Pair your accounts.

Export articles to Mendeley

Get article recommendations from ACS based on references in your Mendeley library.

Pair your accounts.

Export articles to Mendeley

Get article recommendations from ACS based on references in your Mendeley library.

You’ve supercharged your research process with ACS and Mendeley!

Click to create an ACS ID

Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

Your Mendeley pairing has expired. Please reconnect
ACS Publications. Most Trusted. Most Cited. Most Read
My Activity

ICBM-OCEAN: Processing Ultrahigh-Resolution Mass Spectrometry Data of Complex Molecular Mixtures

  • Julian Merder*
    Julian Merder
    Institute for Chemistry and Biology of the Marine Environment, University of Oldenburg, Carl-von-Ossietzky-Str. 9-11, 26129 Oldenburg, Germany
    *Email: [email protected] (J.M.).
  • Jan A. Freund
    Jan A. Freund
    Institute for Chemistry and Biology of the Marine Environment, University of Oldenburg, Carl-von-Ossietzky-Str. 9-11, 26129 Oldenburg, Germany
  • Ulrike Feudel
    Ulrike Feudel
    Institute for Chemistry and Biology of the Marine Environment, University of Oldenburg, Carl-von-Ossietzky-Str. 9-11, 26129 Oldenburg, Germany
  • Christian T. Hansen
    Christian T. Hansen
    Institute for Chemistry and Biology of the Marine Environment, University of Oldenburg, Carl-von-Ossietzky-Str. 9-11, 26129 Oldenburg, Germany
  • Jeffrey A. Hawkes
    Jeffrey A. Hawkes
    Department of Chemistry−BMC, Uppsala University, Husargatan 3 (D5), 752 37 Uppsala, Sweden
  • Benjamin Jacob
    Benjamin Jacob
    Helmholtz-Centre Geesthacht, Centre for Materials and Coastal Research, Max-Planck-Straße 1, 21502 Geesthacht, Germany
  • Katrin Klaproth
    Katrin Klaproth
    Institute for Chemistry and Biology of the Marine Environment, University of Oldenburg, Carl-von-Ossietzky-Str. 9-11, 26129 Oldenburg, Germany
  • Jutta Niggemann
    Jutta Niggemann
    Institute for Chemistry and Biology of the Marine Environment, University of Oldenburg, Carl-von-Ossietzky-Str. 9-11, 26129 Oldenburg, Germany
  • Beatriz E. Noriega-Ortega
    Beatriz E. Noriega-Ortega
    Leibniz-Institute of Freshwater Ecology and Inland Fisheries, Müggelseedamm 310, 12587, Berlin, Germany
  • Helena Osterholz
    Helena Osterholz
    Leibniz Institute for Baltic Sea Research Warnemuende, Seestraße 15, 18119 Rostock, Germany
  • Pamela E. Rossel
    Pamela E. Rossel
    Institute for Chemistry and Biology of the Marine Environment, University of Oldenburg, Carl-von-Ossietzky-Str. 9-11, 26129 Oldenburg, Germany
  • Michael Seidel
    Michael Seidel
    Institute for Chemistry and Biology of the Marine Environment, University of Oldenburg, Carl-von-Ossietzky-Str. 9-11, 26129 Oldenburg, Germany
  • Gabriel Singer
    Gabriel Singer
    Department of Ecology, University of Innsbruck, Technikerstrasse 25, 6020 Innsbruck, Austria
    Leibniz-Institute of Freshwater Ecology and Inland Fisheries, Müggelseedamm 310, 12587, Berlin, Germany
  • Aron Stubbins
    Aron Stubbins
    Departments of Marine and Environmental Science, Chemistry and Chemical Biology, and Civil and Environmental Engineering, Northeastern University, 102 HT, Boston, Massachusetts 02115, United States
  • Hannelore Waska
    Hannelore Waska
    Institute for Chemistry and Biology of the Marine Environment, University of Oldenburg, Carl-von-Ossietzky-Str. 9-11, 26129 Oldenburg, Germany
  • , and 
  • Thorsten Dittmar*
    Thorsten Dittmar
    Institute for Chemistry and Biology of the Marine Environment, University of Oldenburg, Carl-von-Ossietzky-Str. 9-11, 26129 Oldenburg, Germany
    *Email: [email protected] (T.D.).
Cite this: Anal. Chem. 2020, 92, 10, 6832–6838
Publication Date (Web):April 16, 2020
Copyright © 2020 American Chemical Society

