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Toxicity of Polyamines and Their Metabolic Products

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Download Hi-Res ImageDownload to MS-PowerPointCite This:Chem. Res. Toxicol. 2013, 26, 12, 1782-1800
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    Toxicity of Polyamines and Their Metabolic Products
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    Department of Cellular and Molecular Physiology, Milton S. Hershey Medical Center, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, United States
    *Department of Cellular and Molecular Physiology, Room C4739B, Pennsylvania State University College of Medicine, The Milton S. Hershey Medical Center, P.O. Box 850, 500 University Drive, Hershey, PA 17033, USA. Phone: 717-531-8152. E-mail: [email protected]
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    Chemical Research in Toxicology

    Cite this: Chem. Res. Toxicol. 2013, 26, 12, 1782–1800
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    https://doi.org/10.1021/tx400316s
    Published November 13, 2013
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    Abstract

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    Polyamines are ubiquitous and essential components of mammalian cells. They have multiple functions including critical roles in nucleic acid and protein synthesis, gene expression, protein function, protection from oxidative damage, the regulation of ion channels, and maintenance of the structure of cellular macromolecules. It is essential to maintain a correct level of polyamines, and this amount is tightly regulated at the levels of transport, synthesis, and degradation. Catabolic pathways generate reactive aldehydes including acrolein and hydrogen peroxide via a number of oxidases. These metabolites, particularly those from spermine, can cause significant toxicity with damage to proteins, DNA, and other cellular components. Their production can be increased as a result of infection or cell damage that releases free polyamines and activates the oxidative catabolic pathways. Since polyamines also have an important physiological role in protection from oxidative damage, the reduction in polyamine content may exacerbate the toxic potential of these agents. Increases in polyamine catabolism have been implicated in the development of diseases including stroke, other neurological diseases, renal failure, liver disease, and cancer. These results provide new opportunities for the early diagnosis, prevention, and treatment of disease.

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    3. Chiao Lo, Ya-Lin Hsu, Chih-Ning Cheng, Ching-Hung Lin, Han-Chun Kuo, Chiun-Sheng Huang, Ching-Hua Kuo. Investigating the Association of the Biogenic Amine Profile in Urine with Therapeutic Response to Neoadjuvant Chemotherapy in Breast Cancer Patients. Journal of Proteome Research 2020, 19 (10) , 4061-4070. https://doi.org/10.1021/acs.jproteome.0c00362
    4. Xiaoyun Jiang, Dingmin Zhang, Yongling Lu, Lishuang Lv. Acrolein-Trapping Mechanism of Theophylline in Green Tea, Coffee, and Cocoa: Speedy and Successful. Journal of Agricultural and Food Chemistry 2020, 68 (36) , 9718-9724. https://doi.org/10.1021/acs.jafc.0c03895
