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Characterization of Adipogenic Activity of House Dust Extracts and Semi-Volatile Indoor Contaminants in 3T3-L1 Cells

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    Characterization of Adipogenic Activity of House Dust Extracts and Semi-Volatile Indoor Contaminants in 3T3-L1 Cells
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    † Nicholas School of the Environment, Duke University, Durham, North Carolina 27708, United States
    *Phone: 919-613-8717; e-mail: [email protected]
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    Environmental Science & Technology

    Cite this: Environ. Sci. Technol. 2017, 51, 15, 8735–8745
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    https://doi.org/10.1021/acs.est.7b01788
    Published July 12, 2017
    Copyright © 2017 American Chemical Society
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    Obesity and metabolic disorders are of great societal concern and generate significant human health care costs. Recently, attention has focused on the potential for environmental contaminants to act as metabolic disruptors. This study sought to evaluate the adipogenic activity of indoor house dust extracts and a suite of semivolatile organic chemicals (SVOCs) that are often ubiquitously detected in indoor environments. 3T3-L1 cells were exposed to extracts of indoor dust or individual SVOCs and assessed for triglyceride accumulation and preadipocyte proliferation. Ten of 11 house dust extracts exhibited significant triglyceride accumulation and/or proliferation at environmentally relevant levels (<20 μg of dust/well), and significant adipogenic activity was also exhibited by 28 of the SVOCs. Notably, pyraclostrobin, dibutyl phthalate, tert-butyl-phenyl diphenyl phosphate, and the isopropylated triaryl phosphates (ITPs) exhibited near maximal or supra-maximal triglyceride accumulation relative to the rosiglitazone-induced maximum. The adipogenic activity in house dust occurred at concentrations below EPA estimated child exposure levels, and raises concerns for human health impacts, particularly in children. Our results delineate a novel potential health threat and identify putative causative SVOCs that are likely contributing to this activity.

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    The Supporting Information is available free of charge on the ACS Publications website at DOI: 10.1021/acs.est.7b01788.

    • Positive control and paraben responses, strobin family cell viability response, correlations between PPARγ activities and adipogenic outcomes, chemical purity and ordering information, and a list of putative adipogenic pathways for tested chemicals (PDF)

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    Cite this: Environ. Sci. Technol. 2017, 51, 15, 8735–8745
    Click to copy citationCitation copied!
    https://doi.org/10.1021/acs.est.7b01788
    Published July 12, 2017
    Copyright © 2017 American Chemical Society
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