ACS Publications. Most Trusted. Most Cited. Most Read
My Activity
CONTENT TYPES

Figure 1Loading Img

Metal Allergy—A Review on Exposures, Penetration, Genetics, Prevalence, and Clinical Implications

View Author Information
National Allergy Research Centre and Department of Dermato-Allergology, Gentofte Hospital, University of Copenhagen, Niels Andersens Vej 65, 2900 Hellerup, Denmark
* To whom correspondence should be addressed. Tel: +45 3977 7307. Fax: +45 3977 7118. E-mail: [email protected]
†National Allergy Research Centre.
‡Department of Dermato-Allergology.
Cite this: Chem. Res. Toxicol. 2010, 23, 2, 309–318
Publication Date (Web):October 16, 2009
https://doi.org/10.1021/tx9002726
Copyright © 2009 American Chemical Society

    Article Views

    5057

    Altmetric

    -

    Citations

    LEARN ABOUT THESE METRICS
    Other access options

    Abstract

    Abstract Image

    The prevalence of metal allergy is high in the general population, and it is estimated that up to 17% of women and 3% of men are allergic to nickel and that 1−3% are allergic to cobalt and chromium. Among dermatitis patients, the prevalence of metal allergy is even higher. Metal allergy is mainly an environmental disorder although null mutations in the filaggrin gene complex were recently found to be associated with nickel allergy and dermatitis. Environmental metal exposures include jewelry, buttons, clothing fasteners, dental restorations, mobile phones, and leather. Although consumer exposure is responsible for most cases of metal allergy, the importance of occupational metal exposure remains present and should always be taken into consideration when one interprets allergic patch test reactions to metals. Traditionally, nickel, cobalt, and chromium have been the most important contact allergens. However, recently, gold and palladium have drawn much attention as the prevalence of contact allergy to these metals is high. Palladium allergy is mainly a result of cross-sensitization to nickel, whereas gold allergy is rarely clinically relevant when one takes its high prevalence into account. The epidemiology of metal allergy has recently changed in Europe as nickel allergy among ear-pierced Danish women has decreased following regulatory intervention on nickel release from consumer products. In the United States, the prevalence of nickel allergy is still increasing, which may be explained by the absence of regulation. The prevalence of chromium allergy is increasing in the United States, Singapore, and Denmark among dermatitis patients. This increase is significantly associated with leather exposure in Denmark. Metal allergy may result in allergic contact dermatitis and systemic allergic (contact) dermatitis. Furthermore, metal allergy has been associated with device failure following insertion of intracoronary stents, hip and knee prostheses, as well as other implants. This area is in need of more research.

    Read this article

    To access this article, please review the available access options below.

    Get instant access

    Purchase Access

    Read this article for 48 hours. Check out below using your ACS ID or as a guest.

    Recommended

    Access through Your Institution

    You may have access to this article through your institution.

    Your institution does not have access to this content. You can change your affiliated institution below.

    Cited By

    This article is cited by 296 publications.