    5. Rupam Roy, Nihara R. Sajeev, Vikas Sharma, Apurba Lal Koner. Aggregation Induced Emission Switching Based Ultrasensitive Ratiometric Detection of Biogenic Diamines Using a Perylenediimide-Based Smart Fluoroprobe. ACS Applied Materials & Interfaces 2019, 11 (50) , 47207-47217. https://doi.org/10.1021/acsami.9b14690
    6. Philip C. Burcham . Acrolein and Human Disease: Untangling the Knotty Exposure Scenarios Accompanying Several Diverse Disorders. Chemical Research in Toxicology 2017, 30 (1) , 145-161. https://doi.org/10.1021/acs.chemrestox.6b00310
    7. Marianna Nicoletta Rossi, Cristian Fiorucci, Paolo Mariottini, Manuela Cervelli. Unveiling the hidden players: noncoding RNAs orchestrating polyamine metabolism in disease. Cell & Bioscience 2024, 14 (1) https://doi.org/10.1186/s13578-024-01235-3
    8. Izabela Łukaszewska, Karolina Stachowicz, Paulina Zając, Krzysztof Pielichowski, Konstantinos N. Raftopoulos. Poly(ethylene oxide) bis(cyclic carbonate) based hydrophilic non-isocyanate polyhydroxyurethanes: Polymer-water interactions and glass transition behavior. Polymer 2024, 311 , 127570. https://doi.org/10.1016/j.polymer.2024.127570
    9. Fugang Liu, Jiaqing Liu, Yang Luo, Siyi Wu, Xu Liu, Haoran Chen, Zhewen Luo, Haitao Yuan, Feng Shen, Fangfang Zhu, Jian Ye. A Single‐Cell Metabolic Profiling Characterizes Human Aging via SlipChip‐SERS. Advanced Science 2024, 22 https://doi.org/10.1002/advs.202406668
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    11. Hatice Yazgan, Esmeray Kuley, Yesim Ozogul, Fatih Ozogul, Elena Bartkiene, João Miguel Rocha. The effectiveness of garlic extracts on biogenic amine formation by foodborne pathogens and fish spoilage bacteria. International Journal of Food Science & Technology 2024, 59 (8) , 5576-5586. https://doi.org/10.1111/ijfs.17280
    12. Xinyi Zeng, Shen Du, Lou Geng, Jiexian Ma. Nc‐ RNA ‐mediated low expression of AZIN1 correlated with unfavorable prognosis in kidney renal clear cell carcinoma. Cancer Medicine 2024, 13 (15) https://doi.org/10.1002/cam4.70105
    13. Luís Moreira, Juliana Milheiro, Luís Filipe-Ribeiro, Fernanda Cosme, Fernando M. Nunes. Exploring factors influencing the levels of biogenic amines in wine and microbiological strategies for controlling their occurrence in winemaking. Food Research International 2024, 190 , 114558. https://doi.org/10.1016/j.foodres.2024.114558
    14. Tianxiang Yin, Xiang Zhang, Yan Xiong, Bohao Li, Dong Guo, Zhou Sha, Xiaoyuan Lin, Haibo Wu. Exploring Gut Microbial Metabolites as Key Players in Inhibition of Cancer Progression: Mechanisms and Therapeutic Implications. Microbiological Research 2024, 12 , 127871. https://doi.org/10.1016/j.micres.2024.127871
    15. Natavan Dudkina, Hyun Bong Park, Deguang Song, Abhishek Jain, Sajid A. Khan, Richard A. Flavell, Caroline H. Johnson, Noah W. Palm, Jason M. Crawford. Human AKR1C3 binds agonists of GPR84 and participates in an expanded polyamine pathway. Cell Chemical Biology 2024, 17 https://doi.org/10.1016/j.chembiol.2024.07.011
    16. Bingsen Zhang, James Mullmann, Andreas H. Ludewig, Irma R. Fernandez, Tyler R. Bales, Robert S. Weiss, Frank C. Schroeder. Acylspermidines are conserved mitochondrial sirtuin-dependent metabolites. Nature Chemical Biology 2024, 20 (7) , 812-822. https://doi.org/10.1038/s41589-023-01511-2
