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Combining Nanomedicine and Immunotherapy

  • Yang Shi*
    Yang Shi
    Department of Nanomedicine and Theranostics, Institute for Experimental Molecular Imaging, Uniklinik RWTH Aachen and Helmholtz Institute for Biomedical Engineering, Faculty of Medicine, RWTH Aachen University, 52074 Aachen, Germany
    *E-mail: [email protected]
    More by Yang Shi
  •  and 
  • Twan Lammers*
    Twan Lammers
    Department of Nanomedicine and Theranostics, Institute for Experimental Molecular Imaging, Uniklinik RWTH Aachen and Helmholtz Institute for Biomedical Engineering, Faculty of Medicine, RWTH Aachen University, 52074 Aachen, Germany
    Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3584 CG Utrecht, The Netherlands
    Department of Targeted Therapeutics, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, 7500 AE Enschede, The Netherlands
    *E-mail: [email protected]
    More by Twan Lammers
Cite this: Acc. Chem. Res. 2019, 52, 6, 1543–1554
Publication Date (Web):May 23, 2019
Copyright © 2019 American Chemical Society

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    Abstract Image

    Nanomedicine holds significant potential to improve the efficacy of cancer immunotherapy. Thus far, nanomedicines, i.e., 1–100(0) nm sized drug delivery systems, have been primarily used to improve the balance between the efficacy and toxicity of conjugated or entrapped chemotherapeutic drugs. The clinical performance of cancer nanomedicines has been somewhat disappointing, which is arguably mostly due to the lack of tools and technologies for patient stratification. Conversely, the clinical progress made with immunotherapy has been spectacular, achieving complete cures and inducing long-term survival in advanced-stage patients. Unfortunately, however, immunotherapy only works well in relatively small subsets of patients. Increasing amounts of preclinical and clinical data demonstrate that combining nanomedicine with immunotherapy can boost therapeutic outcomes, by turning “cold” nonimmunoresponsive tumors and metastases into “hot” immunoresponsive lesions.

    Nano-immunotherapy can be realized via three different approaches, in which nanomedicines are used (1) to target cancer cells, (2) to target the tumor immune microenvironment, and (3) to target the peripheral immune system. When targeting cancer cells, nanomedicines typically aim to induce immunogenic cell death, thereby triggering the release of tumor antigens and danger-associated molecular patterns, such as calreticulin translocation, high mobility group box 1 protein and adenosine triphosphate. The latter serve as adjuvants to alert antigen-presenting cells to take up, process and present the former, thereby promoting the generation of CD8+ cytotoxic T cells. Nanomedicines targeting the tumor immune microenvironment potentiate cancer immunotherapy by inhibiting immunosuppressive cells, such as M2-like tumor-associated macrophages, as well as by reducing the expression of immunosuppressive molecules, such as transforming growth factor beta. In addition, nanomedicines can be employed to promote the activity of antigen-presenting cells and cytotoxic T cells in the tumor immune microenvironment. Nanomedicines targeting the peripheral immune system aim to enhance antigen presentation and cytotoxic T cell production in secondary lymphoid organs, such as lymph nodes and spleen, as well as to engineer and strengthen peripheral effector immune cell populations, thereby promoting anticancer immunity.

    While the majority of immunomodulatory nanomedicines are in preclinical development, exciting results have already been reported in initial clinical trials. To ensure efficient translation of nano-immunotherapy constructs and concepts, we have to consider biomarkers in their clinical development, to make sure that the right nanomedicine formulation is combined with the right immunotherapy in the right patient. In this context, we have to learn from currently ongoing efforts in nano-biomarker identification as well as from partially already established immuno-biomarker initiatives, such as the Immunoscore and the cancer immunogram. Together, these protocols will help to capture the nano-immuno status in individual patients, enabling the identification and use of individualized and improved nanomedicine-based treatments to boost the performance of cancer immunotherapy.

