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Mobilization of Iron from Urban Particulates Leads to Generation of Reactive Oxygen Species in Vitro and Induction of Ferritin Synthesis in Human Lung Epithelial Cells

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Department of Chemistry and Biochemistry, Utah State University, Logan, Utah 84322-0300
Cite this: Chem. Res. Toxicol. 1997, 10, 7, 828–834
Publication Date (Web):July 16, 1997
Copyright © 1997 American Chemical Society

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    Many of the biochemical effects of asbestos in cultured cells have been shown to be due to iron, which can be as high as 27% by weight. Urban air particulates also contain iron, and some of the pathological effects after inhalation may be due to reactive oxygen species produced by iron-catalyzed reactions. Two standard reference material (SRM) urban air particulate samples were used for the studies described here. SRM 1648 (3.9% iron by weight) was collected in the St. Louis, MO, area, and SRM 1649 (3% iron by weight) was collected in the Washington, DC, area. To determine if iron associated with urban particulates could be mobilized, as it is from asbestos, SRMs 1648 and 1649 were incubated with 1 mM citrate or EDTA, in the presence or absence of ascorbate. Iron was mobilized from both particulates by either chelator, especially in the presence of ascorbate. Citrate, in the presence of ascorbate, mobilized 30.9 nmol of Fe/mg of SRM 1648 and 65.1 nmol of Fe/mg of SRM 1649 in 24 h. EDTA, in the presence of ascorbate, mobilized 53.8 nmol of Fe/mg of SRM 1648 and 98.8 nmol of Fe/mg of SRM 1649 in 24 h. To determine whether reactive oxygen species were being produced by the particulate iron, each particulate was incubated with φX174 RFI DNA in the presence or absence of ascorbate. Single-strand breaks (SSBs) were produced by either particulate, but only in the presence of ascorbate. Incubation of SRM 1648 or 1649 (0.5 mg/mL) with DNA in the presence of ascorbate and citrate resulted in 20% or 34% DNA with SSBs, respectively. Incubation of SRM 1648 or 1649 (0.1 mg/mL) with DNA in the presence of ascorbate and EDTA resulted in 26% or 45% DNA with SSBs, respectively. To determine if iron associated with urban particulates could be mobilized by human lung epithelial cells (A549), cells were treated with particulates and the amount of the iron storage protein ferritin was determined at the end of treatment. The 6.4- or 8.4-fold increase in ferritin observed in cells treated with SRM 1648 or 1649, respectively, over that of control (untreated) cells strongly suggested that iron was mobilized in the cultured cells. If similar mobilization and reactivity of the iron occurs in the lung, this may explain some of the pathological effects of urban particulates.

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     Author to whom correspondence should be addressed. Phone:  (801) 797-1629. Fax:  (801) 797-3390. E-mail:  [email protected].

     Abstract published in Advance ACS Abstracts, June 15, 1997.

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    27. Luca Alessandria, Tiziana Schilirò, Raffaella Degan, Deborah Traversi, Giorgio Gilli. Cytotoxic response in human lung epithelial cells and ion characteristics of urban-air particles from Torino, a northern Italian city. Environmental Science and Pollution Research 2014, 21 (8) , 5554-5564.
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    29. Lise K Vesterdal, Kim Jantzen, Majid Sheykhzade, Martin Roursgaard, Janne K Folkmann, Steffen Loft, Peter Møller. Pulmonary exposure to particles from diesel exhaust, urban dust or single-walled carbon nanotubes and oxidatively damaged DNA and vascular function in apoE -/- mice. Nanotoxicology 2014, 8 (1) , 61-71.
    30. Elena Avzianova, Sarah D. Brooks. Analysis of nickel (II) in particulate matter by Raman microspectroscopy. Journal of Aerosol Science 2014, 67 , 207-214.
    31. Robert J. Mitkus, Jan L. Powell, Rolf Zeisler, Katherine S. Squibb. Comparative physicochemical and biological characterization of NIST Interim Reference Material PM2.5 and SRM 1648 in human A549 and mouse RAW264.7 cells. Toxicology in Vitro 2013, 27 (8) , 2289-2298.
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    34. Janvier Gasana, Deepa Dillikar, Angelico Mendy, Erick Forno, Edgar Ramos Vieira. Motor vehicle air pollution and asthma in children: A meta-analysis. Environmental Research 2012, 117 , 36-45.