    Article Views





    Other access options
    Supporting Info (1)»


    Abstract Image

    Untargeted molecular analyses of complex mixtures are relevant for many fields of research, including geochemistry, pharmacology, and medicine. Ultrahigh-resolution mass spectrometry is one of the most powerful tools in this context. The availability of open scripts and online tools for specific data processing steps such as noise removal or molecular formula assignment is growing, but an integrative tool where all crucial steps are reproducibly evaluated and documented is lacking. We developed a novel, server-based tool (ICBM-OCEAN, Institute for Chemistry and Biology of the Marine Environment, Oldenburg–complex molecular mixtures, evaluation & analysis) that integrates published and novel approaches for standardized processing of ultrahigh-resolution mass spectrometry data of complex molecular mixtures. Different from published approaches, we offer diagnostic and validation tools for all relevant steps. Among other features, we included objective and reproducible reduction of noise and systematic errors, spectra recalibration and alignment, and identification of likeliest molecular formulas. With 15 chemical elements, the tool offers high flexibility in formula attribution. Alignment of mass spectra among different samples prior to molecular formula assignment improves mass error and facilitates molecular formula confirmation with the help of isotopologues. The online tool and the detailed instruction manual are freely accessible at

    Read this article

    To access this article, please review the available access options below.

    Get instant access

    Purchase Access

    Read this article for 48 hours. Check out below using your ACS ID or as a guest.


    Access through Your Institution

    You may have access to this article through your institution.

    Your institution does not have access to this content. You can change your affiliated institution below.

    Supporting Information

    Jump To

    The Supporting Information is available free of charge at

    • Major features of ICBM-OCEAN; common chemical parameters in DOM geochemistry and parameters used in ICBM-OCEAN (PDF)

    Terms & Conditions

    Most electronic Supporting Information files are available without a subscription to ACS Web Editions. Such files may be downloaded by article for research use (if there is a public use license linked to the relevant article, that license may permit other uses). Permission may be obtained from ACS for other uses through requests via the RightsLink permission system:

    Cited By

    This article is cited by 73 publications.

