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Raman Spectroscopic Detection in Continuous Microflow Using a Chip-Integrated Silver Electrode as an Electrically Regenerable Surface-Enhanced Raman Spectroscopy Substrate

  • Eva-Maria Höhn
    Eva-Maria Höhn
    Institut für Analytische Chemie, Universität Leipzig, Johannisallee 29, Leipzig 04103, Germany
  • Rajapandiyan Panneerselvam
    Rajapandiyan Panneerselvam
    Institut für Analytische Chemie, Universität Leipzig, Johannisallee 29, Leipzig 04103, Germany
  • Anish Das
    Anish Das
    Institut für Analytische Chemie, Universität Leipzig, Johannisallee 29, Leipzig 04103, Germany
    More by Anish Das
  • , and 
  • Detlev Belder*
    Detlev Belder
    Institut für Analytische Chemie, Universität Leipzig, Johannisallee 29, Leipzig 04103, Germany
    *Phone: +49 341 97 36091. Fax: +49 341 97 36115. E-mail: [email protected]
Cite this: Anal. Chem. 2019, 91, 15, 9844–9851
Publication Date (Web):July 1, 2019
https://doi.org/10.1021/acs.analchem.9b01514
Copyright © 2019 American Chemical Society

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    Abstract

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    An electrochemical approach to enable surface-enhanced Raman spectroscopy (SERS) detection in continuous microflow is presented. This is achieved by the integration of a silver electrode as SERS substrate in a microfluidic chip device. By the application of actuation pulses of about 4 V, otherwise irreversibly adsorbed analytes are stripped off, which enables quasi-real-time SERS detection in a continuous microflow. The approach opens up a way for in situ SERS monitoring of compounds in microflow with high application potential in microseparation techniques like HPLC and lab-on-a-chip devices.

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    The Supporting Information is available free of charge on the ACS Publications website at DOI: 10.1021/acs.analchem.9b01514.

    • Schematic of the lamination technique; SERS substrate characterization; comparison of different microfluidic conditions on signal stability/effect of photobleaching; evaluation of SERS active electrode as anode; effect of AC voltage in electrical regeneration; comparison of different channel widths on the regeneration strategy; effect of potential in electrical regeneration; effect of chip configuration; evaluation of the SERS substrate lifetime in a microfluidic flow cell; SERS spectra of the used model analytes; regeneration experiment with 4-mercaptobenzoic acid (PDF)

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    Cited By

    This article is cited by 18 publications.

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