    1. Xi Lu, Wenhui Shang, Guokang Chen, Haifei Wang, Peng Tan, Xiaobo Deng, Huafeng Song, Ziyao Xu, Junqiao Huang, Xuechang Zhou. Environmentally Stable, Highly Conductive, and Mechanically Robust Metallized Textiles. ACS Applied Electronic Materials 2021, 3 (3) , 1477-1488. https://doi.org/10.1021/acsaelm.1c00088
    2. Augustine Apiamu, Oghenetega J. Avwioroko, Uduenevwo F. Evuen, Helen E. Kadiri, Enyohwo D. Kpomah, Akpovwehwee A. Anigboro, Gilbert Ugbebor, Samuel O. Asagba. Exposure to Nickel–Cadmium Contamination of Drinking Water Culminates in Liver Cirrhosis, Renal Azotemia, and Metabolic Stress in Rats. Biological Trace Element Research 2024, 202 (4) , 1628-1643. https://doi.org/10.1007/s12011-023-03777-y
    3. Semiha Kopru, Mustafa Soylak. Inductively coupled plasma-mass spectrometry (ICP-MS) detection of trace metal contents of children cosmetics. Optical and Quantum Electronics 2024, 56 (3) https://doi.org/10.1007/s11082-023-06166-w
    4. Nikitha Murali, Ramona Gupta, Kush R. Desai. The role of iliac vein stent placement in pelvic venous disorder management. Journal of Vascular Surgery: Venous and Lymphatic Disorders 2024, 12 (2) , 101696. https://doi.org/10.1016/j.jvsv.2023.101696
    5. Azar Rezaei, Sven Heiles, Bernhard Spengler, Siegfried Schindler. Mass spectrometric analysis of transition metal complexes formed through contact of artificial sweat with circulating Euro coins. Zeitschrift für anorganische und allgemeine Chemie 2024, 650 (4) https://doi.org/10.1002/zaac.202300213
    6. Dhrumil Vaishnav, Muhammed Amir Essibayi, Aureliana Toma, Genesis Liriano, Raja Sandeep Perkash, Ariel Stock, Ryan Holland, Adam A Dmytriw, Stacey Q Wolfe, Sami Al Kasab, Alejandro Spiotta, Neil Haranhalli, David J Altschul. Metal allergy and neurovascular stenting: A systematic review. Interventional Neuroradiology 2024, 2015 https://doi.org/10.1177/15910199231226283
    7. Yasunari Kageyama, Koichi Aida, Yasuhiro Nishizaki, Tomoka Ebisui, Tetsu Akiyama, Tsutomu Nakamura. Increased prevalence of zinc hypersensitivity in patients with primary Sjögren syndrome: A case–control study. International Journal of Rheumatic Diseases 2024, 27 (1) https://doi.org/10.1111/1756-185X.14861
    8. Hlib O. Lazarenko, Serhii I. Savosko, Mykhailo M. Guzyk, Igor V. Boiko. FEATURES OF USING ORTHOPEDIC IMPLANTS ON AN EXPERIMENTAL MODEL OF SENSITIZATION TO NICKEL (NI). Clinical and Preventive Medicine 2023, (6) , 78-90. https://doi.org/10.31612/2616-4868.6.2023.10
    9. Ilario Biblioteca, Matteo Sambucci, Marco Valente. Zeolite-Clinoptilolite conditioning for improved heavy metals ions removal: A preliminary assessment. Ceramics International 2023, 49 (23) , 39649-39656. https://doi.org/10.1016/j.ceramint.2023.09.319
    10. Dzifa Dordunoo, Gweneth Doane, Jett Carey, Jell Adrienne Lagura, Anastasia Mallidou, Jans van der Merwe, Scott Schroeder. The lived experiences of metal hypersensitivity. Journal of Patient Safety and Risk Management 2023, 28 (6) , 275-285. https://doi.org/10.1177/25160435231190197
    11. Eric Tille, Franziska Beyer, Cornelia Lützner, Anne Postler, Peter Thomas, Burkhard Summer, Jörg Lützner. No difference in patient reported outcome and inflammatory response after coated and uncoated total knee arthroplasty – a randomized controlled study. BMC Musculoskeletal Disorders 2023, 24 (1) https://doi.org/10.1186/s12891-023-07061-x
    12. Qianyi Liu, Weifeng Mao, Daoyuan Yang, Yan Song, Ling Yong, Haixia Sui, Weidong Hao. An analysis of cumulative risks for 6 kinds of metal elements released from stainless-steel products intended to contact with food using the Maximum Cumulative Ratio. Food Packaging and Shelf Life 2023, 40 , 101210. https://doi.org/10.1016/j.fpsl.2023.101210
    13. Luc Schuler, Danny Zust, Georges Dahm, Fabienne Clabots. Nickel in foodstuffs available on the Luxembourgish market and dietary intake. Food Additives & Contaminants: Part B 2023, 16 (4) , 350-360. https://doi.org/10.1080/19393210.2023.2249434
    14. Meesala Krishna Murthy, Pratima Khandayataray, Samprit Padhiary, Dibyaranjan Samal. A review on chromium health hazards and molecular mechanism of chromium bioremediation. Reviews on Environmental Health 2023, 38 (3) , 461-478. https://doi.org/10.1515/reveh-2021-0139