    1. Ruanhong Cai, Piao Yao, Yuanbi Yi, Julian Merder, Penghui Li, Ding He. The Hunt for Chemical Dark Matter across a River-to-Ocean Continuum. Environmental Science & Technology 2024, Article ASAP.
    2. Shuxian Gao, Elaine K. Jennings, Limei Han, Boris P. Koch, Peter Herzsprung, Oliver J. Lechtenfeld. Detection and Exclusion of False-Positive Molecular Formula Assignments via Mass Error Distributions in UHR Mass Spectra of Natural Organic Matter. Analytical Chemistry 2024, Article ASAP.
    3. Xiaohan Mo, Penghui Du, T.-W. Dominic Chan, Pang Chui Shaw, Alex Tat-Shing Chow. Fostering Adequate Data Reporting of Fourier Transform Ion Cyclotron Resonance Mass Spectrometry-Based Environmental Studies. ACS ES&T Water 2024, Article ASAP.
    4. Zhe Zhou, Hannelore Waska, Susann Henkel, Thorsten Dittmar, Sabine Kasten, Moritz Holtappels. Iron Promotes the Retention of Terrigenous Dissolved Organic Matter in Subtidal Permeable Sediments. Environmental Science & Technology 2024, 58 (14) , 6204-6214.
    5. Alexander A. Potemkin, Mikhail A. Proskurnin, Dmitry S. Volkov. Noise Filtering Algorithm Using Gaussian Mixture Models for High-Resolution Mass Spectra of Natural Organic Matter. Analytical Chemistry 2024, 96 (14) , 5455-5461.
    6. Qiong Pan, Chen He, Quan Shi. Graph-Based Method for Calibration of High-Resolution Mass Spectra of Natural Organic Matter. Analytical Chemistry 2024, 96 (9) , 3739-3743.
    7. Yuanbi Yi, Tongcun Liu, Julian Merder, Chen He, Hongyan Bao, Penghui Li, Siliang Li, Quan Shi, Ding He. Unraveling the Linkages between Molecular Abundance and Stable Carbon Isotope Ratio in Dissolved Organic Matter Using Machine Learning. Environmental Science & Technology 2023, 57 (46) , 17900-17909.
    8. Hui Nai, Jun Zhong, Yuanbi Yi, Manting Lai, Ding He, Thorsten Dittmar, Cong-Qiang Liu, Si-Liang Li, Sheng Xu. Anthropogenic Disturbance Stimulates the Export of Dissolved Organic Carbon to Rivers on the Tibetan Plateau. Environmental Science & Technology 2023, 57 (25) , 9214-9223.
    9. Wanzhu Li, Na Liu, Jianfeng Li, Baoli Wang, Xinjie Shi, Xia Liang, Meiling Yang, Sheng Xu, Cong-Qiang Liu. Chemodiversity of Dissolved Organic Matter Is Governed by Microbial Biogeography in Inland Waters. Environmental Science & Technology 2023, 57 (20) , 7753-7763.
    10. Maxime Sueur, Julien F. Maillard, Oscar Lacroix-Andrivet, Christopher P. Rüger, Pierre Giusti, Hélène Lavanant, Carlos Afonso. PyC2MC: An Open-Source Software Solution for Visualization and Treatment of High-Resolution Mass Spectrometry Data. Journal of the American Society for Mass Spectrometry 2023, 34 (4) , 617-626.
    11. Ziqi Zhou, Qing-Long Fu, Manabu Fujii, T. David Waite. Complementary Elucidation of the Molecular Characteristics of Groundwater Dissolved Organic Matter Using Ultrahigh-Resolution Mass Spectrometry Coupled with Negative- and Positive-Ion Electrospray Ionization. Environmental Science & Technology 2023, 57 (11) , 4690-4700.
    12. Qing-Long Fu, Manabu Fujii, Rui Ma. Development of a Gaussian-Based Alignment Algorithm for the Ultrahigh-Resolution Mass Spectra of Dissolved Organic Matter. Analytical Chemistry 2023, 95 (5) , 2796-2803.
    13. Daniil A. Boiko, Konstantin S. Kozlov, Julia V. Burykina, Valentina V. Ilyushenkova, Valentine P. Ananikov. Fully Automated Unconstrained Analysis of High-Resolution Mass Spectrometry Data with Machine Learning. Journal of the American Chemical Society 2022, 144 (32) , 14590-14606.
