logo

OR SEARCH CITATIONS

My Activity
Recently Viewed
You have not visited any articles yet, Please visit some articles to see contents here.
Publications
CONTENT TYPES

Figure 1Loading Img
Download Hi-Res ImageDownload to MS-PowerPointCite This:Environ. Sci. Technol. 2016, 50, 8, 4476-4482
RETURN TO ISSUEPREVArticleNEXT

Human Exposure to Wastewater-Derived Pharmaceuticals in Fresh Produce: A Randomized Controlled Trial Focusing on Carbamazepine

View Author Information
† Braun School of Public Health and Community Medicine, Hadassah-Hebrew University of Jerusalem, Jerusalem 9112001, Israel
‡ Department of Hematology, Hadassah-Hebrew University Medical Center, Jerusalem 9112001, Israel
§ The Hebrew University Center of Excellence in Agriculture and Environmental Health
∥ Department of Soil and Water Sciences, Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot 7610001, Israel
*E-mail: [email protected]
Cite this: Environ. Sci. Technol. 2016, 50, 8, 4476–4482
Publication Date (Web):March 29, 2016
https://doi.org/10.1021/acs.est.5b06256
Copyright © 2016 American Chemical Society
RIGHTS & PERMISSIONS
Article Views
2066
Altmetric
-
Citations
85
LEARN ABOUT THESE METRICS

Article Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.

Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.

The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated.

Read OnlinePDF (1 MB)
Get e-Alerts
Supporting Info (1)»
SUBJECTS:

Abstract

Abstract Image

Fresh water scarcity has led to increased use of reclaimed wastewater as an alternative and reliable source for crop irrigation. Beyond microbiological safety, concerns have been raised regarding contamination of reclaimed wastewater by xenobiotics including pharmaceuticals. This study focuses on carbamazepine, an anticonvulsant drug which is ubiquitously detected in reclaimed wastewater, highly persistent in soil, and taken up by crops. In a randomized controlled trial we demonstrate that healthy individuals consuming reclaimed wastewater-irrigated produce excreted carbamazepine and its metabolites in their urine, while subjects consuming fresh water-irrigated produce excreted undetectable or significantly lower levels of carbamazepine. We also report that the carbamazepine metabolite pattern at this low exposure level differed from that observed at therapeutic doses. This “proof of concept” study demonstrates that human exposure to xenobiotics occurs through ingestion of reclaimed wastewater-irrigated produce, providing real world data which could guide risk assessments and policy designed to ensure the safe use of wastewater for crop irrigation.

Supporting Information

ARTICLE SECTIONS
Jump To

The Supporting Information is available free of charge on the ACS Publications website at DOI: 10.1021/acs.est.5b06256.

  • Recovery values for the analytes for different plants (Figure S1); concentrations of carbamazepine and metabolites in produce samples irrigated with reclaimed wastewater (Figure S2); urinary carbamazepine levels in all participants throughout the trial (Figure S3); study population characteristics (Table S1); and water content in produce (Table S2) (PDF)

Terms & Conditions

Electronic Supporting Information files are available without a subscription to ACS Web Editions. The American Chemical Society holds a copyright ownership interest in any copyrightable Supporting Information. Files available from the ACS website may be downloaded for personal use only. Users are not otherwise permitted to reproduce, republish, redistribute, or sell any Supporting Information from the ACS website, either in whole or in part, in either machine-readable form or any other form without permission from the American Chemical Society. For permission to reproduce, republish and redistribute this material, requesters must process their own requests via the RightsLink permission system. Information about how to use the RightsLink permission system can be found at http://pubs.acs.org/page/copyright/permissions.html.

Cited By

This article is cited by 85 publications.