    17. Qianming Jiang, Danielle N. Sherlock, Ahmed A. Elolimy, Ilkyu Yoon, Juan J. Loor. Feeding a Saccharomyces cerevisiae fermentation product during a gut barrier challenge in lactating Holstein cows impacts the ruminal microbiota and metabolome. Journal of Dairy Science 2024, 107 (7) , 4476-4494. https://doi.org/10.3168/jds.2023-24147
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    27. Paola P. Chrysostomou, Elaine L. Freeman, Mary M. Murphy, Rui Pereira, David J. Esdaile, Patrick Keohane. A toxicological assessment of spermidine trihydrochloride produced using an engineered strain of Saccharomyces cerevisiae. Food and Chemical Toxicology 2024, 184 , 114428. https://doi.org/10.1016/j.fct.2023.114428
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    31. S. Rohini Karnat, Simran Dubey, D. Somashekar. Studies on the Biogenic Amines Produced During Fermentation, Toxicity, and Techniques in Cereal Based Fermented Foods. 2024, 283-303. https://doi.org/10.1007/978-3-031-46046-3_14
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    33. Yanfei Wang, Kathryn J. Coyne. Molecular Insights into the Synergistic Effects of Putrescine and Ammonium on Dinoflagellates. International Journal of Molecular Sciences 2024, 25 (2) , 1306. https://doi.org/10.3390/ijms25021306
    34. Nikita Saha Turna, Rena Chung, Lorraine McIntyre. A review of biogenic amines in fermented foods: Occurrence and health effects. Heliyon 2024, 10 (2) , e24501. https://doi.org/10.1016/j.heliyon.2024.e24501
    35. Keman Zhang, Amin Zakeri, Tyler Alban, Juan Dong, Hieu M. Ta, Ajay H. Zalavadia, Andrelie Branicky, Haoxin Zhao, Ivan Juric, Hana Husic, Prerana B. Parthasarathy, Amit Rupani, Judy A. Drazba, Abhishek A. Chakraborty, Stanley Ching-Cheng Huang, Timothy Chan, Stefanie Avril, Li Lily Wang. VISTA promotes the metabolism and differentiation of myeloid-derived suppressor cells by STAT3 and polyamine-dependent mechanisms. Cell Reports 2024, 43 (1) , 113661. https://doi.org/10.1016/j.celrep.2023.113661
    36. Luis Ramiro Caso Vargas, Norma Angélica Caballero Concha, Leslie Susana Arcila Lozano, Raúl Delgado-Macuil, Efraín Rubio-Rosas, Alma Delia Luna González, Melisa Carmona López, Andrea Lizbeth Cortés Noriega, Xquenda Ríos Aguilar, Erick Saúl González Méndez. Characterization of diamine oxidase-based biosensors for biogenic amines detection assembled onto functionalized SiO₂ substrates using aliphatic and aromatic di-aldehydes as crosslinkers. CyTA - Journal of Food 2023, 21 (1) , 570-579. https://doi.org/10.1080/19476337.2023.2256820
    37. Yahui Zhang, Xiangyu Zhao, Yue Qin, Xiaopei Li, Yongxin Chang, Zhenqiang Shi, Mengyuan Song, Wenjing Sun, Jie Xiao, Zan Li, Guangyan Qing. Order–order assembly transition-driven polyamines detection based on iron−sulfur complexes. Communications Chemistry 2023, 6 (1) https://doi.org/10.1038/s42004-023-00942-1
    38. Mengjuan Xuan, Xinyu Gu, Juan Li, Di Huang, Chen Xue, Yuting He. Polyamines: their significance for maintaining health and contributing to diseases. Cell Communication and Signaling 2023, 21 (1) https://doi.org/10.1186/s12964-023-01373-0