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    39. Zhi Chen, Amir M. Yadghar, Lin Zhao, Zetian Mi. A review of environmental effects and management of nanomaterials. Toxicological & Environmental Chemistry 2011, 93 (6) , 1227-1250.
    40. Lung-Chi Chen, Jing-Shiang Hwang, Ramona Lall, George Thurston, Morton Lippmann. Alteration of cardiac function in ApoE −/− mice by subchronic urban and regional inhalation exposure to concentrated ambient PM 2.5. Inhalation Toxicology 2010, 22 (7) , 580-592.
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    50. John M. Veranth, N. Shane Cutler, Erin G. Kaser, Christopher A. Reilly, Garold S. Yost. Effects of cell type and culture media on Interleukin-6 secretion in response to environmental particles. Toxicology in Vitro 2008, 22 (2) , 498-509.
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    55. William P. Linak, Jong-Ik Yoo, Shirley J. Wasson, Weiyan Zhu, Jost O.L. Wendt, Frank E. Huggins, Yuanzhi Chen, Naresh Shah, Gerald P. Huffman, M. Ian Gilmour. Ultrafine ash aerosols from coal combustion: Characterization and health effects. Proceedings of the Combustion Institute 2007, 31 (2) , 1929-1937.
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    57. John M. Veranth, Tyler A. Moss, Judith C. Chow, Raed Labban, William K. Nichols, John C. Walton, John G. Watson, Garold S. Yost. Correlation of in Vitro Cytokine Responses with the Chemical Composition of Soil-Derived Particulate Matter. Environmental Health Perspectives 2006, 114 (3) , 341-349.
    58. Lotte Risom, Peter Møller, Steffen Loft. Oxidative stress-induced DNA damage by particulate air pollution. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 2005, 592 (1-2) , 119-137.
    59. Michael D. Geller, Satya Brata Sardar, Harish Phuleria, Philip M. Fine, Constantinos Sioutas. Measurements of Particle Number and Mass Concentrations and Size Distributions in a Tunnel Environment. Environmental Science & Technology 2005, 39 (22) , 8653-8663.
    60. Michael DiCicco, Ryan Compton, Thanh Duong, Susan A. Jansen‐Varnum. Electron paramagnetic resonance analyses of surface radical chemistries of γ‐sterilized orthopedic materials: Implications pointing to cytotoxicity via wear debris–induced inflammation. Journal of Biomedical Materials Research Part B: Applied Biomaterials 2005, 75B (1) , 6-17.
    61. G. D'Amato, G. Liccardi, M. D'Amato, S. Holgate. Environmental risk factors and allergic bronchial asthma. Clinical & Experimental Allergy 2005, 35 (9) , 1113-1124.
    62. Xi Huang, Weihong Li, Michael D. Attfield, Arthur Nádas, Krystyna Frenkel, Robert B. Finkelman. Mapping and Prediction of Coal Workers’ Pneumoconiosis with Bioavailable Iron Content in the Bituminous Coals. Environmental Health Perspectives 2005, 113 (8) , 964-968.
    63. A. Valavanidis, K. Fiotakis, E. Bakeas, T. Vlahogianni. Electron paramagnetic resonance study of the generation of reactive oxygen species catalysed by transition metals and quinoid redox cycling by inhalable ambient particulate matter. Redox Report 2005, 10 (1) , 37-51.
    64. Michael DiCicco, Ryan Compton, Susan A. Jansen‐Varnum. In vitro evaluation of orthopedic composite cytotoxicity: Assessing the potential for postsurgical production of hydroxyl radicals. Journal of Biomedical Materials Research Part B: Applied Biomaterials 2005, 72B (1) , 146-155.
    65. Athanasios Valavanidis, Thomais Vlahoyianni, Konstantinos Fiotakis. Comparative study of the formation of oxidative damage marker 8-hydroxy-2′-deoxyguanosine (8-OHdG) adduct from the nucleoside 2′-deoxyguanosine by transition metals and suspensions of particulate matter in relation to metal content and redox reactivity. Free Radical Research 2005, 39 (10) , 1071-1081.
