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    Volumetric Absorptive Microsampling: A Dried Sample Collection Technique for Quantitative Bioanalysis
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    Bioanalytical Science and Toxicokinetics, Drug Metabolism and Pharmacokinetics, GlaxoSmithKline Research and Development, Ware, Hertfordshire SG12 0DP, United Kingdom
    *E-mail: [email protected]
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    Analytical Chemistry

    Cite this: Anal. Chem. 2014, 86, 16, 8489–8495
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    https://doi.org/10.1021/ac5022562
    Published July 24, 2014
    Copyright © 2014 American Chemical Society
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    Abstract

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    Volumetric absorptive microsampling (VAMS) is a novel approach to obtaining a dried blood sample for quantitative bioanalysis that overcomes the area bias and homogeneity issues associated with conventional dried blood spot (DBS) sample when a subpunch is taken. The VAMS sampler absorbs a fixed volume of blood (∼10 μL) in 2–4 s with less than 5% volume variation across the hematocrit range of 20–70% with low tip-to-tip variability. There is no evidence of selective absorption by the tip of the plasma component over whole blood. Recommendations for best practice when collecting samples were developed based upon the results of tests examining a number of potential abuse scenarios.

    Copyright © 2014 American Chemical Society

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    Analytical Chemistry

    Cite this: Anal. Chem. 2014, 86, 16, 8489–8495
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    https://doi.org/10.1021/ac5022562
    Published July 24, 2014
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