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Polypyrrole Nanotube Embedded Reduced Graphene Oxide Transducer for Field-Effect Transistor-Type H2O2 Biosensor
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    Polypyrrole Nanotube Embedded Reduced Graphene Oxide Transducer for Field-Effect Transistor-Type H2O2 Biosensor
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    School of Chemical and Biological Engineering, Seoul National University, Seoul 151-742, Korea
    Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States
    *E-mail: [email protected]. Fax: (+82) 2-888-1604.
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    Analytical Chemistry

    Cite this: Anal. Chem. 2014, 86, 3, 1822–1828
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    https://doi.org/10.1021/ac403770x
    Published January 4, 2014
    Copyright © 2014 American Chemical Society

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    We report a rapid-response and high-sensitivity sensor with specificity toward H2O2 based on a liquid-ion-gated field-effect transistor (FET) using graphene-polypyrrole (PPy) nanotube (NT) composites as the conductive channel. The rGO, PPy, NTs, and nanocomposite materials were characterized using Raman spectroscopy, Fourier transform-infrared (FT-IR) spectroscopy, transmission electron microscopy (TEM), and scanning electron microscopy (SEM). On the basis of these results, a well-organized structure is successfully prepared owing to the specific interactions between the PPy NTs and the rGO sheet. Reliable electrical contacts were developed between the rGO/PPy NTs and the microelectrodes, which remained stable when exposed to the liquid-phase analyte. Liquid-ion-gated FETs composed of these graphene nanocomposites exhibited hole-transport behavior with conductivities higher than those of rGO sheets or PPy NTs. This implies an interaction between the PPy NTs and the rGO layers, which is explained in terms of the PPy NTs forming a bridge between the rGO layers. The FET sensor provided a rapid response in real time and high sensitivity toward H2O2 with a limit of detection of 100 pM. The FET-type biosensing geometry was also highly reproducible and stable in air. Furthermore, the liquid-gated FET-type sensor exhibited specificity toward H2O2 in a mixed solution containing compounds found in biological fluids.

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    Analytical Chemistry

    Cite this: Anal. Chem. 2014, 86, 3, 1822–1828
    Click to copy citationCitation copied!
    https://doi.org/10.1021/ac403770x
    Published January 4, 2014
    Copyright © 2014 American Chemical Society

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