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750 MHz 1H and 1H-13C NMR Spectroscopy of Human Blood Plasma

Cite this: Anal. Chem. 1995, 67, 5, 793–811
Publication Date (Print):March 1, 1995
https://doi.org/10.1021/ac00101a004
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    94. Rudolf Schicho, Alsu Nazyrova, Rustem Shaykhutdinov, Gavin Duggan, Hans J. Vogel, and Martin Storr . Quantitative Metabolomic Profiling of Serum and Urine in DSS-Induced Ulcerative Colitis of Mice by 1H NMR Spectroscopy. Journal of Proteome Research 2010, 9 (12) , 6265-6273. https://doi.org/10.1021/pr100547y
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    96. François-Pierre J. Martin, Ivan Montoliu, Sunil Kochhar, and Serge Rezzi . Chemometric Strategy for Modeling Metabolic Biological Space along the Gastrointestinal Tract and Assessing Microbial Influences. Analytical Chemistry 2010, 82 (23) , 9803-9811. https://doi.org/10.1021/ac102015n
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