    15. Tianwen Huang, Loïc Becerra, Aurélie Gensbittel, Yunlin Zheng, Hakeim Talleb, Ulises Acevedo Salas, Zhuoxiang Ren, Massimiliano Marangolo. Self-Biased Magnetoelectric Ni / Li Nb O 3 / Ni Trilayers for Body-Embedded Electronic Energy Harvesters. Physical Review Applied 2023, 20 (3) https://doi.org/10.1103/PhysRevApplied.20.034059
    16. Dessy Rachmawati, Cornelis J. Kleverlaan. Dental Alloy‐associated Innate Immune Response. 2023, 165-186. https://doi.org/10.1002/9781119893035.ch12
    17. Emmanuel Thienpont. Titanium niobium nitride knee implants are not inferior to chrome cobalt components for primary total knee arthroplasty at medium-term follow-up. Archives of Orthopaedic and Trauma Surgery 2023, 143 (8) , 5269-5275. https://doi.org/10.1007/s00402-022-04754-1
    18. J.F. Baranoski, J.S. Catapano, C. Rutledge, T.S. Cole, N. Majmundar, E.A. Winkler, V.M. Srinivasan, A.P. Jadhav, A.F. Ducruet, F.C. Albuquerque. Endovascular Treatment of Cerebrovascular Lesions Using Nickel- or Nitinol-Containing Devices in Patients with Nickel Allergies. American Journal of Neuroradiology 2023, 44 (8) , 939-942. https://doi.org/10.3174/ajnr.A7936
    19. Qi Wu, Bin Chen, Xin Yu, Zhen Wang, Zhongyang Sun, Jiahua Duan, Hao Ding, Weiwei Wu, Nirong Bao, Jianning Zhao. Bone and soft tissue reaction to Co(II)/Cr(III) ions stimulation in a murine calvaria model: A pioneering in vivo study. Acta Biomaterialia 2023, 164 , 659-670. https://doi.org/10.1016/j.actbio.2023.03.037
    20. Breana R. Siljander, Sonia K. Chandi, Eytan M. Debbi, Alexander S. McLawhorn, Peter K. Sculco, Brian P. Chalmers. A Comparison of Clinical Outcomes After Total Knee Arthroplasty in Patients With Preoperative Nickel Allergy Receiving Cobalt Chromium or Nickel-Free Implant. The Journal of Arthroplasty 2023, 38 (7) , S194-S198. https://doi.org/10.1016/j.arth.2023.04.048
    21. Joshua L. Tidd, Lakshmi Spandana Gudapati, Hannah L. Simmons, Alison K. Klika, Ignacio Pasqualini, Nicolas S. Piuzzi, Carlos A. Higuera, Robert M. Molloy, Trevor G. Murray, Michael R. Bloomfield, Jonathon L. Schaffer, John P. McLaughlin, Matthew E. Deren, Peter A. Surace, Viktor E. Krebs. Do Patients With Hypoallergenic Total Knee Arthroplasty Implants for Metal Allergy Do Worse? An Analysis of Health Care Utilizations and Patient-Reported Outcome Measures. The Journal of Arthroplasty 2023, 56 https://doi.org/10.1016/j.arth.2023.07.005
    22. Zikai Hua, Mindie Hu, Yiwen Chen, Xiuling Huang, Leiming Gao. Investigation of the Friction Properties of a New Artificial Imitation Cartilage Material: PHEMA/Glycerol Gel. Materials 2023, 16 (11) , 4023. https://doi.org/10.3390/ma16114023
    23. Eman M. Khalaf, Masoume Taherian, Sami G. Almalki, Parisa Asban, A. K. Kareem, Firas Rahi Alhachami, Abbas F. Almulla, Rosario Mireya Romero-Parra, Zanko Hassan Jawhar, Fatemeh Kiani, Iman Noroozi Manesh, Mohammad Javad Mohammadi. Relationship between exposure to heavy metals on the increased health risk and carcinogenicity of urinary tract (kidney and bladder). Reviews on Environmental Health 2023, Article ASAP.
    24. Maximilian D. Costa, Stefanie Donner, Jessica Bertrand, Ovidiu-Laurean Pop, Christoph H. Lohmann. Hypersensitivity and lymphocyte activation after total hip arthroplasty. Die Orthopädie 2023, 52 (3) , 214-221. https://doi.org/10.1007/s00132-023-04349-7
    25. S. Dadkhahfar, M. Chehrassan, C. Faldini. Hypersensitivity reactions to metals in spine surgery. MUSCULOSKELETAL SURGERY 2023, 107 (1) , 29-35. https://doi.org/10.1007/s12306-022-00765-8
    26. Maricarmen Lerma, Jesús Cantu, Kazi Saima Banu, Jorge L. Gardea-Torresdey. Environmental assessment in fine jewelry in the U.S.-Mexico's Paso del Norte region: A qualitative study via X-ray fluorescence spectroscopy. Science of The Total Environment 2023, 863 , 161004. https://doi.org/10.1016/j.scitotenv.2022.161004
    27. Sümeyye Altıntaş Kakşi, Filiz Cebeci Kahraman, Necmettin Akdeniz, Tunç Özen. Results of the patch tests with European baseline series in children: Five years of experience from a single center in Turkey and a review of the literature. Journal of Cosmetic Dermatology 2023, 22 (3) , 1071-1076. https://doi.org/10.1111/jocd.15531
