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Glutathione Conjugation of Alkylating Cytostatic Drugs with a Nitrogen Mustard Group and the Role of Glutathione S-Transferases
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    Glutathione Conjugation of Alkylating Cytostatic Drugs with a Nitrogen Mustard Group and the Role of Glutathione S-Transferases
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    TNO Nutrition and Food Research Institute, Division of Toxicology, P.O. Box 360, 3700 AJ Zeist, The Netherlands
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    Chemical Research in Toxicology

    Cite this: Chem. Res. Toxicol. 1996, 9, 2, 351–360
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    https://doi.org/10.1021/tx950143c
    Published February 29, 1996
    Copyright © 1996 American Chemical Society
    Copyright © 1996 American Chemical Society

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     Present address:  Nycomed Imaging, Department of Toxicology, Oslo, Norway.

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     Author for correspondence.

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    This article is cited by 64 publications.

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    40. B. Testa. Principles of Drug Metabolism 2: Hydrolysis and Conjugation Reactions. 2007, 133-166. https://doi.org/10.1016/B0-08-045044-X/00120-6
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    42. Ji-Yeob Choi, Susan A Nowell, Javier G Blanco, Christine B Ambrosone. The Role of Genetic Variability in Drug Metabolism Pathways in Breast Cancer Prognosis. Pharmacogenomics 2006, 7 (4) , 613-624. https://doi.org/10.2217/14622416.7.4.613
    43. S Samel, M Keese, A Lux, R Jesnowski, R Prosst, R Saller, M Hafner, J Sturm, S Post, M Löhr. Peritoneal cancer treatment with CYP2B1 transfected, microencapsulated cells and ifosfamide. Cancer Gene Therapy 2006, 13 (1) , 65-73. https://doi.org/10.1038/sj.cgt.7700849
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    45. Jingping Xie, Keith Shults, Leanne Flye, Fen Jiang, David R. Head, Robert C. Briggs. Overexpression of GSTA2 protects against cell cycle arrest and apoptosis induced by the DNA inter‐strand crosslinking nitrogen mustard, mechlorethamine. Journal of Cellular Biochemistry 2005, 95 (2) , 339-351. https://doi.org/10.1002/jcb.20440
    46. Brian F. Coles, Fred F. Kadlubar. Human Alpha Class Glutathione S‐Transferases: Genetic Polymorphism, Expression, and Susceptibility to Disease. 2005, 9-42. https://doi.org/10.1016/S0076-6879(05)01002-5
    47. Richard F. Branda, Shelly J. Naud, Elice M. Brooks, Zhuan Chen, Hyman Muss. Effect of vitamin B12, folate, and dietary supplements on breast carcinoma chemotherapy–induced mucositis and neutropenia. Cancer 2004, 101 (5) , 1058-1064. https://doi.org/10.1002/cncr.20484
    48. Alok Srivastava, Balasubramanian Poonkuzhali, Ramachandran V. Shaji, Biju George, Vikram Mathews, Mammen Chandy, Rajagopal Krishnamoorthy. Glutathione S-transferase M1 polymorphism: a risk factor for hepatic venoocclusive disease in bone marrow transplantation. Blood 2004, 104 (5) , 1574-1577. https://doi.org/10.1182/blood-2003-11-3778
    49. Marie‐Hélène David‐Cordonnier, William Laine, Alexandra Joubert, Christelle Tardy, Jean‐François Goossens, Mostafa Kouach, Gilbert Briand, Huong Doan Thi Mai, Sylvie Michel, Francois Tillequin, Michel Koch, Stéphane Leonce, Alain Pierre, Christian Bailly. Covalent binding to glutathione of the DNA‐alkylating antitumor agent, S23906‐1. European Journal of Biochemistry 2003, 270 (13) , 2848-2859. https://doi.org/10.1046/j.1432-1033.2003.03663.x
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    51. Brian F. Coles, Fred F. Kadlubar. Detoxification of electrophilic compounds by glutathione S‐transferase catalysis: Determinants of individual response to chemical carcinogens and chemotherapeutic drugs?. BioFactors 2003, 17 (1-4) , 115-130. https://doi.org/10.1002/biof.5520170112
    52. Jens-Christian Kröger, Stefan Benz, Anne Hoffmeyer, Zoltan Bago, Helga Bergmeister, Walter H. Günzburg, Peter Karle, Günter Klöppel, Udo Losert, Petra Müller, Horst Nizze, Robert Obermaier, Alexander Probst, Matthias Renner, Robert Saller, Brian Salmons, Ilse Schwendenwein, Kerstin von Rombs, Reiko Wiessner, Thomas Wagner, Karlheinz Hauenstein, Matthias Löhr. Intra-arterial instillation of microencapsulated, ifosfamide-activating cells in the pig pancreas for chemotherapeutic targeting. Pancreatology 2003, 3 (1) , 55-63. https://doi.org/10.1159/000069147