    39. Abdulkader Yassin-Kassab, Nathaniel Wang, Jackson Foley, Tracy Murray Stewart, Mark R. Burns, Robert A. Casero, R. Alex Harbison, Umamaheswar Duvvuri. Polyamine transport inhibition and cisplatin synergistically enhance tumor control through oxidative stress in murine head and neck cancer models. Oral Oncology Reports 2023, 8 , 100123. https://doi.org/10.1016/j.oor.2023.100123
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    46. Ting Liu, Taiwu Zhang, Yujia Zhai, Lina Sun, Maoqin Zhai, Letian Kang, Xin Zhao, Bohui Wang, Yan Duan, Ye Jin. Effect of Lactiplantibacillus plantarum X22-2 on Biogenic Amine Formation and Quality of Fermented Lamb Sausage during Storage. Fermentation 2023, 9 (10) , 883. https://doi.org/10.3390/fermentation9100883
    47. Kuniyasu Soda. Changes in Whole Blood Polyamine Levels and Their Background in Age-Related Diseases and Healthy Longevity. Biomedicines 2023, 11 (10) , 2827. https://doi.org/10.3390/biomedicines11102827
    48. Makenzie G Newton, Claire Stenhouse, Katherine M Halloran, Nirvay Sah, Robyn M Moses, Wenliang He, Guoyao Wu, Fuller W Bazer. Regulation of synthesis of polyamines by progesterone, estradiol, and their receptors in uteri of cyclic ewes. Biology of Reproduction 2023, 109 (3) , 309-318. https://doi.org/10.1093/biolre/ioad073
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    52. Zorica S. Stojanović, Ana D. Đurović, Snežana Ž. Kravić, Amir M. Ashrafi, Lukáš Richtera. Electrochemical sensing platform based on the use of ZnONPs and MWCNTs as CPE modifiers for a selective and sensitive determination of polyamine spermine in the urine sample. Electroanalysis 2023, 35 (6) https://doi.org/10.1002/elan.202200446
    53. Manuel Sánchez, Lorena Suárez, Gabriela Banda, Eva Barreiro-Alonso, Ignacio Rodríguez-Uña, José Manuel Rubín, Begoña Cantabrana. Age-associated polyamines in peripheral blood cells and plasma in 20 to 70 years of age subjects. Amino Acids 2023, 55 (6) , 789-798. https://doi.org/10.1007/s00726-023-03269-2
    54. Akihiro Nishiguchi, Tetsushi Taguchi. Inflammation-targeting polyamine nanomedicines for the treatment of ulcerative colitis. Journal of Materials Chemistry B 2023, 11 (18) , 4005-4013. https://doi.org/10.1039/D3TB00424D
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    66. Cigdem Kahraman, Duygu Kaya Bilecenoglu, Suna Sabuncuoglu, Irem Tatli Cankaya. Toxicology of pharmaceutical and nutritional longevity compounds. Expert Reviews in Molecular Medicine 2023, 25 https://doi.org/10.1017/erm.2023.18
    67. Stella Givanoudi, Marc Heyndrickx, Tom Depuydt, Mehran Khorshid, Johan Robbens, Patrick Wagner. A Review on Bio- and Chemosensors for the Detection of Biogenic Amines in Food Safety Applications: The Status in 2022. Sensors 2023, 23 (2) , 613. https://doi.org/10.3390/s23020613
    68. Elsie Diaz, Suraj Adhikary, Armand W. J. W. Tepper, Daniel Riley, Rodrigo Ortiz-Meoz, Daniel Krosky, Christophe Buyck, Carolina Martinez Lamenca, Josep Llaveria, Lichao Fang, Jay H. Kalin, Vincent N. A. Klaren, Shorouk Fahmy, Paul L. Shaffer, Robert Kirkpatrick, Rodrigo J. Carbajo, Maren Thomsen, Antonietta Impagliazzo. Structure of human spermine oxidase in complex with a highly selective allosteric inhibitor. Communications Biology 2022, 5 (1) https://doi.org/10.1038/s42003-022-03735-9