    28. Dai Tsuchida, Yuko Matsuki, Jin Tsuchida, Masahiro Iijima, Maki Tanaka. Allergenicity and Bioavailability of Nickel Nanoparticles Compared to Nickel Microparticles in Mice. Materials 2023, 16 (5) , 1834. https://doi.org/10.3390/ma16051834
    29. Alaa A. Aljabali, Mohammad A. Obeid, Rasha M. Bashatwah, Ángel Serrano-Aroca, Vijay Mishra, Yachana Mishra, Mohamed El-Tanani, Altijana Hromić-Jahjefendić, Deepak N. Kapoor, Rohit Goyal, Gowhar A. Naikoo, Murtaza M. Tambuwala. Nanomaterials and Their Impact on the Immune System. International Journal of Molecular Sciences 2023, 24 (3) , 2008. https://doi.org/10.3390/ijms24032008
    30. Max Jaenisch, Dieter Christian Wirtz. Titan – ein zementierbarer Werkstoff für die Endoprothetik. Zeitschrift für Orthopädie und Unfallchirurgie 2023, 51 https://doi.org/10.1055/a-1975-0687
    31. Pedro A. Lamothe, David M. Berkowitz, Matthew E. Schimmel. A Case of Nitinol Airway Stent Placement in a Patient With Known Nickel Skin Sensitivity With No Local or Systemic Reactions After 6 Months of Follow-up. Journal of Bronchology & Interventional Pulmonology 2023, 30 (1) , 83-85. https://doi.org/10.1097/LBR.0000000000000847
    32. Albert T. Anastasio, Lindsey G. Johnson, Jay P. Willhite, Talal Mousallem, Edward F. Hendershot, Selene G. Parekh. Team Approach: Metal Hypersensitivity in Total Joint Arthroplasty. JBJS Reviews 2023, 11 (1) https://doi.org/10.2106/JBJS.RVW.22.00157
    33. Kaveh Mozafari, Shanynn Santos, Shirali Ohri, Manish Prajwal Mane Manohar, Frederick Tiesenga. Rare Metallic Allergy Reaction Presentation to Cholecystectomy Surgical Clip. Cureus 2022, 25 https://doi.org/10.7759/cureus.32934
    34. Kevin N Vanent, Emma M Federico, David I Bass, Guilherme Barros, Jade Keen, Michael R Levitt. Nickels and tines: the myth of nickel allergy in intracranial stents. Journal of NeuroInterventional Surgery 2022, 14 (12) , 1244-1247. https://doi.org/10.1136/neurintsurg-2021-018365
    35. Laura Rubio, Pedro Barrulas, Mafalda Costa, Carmen Garcia-Jares, Marta Lores, Cristina Barrocas Dias. The chemistry behind the body art: unveiling the elemental profile and heavy metal content of natural tattoos and dyes by ICP-MS. RSC Advances 2022, 12 (53) , 34414-34424. https://doi.org/10.1039/D2RA06126K
    36. Ian Kimber, David A. Basketter. Allergic Sensitization to Nickel and Implanted Metal Devices: A Perspective. Dermatitis 2022, 33 (6) , 396-404. https://doi.org/10.1097/DER.0000000000000819
    37. Aurélien M Guéroult, Amer Al-Balah, Alun H Davies, Joseph Shalhoub. Nickel hypersensitivity and endovascular devices: a systematic review and meta-analysis. Heart 2022, 108 (21) , 1707-1715. https://doi.org/10.1136/heartjnl-2021-319940
    38. Tarek Abi El Cheikh, Iris Monica Vargas, Era Alili, Frederick Tiesenga. The Improvement of Nonspecific Chronic Symptoms Post-Gallbladder Clip Removal. Cureus 2022, 136 https://doi.org/10.7759/cureus.30625
    39. Selina Ama Saah, Nathaniel Owusu Boadi, Patrick Opare Sakyi, Godfred Darko, Michael Baah Mensah, . Risk of Exposure to Trace Elements through the Application of Facial Makeup Powders. Journal of Chemistry 2022, 2022 , 1-6. https://doi.org/10.1155/2022/9229134
    40. Ka Roach, Jr Roberts. A comprehensive summary of disease variants implicated in metal allergy. Journal of Toxicology and Environmental Health, Part B 2022, 25 (6) , 279-341. https://doi.org/10.1080/10937404.2022.2104981
    41. Sophie Knox, Lina Hagvall, Per Malmberg, Niamh M. O'Boyle. Topical Application of Metal Allergens Induces Changes to Lipid Composition of Human Skin. Frontiers in Toxicology 2022, 4 https://doi.org/10.3389/ftox.2022.867163
    42. Lauren N. Bowers, Anand C. Ranpara, Katherine A. Roach, Alycia K. Knepp, Elizabeth D. Arnold, Aleksandr B. Stefaniak, M. Abbas Virji. Comparison of product safety data sheet ingredient lists with skin irritants and sensitizers present in a convenience sample of light-curing resins used in additive manufacturing. Regulatory Toxicology and Pharmacology 2022, 133 , 105198. https://doi.org/10.1016/j.yrtph.2022.105198
    43. Alexandra Wright, Lila Laundry-Mottiar, Yolanda S. Hedberg. The ability of sweat and buffer solutions to reduce hexavalent chromium of relevance for leather extraction. Regulatory Toxicology and Pharmacology 2022, 133 , 105222. https://doi.org/10.1016/j.yrtph.2022.105222