    53. Richard F. Branda, Zhuan Chen, Elice M. Brooks, Shelly J. Naud, Thomas D. Trainer, John J. McCormack. Diet modulates the toxicity of cancer chemotherapy in rats. Journal of Laboratory and Clinical Medicine 2002, 140 (5) , 358-368. https://doi.org/10.1067/mlc.2002.128648
    54. Brian F Coles, Guanping Chen, Fred.F Kadlubar, Anna Radominska-Pandya. Interindividual variation and organ-specific patterns of glutathione S-transferase alpha, mu, and pi expression in gastrointestinal tract mucosa of normal individuals. Archives of Biochemistry and Biophysics 2002, 403 (2) , 270-276. https://doi.org/10.1016/S0003-9861(02)00226-6
    55. J.-Matthias Löhr, Robert Saller, Brian Salmons, Walter H Günzburg. [35] Microencapsulation of genetically engineered cells for cancer therapy. 2002, 603-618. https://doi.org/10.1016/S0076-6879(02)46080-6
    56. Barbara Oesch-Bartlomowicz, Bernd Richter, Roger Becker, Stephan Vogel, Palghat R. Padma, Jan-Georg Hengstler, Franz Oesch. cAMP-dependent phosphorylation of CYP2B1 as a functional switch for cyclophosphamide activation and its hormonal controlin vitro andin vivo. International Journal of Cancer 2001, 94 (5) , 733-742. https://doi.org/10.1002/ijc.1517
    57. Brian F. Coles, Fabrice Morel, Claudine Rauch, Wolfgang W. Huber, Mihi Yang, Candee H. Teitel, Bridgett Green, Nicholas P. Lang, Fred F. Kadlubar. Effect of polymorphism in the human glutathione S-transferase A1 promoter on hepatic GSTA1 and GSTA2 expression. Pharmacogenetics 2001, 11 (8) , 663-669. https://doi.org/10.1097/00008571-200111000-00004
    58. Peter J van Bladeren. Glutathione conjugation as a bioactivation reaction. Chemico-Biological Interactions 2000, 129 (1-2) , 61-76. https://doi.org/10.1016/S0009-2797(00)00214-3
    59. Ray Bakhtiar. In vitro exposure of human hemoglobin to the antineoplastic drug thiotepa. Rapid Communications in Mass Spectrometry 2000, 14 (6) , 534-537. https://doi.org/10.1002/(SICI)1097-0231(20000331)14:6<534::AID-RCM894>3.0.CO;2-P
    60. PETRA MÜLLER, RALF JESNOWSKI, PETER KARLE, REGINA RENZ, ROBERT SALLER, HARTMUT STEIN, KATRIN PÜSCHEL, KERSTIN von ROMBS, HORST NIZZE, STEFAN LIEBE, THOMAS WAGNER, WALTER H. GÜNZBURG, BRIAN SALMONS, MATTHIAS LÖHR. Injection of Encapsulated Cells Producing an Ifosfamide‐Activating Cytochrome P450 for Targeted Chemotherapy to Pancreatic Tumors. Annals of the New York Academy of Sciences 1999, 880 (1) , 337-351. https://doi.org/10.1111/j.1749-6632.1999.tb09537.x
    61. JENS C. KRÖGER, HELGA BERGMEISTER, ANNE HOFFMEYER, MANFRED CEIJNA, PETER KARLE, ROBERT SALLER, ILSE SCHWENDENWEIN, KERSTIN von ROMBS, STEFAN LIEBE, WALTER H. GÜNZBURG, BRIAN SALMONS, KARLHEINZ HAUENSTEIN, UDO LOSERT, MATTHIAS LÖHR. Intraarterial Instillation of Microencapsulated Cells in the Pancreatic Arteries in Pig. Annals of the New York Academy of Sciences 1999, 880 (1) , 374-378. https://doi.org/10.1111/j.1749-6632.1999.tb09541.x
    62. Hall. The role of glutathione in the regulation of apoptosis. European Journal of Clinical Investigation 1999, 29 (3) , 238-245. https://doi.org/10.1046/j.1365-2362.1999.00447.x
    63. Detlev Latz, Tobias Schulze, Christian Manegold, Peter Schraube, Michael Flentje, Klaus J Weber. Combined effects of ionizing radiation and 4-hydroperoxyifosfamide in vitro. Radiotherapy and Oncology 1998, 46 (3) , 279-283. https://doi.org/10.1016/S0167-8140(97)00194-1
    64. Peter Karle, Petra Müller, Renate Renz, Ralf Jesnowski, Robert Saller, Kerstin von Rombs, Horst Nizze, Stefan Liebe, Walter H. Günzburg, Brian Salmons, Matthias Löhr. Intratumoral Injection of Encapsulated Cells Producing an Oxazaphosphorine Activating Cytochrome P450 for Targeted Chemotherapy. 1998, 97-106. https://doi.org/10.1007/978-1-4615-5357-1_16

    Chemical Research in Toxicology

    Cite this: Chem. Res. Toxicol. 1996, 9, 2, 351–360
    Click to copy citationCitation copied!
    https://doi.org/10.1021/tx950143c
    Published February 29, 1996
    Copyright © 1996 American Chemical Society

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