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    9. Yun Chen, Rong Cui, Yadong Luo, Pei Jing, Caikun Liu, Bing Li, Xiaoming Liao, Shiyong Zhang. Harnessing Self-Cyclic Cascade System for Reactive Oxygen Species-Boosted Photothermal Immunotherapy. Chemistry of Materials 2022, 34 (18) , 8219-8229.
    10. Liangjie Jin, Dongmei Yang, Yonghong Song, Dongdong Li, Weijia Xu, Yueqiang Zhu, Cong-Fei Xu, Yang Lu, Xianzhu Yang. In Situ Programming of Nanovaccines for Lymph Node-Targeted Delivery and Cancer Immunotherapy. ACS Nano 2022, 16 (9) , 15226-15236.
    11. Weicai Wang, Xiaozu Chen, Junwei Li, Qiu Jin, Hyung Jong Jin, Xuemei Li. Hollow MnO2 Nanoparticles Loaded with Functional Genes as Nanovaccines for Synergistic Cancer Therapy. ACS Applied Nano Materials 2022, 5 (8) , 10537-10547.
    12. Lorena Mendive-Tapia, Marc Vendrell. Activatable Fluorophores for Imaging Immune Cell Function. Accounts of Chemical Research 2022, 55 (8) , 1183-1193.
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    14. Changsong Wu, Meihui Cui, Li Cai, Chen Chen, Xiaohui Zhu, Yihan Wu, Jinliang Liu, Hanjie Wang, Yong Zhang. NIR-Responsive Photodynamic Nanosystem Combined with Antitumor Immune Optogenetics Bacteria for Precise Synergetic Therapy. ACS Applied Materials & Interfaces 2022, 14 (11) , 13094-13106.
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    16. Mengke Xu, Chi Zhang, Ziling Zeng, Kanyi Pu. Semiconducting Polymer Nanoparticles as Activatable Nanomedicines for Combinational Phototherapy. ACS Applied Polymer Materials 2021, 3 (9) , 4375-4389.
    17. Shan Gao, Xiaoye Yang, Jiangkang Xu, Na Qiu, Guangxi Zhai. Nanotechnology for Boosting Cancer Immunotherapy and Remodeling Tumor Microenvironment: The Horizons in Cancer Treatment. ACS Nano 2021, 15 (8) , 12567-12603.
    18. Debasis Banik, Maryam Hamidinia, Joanna Brzostek, Ling Wu, Hannah M. Stephens, Paul A. MacAry, Ellis L. Reinherz, Nicholas R. J. Gascoigne, Matthew J. Lang. Single Molecule Force Spectroscopy Reveals Distinctions in Key Biophysical Parameters of αβ T-Cell Receptors Compared with Chimeric Antigen Receptors Directed at the Same Ligand. The Journal of Physical Chemistry Letters 2021, 12 (31) , 7566-7573.
    19. Elham Bidram, Yasaman Esmaeili, Abbas Amini, Rossella Sartorius, Franklin R. Tay, Laleh Shariati, Pooyan Makvandi. Nanobased Platforms for Diagnosis and Treatment of COVID-19: From Benchtop to Bedside. ACS Biomaterials Science & Engineering 2021, 7 (6) , 2150-2176.
    20. Zhaowei Li, Long Rong. A Homotypic Membrane-Camouflaged Biomimetic Nanoplatform with Gold Nanocrystals for Synergistic Photothermal/Starvation/Immunotherapy. ACS Applied Materials & Interfaces 2021, 13 (20) , 23469-23480.
    21. Minglong Chen, Dan Yang, Ying Sun, Ting Liu, Wenhao Wang, Jintao Fu, Qingqing Wang, Xuequn Bai, Guilan Quan, Xin Pan, Chuanbin Wu. In Situ Self-Assembly Nanomicelle Microneedles for Enhanced Photoimmunotherapy via Autophagy Regulation Strategy. ACS Nano 2021, 15 (2) , 3387-3401.