  1. Ian Zammit, Roberto B. M. Marano, Vincenzo Vaiano, Eddie Cytryn, Luigi Rizzo. Changes in Antibiotic Resistance Gene Levels in Soil after Irrigation with Treated Wastewater: A Comparison between Heterogeneous Photocatalysis and Chlorination. Environmental Science & Technology 2020, 54 (12) , 7677-7686. https://doi.org/10.1021/acs.est.0c01565
  2. Qiuguo Fu, Tomer Malchi, Laura J. Carter, Hui Li, Jay Gan, Benny Chefetz. Pharmaceutical and Personal Care Products: From Wastewater Treatment into Agro-Food Systems. Environmental Science & Technology 2019, 53 (24) , 14083-14090. https://doi.org/10.1021/acs.est.9b06206
  3. Sara L. Nason, Elizabeth L. Miller, K. G. Karthikeyan, Joel A. Pedersen. Effects of Binary Mixtures and Transpiration on Accumulation of Pharmaceuticals by Spinach. Environmental Science & Technology 2019, 53 (9) , 4850-4859. https://doi.org/10.1021/acs.est.8b05515
  4. Myah Goldstein, Tomer Malchi, Moshe Shenker, Benny Chefetz. Pharmacokinetics in Plants: Carbamazepine and Its Interactions with Lamotrigine. Environmental Science & Technology 2018, 52 (12) , 6957-6964. https://doi.org/10.1021/acs.est.8b01682
  5. Khang Huynh, Emily Banach, Dawn Reinhold. Transformation, Conjugation, and Sequestration Following the Uptake of Triclocarban by Jalapeno Pepper Plants. Journal of Agricultural and Food Chemistry 2018, 66 (16) , 4032-4043. https://doi.org/10.1021/acs.jafc.7b06150
  6. Saihong Yan, Miao Wang, Jinmiao Zha, Lifei Zhu, Wei Li, Qian Luo, Jing Sun, and Zijian Wang . Environmentally Relevant Concentrations of Carbamazepine Caused Endocrine-Disrupting Effects on Nontarget Organisms, Chinese Rare Minnows (Gobiocypris rarus). Environmental Science & Technology 2018, 52 (2) , 886-894. https://doi.org/10.1021/acs.est.7b06476
  7. Michael Chys, Wim T. M. Audenaert, Emma Deniere, Séverine Thérèse F. C. Mortier, Herman Van Langenhove, Ingmar Nopens, Kristof Demeestere, and Stijn W. H. Van Hulle . Surrogate-Based Correlation Models in View of Real-Time Control of Ozonation of Secondary Treated Municipal Wastewater—Model Development and Dynamic Validation. Environmental Science & Technology 2017, 51 (24) , 14233-14243. https://doi.org/10.1021/acs.est.7b04905
  8. Kelly G. Aukema, Diego E. Escalante, Meghan M. Maltby, Asim K. Bera, Alptekin Aksan, and Lawrence P. Wackett . In Silico Identification of Bioremediation Potential: Carbamazepine and Other Recalcitrant Personal Care Products. Environmental Science & Technology 2017, 51 (2) , 880-888. https://doi.org/10.1021/acs.est.6b04345
  9. P. Soriano-Molina, S. Miralles-Cuevas, B. Esteban García, P. Plaza-Bolaños, J.A. Sánchez Pérez. Two strategies of solar photo-Fenton at neutral pH for the simultaneous disinfection and removal of contaminants of emerging concern. Comparative assessment in raceway pond reactors. Catalysis Today 2021, 361 , 17-23. https://doi.org/10.1016/j.cattod.2019.11.028
  10. Adeola Julian Sorinolu, Neha Tyagi, Arun Kumar, Mariya Munir. Antibiotic resistance development and human health risks during wastewater reuse and biosolids application in agriculture. Chemosphere 2021, 265 , 129032. https://doi.org/10.1016/j.chemosphere.2020.129032
  11. Majid Bagheri, Xiaolong He, Nadege Oustriere, Wenyan Liu, Honglan Shi, Matt A. Limmer, Joel G. Burken. Investigating plant uptake of organic contaminants through transpiration stream concentration factor and neural network models. Science of The Total Environment 2021, 751 , 141418. https://doi.org/10.1016/j.scitotenv.2020.141418
  12. Willis Gwenzi. Autopsy, thanatopraxy, cemeteries and crematoria as hotspots of toxic organic contaminants in the funeral industry continuum. Science of The Total Environment 2021, 753 , 141819. https://doi.org/10.1016/j.scitotenv.2020.141819