    14. William Bahureksa, Thomas Borch, Robert B. Young, Chad. R. Weisbrod, Greg T. Blakney, Amy M. McKenna. Improved Dynamic Range, Resolving Power, and Sensitivity Achievable with FT-ICR Mass Spectrometry at 21 T Reveals the Hidden Complexity of Natural Organic Matter. Analytical Chemistry 2022, 94 (32) , 11382-11389.
    15. Qing-Long Fu, Manabu Fujii, Eunsang Kwon. Development of an Internal Calibration Algorithm for Ultrahigh-Resolution Mass Spectra of Dissolved Organic Matter. Analytical Chemistry 2022, 94 (30) , 10589-10594.
    16. Carsten Simon, Kai Dührkop, Daniel Petras, Vanessa-Nina Roth, Sebastian Böcker, Pieter C. Dorrestein, Gerd Gleixner. Mass Difference Matching Unfolds Hidden Molecular Structures of Dissolved Organic Matter. Environmental Science & Technology 2022, 56 (15) , 11027-11040.
    17. Can Huo, Zhineng Hao, Chungang Yuan, Yongsheng Chen, Jingfu Liu. Probing the Phytosynthesis Mechanism of Gold and Silver Nanoparticles by Sequential Separation of Plant Extract and Molecular Characterization with Ultra-High-Resolution Mass Spectrometry. ACS Sustainable Chemistry & Engineering 2022, 10 (12) , 3829-3838.
    18. Dini Adyasari, Hannelore Waska, Kirstin Daehnke, Till Oehler, Atas Pracoyo, Doni Prakasa Eka Putra, Nils Moosdorf. Terrestrial Nutrients and Dissolved Organic Matter Input to the Coral Reef Ecosystem via Submarine Springs. ACS ES&T Water 2021, 1 (8) , 1887-1900.
    19. William Bahureksa, Malak M. Tfaily, Rene M. Boiteau, Robert B. Young, Merritt N. Logan, Amy M. McKenna, Thomas Borch. Soil Organic Matter Characterization by Fourier Transform Ion Cyclotron Resonance Mass Spectrometry (FTICR MS): A Critical Review of Sample Preparation, Analysis, and Data Interpretation. Environmental Science & Technology 2021, 55 (14) , 9637-9656.
    20. Morimaru Kida, Nobuhide Fujitake, Taichi Kojima, Yukiko Tanabe, Kentaro Hayashi, Sakae Kudoh, Thorsten Dittmar. Dissolved Organic Matter Processing in Pristine Antarctic Streams. Environmental Science & Technology 2021, 55 (14) , 10175-10185.
    21. Qing-Long Fu, Manabu Fujii, Eunsang Kwon. Development and Application of a High-Precision Algorithm for Nontarget Identification of Organohalogens Based on Ultrahigh-Resolution Mass Spectrometry. Analytical Chemistry 2020, 92 (20) , 13989-13996.
    22. Erika C. Freeman, Erik J. S. Emilson, Thorsten Dittmar, Lucas P. P. Braga, Caroline E. Emilson, Tobias Goldhammer, Christine Martineau, Gabriel Singer, Andrew J. Tanentzap. Universal microbial reworking of dissolved organic matter along environmental gradients. Nature Communications 2024, 15 (1)
    23. Maximilian P. Lau, Ryan H. S. Hutchins, Suzanne E. Tank, Paul A. del Giorgio. The chemical succession in anoxic lake waters as source of molecular diversity of organic matter. Scientific Reports 2024, 14 (1)
    24. Núria Catalán, Carina Rofner, Charles Verpoorter, María Teresa Pérez, Thorsten Dittmar, Lars Tranvik, Ruben Sommaruga, Hannes Peter. Treeline displacement may affect lake dissolved organic matter processing at high latitudes and altitudes. Nature Communications 2024, 15 (1)
    25. Zelong Yan, Jitao Lv, Yuanbi Yi, Xu Ma, Guoqing Zhang, Shaofeng Wang, Xiangfeng Zeng, Yongfeng Jia. Molecular composition and characteristics of Sediment-adsorbed Dissolved Organic Matter (SDOM) along the coast of China. Science of The Total Environment 2024, 928 , 172134.