    22. Junjie Li, Kazunori Kataoka. Chemo-physical Strategies to Advance the in Vivo Functionality of Targeted Nanomedicine: The Next Generation. Journal of the American Chemical Society 2021, 143 (2) , 538-559.
    23. Zhe Yang, Di Gao, Xiaoqing Guo, Lin Jin, Juanjuan Zheng, Ying Wang, Shuojia Chen, Xuewei Zheng, Li Zeng, Ming Guo, Xingcai Zhang, Zhongmin Tian. Fighting Immune Cold and Reprogramming Immunosuppressive Tumor Microenvironment with Red Blood Cell Membrane-Camouflaged Nanobullets. ACS Nano 2020, 14 (12) , 17442-17457.
    24. Yufei Xia, Tiantian Song, Yuning Hu, Guanghui Ma. Synthetic Particles for Cancer Vaccines: Connecting the Inherent Supply Chain. Accounts of Chemical Research 2020, 53 (10) , 2068-2080.
    25. Wenqian Yu, Junlin Sun, Feng Liu, Shuyi Yu, Jialing Hu, Yun Zhao, Xiuyuan Wang, Xiaoqing Liu. Treating Immunologically Cold Tumors by Precise Cancer Photoimmunotherapy with an Extendable Nanoplatform. ACS Applied Materials & Interfaces 2020, 12 (36) , 40002-40012.
    26. Minglong Chen, Guilan Quan, Ting Wen, Peipei Yang, Wanbing Qin, Haoting Mai, Ying Sun, Chao Lu, Xin Pan, Chuanbin Wu. Cold to Hot: Binary Cooperative Microneedle Array-Amplified Photoimmunotherapy for Eliciting Antitumor Immunity and the Abscopal Effect. ACS Applied Materials & Interfaces 2020, 12 (29) , 32259-32269.
    27. Weijing Yang, Fuwu Zhang, Hongzhang Deng, Lisen Lin, Sheng Wang, Fei Kang, Guocan Yu, Joseph Lau, Rui Tian, Mingru Zhang, Zhantong Wang, Liangcan He, Ying Ma, Gang Niu, Shuo Hu, Xiaoyuan Chen. Smart Nanovesicle-Mediated Immunogenic Cell Death through Tumor Microenvironment Modulation for Effective Photodynamic Immunotherapy. ACS Nano 2020, 14 (1) , 620-631.
    28. Hongyan Wei, Zhao Zhao, Yimin Wang, Jiang Zou, Qingyu Lin, Yixiang Duan. One-Step Self-Assembly of Multifunctional DNA Nanohydrogels: An Enhanced and Harmless Strategy for Guiding Combined Antitumor Therapy. ACS Applied Materials & Interfaces 2019, 11 (50) , 46479-46489.
    29. Wei Cao, Mengyao Jin, Weiguo Zhou, Kang Yang, Yixian Cheng, Junjie Chen, Guodong Cao, Maoming Xiong, Bo Chen. Forefronts and hotspots evolution of the nanomaterial application in anti-tumor immunotherapy: a scientometric analysis. Journal of Nanobiotechnology 2024, 22 (1)
    30. Haoyu Sun, Tong Wu, Xinrui Liu, Huanzhang Xia, Hongmei Yuan. Mapping the Nanotechnology Patent Landscape in the Field of Cancer. Recent Patents on Nanotechnology 2024, 18 (3) , 321-334.
    31. Yasi Deng, Hao Zheng, Bin Li, Feibing Huang, Yun Qiu, Yupei Yang, Wenbing Sheng, Caiyun Peng, Xing Tian, Wei Wang, Huanghe Yu. Nanomedicines targeting activated immune cells and effector cells for rheumatoid arthritis treatment. Journal of Controlled Release 2024, 371 , 498-515.
