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Download Hi-Res ImageDownload to MS-PowerPointCite This:Environ. Sci. Technol. 2017, 51, 17, 9940-9949
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Prolonged Exposure to Bisphenol A from Single Dermal Contact Events

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† Department of Laboratory Medicine and Pathology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta T6G 2R3, Canada
‡ Department of Environmental Science and Analytical Chemistry, Stockholm University, Stockholm SE-106 91, Sweden
*Jonathan W. Martin; Phone: +46 072 146 2773; E-mail: [email protected]
Cite this: Environ. Sci. Technol. 2017, 51, 17, 9940–9949
Publication Date (Web):July 31, 2017
https://doi.org/10.1021/acs.est.7b03093
Copyright © 2017 American Chemical Society
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Abstract

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Bisphenol A (BPA) is an endocrine disruptor frequently detected in human biofluids. Dermal absorption of BPA from thermal paper receipts occurs but BPA pharmacokinetics following dermal exposure is not understood. To compare the pharmacokinetics of dermal and dietary BPA exposure, six male participants handled simulated receipts containing relevant levels of BPA (isotope-labeled BPA-d16) for 5 min, followed by hand-washing 2 h later. Urine (0–48 h) and serum (0–7.5 h) were monitored for free and total BPA-d16. One week later, participants returned for a dietary administration with monitoring as above. One participant repeated the dermal administration with extended monitoring of urine (9 days) and serum (2 days). After dietary exposure, urine total BPA-d16 peaked within 5 h and quickly cleared within 24 h. After dermal exposure, cumulative excretion increased linearly for 2 days, and half the participants still had detectable urinary total BPA-d16 after 1 week. The participant repeating the dermal exposure had detectable BPA-d16 in urine for 9 days, showed linear cumulative excretion over 5 days, and had detectable free BPA-d16 in serum. Proportions of free BPA-d16 in urine following dermal exposure (0.71%–8.3% of total BPA-d16) were generally higher than following the dietary exposure (0.29%–1.4%). Compared to dietary BPA exposure, dermal absorption of BPA leads to prolonged exposure and may lead to higher proportions of unconjugated BPA in systemic circulation.

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  2. Zuowei Ji, Jie Liu, Sugunadevi Sakkiah, Wenjing Guo, Huixiao Hong. BPA Replacement Compounds: Current Status and Perspectives. ACS Sustainable Chemistry & Engineering 2021, 9 (6) , 2433-2446. https://doi.org/10.1021/acssuschemeng.0c09276
  3. Elena Reale, Silvia Fustinoni, Rosa Mercadante, Elisa Polledri, Nancy B. Hopf. Simultaneous Quantification of Bisphenol A, Its Glucuronide Metabolite, and Commercial Alternatives by LC-MS/MS for In Vitro Skin Absorption Evaluation. Chemical Research in Toxicology 2020, 33 (9) , 2390-2400. https://doi.org/10.1021/acs.chemrestox.0c00148
  4. Jiajun Han, Diwen Yang, David Ross Hall, Jiabao Liu, Jianxian Sun, Wen Gu, Song Tang, Hattan A. Alharbi, Paul. D. Jones, Henry M. Krause, Hui Peng. Toxicokinetics of Brominated Azo Dyes in the Early Life Stages of Zebrafish (Danio rerio) Is Prone to Aromatic Substituent Changes. Environmental Science & Technology 2020, 54 (7) , 4421-4431. https://doi.org/10.1021/acs.est.9b07178
  5. Mandy Fisher, Tye E. Arbuckle, Susan MacPherson, Joseph M. Braun, Mark Feeley, Éric Gaudreau. Phthalate and BPA Exposure in Women and Newborns through Personal Care Product Use and Food Packaging. Environmental Science & Technology 2019, 53 (18) , 10813-10826. https://doi.org/10.1021/acs.est.9b02372