  13. Rena Gorovits, Iris Sobol, Kazuhito Akama, Benny Chefetz, Henryk Czosnek. Pharmaceuticals in treated wastewater induce a stress response in tomato plants. Scientific Reports 2020, 10 (1) https://doi.org/10.1038/s41598-020-58776-z
  14. Radka Kodešová, Alica Chroňáková, Kateřina Grabicová, Martin Kočárek, Zuzana Schmidtová, Zuzana Frková, Andrea Vojs Staňová, Antonín Nikodem, Aleš Klement, Miroslav Fér, Roman Grabic. How microbial community composition, sorption and simultaneous application of six pharmaceuticals affect their dissipation in soils. Science of The Total Environment 2020, 746 , 141134. https://doi.org/10.1016/j.scitotenv.2020.141134
  15. Yuanbo Li, Jianzhou He, Haonan Qi, Hui Li, Stephen A. Boyd, Wei Zhang. Impact of biochar amendment on the uptake, fate and bioavailability of pharmaceuticals in soil-radish systems. Journal of Hazardous Materials 2020, 398 , 122852. https://doi.org/10.1016/j.jhazmat.2020.122852
  16. Monika Jain, Ackmez Mudhoo, Deepika Lakshmi Ramasamy, Mahsa Najafi, Muhammad Usman, Runliang Zhu, Gopalakrishnan Kumar, Sutha Shobana, Vinod Kumar Garg, Mika Sillanpää. Adsorption, degradation, and mineralization of emerging pollutants (pharmaceuticals and agrochemicals) by nanostructures: a comprehensive review. Environmental Science and Pollution Research 2020, 27 (28) , 34862-34905. https://doi.org/10.1007/s11356-020-09635-x
  17. Elizabeth L. Rylott, Neil C. Bruce. How synthetic biology can help bioremediation. Current Opinion in Chemical Biology 2020, 58 , 86-95. https://doi.org/10.1016/j.cbpa.2020.07.004
  18. Michael Schapira, Orly Manor, Naama Golan, Dorit Kalo, Vered Mordehay, Noam Kirshenbaum, Rebecca Goldsmith, Benny Chefetz, Ora Paltiel. Involuntary human exposure to carbamazepine: A cross-sectional study of correlates across the lifespan and dietary spectrum. Environment International 2020, 143 , 105951. https://doi.org/10.1016/j.envint.2020.105951
  19. Fredrick Owino Gudda, Michael Gatheru Waigi, Emmanuel Stephen Odinga, Bing Yang, Laura Carter, Yanzheng Gao. Antibiotic-contaminated wastewater irrigated vegetables pose resistance selection risks to the gut microbiome. Environmental Pollution 2020, 264 , 114752. https://doi.org/10.1016/j.envpol.2020.114752
  20. Xuan Zou, Xiaoming Li, Can Chen, Xiaofei Zhu, Xiaoding Huang, You Wu, Zhoujie Pi, Zhuo Chen, Ziletao Tao, Dongbo Wang, Qi Yang. Degradation performance of carbamazepine by ferrous-activated sodium hypochlorite: Mechanism and impacts on the soil system. Chemical Engineering Journal 2020, 389 , 123451. https://doi.org/10.1016/j.cej.2019.123451
  21. Inbal Zaibel, Gal Dagan, Shai Arnon, Frieda Schwartsburd, Malka Britzi, Shane Allen Snyder, Dina Zilberg. Tertiary-treated wastewater as a potential water source for sustainable aquaculture: A laboratory-scale experiment with Cyprinus carpio. Aquaculture 2020, 522 , 735161. https://doi.org/10.1016/j.aquaculture.2020.735161
  22. Franz Mlynek, Markus Himmelsbach, Wolfgang Buchberger, Christian W. Klampfl. A new analytical workflow using HPLC with drift-tube ion-mobility quadrupole time-of-flight/mass spectrometry for the detection of drug-related metabolites in plants. Analytical and Bioanalytical Chemistry 2020, 412 (8) , 1817-1824. https://doi.org/10.1007/s00216-020-02429-7
  23. Benjamin Piña, Josep M. Bayona, Anastasis Christou, Despo Fatta-Kassinos, Emmanuel Guillon, Dimitra Lambropoulou, Costas Michael, Fabio Polesel, Stéphanie Sayen. On the contribution of reclaimed wastewater irrigation to the potential exposure of humans to antibiotics, antibiotic resistant bacteria and antibiotic resistance genes – NEREUS COST Action ES1403 position paper. Journal of Environmental Chemical Engineering 2020, 8 (1) , 102131. https://doi.org/10.1016/j.jece.2018.01.011