    32. Victoria Judith Morel, Jochen Rössler, Michele Bernasconi. Targeted immunotherapy and nanomedicine for rhabdomyosarcoma: The way of the future. Medicinal Research Reviews 2024, 42
    33. Zheng Cao, Chaoyong Liu, Jing Wen, Yunfeng Lu. Innovative Formulation Platform: Paving the Way for Superior Protein Therapeutics with Enhanced Efficacy and Broadened Applications. Advanced Materials 2024, 283
    34. Lin Xu, Yijie Zhou, Na Li, Anyu Yang, Hongbo Qi. Platelet membrane encapsulated curcumin nanomaterial-mediated specific thrombolysis and anti-thrombotic treatment among pregnant women. Biomaterials Science 2024, 12 (12) , 3163-3174.
    35. Ashish Pandey, Ines Karmous. Exploring the Potential of Plant-Based Nanotechnology in Cancer Immunotherapy: Benefits, Limitations, and Future Perspectives. Biological Trace Element Research 2024, 29
    36. Jie Liu, Bei Li, Li Li, Xin Ming, Zhi Ping Xu. Advances in Nanomaterials for Immunotherapeutic Improvement of Cancer Chemotherapy. Small 2024, 17
    37. Meiyan Wu, Yuan Liao, Di Guo, Mingyue Zhai, Desong Xia, Zhikun Zhang, Xiyu Liu, Yong Huang. Manganese-based nanomaterials in diagnostics and chemodynamic therapy of cancers: new development. RSC Advances 2024, 14 (21) , 14722-14741.
    38. Hao Xing, Xiaomin Li. Engineered Nanomaterials for Tumor Immune Microenvironment Modulation in Cancer Immunotherapy. Chemistry – A European Journal 2024, 41
    39. Penghui Wang, Ji Chen, Runming Zhong, Yuanyuan Xia, Zhina Wu, Chunye Zhang, Hai Yao. Recent advances of ultrasound-responsive nanosystems in tumor immunotherapy. European Journal of Pharmaceutics and Biopharmaceutics 2024, 198 , 114246.
    40. Farah Rehan, Mingjie Zhang, Jun Fang, Khaled Greish. Therapeutic Applications of Nanomedicine: Recent Developments and Future Perspectives. Molecules 2024, 29 (9) , 2073.
    41. Kimberly S. Ku, Jie Tang, Yuan Chen, Yihui Shi. Current Advancements in Anti-Cancer Chimeric Antigen Receptor T Cell Immunotherapy and How Nanotechnology May Change the Game. International Journal of Molecular Sciences 2024, 25 (10) , 5361.
    42. Twan Lammers. Nanomedicine Tumor Targeting. Advanced Materials 2024, 46
    43. Shukun Li, Xuehai Yan, Jan van Hest. Self‐assembling Bioactive Peptides for Supramolecular Cancer Immunotherapy. 2024, 531-561.
    44. Ya Cui, Shebin Hong, Weidong Jiang, Xiaojing Li, Xingyu Zhou, Xiaoya He, Jiaqiang Liu, Kaili Lin, Lixia Mao. Engineering mesoporous bioactive glasses for emerging stimuli-responsive drug delivery and theranostic applications. Bioactive Materials 2024, 34 , 436-462.
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    48. Mingyuan Li, Han Jiang, Ping Hu, Jianlin Shi. Nanocatalytic Anti‐Tumor Immune Regulation. Angewandte Chemie International Edition 2024, 63 (13)
    49. Mingyuan Li, Han Jiang, Ping Hu, Jianlin Shi. Nanocatalytic Anti‐Tumor Immune Regulation. Angewandte Chemie 2024, 136 (13)
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    51. Xianbo Wu, Yuqing Li, Mei Wen, Yongting Xie, Ke Zeng, You-Nian Liu, Wansong Chen, Yanli Zhao. Nanocatalysts for modulating antitumor immunity: fabrication, mechanisms and applications. Chemical Society Reviews 2024, 53 (5) , 2643-2692.
