DOTA Functionalized Cross-Linked Small-Molecule Micelles for Theranostics Combining Magnetic Resonance Imaging and ChemotherapyClick to copy article linkArticle link copied!
- Jianyue FengJianyue FengCollege of Chemistry, Sichuan University, 29 Wangjiang Road, Chengdu 610064, ChinaMore by Jianyue Feng
- Qiang LuoQiang LuoHuaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, ChinaMore by Qiang Luo
- Yun ChenYun ChenNational Engineering Research Center for Biomaterials, Sichuan University, 29 Wangjiang Road, Chengdu 610064, ChinaMore by Yun Chen
- Bing LiBing LiNational Engineering Research Center for Biomaterials, Sichuan University, 29 Wangjiang Road, Chengdu 610064, ChinaMore by Bing Li
- Kui LuoKui LuoHuaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, ChinaMore by Kui Luo
- Jingbo Lan*Jingbo Lan*E-mail: [email protected]College of Chemistry, Sichuan University, 29 Wangjiang Road, Chengdu 610064, ChinaMore by Jingbo Lan
- Yunlong YuYunlong YuNational Engineering Research Center for Biomaterials, Sichuan University, 29 Wangjiang Road, Chengdu 610064, ChinaMore by Yunlong Yu
- Shiyong Zhang*Shiyong Zhang*E-mail: [email protected]College of Chemistry and National Engineering Research Center for Biomaterials, Sichuan University, 29 Wangjiang Road, Chengdu 610064, ChinaMore by Shiyong Zhang
Abstract
Herein, a new theranostic nanoplatform was built by introducing DOTA on the surface of the cross-linked small molecular micelles. This nanoplatform consisted of three parts: (1) Hydrophobic alkyl chain functioned with alkenes as cross-linkable part to ensure the robust stability in vivo; (2) Hydrophilic DOTA for not only gadolinium ions complexion as MR imaging contrast agents but also platinum ions complexion as drug carriers; (3) Cisplatin as antitumor drug and MR imaging amplifier simultaneously. The metal loading content of the resulting Pt/Gd@DOTA-CSMs was up to 12 and 14 wt % for Gd(III) and Pt(II), respectively. The longitudinal relaxation rate of Gd@DOTA-CSMs (8.46 mM–1 s–1) was 2.6 times than that of the clinical Gd-DTPA (3.23 mM–1 s–1). When cisplatin was involved, not only great antitumor efficiency was achieved, but higher longitudinal relaxation rate of Pt/Gd@DOTA-CSMs (11.17 mM–1 s–1) was carried out due to the extension of rotational correlation time. The experiments of Balb/c mice bearing 4T1 xenograft indicated that Pt/Gd@DOTA-CSMs had better antitumor activity, lower side effect than clinically used cisplatin, and greater MR imaging than Gd-DTPA. All the results proved that the nanoplatform of DOTA-CSMs held remarkable potential in the field of therapeutics.
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