  24. Alexandra Seyer, Franz Mlynek, Markus Himmelsbach, Wolfgang Buchberger, Christian W. Klampfl. Investigations on the uptake and transformation of sunscreen ingredients in duckweed (Lemna gibba) and Cyperus alternifolius using high-performance liquid chromatography drift-tube ion-mobility quadrupole time-of-flight mass spectrometry. Journal of Chromatography A 2020, 1613 , 460673. https://doi.org/10.1016/j.chroma.2019.460673
  25. Giuseppina Iervolino, Ian Zammit, Vincenzo Vaiano, Luigi Rizzo. Limitations and Prospects for Wastewater Treatment by UV and Visible-Light-Active Heterogeneous Photocatalysis: A Critical Review. Topics in Current Chemistry 2020, 378 (1) https://doi.org/10.1007/s41061-019-0272-1
  26. Hélène Fallou, Sylvain Giraudet, Nicolas Cimetière, Dominique Wolbert, Pierre Le Cloirec. Adsorption onto ACFC of mixture of pharmaceutical residues in water – experimental studies and modelling. Environmental Technology 2020, 7 , 1-11. https://doi.org/10.1080/09593330.2020.1716393
  27. Dina Zaman, Manoj Kumar Tiwari, Swati Mishra. Low-Cost Adsorptive Removal Techniques for Pharmaceuticals and Personal Care Products. 2020,,, 397-421. https://doi.org/10.1007/978-981-15-0540-9_19
  28. Hillary A. Craddock, Suraj Panthi, Younes Rjoub, Clive Lipchin, Amir Sapkota, Amy R. Sapkota. Antibiotic and herbicide concentrations in household greywater reuse systems and pond water used for food crop irrigation: West Bank, Palestinian Territories. Science of The Total Environment 2020, 699 , 134205. https://doi.org/10.1016/j.scitotenv.2019.134205
  29. Bhoomika Yadav, Carlos Saúl Osorio González, Balasubramanian Sellamuthu, R.D. Tyagi. Pharmaceuticals roles in microbial evolution. 2020,,, 241-278. https://doi.org/10.1016/B978-0-12-819722-6.00008-0
  30. Seenu Ravi, Yongju Choi, Jong Kwon Choe. Novel phenyl-phosphate-based porous organic polymers for removal of pharmaceutical contaminants in water. Chemical Engineering Journal 2020, 379 , 122290. https://doi.org/10.1016/j.cej.2019.122290
  31. Olga Miarov, Alon Tal, Dror Avisar. A critical evaluation of comparative regulatory strategies for monitoring pharmaceuticals in recycled wastewater. Journal of Environmental Management 2020, 254 , 109794. https://doi.org/10.1016/j.jenvman.2019.109794
  32. Riccardo Delli Compagni, Marco Gabrielli, Fabio Polesel, Andrea Turolla, Stefan Trapp, Luca Vezzaro, Manuela Antonelli. Modeling tools for risk management in reclaimed wastewater reuse systems: Focus on contaminants of emerging concern (CECs). 2020,,, 181-220. https://doi.org/10.1016/bs.apmp.2020.07.010
  33. Ewa Korzeniewska, Monika Harnisz. Sources, Occurrence, and Environmental Risk Assessment of Antibiotics and Antimicrobial-Resistant Bacteria in Aquatic Environments of Poland. 2020,,, 179-193. https://doi.org/10.1007/978-3-030-12139-6_9
  34. Yona Chen, Jorge Tarchitzky. Utilization of Treated Wastewater for Irrigation of Agricultural Crops. 2019,,, 1-20. https://doi.org/10.1002/9781119300762.wsts0046
  35. Peiyi Li, Yizhao Wu, Yali Wang, Jiangping Qiu, Yinsheng Li. Soil Behaviour of the Veterinary Drugs Lincomycin, Monensin, and Roxarsone and Their Toxicity on Environmental Organisms. Molecules 2019, 24 (24) , 4465. https://doi.org/10.3390/molecules24244465
  36. Shenxi Deng, Xueting Yan, Qingqing Zhu, Chunyang Liao. The utilization of reclaimed water: Possible risks arising from waterborne contaminants. Environmental Pollution 2019, 254 , 113020. https://doi.org/10.1016/j.envpol.2019.113020