    52. Xianzhou Huang, Tao He, Xiuqi Liang, Zhongzheng Xiang, Chao Liu, Shiyao Zhou, Rui Luo, Liping Bai, Xiaorong Kou, Xinchao Li, Rui Wu, Xinyu Gou, Xinyue Wu, Dongxue Huang, Wangxian Fu, Yingjie Li, Ruhan Chen, Ningyue Xu, Yixi Wang, Hao Le, Tao Chen, Yangsong Xu, Yuting Tang, Changyang Gong. Advances and applications of nanoparticles in cancer therapy. MedComm – Oncology 2024, 3 (1)
    53. Ningning He, Jingting Jiang. Contribution of immune cells in synergistic anti-tumor effect of ablation and immunotherapy. Translational Oncology 2024, 40 , 101859.
    54. Jiayi Chen, Siyuan Hu, Man Sun, Jianan Shi, Huan Zhang, Hongmei Yu, Zhaogang Yang. Recent advances and clinical translation of liposomal delivery systems in cancer therapy. European Journal of Pharmaceutical Sciences 2024, 193 , 106688.
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    57. Han Wang, Jason Mills, Boran Sun, Honggang Cui. Therapeutic supramolecular polymers: Designs and applications. Progress in Polymer Science 2024, 148 , 101769.
    58. Zakia Sultana, Zarnain Jamil, Arijit Samanta, Syed Sahajada Mahafujul Alam, Safdar Ali, Mehboob Hoque. Current status, challenges, and future perspective of nanomedicine-based cancer immunotherapy. 2024, 495-516.
    59. Xianghe Jiang, Lili Wu, Mengya Zhang, Tinglin Zhang, Cuimin Chen, Jie Gao. Biomembrane-based nanoparticles for cancer immunotherapy. 2024, 299-316.
    60. Wenshe Sun, Shaowei Xie, Shi Feng Liu, Xiaokun Hu, Dongming Xing. Evolving Tumor Characteristics and Smart Nanodrugs for Tumor Immunotherapy. International Journal of Nanomedicine 2024, Volume 19 , 3919-3942.
    61. Shuai Chen, Rui Huang, Feiyang Shen, Yijia Wu, Yao Lin, Xiaoyu Yang, Jianfeng Shen, Yan Fang. Enhancing antitumor immunity with stimulus-responsive mesoporous silicon in combination with chemotherapy and photothermal therapy. Biomaterials Science 2024, 1876
    62. Xiaoxue Lang, Xiangtao Wang, Meihua Han, Yifei Guo. Nanoparticle-Mediated Synergistic Chemoimmunotherapy for Cancer Treatment. International Journal of Nanomedicine 2024, Volume 19 , 4533-4568.
    63. Hao Cui, Yan You, Guo-Wang Cheng, Zhou Lan, Ke-Long Zou, Qiu-Ying Mai, Yan-Hua Han, Hao Chen, Yu-Yue Zhao, Guang-Tao Yu. Advanced materials and technologies for oral diseases. Science and Technology of Advanced Materials 2023, 24 (1)
    64. Lan Xu, Shuli Ma, Bozhen Fan, Zeting Yuan, Peihao Yin. Bufalin-loaded vitamin E succinate-grafted chitosan oligosaccharide/RGD-conjugated TPGS mixed micelles inhibit intraperitoneal metastasis of ovarian cancer. Cancer Nanotechnology 2023, 14 (1)
    65. Esmaeel Sharifi, Satar Yousefiasl, Maria Trovato, Rossella Sartorius, Yasaman Esmaeili, Hamid Goodarzi, Matineh Ghomi, Ashkan Bigham, Farnaz Dabbagh Moghaddam, Maryam Heidarifard, Samiramis Pourmotabed, Ehsan Nazarzadeh Zare, Ana Cláudia Paiva-Santos, Navid Rabiee, Xiangdong Wang, Franklin R. Tay. Nanostructures for prevention, diagnosis, and treatment of viral respiratory infections: from influenza virus to SARS-CoV-2 variants. Journal of Nanobiotechnology 2023, 21 (1)
    66. Xiangyi Kong, Peng Gao, Jing Wang, Yi Fang, Kuo Chu Hwang. Advances of medical nanorobots for future cancer treatments. Journal of Hematology & Oncology 2023, 16 (1)
    67. Yao-Ge Liu, Shi-Tao Jiang, Lei Zhang, Han Zheng, Ting Zhang, Jun-Wei Zhang, Hai-Tao Zhao, Xin-Ting Sang, Yi-Yao Xu, Xin Lu. Worldwide productivity and research trend of publications concerning tumor immune microenvironment (TIME): a bibliometric study. European Journal of Medical Research 2023, 28 (1)
    68. Zitao Liu, Liang Sun, Xingyu Peng, Sicheng Liu, Zhengming Zhu, Chao Huang. An immunogenic cell death-related signature predicts prognosis and immunotherapy response in stomach adenocarcinoma. Apoptosis 2023, 28 (11-12) , 1564-1583.
