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A Comparative Environmental Assessment for the Synthesis of 1,3-Oxazin-2-one by Metrics: Greenness Evaluation and Blind Spots

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Department of Environmental Science, Informatics and Statistics, University Ca’ Foscari of Venice, 2137 Dorsoduro, 30123 Venezia, Italy
*Fax: +39 041 234 8600. Tel: +39 041 234 8642. E-mail: [email protected]
Cite this: ACS Sustainable Chem. Eng. 2014, 2, 4, 1056–1062
Publication Date (Web):March 6, 2014
https://doi.org/10.1021/sc500070t
Copyright © 2014 American Chemical Society
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    Abstract

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    Alternative syntheses for the production of 3-benzyl-1,3-oxazinan-2-one are compared and evaluated employing green metrics. An environmental assessment has been performed using the algorithm recently developed by Andraos that takes into account the mass flows and the software EATOS that considers mass flows, environmental impacts of the substances involved, and waste produced. Strengths and critical spots of the environmental tools employed are also discussed. Data collected showed that the synthesis employing diethyl carbonate is the most promising one, having the lowest environmental impact.

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    S–1, EIin, E, and EIout data calculated by EATOS software, as well as the spreadsheets of the Andraos algorithm for syntheses A–D. This material is available free of charge via the Internet at http://pubs.acs.org.

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