    26. Patricia Aguilar-Alarcón, Meritxell Gros, Maria José Farré. Non-targeted (ultra-)high-resolution mass spectrometry of dissolved organic matter to predict the formation of disinfection byproducts. Trends in Environmental Analytical Chemistry 2024, 42 , e00231.
    27. Julia Orlova, Fariba Amiri, Alyssa K. Bourgeois, Jim M. Buttle, Erin Cherlet, Chad W. Cuss, Kevin J. Devito, Monica B. Emelko, William C. Floyd, David E. Foster, Ryan H. S. Hutchins, Rob Jamieson, Mark S. Johnson, Hannah J. McSorley, Uldis Silins, Suzanne E. Tank, Lauren M. Thompson, Kara L. Webster, Chris H. S. Williams, David Olefeldt. Composition of Stream Dissolved Organic Matter Across Canadian Forested Ecozones Varies in Three Dimensions Linked to Landscape and Climate. Water Resources Research 2024, 60 (5)
    28. Youtao Si, Yapei Ma, Hui Chen, Fei Ge, Hongliang Ma, Ren Gao, Yunfeng Yin, Julian Merder. Biochar mediates nitrogen investment strategy involved in Chinese fir growth as revealed by molecular information on soil dissolved organic matter. Geoderma 2024, 443 , 116822.
    29. Linn G. Speidel, Roger Carvalho da Silva, Melanie Beck, Olaf Dellwig, Jochen Wollschläger, Thorsten Dittmar, Michael Seidel. Rivers and tidal flats as sources of dissolved organic matter and trace metals in the German Bight (North Sea). Biogeochemistry 2024, 167 (3) , 225-250.
    30. Dini Adyasari, Natasha T. Dimova, Sinéad M. Ní Chadhain, Hannelore Waska. Microbial Assemblages and Metabolic Activity in Organic‐Rich Subterranean Estuaries: Impact of Climate and Land Use Changes. Journal of Geophysical Research: Biogeosciences 2024, 129 (3)
    31. Yi-Jia Ma, Yu Xu, Ting Yang, Hong-Wei Xiao, Hua-Yun Xiao. Measurement report: Characteristics of nitrogen-containing organics in PM 2.5 in Ürümqi, northwestern China – differential impacts of combustion of fresh and aged biomass materials. Atmospheric Chemistry and Physics 2024, 24 (7) , 4331-4346.
    32. Dini Adyasari, Natasha Dimova, Hannelore Waska, Sinead Ni Chadhain. Dissolved organic matter and nutrient processing in organic-rich subterranean estuaries: Implications for future land use and climate scenarios. Geochimica et Cosmochimica Acta 2023, 362 , 65-76.
    33. Teresa S. Catalá, Linn G. Speidel, Arlette Wenzel-Storjohann, Thorsten Dittmar, Deniz Tasdemir. Bioactivity profile of dissolved organic matter and its relation to molecular composition. Natural Products and Bioprospecting 2023, 13 (1)
    34. Sarah K. Bercovici, Thorsten Dittmar, Jutta Niggemann. Processes in the Surface Ocean Regulate Dissolved Organic Matter Distributions in the Deep. Global Biogeochemical Cycles 2023, 37 (12)
    35. Hongyan Bao, Jutta Niggemann, Moge Du, Weiqiang Zhao, Dekun Huang, Yuanbi Yi, Jin‐Yu Terence Yang, Thorsten Dittmar, Shuh‐Ji Kao. Deciphering sources and processing of dissolved black carbon in coastal seas. Limnology and Oceanography 2023, 68 (11) , 2562-2575.
    36. Shixi Wu, Manabu Fujii, Xin Yang, Qing-Long Fu. Characterization of halogenated organic compounds by the Fourier transform ion cyclotron resonance mass spectrometry: A critical review. Water Research 2023, 246 , 120694.
    37. Aleksandar I. Goranov, Rachel L. Sleighter, Dobromir A. Yordanov, Patrick G. Hatcher. TEnvR: MATLAB-based toolbox for environmental research. Analytical Methods 2023, 15 (40) , 5390-5400.
    38. Katarina Kajan, Helena Osterholz, James Stegen, Marija Gligora Udovič, Sandi Orlić. Mechanisms shaping dissolved organic matter and microbial community in lake ecosystems. Water Research 2023, 245 , 120653.