  37. Jianzhou He, Yaozhong Zhang, Yang Guo, Geoff Rhodes, Junghoon Yeom, Hui Li, Wei Zhang. Photocatalytic degradation of cephalexin by ZnO nanowires under simulated sunlight: Kinetics, influencing factors, and mechanisms. Environment International 2019, 132 , 105105. https://doi.org/10.1016/j.envint.2019.105105
  38. Radka Kodešová, Aleš Klement, Oksana Golovko, Miroslav Fér, Martin Kočárek, Antonín Nikodem, Roman Grabic. Soil influences on uptake and transfer of pharmaceuticals from sewage sludge amended soils to spinach. Journal of Environmental Management 2019, 250 , 109407. https://doi.org/10.1016/j.jenvman.2019.109407
  39. Ayelet Kohl, Naama Golan, Yuval Cinnamon, Olga Genin, Benny Chefetz, Dalit Sela-Donenfeld. A proof of concept study demonstrating that environmental levels of carbamazepine impair early stages of chick embryonic development. Environment International 2019, 129 , 583-594. https://doi.org/10.1016/j.envint.2019.03.064
  40. Benny Chefetz, Rotem Marom, Orit Salton, Mariana Oliferovsky, Vered Mordehay, Julius Ben-Ari, Yitzhak Hadar. Transformation of lamotrigine by white-rot fungus Pleurotus ostreatus. Environmental Pollution 2019, 250 , 546-553. https://doi.org/10.1016/j.envpol.2019.04.057
  41. Chinmoy Deb, Bonny Thawani, Sujith Menon, Varun Gore, Vijayalakshmi Chellappan, Shivendu Ranjan, Mahesh Ganesapillai. Design and analysis for the removal of active pharmaceutical residues from synthetic wastewater stream. Environmental Science and Pollution Research 2019, 26 (18) , 18739-18751. https://doi.org/10.1007/s11356-019-05070-9
  42. Mariano González García, Carmen Fernández-López, Fabio Polesel, Stefan Trapp. Predicting the uptake of emerging organic contaminants in vegetables irrigated with treated wastewater – Implications for food safety assessment. Environmental Research 2019, 172 , 175-181. https://doi.org/10.1016/j.envres.2019.02.011
  43. Laura J. Carter, Benny Chefetz, Ziad Abdeen, Alistair B. A. Boxall. Emerging investigator series: towards a framework for establishing the impacts of pharmaceuticals in wastewater irrigation systems on agro-ecosystems and human health. Environmental Science: Processes & Impacts 2019, 21 (4) , 605-622. https://doi.org/10.1039/C9EM00020H
  44. Amy R. Sapkota. Water reuse, food production and public health: Adopting transdisciplinary, systems-based approaches to achieve water and food security in a changing climate. Environmental Research 2019, 171 , 576-580. https://doi.org/10.1016/j.envres.2018.11.003
  45. Radka Kodešová, Aleš Klement, Oksana Golovko, Miroslav Fér, Antonín Nikodem, Martin Kočárek, Roman Grabic. Root uptake of atenolol, sulfamethoxazole and carbamazepine, and their transformation in three soils and four plants. Environmental Science and Pollution Research 2019, 26 (10) , 9876-9891. https://doi.org/10.1007/s11356-019-04333-9
  46. Yuanbo Li, J. Brett Sallach, Wei Zhang, Stephen A. Boyd, Hui Li. Insight into the distribution of pharmaceuticals in soil-water-plant systems. Water Research 2019, 152 , 38-46. https://doi.org/10.1016/j.watres.2018.12.039
  47. Natalia Goykhman, Ishai Dror, Brian Berkowitz. Transport of platinum-based pharmaceuticals in water-saturated sand and natural soil: Carboplatin and cisplatin species. Chemosphere 2019, 219 , 390-399. https://doi.org/10.1016/j.chemosphere.2018.12.005
  48. Kai He, Takashi Yonetani, Yasuhiro Asada, Shinya Echigo, Sadahiko Itoh. Simultaneous determination of carbamazepine-N-glucuronide and carbamazepine phase I metabolites in the wastewater by liquid chromatography-tandem mass spectrometry. Microchemical Journal 2019, 145 , 1191-1198. https://doi.org/10.1016/j.microc.2018.12.014
  49. Klaus Kümmerer, Dionysios D. Dionysiou, Oliver Olsson, Despo Fatta-Kassinos. Reducing aquatic micropollutants – Increasing the focus on input prevention and integrated emission management. Science of The Total Environment 2019, 652 , 836-850. https://doi.org/10.1016/j.scitotenv.2018.10.219
