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Download Hi-Res ImageDownload to MS-PowerPointCite This:Anal. Chem. 2009, 81, 1, 123-129
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Detection of Diethyl Phthalate in Perfumes by Extractive Electrospray Ionization Mass Spectrometry

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Department of Chemistry and Applied Biosciences, ETH Zürich CH-8093 Zürich Switzerland, and Applied Chemistry Department, East China Institute of Technology, Fuzhou, China
* To whom correspondence should be addressed. Prof. Dr. Renato Zenobi, Chemistry Department and Applied Biosciences, ETH Zürich, CH-8093 Zürich, Switzerland. Fax: (+) 41-44-632-1292. E-mail: [email protected]. Dr. Huanwen Chen, Applied Chemistry Department, East China Institute of Technology, Fuzhou, China. Fax: (+)86-794-8258-320. E-mail: [email protected]
†ETH Zurich.
‡East China Institute of Technology.
Cite this: Anal. Chem. 2009, 81, 1, 123–129
Publication Date (Web):December 8, 2008
https://doi.org/10.1021/ac801572d
Copyright © 2008 American Chemical Society
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Abstract

Recent findings suggest that long-term exposure to diethyl phthalate (DEP), one of the widely used phthalate esters, can lead to serious health problems. Most perfumes contain non-negligible amounts of DEP. Rapid and sensitive detection of DEP in perfumes is thus of increasing importance. A novel procedure based on extractive electrospray ionization mass spectrometry (EESI-MS) has been developed for fast detection and identification of DEP in perfumes without the need for any sample pretreatment. The limit of determination for DEP in perfume was less than 100 ppb using tandem mass spectrometry on a commercial quadrupole time-of-flight mass spectrometer. The dynamic range of this method was about 4 orders of magnitude. A single sample analysis was completed within a few seconds, providing a rapid way to obtain semiquantitative information on the DEP content in perfumes. This study shows that both volatile and nonvolatile analytes (e.g., amino acids) in liquids can be directly sampled by neutral desorption, providing a convenient way for high-throughput screening of target compounds using EESI-MS.

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