    69. Zhiyuan Xie, Linghao Wang, Yan Zhang. Advances in Organoid Culture Research. Global Medical Genetics 2022, 09 (04) , 268-276. https://doi.org/10.1055/s-0042-1756662
    70. Jiayu Liu, Zhi Yu, Buajieerguli Maimaiti, Qian Meng, Hongmei Meng. The Potential Role of Polyamines in Epilepsy and Epilepsy-Related Pathophysiological Changes. Biomolecules 2022, 12 (11) , 1596. https://doi.org/10.3390/biom12111596
    71. Xiaofu Wang, Yunsong Zhao, Sufang Zhang, Xinping Lin, Huipeng Liang, Yingxi Chen, Chaofan Ji. Heterologous Expression of the Lactobacillus sakei Multiple Copper Oxidase to Degrade Histamine and Tyramine at Different Environmental Conditions. Foods 2022, 11 (20) , 3306. https://doi.org/10.3390/foods11203306
    72. Jiachun Lian, Yanfang Liang, Hailiang Zhang, Minsheng Lan, Ziyu Ye, Bihua Lin, Xianxiu Qiu, Jincheng Zeng. The role of polyamine metabolism in remodeling immune responses and blocking therapy within the tumor immune microenvironment. Frontiers in Immunology 2022, 13 https://doi.org/10.3389/fimmu.2022.912279
    73. M. G. Makletsova, G. T. Rikhireva, E. Yu. Kirichenko, I. Yu. Trinitatsky, M. Yu. Vakulenko, A. M. Ermakov. The Role of Polyamines in the Mechanisms of Cognitive Impairment. Neurochemical Journal 2022, 16 (3) , 283-294. https://doi.org/10.1134/S1819712422030059
    74. Kamyar Zahedi, Sharon Barone, Manoocher Soleimani. Polyamines and Their Metabolism: From the Maintenance of Physiological Homeostasis to the Mediation of Disease. Medical Sciences 2022, 10 (3) , 38. https://doi.org/10.3390/medsci10030038
    75. Surabhi Bangarbale, Blythe D. Shepard, Shivani Bansal, Meth M. Jayatilake, Ryan Kurtz, Moshe Levi, Carolyn M. Ecelbarger. Renal Metabolome in Obese Mice Treated with Empagliflozin Suggests a Reduction in Cellular Respiration. Biomolecules 2022, 12 (9) , 1176. https://doi.org/10.3390/biom12091176
    76. Hae Dong Jeong, Jin Hyung Kim, Go Eun Kwon, Seung-Taek Lee. Expression of Polyamine Oxidase in Fibroblasts Induces MMP-1 and Decreases the Integrity of Extracellular Matrix. International Journal of Molecular Sciences 2022, 23 (18) , 10487. https://doi.org/10.3390/ijms231810487
    77. Ehsan Irajizad, Ranran Wu, Jody Vykoukal, Eunice Murage, Rachelle Spencer, Jennifer B. Dennison, Stacy Moulder, Elizabeth Ravenberg, Bora Lim, Jennifer Litton, Debu Tripathym, Vicente Valero, Senthil Damodaran, Gaiane M. Rauch, Beatriz Adrada, Rosalind Candelaria, Jason B. White, Abenaa Brewster, Banu Arun, James P. Long, Kim Anh Do, Sam Hanash, Johannes F. Fahrmann. Application of Artificial Intelligence to Plasma Metabolomics Profiles to Predict Response to Neoadjuvant Chemotherapy in Triple-Negative Breast Cancer. Frontiers in Artificial Intelligence 2022, 5 https://doi.org/10.3389/frai.2022.876100
    78. Mirja Harms, Pascal von Maltitz, Rüdiger Groß, Benjamin Mayer, Miriam Deniz, Janis Müller, Jan Münch. Utilization of Aminoguanidine Prevents Cytotoxic Effects of Semen. International Journal of Molecular Sciences 2022, 23 (15) , 8563. https://doi.org/10.3390/ijms23158563
    79. Bingli Lu, Lingyun Wang, Xueguang Ran, Hao Tang, Derong Cao. Recent Advances in Fluorescent Methods for Polyamine Detection and the Polyamine Suppressing Strategy in Tumor Treatment. Biosensors 2022, 12 (8) , 633. https://doi.org/10.3390/bios12080633