    66. Hanna L Karlsson, Jonas Nygren, Lennart Möller. Genotoxicity of airborne particulate matter: the role of cell–particle interaction and of substances with adduct-forming and oxidizing capacity. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 2004, 565 (1) , 1-10.
    67. Augustin Baulig, Jean-Jacques Poirault, Patrick Ausset, Roel Schins, Tingming Shi, Delphine Baralle, Pascal Dorlhene, Martine Meyer, Roger Lefevre, Armelle Baeza-Squiban, Francelyne Marano. Physicochemical Characteristics and Biological Activities of Seasonal Atmospheric Particulate Matter Sampling in Two Locations of Paris. Environmental Science & Technology 2004, 38 (22) , 5985-5992.
    68. Karim Bagate, James J Meiring, Miriam E Gerlofs-Nijland, Renaud Vincent, Flemming R Cassee, Paul J.A Borm. Vascular effects of ambient particulate matter instillation in spontaneous hypertensive rats. Toxicology and Applied Pharmacology 2004, 197 (1) , 29-39.
    69. Frank E. Huggins, Gerald P. Huffman, William P. Linak, C. Andrew Miller. Quantifying Hazardous Species in Particulate Matter Derived from Fossil-Fuel Combustion. Environmental Science & Technology 2004, 38 (6) , 1836-1842.
    70. Gennaro D’Amato. Air Pollution, Reactive Oxygen Species, and Allergic Bronchial Asthma. 2004, 397-409.
    71. Adrian R. Muxworthy, Jürgen Matzka, Alfonso Fernández Davila, Nikolai Petersen. Magnetic signature of daily sampled urban atmospheric particles. Atmospheric Environment 2003, 37 (29) , 4163-4169.
    72. Florence Tao, Beatriz Gonzalez-Flecha, Lester Kobzik. Reactive oxygen species in pulmonary inflammation by ambient particulates. Free Radical Biology and Medicine 2003, 35 (4) , 327-340.
    73. Ya-Mei Zhou, Cai-Yun Zhong, Ian M Kennedy, Valerie J Leppert, Kent E Pinkerton. Oxidative stress and NFκB activation in the lungs of rats: a synergistic interaction between soot and iron particles. Toxicology and Applied Pharmacology 2003, 190 (2) , 157-169.
    74. Ken Donaldson, Vicki Stone, Paul J.A. Borm, Luis A. Jimenez, Peter S. Gilmour, Roel P.F. Schins, Ad M. Knaapen, Irfan Rahman, Stephen P. Faux, David M. Brown, William MacNee. Oxidative stress and calcium signaling in the adverse effects of environmental particles (PM10). Free Radical Biology and Medicine 2003, 34 (11) , 1369-1382.
    75. Kevin R Smith, Seongheon Kim, Julian J Recendez, Stephen V Teague, Margaret G Ménache, David E Grubbs, Constantinos Sioutas, Kent E Pinkerton. Airborne particles of the california central valley alter the lungs of healthy adult rats.. Environmental Health Perspectives 2003, 111 (7) , 902-908.
    76. Ya‐Mei Zhou, Cai‐Yun Zhong, Ian M. Kennedy, Kent E. Pinkerton. Pulmonary responses of acute exposure to ultrafine iron particles in healthy adult rats. Environmental Toxicology 2003, 18 (4) , 227-235.
    77. John Sternbeck, Åke Sjödin, Kenth Andréasson. Metal emissions from road traffic and the influence of resuspension—results from two tunnel studies. Atmospheric Environment 2002, 36 (30) , 4735-4744.
    78. Xi Huang, Jisen Dai, Jeanine Fournier, Aktar M. Ali, Qi Zhang, Krystyna Frenkel. Ferrous ion autoxidation and its chelation in iron-loaded human liver HepG2 cells. Free Radical Biology and Medicine 2002, 32 (1) , 84-92.
    79. R.N. Colvile, E.J. Hutchinson, R.F. Warren. Chapter 6 The transport sector as a source of air pollution. 2002, 187-239.
    80. G. D'AMATO, G. LICCARDI, M. D'AMATO, M. CAZZOLA. The role of outdoor air pollution and climatic changes on the rising trends in respiratory allergy. Respiratory Medicine 2001, 95 (7) , 606-611.