    69. Yiming Xia, Shunli Fu, Qingping Ma, Yongjun Liu, Na Zhang. Application of Nano-Delivery Systems in Lymph Nodes for Tumor Immunotherapy. Nano-Micro Letters 2023, 15 (1)
    70. Lamei Guo, Jinjun Yang, Hao Wang, Yu Yi. Multistage Self-Assembled Nanomaterials for Cancer Immunotherapy. Molecules 2023, 28 (23) , 7750.
    71. Zhenyu Wang, Tingting You, Qianyi Su, Wenjia Deng, JiaBao Li, Saixiang Hu, Shengjun Shi, Zhaowei Zou, Jisheng Xiao, Xiaopin Duan. Laser‐Activatable In Situ Vaccine Enhances Cancer‐Immunity Cycle. Advanced Materials 2023, 35 (52)
    72. Dong Wang, Jia-Tao Zhang. Metal-based inorganic nanocrystals for biological sonodynamic therapy applications: recent progress and perspectives. Rare Metals 2023, 41
    73. Zhiyang Chen, Liang Chen, Yiqun Ma, Yuyi Liu, Qianyi Zhang, Hao Qin, Yu Chen, Bo Tian, Jian Dong. Peptide‐Appended Nanosonosensitizers Targeting Tumor Glycolysis for Synergistic Sonodynamic–Immunometabolic Therapy of Spinal‐Metastasized Tumors. Advanced Materials 2023, 35 (42)
    74. Ruimin Chang, Tan Li, Yao Fu, Zeyu Chen, Yilang He, Xin Sun, Yiyi Deng, Yanqing Zhong, Zuozhong Xie, Yang Yang, Jing Liu, Xiang Chen, Hong Liu, Yuetao Zhao. A PD-L1 targeting nanotheranostic for effective photoacoustic imaging guided photothermal-immunotherapy of tumor. Journal of Materials Chemistry B 2023, 11 (35) , 8492-8505.
    75. Yang Qin, Haitao Zhang, Yunxian Li, Ting Xie, Shuang Yan, Jiaqi Wang, Jun Qu, Feijun Ouyang, Shaoyang Lv, Zifen Guo, Hua Wei, Cui‐Yun Yu. Promotion of ICD via Nanotechnology. Macromolecular Bioscience 2023, 23 (9)
    76. Mei Lu, Haonan Xing, Wanxuan Shao, Pengfei Wu, Yuchuan Fan, Huining He, Stefan Barth, Aiping Zheng, Xing-Jie Liang, Yuanyu Huang. Antitumor synergism between PAK4 silencing and immunogenic phototherapy of engineered extracellular vesicles. Acta Pharmaceutica Sinica B 2023, 13 (9) , 3945-3955.