  50. Christian W. Klampfl. Metabolization of pharmaceuticals by plants after uptake from water and soil: A review. TrAC Trends in Analytical Chemistry 2019, 111 , 13-26. https://doi.org/10.1016/j.trac.2018.11.042
  51. Majid Bagheri, Khalid Al-jabery, Donald C. Wunsch, Joel G. Burken. A deeper look at plant uptake of environmental contaminants using intelligent approaches. Science of The Total Environment 2019, 651 , 561-569. https://doi.org/10.1016/j.scitotenv.2018.09.048
  52. Sally Brown, Laura Kennedy, Mark Cullington, Ashley Mihle, Maile Lono‐Batura. Relating Pharmaceuticals and Personal Care Products in Biosolids to Home Exposure. Urban Agriculture & Regional Food Systems 2019, 4 (1) , 1-14. https://doi.org/10.2134/urbanag2018.12.0005
  53. Hans Merzendorfer, Ephraim Cohen. Chitin/Chitosan: Versatile Ecological, Industrial, and Biomedical Applications. 2019,,, 541-624. https://doi.org/10.1007/978-3-030-12919-4_14
  54. Rachel A. Mullen, Jerod J. Hurst, Kayla M. Naas, Lauren M. Sassoubre, Diana S. Aga. Assessing uptake of antimicrobials by Zea mays L. and prevalence of antimicrobial resistance genes in manure-fertilized soil. Science of The Total Environment 2019, 646 , 409-415. https://doi.org/10.1016/j.scitotenv.2018.07.199
  55. Ming Li, Tengda Ding, Haiyan Wang, Wei Wang, Juying Li, Qingfu Ye. Uptake and translocation of 14C-Carbamazepine in soil-plant systems. Environmental Pollution 2018, 243 , 1352-1359. https://doi.org/10.1016/j.envpol.2018.09.079
  56. Saihong Yan, Miao Wang, Xuefang Liang, Christopher J. Martyniuk, Jinmiao Zha, Zijian Wang. Environmentally relevant concentrations of carbamazepine induce liver histopathological changes and a gender-specific response in hepatic proteome of Chinese rare minnows (Gobiocypris rarus). Environmental Pollution 2018, 243 , 480-491. https://doi.org/10.1016/j.envpol.2018.09.009
  57. Yuanbo Li, Ya-Hui Chuang, J. Brett Sallach, Wei Zhang, Stephen A. Boyd, Hui Li. Potential metabolism of pharmaceuticals in radish: Comparison of in vivo and in vitro exposure. Environmental Pollution 2018, 242 , 962-969. https://doi.org/10.1016/j.envpol.2018.07.060
  58. Stacia Dudley, Chengliang Sun, Ji Jiang, Jay Gan. Metabolism of sulfamethoxazole in Arabidopsis thaliana cells and cucumber seedlings. Environmental Pollution 2018, 242 , 1748-1757. https://doi.org/10.1016/j.envpol.2018.07.094
  59. Venkata L. Reddy Pullagurala, Swati Rawat, Ishaq O. Adisa, Jose A. Hernandez-Viezcas, Jose R. Peralta-Videa, Jorge L. Gardea-Torresdey. Plant uptake and translocation of contaminants of emerging concern in soil. Science of The Total Environment 2018, 636 , 1585-1596. https://doi.org/10.1016/j.scitotenv.2018.04.375
  60. Klaus Kümmerer, Dionysios D. Dionysiou, Oliver Olsson, Despo Fatta-Kassinos. A path to clean water. Science 2018, 361 (6399) , 222-224. https://doi.org/10.1126/science.aau2405
  61. Lisa Emhofer, Markus Himmelsbach, Wolfgang Buchberger, Christian W. Klampfl. Insights into the uptake, metabolization, and translocation of four non-steroidal anti-inflammatory drugs in cress ( Lepidium sativum ) by HPLC-MS 2. ELECTROPHORESIS 2018, 39 (9-10) , 1294-1300. https://doi.org/10.1002/elps.201700438
  62. Jessica Chopyk, Sarah Allard, Daniel J. Nasko, Anthony Bui, Emmanuel F. Mongodin, Amy R. Sapkota. Agricultural Freshwater Pond Supports Diverse and Dynamic Bacterial and Viral Populations. Frontiers in Microbiology 2018, 9 https://doi.org/10.3389/fmicb.2018.00792
