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Binding of Perfluorooctanoic Acid to Rat and Human Plasma Proteins

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DuPont Haskell Laboratory for Health and Environmental Sciences, P.O. Box 50, Newark, Delaware 19714
Cite this: Chem. Res. Toxicol. 2003, 16, 6, 775–781
Publication Date (Web):May 16, 2003
Copyright © 2003 American Chemical Society

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    Perfluorooctanoic acid (PFOA) is a commercially important organic fluorochemical and is considered to have a long half-life in human blood. In this paper, PFOA binding to rat and human plasma proteins was investigated. On the basis of results from size-exclusion chromatography and ligand blotting, most PFOA was in protein-bound form in male and female rat plasma, and the primary PFOA binding protein in plasma was serum albumin. PFOA binding to rat serum albumin (RSA) in the gas phase was observed by electrospray ionization MS. 19F NMR experiments revealed that binding to RSA caused peak broadening and chemical shift changes of PFOA resonances, and on the basis of this observation, the dissociation constant was determined to be ∼0.3 mM. The dissociation constants for PFOA binding to RSA and human serum albumin (HSA) and the numbers of PFOA binding sites on RSA and HSA were also determined by a separation method using microdesalting columns. No significant difference was found between PFOA binding to RSA and PFOA binding to HSA. The dissociation constants for binding of PFOA to RSA or HSA and the numbers of PFOA binding sites were in the range of 0.3−0.4 mM and 6−9, respectively. On the basis of these binding parameters and the estimated plasma concentration of serum albumin, greater than 90% of PFOA would be bound to serum albumin in both rat and human blood.

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    91. Alexander East, Daniel E. Dawson, Sydney Brady, Daniel A. Vallero, Rogelio Tornero-Velez. A Scoping Assessment of Implemented Toxicokinetic Models of Per- and Polyfluoro-Alkyl Substances, with a Focus on One-Compartment Models. Toxics 2023, 11 (2) , 163.
    92. G. Moro, F. Chiavaioli, P. Zubiate, I. Del Villar, F. Baldini, K. De Wael, L. M. Moretto, A. Giannetti. Albumin-Based Optical and Electrochemical Biosensors for PFAS Detection: A Comparison. 2023, 1-15.
    93. S. Mikolajczyk, M. Warenik-Bany, M. Pajurek. Infant formula and baby food as a source of perfluoroalkyl substances for infants. Environmental Pollution 2023, 317 , 120810.
    94. Wei Wang, Xiang Hong, Fanqi Zhao, Jingying Wu, Bei Wang. The effects of perfluoroalkyl and polyfluoroalkyl substances on female fertility: A systematic review and meta-analysis. Environmental Research 2023, 216 , 114718.
    95. Sandra Nilsson, Kayla Smurthwaite, Lesa L. Aylward, Margaret Kay, Leisa-Maree Toms, Leisa King, Shelby Marrington, Martyn D. Kirk, Jochen F. Mueller, Jennifer Bräunig. Associations between serum perfluoroalkyl acid (PFAA) concentrations and health related biomarkers in firefighters. Environmental Research 2022, 215 , 114370.
    96. Åsa Gustafsson, Bei Wang, Per Gerde, Åke Bergman, Leo W. Y. Yeung. Bioavailability of inhaled or ingested PFOA adsorbed to house dust. Environmental Science and Pollution Research 2022, 29 (52) , 78698-78710.
    97. Heidelore Fiedler, Mohammad Sadia, Thomas Krauss, Abeer Baabish, Leo W. Y. Yeung. Perfluoroalkane acids in human milk under the global monitoring plan of the Stockholm Convention on Persistent Organic Pollutants (2008–2019). Frontiers of Environmental Science & Engineering 2022, 16 (10)
    98. S. Nilsson, K. Smurthwaite, L.L. Aylward, M. Kay, L.M. Toms, L. King, S. Marrington, C. Barnes, M.D. Kirk, J.F. Mueller, J. Bräunig. Serum concentration trends and apparent half-lives of per- and polyfluoroalkyl substances (PFAS) in Australian firefighters. International Journal of Hygiene and Environmental Health 2022, 246 , 114040.
    99. Yingxue Liu, An Li, Qi An, Kai Liu, Ping Zheng, Shanshan Yin, Weiping Liu. Prenatal and postnatal transfer of perfluoroalkyl substances from mothers to their offspring. Critical Reviews in Environmental Science and Technology 2022, 52 (14) , 2510-2537.
    100. Erik T. Hernandez, Byungjin Koo, Laura E. Sofen, Radhesh Amin, Riley K. Togashi, Arya I. Lall, Daryl J. Gisch, Brandon J. Kern, Mark A. Rickard, Matthew B. Francis. Proteins as adsorbents for PFAS removal from water. Environmental Science: Water Research & Technology 2022, 8 (6) , 1188-1194.
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