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Torsional and Lateral Resonant Modes of Cantilevers as Biosensors: Alternatives to Bending Modes

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Download Hi-Res ImageDownload to MS-PowerPointCite This:Anal. Chem. 2013, 85, 3, 1760-1766
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    Torsional and Lateral Resonant Modes of Cantilevers as Biosensors: Alternatives to Bending Modes
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    Department of Chemical and Biological Engineering, Drexel University, Philadelphia, Pennsylvania 19104, United States
    *Tel.: (215) 895-2236. Fax: (215) 895-5837. E-mail: [email protected]
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    Analytical Chemistry

    Cite this: Anal. Chem. 2013, 85, 3, 1760–1766
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    https://doi.org/10.1021/ac303092q
    Published December 31, 2012
    Copyright © 2012 American Chemical Society
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    Abstract

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    We show here novel cantilever designs that express torsional and lateral modes exhibit excellent mass-change sensitivity to molecular self-assembly on gold (75–135 fg/Hz) which is superior to that of widely investigated bending modes. Lead zirconate titanate (PZT) millimeter-sized cantilevers were designed with two types of anchor asymmetry that induced expression of either torsional or lateral modes in the 0–80 kHz frequency range. Experiments and supporting calculations show that anchor asymmetry enables resonant mode impedance-coupling. The sensitive torsional and lateral modes enabled measurement of self-assembled monolayer formation rate at picomolar levels. The anchor design principle was extended to microcantilevers via finite element simulations, which caused both 97% sensitivity improvement relative to conventional designs, as well as new nonclassical resonant mode shapes.

    Copyright © 2012 American Chemical Society

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    Additional information available as noted in text. This material is available free of charge via the Internet at http://pubs.acs.org.

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    Cited By

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    This article is cited by 17 publications.

    1. Blake N. Johnson and Raj Mutharasan . A Cantilever Biosensor-Based Assay for Toxin-Producing Cyanobacteria Microcystis aeruginosa using 16S rRNA. Environmental Science & Technology 2013, 47 (21) , 12333-12341. https://doi.org/10.1021/es402925k
    2. Junru Zhang, Yang Liu, Durga Chandra Sekhar.P, Manjot Singh, Yuxin Tong, Ezgi Kucukdeger, Hu Young Yoon, Alexander P. Haring, Maren Roman, Zhenyu (James) Kong, Blake N. Johnson. Rapid, autonomous high-throughput characterization of hydrogel rheological properties via automated sensing and physics-guided machine learning. Applied Materials Today 2023, 30 , 101720. https://doi.org/10.1016/j.apmt.2022.101720
    3. Linya Huang, Wei Li, Guoxi Luo, Dejiang Lu, Libo Zhao, Ping Yang, Xiaozhang Wang, Jiuhong Wang, Qijing Lin, Zhuangde Jiang. Piezoelectric-AlN resonators at two-dimensional flexural modes for the density and viscosity decoupled determination of liquids. Microsystems & Nanoengineering 2022, 8 (1) https://doi.org/10.1038/s41378-022-00368-0
    4. Ellen Cesewski, Manjot Singh, Yang Liu, Junru Zhang, Alexander P. Haring, Blake N. Johnson. Real-time monitoring of hydrogel rheological property changes and gelation processes using high-order modes of cantilever sensors. Journal of Applied Physics 2020, 128 (17) https://doi.org/10.1063/5.0020547
    5. Aviru Kumar Basu, Adreeja Basu, Shantanu Bhattacharya. Micro/Nano fabricated cantilever based biosensor platform: A review and recent progress. Enzyme and Microbial Technology 2020, 139 , 109558. https://doi.org/10.1016/j.enzmictec.2020.109558
    6. Alexander P. Haring, Manjot Singh, Miharu Koh, Ellen Cesewski, David A. Dillard, Zhenyu “James” Kong, Blake N. Johnson. Real-time characterization of hydrogel viscoelastic properties and sol-gel phase transitions using cantilever sensors. Journal of Rheology 2020, 64 (4) , 837-850. https://doi.org/10.1122/8.0000009
    7. M. A. Mahmoud, Mosab A. Alrahmani, Hameed A. Alawadi. Resonance patterns in cantilevered plates with micro electromechanical systems (MEMS) applications. Microsystem Technologies 2019, 25 (3) , 997-1016. https://doi.org/10.1007/s00542-018-4052-6
    8. Stephane Leahy, Yongjun Lai. Doubling the quality factor of cantilevers in liquid through fluid coupling-based actuation. Journal of Applied Physics 2018, 124 (16) https://doi.org/10.1063/1.5021791
    9. Ali Najafi Sohi, Patricia M. Nieva. Size-dependent effects of surface stress on resonance behavior of microcantilever-based sensors. Sensors and Actuators A: Physical 2018, 269 , 505-514. https://doi.org/10.1016/j.sna.2017.12.001
    10. Ellen Cesewski, Alexander P. Haring, Yuxin Tong, Manjot Singh, Rajan Thakur, Sahil Laheri, Kaitlin A. Read, Michael D. Powell, Kenneth J. Oestreich, Blake N. Johnson. Additive manufacturing of three-dimensional (3D) microfluidic-based microelectromechanical systems (MEMS) for acoustofluidic applications. Lab on a Chip 2018, 18 (14) , 2087-2098. https://doi.org/10.1039/C8LC00427G
    11. Alexander P. Haring, Ellen Cesewski, Blake N. Johnson. Piezoelectric Cantilever Biosensors for Label-free, Real-time Detection of DNA and RNA. 2017, 247-262. https://doi.org/10.1007/978-1-4939-6911-1_17
    12. Stephane Leahy, Yongjun Lai. A cantilever biosensor exploiting electrokinetic capture to detect Escherichia coli in real time. Sensors and Actuators B: Chemical 2017, 238 , 292-297. https://doi.org/10.1016/j.snb.2016.07.069
    13. Blake N. Johnson, Raj Mutharasan. Acoustofluidic particle trapping, manipulation, and release using dynamic-mode cantilever sensors. The Analyst 2017, 142 (1) , 123-131. https://doi.org/10.1039/C6AN01743F
    14. Mohamed A. Mahmoud. Validity and Accuracy of Resonance Shift Prediction Formulas for Microcantilevers: A Review and Comparative Study. Critical Reviews in Solid State and Materials Sciences 2016, 41 (5) , 386-429. https://doi.org/10.1080/10408436.2016.1142858
    15. Wen-Ming Zhang, Kai-Ming Hu, Zhi-Ke Peng, Guang Meng. Tunable Micro- and Nanomechanical Resonators. Sensors 2015, 15 (10) , 26478-26566. https://doi.org/10.3390/s151026478
    16. Huacheng Qiu, Dara Feili, Xuezhong Wu, Helmut Seidel. Resonant-mode effect on fluidic damping of piezoelectric microcantilevers vibrating in an infinite viscous gaseous environment. Sensors and Actuators A: Physical 2015, 232 , 1-7. https://doi.org/10.1016/j.sna.2015.05.003
    17. R. Sriramshankar, G. R. Jayanth. Design and Evaluation of Torsional Probes for Multifrequency Atomic Force Microscopy. IEEE/ASME Transactions on Mechatronics 2015, 20 (4) , 1843-1853. https://doi.org/10.1109/TMECH.2014.2356719
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    Analytical Chemistry

    Cite this: Anal. Chem. 2013, 85, 3, 1760–1766
    Click to copy citationCitation copied!
    https://doi.org/10.1021/ac303092q
    Published December 31, 2012
    Copyright © 2012 American Chemical Society
    Request reuse permissions

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