  63. Marcelo L. Wilde, Jakob Menz, Christoph Leder, Klaus Kümmerer. Combination of experimental and in silico methods for the assessment of the phototransformation products of the antipsychotic drug/metabolite Mesoridazine. Science of The Total Environment 2018, 618 , 697-711. https://doi.org/10.1016/j.scitotenv.2017.08.040
  64. Klaus Kuemmerer. OBSOLETE: Human and Veterinary Drugs in the Environment. 2018,,https://doi.org/10.1016/B978-0-12-409548-9.09991-7
  65. T. Rastogi, W.M.M. Mahmoud, K. Kümmerer. Human and Veterinary Drugs in the Environment. 2018,,, 263-268. https://doi.org/10.1016/B978-0-12-809665-9.09991-2
  66. Alistair B.A. Boxall. Pharmaceuticals in the Environment and Human Health. 2018,,, 123-136. https://doi.org/10.1016/B978-0-444-63857-1.00007-3
  67. A.B. Martínez-Piernas, M.I. Polo-López, P. Fernández-Ibáñez, A. Agüera. Validation and application of a multiresidue method based on liquid chromatography-tandem mass spectrometry for evaluating the plant uptake of 74 microcontaminants in crops irrigated with treated municipal wastewater. Journal of Chromatography A 2018, 1534 , 10-21. https://doi.org/10.1016/j.chroma.2017.12.037
  68. Evyatar Ben Mordechay, Jorge Tarchitzky, Yona Chen, Moshe Shenker, Benny Chefetz. Composted biosolids and treated wastewater as sources of pharmaceuticals and personal care products for plant uptake: A case study with carbamazepine. Environmental Pollution 2018, 232 , 164-172. https://doi.org/10.1016/j.envpol.2017.09.029
  69. Shiqiang Zou, Zhen He. Electrodialysis recovery of reverse-fluxed fertilizer draw solute during forward osmosis water treatment. Chemical Engineering Journal 2017, 330 , 550-558. https://doi.org/10.1016/j.cej.2017.07.181
  70. Anna Margenat, Víctor Matamoros, Sergi Díez, Núria Cañameras, Jordi Comas, Josep M. Bayona. Occurrence of chemical contaminants in peri-urban agricultural irrigation waters and assessment of their phytotoxicity and crop productivity. Science of The Total Environment 2017, 599-600 , 1140-1148. https://doi.org/10.1016/j.scitotenv.2017.05.025
  71. Ling Zhang, Yong Wang, SuWan Jin, QunZan Lu, Jiang Ji. Adsorption isotherm, kinetic and mechanism of expanded graphite for sulfadiazine antibiotics removal from aqueous solutions. Environmental Technology 2017, 38 (20) , 2629-2638. https://doi.org/10.1080/09593330.2016.1272637
  72. Kshitiz Dwivedi, Amruta Morone, Vishwas Pratape, Tapan Chakrabarti, Ram Avtar Pandey. Carbamazepine and oxcarbazepine removal in pharmaceutical wastewater treatment plant using a mass balance approach: A case study. Korean Journal of Chemical Engineering 2017, 34 (10) , 2662-2671. https://doi.org/10.1007/s11814-017-0190-2
  73. Anastasis Christou, Ana Agüera, Josep Maria Bayona, Eddie Cytryn, Vasileios Fotopoulos, Dimitra Lambropoulou, Célia M. Manaia, Costas Michael, Mike Revitt, Peter Schröder, Despo Fatta-Kassinos. The potential implications of reclaimed wastewater reuse for irrigation on the agricultural environment: The knowns and unknowns of the fate of antibiotics and antibiotic resistant bacteria and resistance genes – A review. Water Research 2017, 123 , 448-467. https://doi.org/10.1016/j.watres.2017.07.004
  74. Yolanda Picó, Ahmed Alfarham, Damià Barceló. Analysis of emerging contaminants and nanomaterials in plant materials following uptake from soils. TrAC Trends in Analytical Chemistry 2017, 94 , 173-189. https://doi.org/10.1016/j.trac.2017.07.016
  75. Bahman Sheikh. Significance to human health of carbamazepine detected in fruits and vegetables irrigated with recycled water. Water Science and Technology 2017, 75 (5) , 1059-1062. https://doi.org/10.2166/wst.2016.585
