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Vascular MMP-9/TIMP-2 and Neuronal MMP-10 Up-Regulation in Human Brain after Stroke: A Combined Laser Microdissection and Protein Array Study

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    Vascular MMP-9/TIMP-2 and Neuronal MMP-10 Up-Regulation in Human Brain after Stroke: A Combined Laser Microdissection and Protein Array Study
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    Neurovascular Research Laboratory, Neurovascular Unit, Department of Neurology, Department of Internal Medicine, Universitat Autònoma de Barcelona, Institut de Recerca, Hospital Vall d’Hebron, Barcelona, Spain, SBCHS, Manchester Metropolitan University, Manchester, United Kingdom, and Neuropathology Unit, Department of Pathology, Hospital Vall d’Hebron, Barcelona, Spain
    * To whom correspondence should be addressed. Dr Joan Montaner, Neurovascular Research Laboratory, Neurovascular Unit, Institut de Recerca, Hospital Vall d’Hebron, Pg Vall d’Hebron 119-129, 08035 Barcelona, Spain. Telephone number: +34934894073. Fax number: +34934894015. E-mail: [email protected]
    †Institut de Recerca, Hospital Vall d’Hebron.
    ‡Manchester Metropolitan University.
    §Department of Pathology, Hospital Vall d’Hebron.
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    Journal of Proteome Research

    Cite this: J. Proteome Res. 2009, 8, 6, 3191–3197
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    https://doi.org/10.1021/pr801012x
    Published March 24, 2009
    Copyright © 2009 American Chemical Society
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    Abstract

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    Matrix Metalloproteinases (MMPs) play an important role in brain injury after ischemic stroke. In the present study, we aimed to assess the global expression of MMP-Family proteins in the human brain after stroke by using a combination of Searchlight Protein Array and Laser Microdissection to determine their cellular origin. This study demonstrated that MMP-1, MMP-2, MMP-3, MMP-8, MMP-9, MMP-10, MMP-13, and TIMP-1 were upregulated in the infarcted tissue compared to healthy control areas. Using laser microdissection we obtained specific neuronal and vascular populations from both infarcted and control areas. From these fractions, we showed that MMP-9 and TIMP-2 were highly produced in brain microvessels while MMP-10 was notably increased in neurons of the ischemic brain but not in healthy areas. These findings demonstrate a selective cell-dependent MMP secretion, opening the possibility of selectively targeting specific MMPs for neuroprotection or vasculoprotection following stroke.

    Copyright © 2009 American Chemical Society

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    Cite this: J. Proteome Res. 2009, 8, 6, 3191–3197
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    Published March 24, 2009
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