    44. Tamara Attard, Everaldo Attard. Heavy Metals in Cosmetics. 2022https://doi.org/10.5772/intechopen.102406
    45. Anastasios Apostolos, Maria Drakopoulou, Stamatios Gregoriou, Andreas Synetos, George Trantalis, Georgios Tsivgoulis, Spyridon Deftereos, Konstantinos Tsioufis, Konstantinos Toutouzas. Nickel Hypersensitivity to Atrial Septal Occluders: Smoke Without Fire?. Clinical Reviews in Allergy & Immunology 2022, 62 (3) , 476-483. https://doi.org/10.1007/s12016-021-08867-0
    46. Eva Oppel, Florian Kapp, Ann‐Sophie Böhm, Ralf Pohl, Peter Thomas, Burkhard Summer. Contact sensitization to iron: A potentially underestimated metal allergen and elicitor of complications in patients with metal implants. Contact Dermatitis 2022, 86 (6) , 531-538. https://doi.org/10.1111/cod.14074
    47. Ze Liu, Jianqun Wang, Xuetong Yang, Qian'en Huang, Kecheng Zhu, Yajiao Sun, Stijn Van Hulle, Hanzhong Jia. Generation of environmental persistent free radicals (EPFRs) enhances ecotoxicological effects of the disposable face mask waste with the COVID-19 pandemic. Environmental Pollution 2022, 301 , 119019. https://doi.org/10.1016/j.envpol.2022.119019
    48. Chia-Hua Lin, Chia-Hsiang Lai, Tsang-Hsien Hsieh, Cheng-Yun Tsai. Source apportionment and health effects of particle-bound metals in PM2.5 near a precision metal machining factory. Air Quality, Atmosphere & Health 2022, 15 (4) , 605-617. https://doi.org/10.1007/s11869-021-01147-y
    49. Shuye Zhang, Peng He, Zhenfeng Li, Xingxing Wang, Di Gao, Dusan P. Sekulic. Joining High Nitrogen Steels with Ag–Cu–Ni Metal Filler. 2022, 127-149. https://doi.org/10.1007/978-3-030-95463-5_9
    50. Greta Camilla Magnano, Giovanna Marussi, Elena Pavoni, Gianpiero Adami, Francesca Larese Filon, Matteo Crosera. Percutaneous metals absorption following exposure to road dust powder. Environmental Pollution 2022, 292 , 118353. https://doi.org/10.1016/j.envpol.2021.118353
    51. Hideyuki Shima, Hidekazu Yasunaga. Fibre Treatment Technique by Using Alizarin to Confer Functions of Scavenging and Detecting Hapten Nickel and Cobalt Ions upon Cotton Fabric for the Control of Metal Allergy Symptoms. Journal of Fiber Science and Technology 2022, 78 (10) , 178-183. https://doi.org/10.2115/fiberst.2022-0022
    52. Blake K. Montgomery, James G. Gamble, Stephanie T. Kha, Garin G. Hecht, John S. Vorhies, Justin F. Lucas. Indications for and Risks Associated With Implant Removal After Pediatric Trauma. JAAOS: Global Research and Reviews 2022, 6 (4) https://doi.org/10.5435/JAAOSGlobal-D-22-00050
    53. Zhouxian Pan, Yongshi Yang, Lishan Zhang, Xianjie Zhou, Yueping Zeng, Rui Tang, Christopher Chang, Jinlyu Sun, Jing Zhang. Systemic Contact Dermatitis: The Routes of Allergen Entry. Clinical Reviews in Allergy & Immunology 2021, 61 (3) , 339-350. https://doi.org/10.1007/s12016-021-08873-2
    54. Pamela L. Scheinman, Marc Vocanson, Jacob P. Thyssen, Jeanne Duus Johansen, Rosemary L. Nixon, Kate Dear, Nina C. Botto, Johanna Morot, Ari M. Goldminz. Contact dermatitis. Nature Reviews Disease Primers 2021, 7 (1) https://doi.org/10.1038/s41572-021-00271-4
    55. Austin Brown, Nataniel J. Mandelberg, Diana Munoz-Mendoza, Viktoras Palys, Peter C. Schalock, Alon Mogilner, Richard North, Erika A. Petersen. Allergy Considerations in Implanted Neuromodulation Devices. Neuromodulation: Technology at the Neural Interface 2021, 24 (8) , 1307-1316. https://doi.org/10.1111/ner.13332
    56. Yan Zhang, Niels P. J. de Graaf, Rosalien Veldhuizen, Sanne Roffel, Sander W. Spiekstra, Thomas Rustemeyer, Cees J. Kleverlaan, Albert J. Feilzer, Hetty Bontkes, Dongmei Deng, Susan Gibbs. Patch test–relevant concentrations of metal salts cause localized cytotoxicity, including apoptosis, in skin ex vivo. Contact Dermatitis 2021, 85 (5) , 531-542. https://doi.org/10.1111/cod.13940
    57. Lina Hagvall, Masoumeh Dowlatshahi Pour, Jiabao Feng, Moshtak Karma, Yolanda Hedberg, Per Malmberg. Skin permeation of nickel, cobalt and chromium salts in ex vivo human skin, visualized using mass spectrometry imaging. Toxicology in Vitro 2021, 76 , 105232. https://doi.org/10.1016/j.tiv.2021.105232