  76. Lisa Emhofer, Markus Himmelsbach, Wolfgang Buchberger, Christian W. Klampfl. High-performance liquid chromatography – mass spectrometry analysis of the parent drugs and their metabolites in extracts from cress ( Lepidium sativum ) grown hydroponically in water containing four non-steroidal anti-inflammatory drugs. Journal of Chromatography A 2017, 1491 , 137-144. https://doi.org/10.1016/j.chroma.2017.02.057
  77. Imen Rekik, Zayneb Chaabane, Amara Missaoui, Ali Chenari Bouket, Lenka Luptakova, Amine Elleuch, Lassaad Belbahri. Effects of untreated and treated wastewater at the morphological, physiological and biochemical levels on seed germination and development of sorghum ( Sorghum bicolor (L.) Moench), alfalfa ( Medicago sativa L.) and fescue ( Festuca arundinacea Schreb.). Journal of Hazardous Materials 2017, 326 , 165-176. https://doi.org/10.1016/j.jhazmat.2016.12.033
  78. Xiaoxue Xiang, Shiqiang Zou, Zhen He. Energy consumption of water recovery from wastewater in a submerged forward osmosis system using commercial liquid fertilizer as a draw solute. Separation and Purification Technology 2017, 174 , 432-438. https://doi.org/10.1016/j.seppur.2016.10.052
  79. Qiuguo Fu, Qingfu Ye, Jianbo Zhang, Jaben Richards, Dan Borchardt, Jay Gan. Diclofenac in Arabidopsis cells: Rapid formation of conjugates. Environmental Pollution 2017, 222 , 383-392. https://doi.org/10.1016/j.envpol.2016.12.022
  80. Andrew D. McEachran, Damian Shea, Elizabeth Guthrie Nichols. Pharmaceuticals in a temperate forest-water reuse system. Science of The Total Environment 2017, 581-582 , 705-714. https://doi.org/10.1016/j.scitotenv.2016.12.185
  81. Tamar Berman, Rebecca Goldsmith, Hagai Levine, Itamar Grotto. Human biomonitoring in Israel: Recent results and lessons learned. International Journal of Hygiene and Environmental Health 2017, 220 (2) , 6-12. https://doi.org/10.1016/j.ijheh.2016.09.008
  82. Avni Solanki, Treavor H. Boyer. Pharmaceutical removal in synthetic human urine using biochar. Environmental Science: Water Research & Technology 2017, 3 (3) , 553-565. https://doi.org/10.1039/C6EW00224B
  83. Gregory H. LeFevre, Alicia Lipsky, Katherine C. Hyland, Andrea C. Blaine, Christopher P. Higgins, Richard G. Luthy. Benzotriazole (BT) and BT plant metabolites in crops irrigated with recycled water. Environmental Science: Water Research & Technology 2017, 3 (2) , 213-223. https://doi.org/10.1039/C6EW00270F
  84. Rachel A. Mullen, Krista R. Wigginton, Abraham Noe-Hays, Kim Nace, Nancy G. Love, Charles B. Bott, Diana S. Aga. Optimizing extraction and analysis of pharmaceuticals in human urine, struvite, food crops, soil, and lysimeter water by liquid chromatography-tandem mass spectrometry. Anal. Methods 2017, 9 (41) , 5952-5962. https://doi.org/10.1039/C7AY01801K
  85. Anat Paz, Galit Tadmor, Tomer Malchi, Jens Blotevogel, Thomas Borch, Tamara Polubesova, Benny Chefetz. Fate of carbamazepine, its metabolites, and lamotrigine in soils irrigated with reclaimed wastewater: Sorption, leaching and plant uptake. Chemosphere 2016, 160 , 22-29. https://doi.org/10.1016/j.chemosphere.2016.06.048

Pair your accounts.

Export articles to Mendeley

Get article recommendations from ACS based on references in your Mendeley library.

Pair your accounts.

Export articles to Mendeley

Get article recommendations from ACS based on references in your Mendeley library.

You’ve supercharged your research process with ACS and Mendeley!

STEP 1:
Click to create an ACS ID

Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

OOPS

You have to login with your ACS ID befor you can login with your Mendeley account.

MENDELEY PAIRING EXPIRED
Your Mendeley pairing has expired. Please reconnect

This website uses cookies to improve your user experience. By continuing to use the site, you are accepting our use of cookies. Read the ACS privacy policy.

CONTINUE