    81. Agasanur K. Prahalad, Jeff Inmon, Lisa A. Dailey, Michael C. Madden, Andrew J. Ghio, Jane E. Gallagher. Air Pollution Particles Mediated Oxidative DNA Base Damage in a Cell Free System and in Human Airway Epithelial Cells in Relation to Particulate Metal Content and Bioreactivity. Chemical Research in Toxicology 2001, 14 (7) , 879-887.
    82. R.N Colvile, E.J Hutchinson, J.S Mindell, R.F Warren. The transport sector as a source of air pollution. Atmospheric Environment 2001, 35 (9) , 1537-1565.
    83. Kenneth Donaldson, William MacNee. Potential mechanisms of adverse pulmonary and cardiovascular effects of particulate air pollution (PM10). International Journal of Hygiene and Environmental Health 2001, 203 (5-6) , 411-415.
    84. Roemer, Hoek, Brunekreef. Pollution effects on asthmatic children in Europe, the PEACE study. Clinical & Experimental Allergy 2000, 30 (8) , 1067-1075.
    85. Arti Shukla, Cynthia Timblin, Kelly BeruBe, Terry Gordon, Willie McKinney, Kevin Driscoll, Pamela Vacek, Brooke T. Mossman. Inhaled Particulate Matter Causes Expression of Nuclear Factor (NF)- κ B–Related Genes and Oxidant-Dependent NF- κ B Activation In Vitro. American Journal of Respiratory Cell and Molecular Biology 2000, 23 (2) , 182-187.
    86. John M. Veranth, Kevin R. Smith, Autumn A. Hu, JoAnn S. Lighty, Ann E. Aust. Mobilization of Iron from Coal Fly Ash Was Dependent upon the Particle Size and Source of Coal:  Analysis of Rates and Mechanisms. Chemical Research in Toxicology 2000, 13 (5) , 382-389.
    87. John M. Veranth, Kevin R. Smith, Frank Huggins, Autumn A. Hu, JoAnn S. Lighty, Ann E. Aust. Mössbauer Spectroscopy Indicates That Iron in an Aluminosilicate Glass Phase Is the Source of the Bioavailable Iron from Coal Fly Ash. Chemical Research in Toxicology 2000, 13 (3) , 161-164.
    88. Kevin R. Smith, John M. Veranth, Autumn A. Hu, JoAnn S. Lighty, Ann E. Aust. Interleukin-8 Levels in Human Lung Epithelial Cells Are Increased in Response to Coal Fly Ash and Vary with the Bioavailability of Iron, as a Function of Particle Size and Source of Coal. Chemical Research in Toxicology 2000, 13 (2) , 118-125.
    89. B. Ryan Ball, Kevin R. Smith, John M. Veranth, Ann E. Aust. BIOAVAILABILITY OF IRON FROM COAL FLY ASH: Mechanisms of Mobilization and of Biological Effects. Inhalation Toxicology 2000, 12 (sup4) , 209-225.
    90. B. Sitzmann, M. Kendall, J. Watt, I. Williams. Characterisation of airborne particles in London by computer-controlled scanning electron microscopy. Science of The Total Environment 1999, 241 (1-3) , 63-73.
    91. Eugene D. Weinberg. Iron therapy and cancer. Kidney International 1999, 55 , S131-S134.
    92. Jan M. S. van Maanen, Paul J. A. Bo. IN VITRO EFFECTS OF COAL FLY ASHES: Hydroxyl Radical Generation, Iron Release, and DNA Damage and Toxicity in Rat Lung Epithelial Cells. Inhalation Toxicology 1999, 11 (12) , 1123-1141.
    93. Kevin R. Smith, John M. Veranth, JoAnn S. Lighty, Ann E. Aust. Mobilization of Iron from Coal Fly Ash Was Dependent upon the Particle Size and the Source of Coal. Chemical Research in Toxicology 1998, 11 (12) , 1494-1500.
    94. Bice Fubini, Ann E. Aust, Robert E. Bolton, Paul J.A. Borm, Joachim Bruch, Gabriela Ciapetti, Ken Donaldson, Zoe Elias, Julie Gold, Marie Claude Jaurand, Agnes B. Kane, Dominique Lison, Hartwig Muhle. Non-animal Tests for Evaluating the Toxicity of Solid Xenobiotics. Alternatives to Laboratory Animals 1998, 26 (5) , 579-615.

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    Your Mendeley pairing has expired. Please reconnect