    58. Hosam E. Matar, Patrick J. Porter, Martyn L. Porter. Metal allergy in primary and revision total knee arthroplasty. Bone & Joint Open 2021, 2 (10) , 785-795. https://doi.org/10.1302/2633-1462.210.BJO-2021-0098.R1
    59. Franziska Riedel, Marina Aparicio-Soto, Caterina Curato, Hermann-Josef Thierse, Katherina Siewert, Andreas Luch. Immunological Mechanisms of Metal Allergies and the Nickel-Specific TCR-pMHC Interface. International Journal of Environmental Research and Public Health 2021, 18 (20) , 10867. https://doi.org/10.3390/ijerph182010867
    60. Tanzeela Ashraf, Mehwish Taneez, Saima Kalsoom, Tahira Irfan, Munib Ahmed Shafique. Experimental Calculations of Metals Content in Skin-Whitening Creams and Theoretical Investigation for Their Biological Effect Against Tyrosinase Enzyme. Biological Trace Element Research 2021, 199 (9) , 3562-3569. https://doi.org/10.1007/s12011-020-02441-z
    61. Enkhmaa Luvsannyam, Arathi Jayaraman, Molly S Jain, Ravi P Jagani, Veronica Velez, Anushka S Mirji, Frederick Tiesenga, Juaquito Jorge. Diffuse Nickel Hypersensitivity Reaction Post-cholecystectomy in a Young Female. Cureus 2021, 24 https://doi.org/10.7759/cureus.17146
    62. Annyce S. Mayer, Samantha Erb, Raymond H. Kim, Douglas A. Dennis, Lata Shirname-More, Katherine A. Pratte, Elizabeth A. Barker, Lisa A. Maier, Karin A. Pacheco. Sensitization to Implant Components Is Associated with Joint Replacement Failure: Identification and Revision to Nonallergenic Hardware Improves Outcomes. The Journal of Allergy and Clinical Immunology: In Practice 2021, 9 (8) , 3109-3117.e1. https://doi.org/10.1016/j.jaip.2020.12.068
    63. Lars H. Blom, Sali A. Elrefaii, Claus Zachariae, Jacob P. Thyssen, Lars K. Poulsen, Jeanne D. Johansen. Memory T helper cells identify patients with nickel, cobalt, and chromium metal allergy. Contact Dermatitis 2021, 85 (1) , 7-16. https://doi.org/10.1111/cod.13809
    64. Thanet Pongcharoensuk, Supitchaya Thaiwat. Systemic pigmented contact dermatitis to cobalt following ingestion of cobalamin supplement. Clinical Case Reports 2021, 9 (5) https://doi.org/10.1002/ccr3.4103
    65. Levi Keller, Craig Hogan, Alan Schocket. The role of metal patch testing in evaluating patients for metallic prosthetic joint failure. Annals of Allergy, Asthma & Immunology 2021, 126 (5) , 542-547.e1. https://doi.org/10.1016/j.anai.2021.02.018
    66. Reydson Alcides de Lima‐Souza, Andrelou Fralete Ayres Vallarelli, Fernanda Viviane Mariano, Maria Letícia Cintra. Multiple cutaneous fistula after titanium dental implant: A case report. Clinical Implant Dentistry and Related Research 2021, 23 (2) , 270-274. https://doi.org/10.1111/cid.12972
    67. Alexander W. Grimberg, Thomas M. Grupp, Johanna Elliott, Oliver Melsheimer, Volkmar Jansson, Arnd Steinbrück. Ceramic Coating in Cemented Primary Total Knee Arthroplasty is Not Associated With Decreased Risk of Revision due to Early Prosthetic Joint Infection. The Journal of Arthroplasty 2021, 36 (3) , 991-997. https://doi.org/10.1016/j.arth.2020.09.011
    68. Thea Magrone, Emilio Jirillo, Manrico Magrone, Matteo A. Russo, Paolo Romita, Francesco Massari, Caterina Foti. Red Grape Polyphenol Oral Administration Improves Immune Response in Women Affected by Nickel-Mediated Allergic Contact Dermatitis. Endocrine, Metabolic & Immune Disorders - Drug Targets 2021, 21 (2) , 374-384. https://doi.org/10.2174/1871530320666200313152648
    69. Hideki Ogasawara, Moriaki Hayasaka, Atsuo Maemoto, Shigeru Furukawa, Takahiro Ito, Osamu Kimura, Tetsuya Endo. Levels of major and trace metals in the scalp hair of Crohn’s disease patients: correlations among transition metals. BioMetals 2021, 34 (1) , 197-210. https://doi.org/10.1007/s10534-020-00272-y
    70. Dzifa Dordunoo, Michelle Hass, Catherine Smith, Martha L. Aviles‐Granados, Miriam Weinzierl, Judith A. Anaman‐Torgbor, Ajijoon Shaik, Anastasia Mallidou, Farzad Adib. Metal hypersensitivity screening among frontline healthcare workers—A descriptive study. Journal of Clinical Nursing 2021, 30 (3-4) , 541-549. https://doi.org/10.1111/jocn.15571
    71. Jumina Jumina, Harizal Harizal. Dermatologic Toxicities and Biological Activities of Chromium. 2021https://doi.org/10.5772/intechopen.90347
    72. Jacob P. Thyssen, Malin G. Ahlström, Magnus Bruze, Thomas Rustemeyer, Carola Lidén. Contact Allergy to Metals. 2021, 757-802. https://doi.org/10.1007/978-3-030-36335-2_35