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    80. Pratikshya Sa, Sanjeeb K. Sahoo, Fahima Dilnawaz. Responsive Role of Nanomedicine in the Tumor Microenvironment and Cancer Drug Resistance. Current Medicinal Chemistry 2023, 30 (29) , 3335-3355.
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    86. Jin Li, Xianyanling Yi, Liangren Liu, Xiaohui Wang, Jianzhong Ai. Advances in tumor nanotechnology: theragnostic implications in tumors via targeting regulated cell death. Apoptosis 2023, 28 (7-8) , 1198-1215.
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    89. Jingchao Li, Ningyue Yu, Dong Cui, Jiaguo Huang, Yu Luo, Kanyi Pu. Activatable Semiconducting Polymer Pro‐nanomodulators for Deep‐Tissue Sono‐immunotherapy of Orthotopic Pancreatic Cancer. Angewandte Chemie 2023, 135 (30)
    90. Jingchao Li, Ningyue Yu, Dong Cui, Jiaguo Huang, Yu Luo, Kanyi Pu. Activatable Semiconducting Polymer Pro‐nanomodulators for Deep‐Tissue Sono‐immunotherapy of Orthotopic Pancreatic Cancer. Angewandte Chemie International Edition 2023, 62 (30)
    91. Xiwang Zheng, Defei Zheng, Chunming Zhang, Huina Guo, Yuliang Zhang, Xuting Xue, Zhaohui Shi, Xiangmin Zhang, Xianhai Zeng, Yongyan Wu, Wei Gao. A cuproptosis-related lncRNA signature predicts the prognosis and immune cell status in head and neck squamous cell carcinoma. Frontiers in Oncology 2023, 13
    92. Tingjun Yan, Mengyao Su, Zhimin Wang, Jiatao Zhang. Second Near‐Infrared Plasmonic Nanomaterials for Photoacoustic Imaging and Photothermal Therapy. Small 2023, 19 (30)
    93. Hao Yu, Zhihai Han, Cunrong Chen, Leisheng Zhang. Nanomaterials as Novel Biomarkers for Cancer Nanotheranostics: State of the Art. 2023
    94. Chenchao Feng, Peng Tan, Guangjun Nie, Motao Zhu. Biomimetic and bioinspired nano‐platforms for cancer vaccine development. Exploration 2023, 3 (3)
    95. Hongda Zhu, Chaobo Yang, Aqin Yan, Wei Qiang, Rui Ruan, Kai Ma, Yeneng Guan, Jing Li, Qi Yu, Hongmei Zheng, Le Tu, Shuang Liu, Zhu Dai, Yao Sun. Tumor‐targeted nano‐adjuvants to synergize photomediated immunotherapy enhanced antitumor immunity. VIEW 2023, 4 (3)
    96. Xu Li, Yuhui Ma. MnO 2 nanodrug mediates the expression of antigen-presenting cell through combined chemotherapy to enhance the antineoplastic curative function. Materials Express 2023, 13 (6) , 935-941.
    97. Fengshuo Wang, Kanyi Pu, Jingchao Li. Activating Nanomedicines with Electromagnetic Energy for Deep‐Tissue Induction of Immunogenic Cell Death in Cancer Immunotherapy. Small Methods 2023, 7 (5)
    98. Run Tian, Yingxu Shang, Yiming Wang, Qiao Jiang, Baoquan Ding. DNA Nanomaterials‐Based Platforms for Cancer Immunotherapy. Small Methods 2023, 7 (5)
    99. Minhan Jiang, Steven Fiering, Qi Shao. Combining energy-based focal ablation and immune checkpoint inhibitors: preclinical research and clinical trials. Frontiers in Oncology 2023, 13
    100. Irina Naletova, Barbara Tomasello, Francesco Attanasio, Victor V. Pleshkan. Prospects for the Use of Metal-Based Nanoparticles as Adjuvants for Local Cancer Immunotherapy. Pharmaceutics 2023, 15 (5) , 1346.
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