    39. Qiong Pan, Wenya Hu, Ding He, Chen He, Linzhou Zhang, Quan Shi. Machine-learning assisted molecular formula assignment to high-resolution mass spectrometry data of dissolved organic matter. Talanta 2023, 259 , 124484.
    40. Yuanbi Yi, Chen He, Katrin Klaproth, Julian Merder, Penghui Li, Yulin Qi, Pingqing Fu, Siliang Li, Thorsten Dittmar, Quan Shi, Ding He. Will various interpretation strategies of the same ultrahigh‐resolution mass spectrometry data tell different biogeochemical stories? A first assessment based on natural aquatic dissolved organic matter. Limnology and Oceanography: Methods 2023, 21 (6) , 320-333.
    41. Wei Jia, Xixuan Wu, Ning Liu, Zengrun Xia, Lin Shi. Quantitative fusion omics reveals that refrigeration drives methionine degradation through perturbing 5-methyltetrahydropteroyltriglutamate-homocysteine activity. Food Chemistry 2023, 409 , 135322.
    42. Hongyan Bao, Jing Qiao, Dekun Huang, Jutta Niggemann, Yuanbi Yi, Weiqiang Zhao, Silin Ni, Thorsten Dittmar, Shuh-Ji Kao. Molecular level characterization of the biolability of rainwater dissolved organic matter. Science of The Total Environment 2023, 862 , 160709.
    43. Roger Carvalho da Silva, Michael Seidel, Thorsten Dittmar, Hannelore Waska. Groundwater springs in the German Wadden Sea tidal flat: A fast-track terrestrial transfer route for nutrients and dissolved organic matter. Frontiers in Marine Science 2023, 10
    44. Daniele De Corte, Marta M. Varela, Angeles M. Louro, Sarah K. Bercovici, Joaquín Valencia‐Vila, Eva Sintes, Federico Baltar, Tamara Rodríguez‐Ramos, Meinhard Simon, Antonio Bode, Thorsten Dittmar, Jutta Niggemann. Zooplankton‐derived dissolved organic matter composition and its bioavailability to natural prokaryotic communities. Limnology and Oceanography 2023, 68 (2) , 336-347.
    45. Jinfeng Ge, Yulin Qi, Wenrui Yao, Daohe Yuan, Qiaozhuan Hu, Chao Ma, Dietrich A. Volmer, Cong-Qiang Liu. Identification of Trace Components in Sauce-Flavor Baijiu by High-Resolution Mass Spectrometry. Molecules 2023, 28 (3) , 1273.
    46. Xosé Antón Álvarez-Salgado, Mar Nieto-Cid, Pamela E. Rossel. Dissolved Organic Matter. 2023, 39-102.
    47. Weiqiang Zhao, Hongyan Bao, Dekun Huang, Jutta Niggemann, Thorsten Dittmar, Shuh-Ji Kao. Evidence from molecular marker and FT-ICR-MS analyses for the source and transport of dissolved black carbon under variable water discharge of a subtropical Estuary. Biogeochemistry 2023, 162 (1) , 43-55.
    48. Julia Vega, Teresa S. Catalá, Jorge García-Márquez, Linn G. Speidel, Salvador Arijo, Niklas Cornelius Kunz, Christoph Geisler, Félix L. Figueroa. Molecular Diversity and Biochemical Content in Two Invasive Alien Species: Looking for Chemical Similarities and Bioactivities. Marine Drugs 2023, 21 (1) , 5.
    49. Shujun Zhong, Shuang Chen, Junjun Deng, Yanbing Fan, Qiang Zhang, Qiaorong Xie, Yulin Qi, Wei Hu, Libin Wu, Xiaodong Li, Chandra Mouli Pavuluri, Jialei Zhu, Xin Wang, Di Liu, Xiaole Pan, Yele Sun, Zifa Wang, Yisheng Xu, Haijie Tong, Hang Su, Yafang Cheng, Kimitaka Kawamura, Pingqing Fu. Impact of biogenic secondary organic aerosol (SOA) loading on the molecular composition of wintertime PM 2.5 in urban Tianjin: an insight from Fourier transform ion cyclotron resonance mass spectrometry. Atmospheric Chemistry and Physics 2023, 23 (3) , 2061-2077.