  6. Runzeng Liu, Scott A. Mabury. First Detection of Photoinitiators and Metabolites in Human Sera from United States Donors. Environmental Science & Technology 2018, 52 (17) , 10089-10096. https://doi.org/10.1021/acs.est.8b02457
  7. Glenn C. Morrison, Gabriel Bekö, Charles J. Weschler, Tobias Schripp, Tunga Salthammer, Jonathan Hill, Anna-Maria Andersson, Jørn Toftum, Geo Clausen, and Hanne Frederiksen . Dermal Uptake of Benzophenone-3 from Clothing. Environmental Science & Technology 2017, 51 (19) , 11371-11379. https://doi.org/10.1021/acs.est.7b02623
  8. Jiaying Liu, Leah J. Martin, Irina Dinu, Catherine J. Field, Deborah Dewey, Jonathan W. Martin. Interaction of prenatal bisphenols, maternal nutrients, and toxic metal exposures on neurodevelopment of 2-year-olds in the APrON cohort. Environment International 2021, 155 , 106601. https://doi.org/10.1016/j.envint.2021.106601
  9. Eva Ougier, Florence Zeman, Jean-Philippe Antignac, Christophe Rousselle, Rosa Lange, Marike Kolossa-Gehring, Petra Apel. Human biomonitoring initiative (HBM4EU): Human biomonitoring guidance values (HBM-GVs) derived for bisphenol A. Environment International 2021, 154 , 106563. https://doi.org/10.1016/j.envint.2021.106563
  10. Jaewoong Lee, Soyeon Park, Jinyeo Byun, Myungsung Lee, Young-Sun Do, Younghun Kim, Myunghee Kwon. Distribution and Potential Transdermal Human Intake of Bisphenol A and Bisphenol S from Thermal Receipt Papers in Korea Market. Exposure and Health 2021, 13 (3) , 477-485. https://doi.org/10.1007/s12403-021-00397-6
  11. Radia Bousoumah, Veruscka Leso, Ivo Iavicoli, Pasi Huuskonen, Susana Viegas, Simo P. Porras, Tiina Santonen, Nadine Frery, Alain Robert, Sophie Ndaw. Biomonitoring of occupational exposure to bisphenol A, bisphenol S and bisphenol F: A systematic review. Science of The Total Environment 2021, 783 , 146905. https://doi.org/10.1016/j.scitotenv.2021.146905
  12. Oluwakemi A. Rotimi, Tolulope D. Olawole, Opeyemi C. De Campos, Isaacson B. Adelani, Solomon O. Rotimi. Bisphenol A in Africa: A review of environmental and biological levels. Science of The Total Environment 2021, 764 , 142854. https://doi.org/10.1016/j.scitotenv.2020.142854
  13. Rafael Moreno-Gómez-Toledano, María I. Arenas, Sandra Sánchez-Esteban, Alberto Cook, Marta Saura, Ricardo J. Bosch. Critical Analysis of Human Exposure to Bisphenol a and its Novel Implications on Renal, Cardiovascular and Hypertensive Diseases. 2021,,https://doi.org/10.5772/intechopen.96309
  14. Sori Mok, Yunsun Jeong, Minkyu Park, Sunmi Kim, Inae Lee, Jeongim Park, Sungkyoon Kim, Kyungho Choi, Hyo-Bang Moon. Exposure to phthalates and bisphenol analogues among childbearing-aged women in Korea: Influencing factors and potential health risks. Chemosphere 2021, 264 , 128425. https://doi.org/10.1016/j.chemosphere.2020.128425
  15. Alan F. Sasso, Ralph Pirow, Syam S. Andra, Rebecca Church, Rebecca M. Nachman, Susanne Linke, Dustin F. Kapraun, Shepherd H. Schurman, Manish Arora, Kristina A. Thayer, John R. Bucher, Linda S. Birnbaum. Pharmacokinetics of bisphenol A in humans following dermal administration. Environment International 2020, 144 , 106031. https://doi.org/10.1016/j.envint.2020.106031
  16. Yan Lin, Xinghua Qiu, Jinming Liu, Chi-Hong Tseng, Patrick Allard, Jesus A. Araujo, Yifang Zhu. Different temporal trends of exposure to Bisphenol A among international travelers between Los Angeles and Beijing. Environment International 2020, 141 , 105758. https://doi.org/10.1016/j.envint.2020.105758
  17. Yunsheng Wang, Jie Yang, Manman Fang, Yishuai Yu, Bo Zou, Liwei Wang, Yu Tian, Jingxi Cheng, Ben Zhong Tang, Zhen Li. Förster Resonance Energy Transfer: An Efficient Way to Develop Stimulus-Responsive Room-Temperature Phosphorescence Materials and Their Applications. Matter 2020, 3 (2) , 449-463. https://doi.org/10.1016/j.matt.2020.05.005
