix-Assisted Laser Desorption/Ionization-Fourier Transform Ion Cyclotron Resonance-MS Associates with Markers of Inflammation and Metabolic Health. Molecular & Cellular Proteomics 2017, 16 (2) , 228-242.
    98. Jasminka Krištić, Gordan Lauc. Ubiquitous Importance of Protein Glycosylation. 2017, 1-12.
    99. Barbara Adamczyk, Henning Stöckmann, Róisín O’Flaherty, Niclas G. Karlsson, Pauline M. Rudd. High-Throughput Analysis of the Plasma N-Glycome by UHPLC. 2017, 97-108.
    100. Yoshie NAGATOMO, Shinichi HASHIMOTO, Yuka KISHIMOTO, Takao HAYAKAWA, Sachio YAMAMOTO, Mitsuhiro KINOSHITA, Shigeo SUZUKI. Online Cleanup Liquid Chromatography for the Analysis of Glycoprotein-Derived Oligosaccharides Labeled with 7-Amino-4-methylcoumarin. CHROMATOGRAPHY 2017, 38 (1) , 23-30.
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