    73. Hiromi Mizutani, Rosemary L. Nixon. The Australian Baseline Series. 2021, 745-754. https://doi.org/10.1007/978-3-030-36335-2_68
    74. Arne Biesiekierski, Khurram Munir, Yuncang Li, Cuie Wen. Titanium alloys. 2021, 157-187. https://doi.org/10.1016/B978-0-12-818831-6.00004-5
    75. Venkatanaidu Karri, Carola Lidén, Nanna Fyhrquist, Johan Högberg, Hanna L. Karlsson. Impact of mono-culture vs. Co-culture of keratinocytes and monocytes on cytokine responses induced by important skin sensitizers. Journal of Immunotoxicology 2021, 18 (1) , 74-84. https://doi.org/10.1080/1547691X.2021.1905754
    76. Dzifa Dordunoo, Judith Anaman-Torgbor, Catherine Smith, Ajijoon Shaik, Michelle Hass, Carol Gordon, Minjeong An, Martha L. Aviles-G, Miriam Weinzierl. Hypersensitivity in patients receiving metal implants: a scoping review protocol. JBI Evidence Synthesis 2021, 19 (6) , 1404-1411. https://doi.org/10.11124/JBIES-20-00171
    77. Thacharamban Mansoorali, Abdulsalam Sarin. Results of patch tests (using Indian standard battery of allergens) in cement workers with clinically diagnosed allergic contact dermatitis to cement: A cross-sectional study. Journal of Skin and Sexually Transmitted Diseases 2021, 4 , 222-226. https://doi.org/10.25259/JSSTD_60_2021
    78. Florian Kapp, Burkhard Summer, Peter Thomas. Usefulness of lymphocyte transformation test and in vitro cytokine release in differentiating between independent and cross‐reacting nickel/palladium allergy. Immunity, Inflammation and Disease 2020, 8 (4) , 483-492. https://doi.org/10.1002/iid3.329
    79. Małgorzata Tarnowska, Stéphanie Briançon, Jacqueline Resende de Azevedo, Yves Chevalier, Marie-Alexandrine Bolzinger. Inorganic ions in the skin: Allies or enemies?. International Journal of Pharmaceutics 2020, 591 , 119991. https://doi.org/10.1016/j.ijpharm.2020.119991
    80. Yan Zhang, Kirsten M. Anderson, Brian M. Freed, Shaodong Dai, Karin A. Pacheco. HLA-DR53 (DRB4∗01) associates with nickel sensitization. Annals of Allergy, Asthma & Immunology 2020, 125 (5) , 614-616. https://doi.org/10.1016/j.anai.2020.07.011
    81. Idy Tam, JiaDe Yu, Lauren N. Ko, Peter C. Schalock. Patch Testing With an Extended Metal Allergen Series at the Massachusetts General Hospital (2006–2017). Dermatitis 2020, 31 (6) , 359-366. https://doi.org/10.1097/DER.0000000000000609
    82. David Chen, Josephine Y. Wu, Kelsey M. Kennedy, Keith Yeager, Jonathan C. Bernhard, Johnathan J. Ng, Brandon K. Zimmerman, Samuel Robinson, Krista M. Durney, Courtney Shaeffer, Olaia F. Vila, Catherine Takawira, Jeffrey M. Gimble, X. Edward Guo, Gerard A. Ateshian, Mandi J. Lopez, Sidney B. Eisig, Gordana Vunjak-Novakovic. Tissue engineered autologous cartilage-bone grafts for temporomandibular joint regeneration. Science Translational Medicine 2020, 12 (565) https://doi.org/10.1126/scitranslmed.abb6683
    83. Laurent Chavatte, Milène Juan, Sandra Mounicou, Emmanuelle Leblanc Noblesse, Karl Pays, Carine Nizard, Anne-Laure Bulteau. Elemental and molecular imaging of human full thickness skin after exposure to heavy metals. Metallomics 2020, 12 (10) , 1555-1562. https://doi.org/10.1039/d0mt00121j
    84. Kossara Drenovska, Martin Shahid, Snejina Vassileva. Nickel and Skin: From Allergy to Autoimmunity. Endocrine, Metabolic & Immune Disorders - Drug Targets 2020, 20 (7) , 1032-1040. https://doi.org/10.2174/1871530320666191231115437
    85. Dana Filatova, Christine Cherpak. Mechanisms of Nickel-Induced Cell Damage in Allergic Contact Dermatitis and Nutritional Intervention Strategies. Endocrine, Metabolic & Immune Disorders - Drug Targets 2020, 20 (7) , 1010-1014. https://doi.org/10.2174/1871530320666200122155804
    86. Ryoichi Tanaka. Recent Update on Peripheral Arterial Endovascular Therapy for Peripheral Arterial Occlusive Disease. Interventional Radiology 2020, 5 (3) , 120-127. https://doi.org/10.22575/interventionalradiology.2020-0014
    87. Christophe Charousset, Yves Lefebvre, Nicolas Bonnevialle, Thierry Joudet, Stephane Audebert, Julien Berhouet, Aude Michelet, Laurent Geais, Arnaud Godenèche. Prevalence of metal hypersensitivity in patients with shoulder pathologies. Journal of Shoulder and Elbow Surgery 2020, 29 (9) , 1789-1795. https://doi.org/10.1016/j.jse.2020.01.100