    50. Philipp Maurischat, Michael Seidel, Thorsten Dittmar, Georg Guggenberger. Complex dissolved organic matter (DOM) on the roof of the world – Tibetan DOM molecular characteristics indicate sources, land use effects, and processing along the fluvial–limnic continuum. Biogeosciences 2023, 20 (14) , 3011-3026.
    51. Yulin Qi, Qiaorong Xie, Jun-Jian Wang, Ding He, Hongyan Bao, Qing-Long Fu, Sihui Su, Ming Sheng, Si-Liang Li, Dietrich A. Volmer, Fengchang Wu, Guibin Jiang, Cong-Qiang Liu, Pingqing Fu. Deciphering dissolved organic matter by Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS): from bulk to fractions and individuals. Carbon Research 2022, 1 (1)
    52. Eleanor A. Sheridan, Jérémy A. Fonvielle, Samuel Cottingham, Yi Zhang, Thorsten Dittmar, David C. Aldridge, Andrew J. Tanentzap. Plastic pollution fosters more microbial growth in lakes than natural organic matter. Nature Communications 2022, 13 (1)
    53. Helena Osterholz, Stephanie Turner, Linda J. Alakangas, Eva-Lena Tullborg, Thorsten Dittmar, Birgitta E. Kalinowski, Mark Dopson. Terrigenous dissolved organic matter persists in the energy-limited deep groundwaters of the Fennoscandian Shield. Nature Communications 2022, 13 (1)
    54. Christian T. Hansen, Charlotte Kleint, Stefanie Böhnke, Lukas Klose, Nicole Adam-Beyer, Katharina Sass, Rebecca Zitoun, Sylvia G. Sander, Daniela Indenbirken, Thorsten Dittmar, Andrea Koschinsky, Mirjam Perner. Impact of high Fe-concentrations on microbial community structure and dissolved organics in hydrothermal plumes: an experimental study. Scientific Reports 2022, 12 (1)
    55. Weilin Yang, Chunlei Huang, Xiang Wan, Yunyun Zhao, Zhengyu Bao, Wu Xiang. Enhanced Adsorption of Cd on Iron–Organic Associations Formed by Laccase-Mediated Modification: Implications for the Immobilization of Cadmium in Paddy Soil. International Journal of Environmental Research and Public Health 2022, 19 (23) , 15650.
    56. Tabea Hildebrand, Helena Osterholz, Carina Bunse, Hendrik Grotheer, Thorsten Dittmar, Peter J. Schupp. Transformation of dissolved organic matter by two Indo‐Pacific sponges. Limnology and Oceanography 2022, 67 (11) , 2483-2496.
    57. E. Maggie Sogin, Dolma Michellod, Harald R. Gruber-Vodicka, Patric Bourceau, Benedikt Geier, Dimitri V. Meier, Michael Seidel, Soeren Ahmerkamp, Sina Schorn, Grace D’Angelo, Gabriele Procaccini, Nicole Dubilier, Manuel Liebeke. Sugars dominate the seagrass rhizosphere. Nature Ecology & Evolution 2022, 6 (7) , 866-877.
    58. Sujatha Srinivas, Martine Berger, Thorsten Brinkhoff, Jutta Niggemann. Impact of Quorum Sensing and Tropodithietic Acid Production on the Exometabolome of Phaeobacter inhibens. Frontiers in Microbiology 2022, 13
    59. Mara E. Heinrichs, Benedikt Heyerhoff, Berin S. Arslan-Gatz, Michael Seidel, Jutta Niggemann, Bert Engelen. Deciphering the Virus Signal Within the Marine Dissolved Organic Matter Pool. Frontiers in Microbiology 2022, 13
    60. Lorena Selak, Helena Osterholz, Igor Stanković, Nikola Hanžek, Marija Gligora Udovič, Thorsten Dittmar, Sandi Orlić. Adaptations of microbial communities and dissolved organics to seasonal pressures in a mesotrophic coastal Mediterranean lake. Environmental Microbiology 2022, 24 (5) , 2282-2298.
    61. William D Orsi, Aurèle Vuillemin, Ömer K Coskun, Paula Rodriguez, Yanik Oertel, Jutta Niggemann, Volker Mohrholz, Gonzalo V Gomez-Saez. Carbon assimilating fungi from surface ocean to subseafloor revealed by coupled phylogenetic and stable isotope analysis. The ISME Journal 2022, 16 (5) , 1245-1261.