    80. N. E. Diether, B. P. Willing. The Microbiome and Amino Acid Metabolism. 2022, 48-67. https://doi.org/10.1039/9781839160950-00048
    81. Stephanie Vrijsen, Céline Vrancx, Mara Del Vecchio, Johannes V. Swinnen, Patrizia Agostinis, Joris Winderickx, Peter Vangheluwe, Wim Annaert. Inter-organellar Communication in Parkinson's and Alzheimer's Disease: Looking Beyond Endoplasmic Reticulum-Mitochondria Contact Sites. Frontiers in Neuroscience 2022, 16 https://doi.org/10.3389/fnins.2022.900338
    82. Yudy V. Cardona‐Cardona, Ignacio Regla, Javier Andrés Juárez‐Díaz, Javier Carrillo‐Campos, Manuel López‐Ortiz, Alejandro Aguilera‐Cruz, Carlos Mújica‐Jiménez, Rosario A. Muñoz‐Clares. The critical role of the aldehyde dehydrogenase PauC in spermine, spermidine, and diaminopropane toxicity in Pseudomonas aeruginosa : Its possible use as a drug target. The FEBS Journal 2022, 289 (9) , 2685-2705. https://doi.org/10.1111/febs.16277
    83. Shatakashi Mishra, Kalyan Barman, Anil K. Singh, Basudev Kole. Exogenous polyamine treatment preserves postharvest quality, antioxidant compounds and reduces lipid peroxidation in black plum fruit. South African Journal of Botany 2022, 146 , 662-668. https://doi.org/10.1016/j.sajb.2021.12.002
    84. Vineet Kumar, Rajesh Kumar Mishra, Debarghya Ghose, Arunima Kalita, Pulkit Dhiman, Anand Prakash, Nirja Thakur, Gopa Mitra, Vinod D Chaudhari, Amit Arora, Dipak Dutta. Free spermidine evokes superoxide radicals that manifest toxicity. eLife 2022, 11 https://doi.org/10.7554/eLife.77704
    85. Sergii Krysenko, Nicole Okoniewski, Merle Nentwich, Arne Matthews, Moritz Bäuerle, Alina Zinser, Tobias Busche, Andreas Kulik, Stephanie Gursch, Annika Kemeny, Agnieszka Bera, Wolfgang Wohlleben. A Second Gamma-Glutamylpolyamine Synthetase, GlnA2, Is Involved in Polyamine Catabolism in Streptomyces coelicolor. International Journal of Molecular Sciences 2022, 23 (7) , 3752. https://doi.org/10.3390/ijms23073752
    86. Jipeng Jiang, Jie Mei, Yongfu Ma, Shasha Jiang, Jian Zhang, Shaoqiong Yi, Changjiang Feng, Yang Liu, Ying Liu. Tumor hijacks macrophages and microbiota through extracellular vesicles. Exploration 2022, 2 (1) https://doi.org/10.1002/EXP.20210144
    87. Yulia A. Gladilina, Lylia Bey, Abdullah Hilal, Ekaterina V. Neborak, Varvara G. Blinova, Dmitry D. Zhdanov. Cytoprotective Activity of Polyamines Is Associated with the Alternative Splicing of RAD51A Pre-mRNA in Normal Human CD4+ T Lymphocytes. International Journal of Molecular Sciences 2022, 23 (3) , 1863. https://doi.org/10.3390/ijms23031863
    88. Yinping Shi, Yuqing Hua, Baobao Wang, Ruiqiu Zhang, Xiao Li. In Silico Prediction and Insights Into the Structural Basis of Drug Induced Nephrotoxicity. Frontiers in Pharmacology 2022, 12 https://doi.org/10.3389/fphar.2021.793332
    89. Mustapha Aouida, Dindial Ramotar. A Screening Method to Identify Essential Yeast Genes for Responses Towards Spermine. 2022, 363-369. https://doi.org/10.1007/978-1-0716-1720-5_20
    90. Francesca Mocci, Aatto Laaksonen, Leon Engelbrecht, Tudor Vasiliu, Sergiy Perepelytsya. DNA-Polyamine Interactions: Insight from Molecular Dynamics Simulations on the Sequence-Specific Binding of Spermidine3+. 2022, 163-192. https://doi.org/10.1007/978-3-030-80924-9_6