    88. José Arnaldo S. Costa, Vinicius C. Costa, Edenir R. Pereira-Filho, Caio M. Paranhos. Removal of Cr(VI) from Wastewater of the Tannery Industry by Functionalized Mesoporous Material. Silicon 2020, 12 (8) , 1895-1903. https://doi.org/10.1007/s12633-019-00315-1
    89. Kevin Sule, Jenelle Umbsaar, Elmar J. Prenner. Mechanisms of Co, Ni, and Mn toxicity: From exposure and homeostasis to their interactions with and impact on lipids and biomembranes. Biochimica et Biophysica Acta (BBA) - Biomembranes 2020, 1862 (8) , 183250. https://doi.org/10.1016/j.bbamem.2020.183250
    90. Charles A. Baumann, Brett D. Crist. Nickel allergy to orthopaedic implants: A review and case series. Journal of Clinical Orthopaedics and Trauma 2020, 11 , S596-S603. https://doi.org/10.1016/j.jcot.2020.02.008
    91. Samir Hassan, Louis G. Mercuri, Michael Miloro. Does Metal Hypersensitivity Have Relevance in Patients Undergoing TMJ Prosthetic Replacement?. Journal of Oral and Maxillofacial Surgery 2020, 78 (6) , 908-915. https://doi.org/10.1016/j.joms.2020.01.020
    92. Aneta Dvořáková, Karel Kopřiva, Martin Mates. Allergic reactions after ASD/PFO occluder implantation. Intervenční a akutní kardiologie 2020, 19 (1) , 60-62. https://doi.org/10.36290/kar.2020.019
    93. Nina Ewa Wezynfeld, Tomasz Frączyk, Arkadiusz Bonna, Wojciech Bal. Peptide bond cleavage in the presence of Ni-containing particles. Metallomics 2020, 12 (5) , 649-653. https://doi.org/10.1039/d0mt00070a
    94. Francesca Lombardi, Fabiana Fiasca, Martina Minelli, Dominga Maio, Antonella Mattei, Ilaria Vergallo, Maria Grazia Cifone, Benedetta Cinque, Mauro Minelli. The Effects of Low-Nickel Diet Combined with Oral Administration of Selected Probiotics on Patients with Systemic Nickel Allergy Syndrome (SNAS) and Gut Dysbiosis. Nutrients 2020, 12 (4) , 1040. https://doi.org/10.3390/nu12041040
    95. Andrew J. Pearson, Ellen Ashmore. Risk assessment of antimony, barium, beryllium, boron, bromine, lithium, nickel, strontium, thallium and uranium concentrations in the New Zealand diet. Food Additives & Contaminants: Part A 2020, 37 (3) , 451-464. https://doi.org/10.1080/19440049.2019.1704445
    96. Mansour Ghaderpoori, Bahram Kamarehie, Ali Jafari, Abdol Azim Alinejad, Yalda Hashempour, Mohammad Hossein Saghi, Mahmood Yousefi, Gea Oliveri Conti, Ali Akbar Mohammadi, Afshin Ghaderpoury, Margherita Ferrante. Health risk assessment of heavy metals in cosmetic products sold in Iran: the Monte Carlo simulation. Environmental Science and Pollution Research 2020, 27 (7) , 7588-7595. https://doi.org/10.1007/s11356-019-07423-w
    97. Nan An, Selma Pourzal, Stefano Luccioli, Stanislav Vukmanović. Effects of diet on skin sensitization by nickel, poison ivy, and sesquiterpene lactones. Food and Chemical Toxicology 2020, 137 , 111137. https://doi.org/10.1016/j.fct.2020.111137
    98. Isabel Fragata, Catarina Perry, Rita Nogueira, Jaime Pamplona, João Reis. Superior Hypophyseal Artery Aneurysm: Nickel Allergy and Autoimmune Inflammatory Syndrome (ASIA) After Flow Diverter Implantation as a Treatment of an Internal Carotid Artery Aneurysm. 2020, 1-8. https://doi.org/10.1007/978-3-319-70267-4_158-1
    99. Jacob P. Thyssen, Malin G. Ahlström, Magnus Bruze, Thomas Rustemeyer, Carola Lidén. Metals. 2020, 1-46. https://doi.org/10.1007/978-3-319-72451-5_35-1
    100. Jacob P. Thyssen, Malin G. Ahlström, Magnus Bruze, Thomas Rustemeyer, Carola Lidén. Contact Allergy to Metals. 2020, 1-46. https://doi.org/10.1007/978-3-319-72451-5_35-2
    Load more citations

    Pair your accounts.

    Export articles to Mendeley

    Get article recommendations from ACS based on references in your Mendeley library.

    Pair your accounts.

    Export articles to Mendeley

    Get article recommendations from ACS based on references in your Mendeley library.

    You’ve supercharged your research process with ACS and Mendeley!

    STEP 1:
    Click to create an ACS ID

    Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

    Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

    Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

    MENDELEY PAIRING EXPIRED
    Your Mendeley pairing has expired. Please reconnect