    62. Alexandra L. Klodt, Marley Adamek, Monica Dibley, Sergey A. Nizkorodov, Rachel E. O'Brien. Effects of the sample matrix on the photobleaching and photodegradation of toluene-derived secondary organic aerosol compounds. Atmospheric Chemistry and Physics 2022, 22 (15) , 10155-10171.
    63. Julian Merder, Heidelinde Röder, Thorsten Dittmar, Ulrike Feudel, Jan A. Freund, Gunnar Gerdts, Alexandra Kraberg, Jutta Niggemann. Dissolved organic compounds with synchronous dynamics share chemical properties and origin. Limnology and Oceanography 2021, 66 (11) , 4001-4016.
    64. Teresa S. Catalá, Spencer Shorte, Thorsten Dittmar. Marine dissolved organic matter: a vast and unexplored molecular space. Applied Microbiology and Biotechnology 2021, 105 (19) , 7225-7239.
    65. Thorsten Dittmar, Sinikka T. Lennartz, Hagen Buck-Wiese, Dennis A. Hansell, Chiara Santinelli, Chiara Vanni, Bernd Blasius, Jan-Hendrik Hehemann. Enigmatic persistence of dissolved organic matter in the ocean. Nature Reviews Earth & Environment 2021, 2 (8) , 570-583.
    66. Julius Degenhardt, Julian Merder, Benedikt Heyerhoff, Heike Simon, Bert Engelen, Hannelore Waska. Cross-Shore and Depth Zonations in Bacterial Diversity Are Linked to Age and Source of Dissolved Organic Matter across the Intertidal Area of a Sandy Beach. Microorganisms 2021, 9 (8) , 1720.
    67. Gonzalo V. Gomez-Saez, Thorsten Dittmar, Moritz Holtappels, Anika M. Pohlabeln, Anna Lichtschlag, Bernhard Schnetger, Antje Boetius, Jutta Niggemann. Sulfurization of dissolved organic matter in the anoxic water column of the Black Sea. Science Advances 2021, 7 (25)
    68. Stephan L. Seibert, Michael E. Böttcher, Hannelore Waska, Tobias Holt, Thomas Pollmann, Janek Greskowiak, Gudrun Massmann. Hydrogeochemistry of near-surface groundwater on a developing barrier island (Spiekeroog, Germany): The role of inundation, season and vegetation. Journal of Hydrology 2021, 597 , 126139.
    69. Helena Osterholz, David P.A. Kilgour, Dominik Sebastian Storey, Gaute Lavik, Timothy G. Ferdelman, Jutta Niggemann, Thorsten Dittmar. Accumulation of DOC in the South Pacific Subtropical Gyre from a molecular perspective. Marine Chemistry 2021, 231 , 103955.
    70. Hannelore Waska, Heike Simon, Soeren Ahmerkamp, Janek Greskowiak, Janis Ahrens, Stephan L. Seibert, Kai Schwalfenberg, Oliver Zielinski, Thorsten Dittmar. Molecular Traits of Dissolved Organic Matter in the Subterranean Estuary of a High-Energy Beach: Indications of Sources and Sinks. Frontiers in Marine Science 2021, 8
    71. Erin N MacDonald, Suzanne E Tank, Steven V Kokelj, Duane G Froese, Ryan H S Hutchins. Permafrost-derived dissolved organic matter composition varies across permafrost end-members in the western Canadian Arctic. Environmental Research Letters 2021, 16 (2) , 024036.
    72. Brandon M. Stephens, Keri Opalk, Daniel Petras, Shuting Liu, Jacqueline Comstock, Lihini I. Aluwihare, Dennis A. Hansell, Craig A. Carlson. Organic Matter Composition at Ocean Station Papa Affects Its Bioavailability, Bacterioplankton Growth Efficiency and the Responding Taxa. Frontiers in Marine Science 2020, 7
    73. Teresa S. Catalá, Pamela E. Rossel, Félix Álvarez-Gómez, Jan Tebben, Félix L. Figueroa, Thorsten Dittmar. Antioxidant Activity and Phenolic Content of Marine Dissolved Organic Matter and Their Relation to Molecular Composition. Frontiers in Marine Science 2020, 7