    91. Letícia Rocha Gonçalves, Matheus Mantuanelli Roberto, Ana Paula Andrade Braga, Gabriel Bertoletti Barozzi, Giovanna Segati Canizela, Letícia de Souza Gigeck, Letícia Rosa de Souza, Maria Aparecida Marin-Morales. Another casualty of the SARS-CoV-2 pandemic—the environmental impact. Environmental Science and Pollution Research 2022, 29 (2) , 1696-1711. https://doi.org/10.1007/s11356-021-17098-x
    92. Jipeng Jiang, Jie Mei, Shaoqiong Yi, Changjiang Feng, Yongfu Ma, Yang Liu, Ying Liu, Chunying Chen. Tumor associated macrophage and microbe: The potential targets of tumor vaccine delivery. Advanced Drug Delivery Reviews 2022, 180 , 114046. https://doi.org/10.1016/j.addr.2021.114046
    93. Gui-Mei Chen, Wen-Long Li, Shan-Gong Tong, Yun-Tao Qiu, Jin-Zhi Han, Xu-Cong Lv, Lian-Zhong Ai, Jin-Yuan Sun, Bao-Guo Sun, Li Ni. Effects of the microbial community on the formation of volatile compounds and biogenic amines during the traditional brewing of Hongqu rice wine. Current Research in Food Science 2022, 5 , 1433-1444. https://doi.org/10.1016/j.crfs.2022.08.020
    94. Husham A. Shaker, Jwan A. Zainulabdeen. Estimation the levels of spermidine and spermine in sera of inflammatory bowel disease patients. 2022, 030025. https://doi.org/10.1063/5.0093817
    95. Stephan Klatt, James D. Doecke, Anne Roberts, Berin A. Boughton, Colin L. Masters, Malcolm Horne, Blaine R. Roberts. A six-metabolite panel as potential blood-based biomarkers for Parkinson’s disease. npj Parkinson's Disease 2021, 7 (1) https://doi.org/10.1038/s41531-021-00239-x
    96. Wenting Li, Lingyun Wang, Tianlei Sun, Hao Tang, Brian Bui, Derong Cao, Ruibing Wang, Wei Chen. Characterization of nanoparticles combining polyamine detection with photodynamic therapy. Communications Biology 2021, 4 (1) https://doi.org/10.1038/s42003-021-02317-5
    97. Qi-Zhang Li, Zan-Wen Zuo, Ze-Rong Zhou, Yan Ji. Polyamine homeostasis-based strategies for cancer: The role of combination regimens. European Journal of Pharmacology 2021, 910 , 174456. https://doi.org/10.1016/j.ejphar.2021.174456
    98. Garima Mamgain, Priyanka Patra, Manisha Naithani, Uttam Kumar Nath. The Role of Microbiota in the Development of Cancer Tumour Cells and Lymphoma of B and T Cells. Cureus 2021, 474 https://doi.org/10.7759/cureus.19047
    99. Lihui Zhang, Min Zhang, Arun S. Mujumdar. New technology to overcome defects in production of fermented plant products- a review. Trends in Food Science & Technology 2021, 116 , 829-841. https://doi.org/10.1016/j.tifs.2021.08.014
    100. Patrizia Andreozzi, Cristina Simó, Paolo Moretti, Joaquin Martinez Porcel, Tanja Ursula Lüdtke, Maria de los Angeles Ramirez, Lorenza Tamberi, Marco Marradi, Heinz Amenitsch, Jordi Llop, Maria Grazia Ortore, Sergio Enrique Moya. Novel Core–Shell Polyamine Phosphate Nanoparticles Self‐Assembled from PEGylated Poly(allylamine hydrochloride) with Low Toxicity and Increased In Vivo Circulation Time. Small 2021, 17 (35) https://doi.org/10.1002/smll.202102211
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    Cite this: Chem. Res. Toxicol. 2013, 26, 12, 1782–1800
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