  18. Silke Schmidt. 皮肤吸收双酚类物质的新证据. Environmental Health Perspectives (Chinese) 2020, 128 (2) , 024004. https://doi.org/10.1289/EHP6249-zh
  19. Imèn Khmiri, Jonathan Côté, Marc Mantha, Rania Khemiri, Marlène Lacroix, Clémence Gely, Pierre-Louis Toutain, Nicole Picard-Hagen, Véronique Gayrard, Michèle Bouchard. Toxicokinetics of bisphenol-S and its glucuronide in plasma and urine following oral and dermal exposure in volunteers for the interpretation of biomonitoring data. Environment International 2020, 138 , 105644. https://doi.org/10.1016/j.envint.2020.105644
  20. Shuhui Wang, Yongjia Xiong, Jacques Lalevée, Pu Xiao, Jing Liu, Feiyue Xing. Biocompatibility and cytotoxicity of novel photoinitiator π-conjugated dithienophosphole derivatives and their triggered polymers. Toxicology in Vitro 2020, 63 , 104720. https://doi.org/10.1016/j.tiv.2019.104720
  21. Silke Schmidt. Acknowledging Receipts? New Evidence for Dermal Absorption of Bisphenols. Environmental Health Perspectives 2020, 128 (3) , 034003. https://doi.org/10.1289/EHP6249
  22. Traci N. Bethea, Amelia K. Wesselink, Jennifer Weuve, Michael D. McClean, Russ Hauser, Paige L. Williams, Xiaoyun Ye, Antonia M. Calafat, Donna D. Baird, Lauren A. Wise. Correlates of exposure to phenols, parabens, and triclocarban in the Study of Environment, Lifestyle and Fibroids. Journal of Exposure Science & Environmental Epidemiology 2020, 30 (1) , 117-136. https://doi.org/10.1038/s41370-019-0114-9
  23. G. Castro, I. Rodríguez, M. Ramil, R. Cela. Direct analysis in real time accurate mass spectrometry determination of bisphenol A in thermal printing paper. Talanta 2019, 205 , 120086. https://doi.org/10.1016/j.talanta.2019.06.086
  24. Ya Ma, Haohao Liu, Jinxia Wu, Le Yuan, Yueqin Wang, Xingde Du, Rui Wang, Phelisters Wegesa Marwa, Pavankumar Petlulu, Xinghai Chen, Huizhen Zhang. The adverse health effects of bisphenol A and related toxicity mechanisms. Environmental Research 2019, 176 , 108575. https://doi.org/10.1016/j.envres.2019.108575
  25. Frederick S. vom Saal. Flaws in design, execution and interpretation limit CLARITY‐BPA’s value for risk assessments of bisphenol A. Basic & Clinical Pharmacology & Toxicology 2019, 125 (S3) , 32-43. https://doi.org/10.1111/bcpt.13195
  26. Jiaying Liu, Jonathan W. Martin. Comparison of Bisphenol A and Bisphenol S Percutaneous Absorption and Biotransformation. Environmental Health Perspectives 2019, 127 (6) , 067008. https://doi.org/10.1289/EHP5044
  27. J.M. Molina-Molina, I. Jiménez-Díaz, M.F. Fernández, A. Rodriguez-Carrillo, F.M. Peinado, V. Mustieles, R. Barouki, C. Piccoli, N. Olea, C. Freire. Determination of bisphenol A and bisphenol S concentrations and assessment of estrogen- and anti-androgen-like activities in thermal paper receipts from Brazil, France, and Spain. Environmental Research 2019, 170 , 406-415. https://doi.org/10.1016/j.envres.2018.12.046
  28. Akio Makishima. Flu Virus and Chemical Detectors, and Diagnostics. 2019,,, 219-231. https://doi.org/10.1016/B978-0-12-817054-0.00019-9
  29. Yunjia Yang, Yi Yang, Jing Zhang, Bing Shao, Jie Yin. Assessment of bisphenol A alternatives in paper products from the Chinese market and their dermal exposure in the general population. Environmental Pollution 2019, 244 , 238-246. https://doi.org/10.1016/j.envpol.2018.10.049
  30. Ramzan Ullah, Xiangzhao Wang. Raman spectroscopy of Bisphenol ‘S’ and its analogy with Bisphenol ‘A’ uncovered with a dimensionality reduction technique. Journal of Molecular Structure 2019, 1175 , 927-934. https://doi.org/10.1016/j.molstruc.2018.08.025
  31. Sophie Ndaw, Aurélie Remy, Flavien Denis, Philippe Marsan, Danièle Jargot, Alain Robert. Occupational exposure of cashiers to bisphenol S via thermal paper. Toxicology Letters 2018, 298 , 106-111. https://doi.org/10.1016/j.toxlet.2018.05.026
  32. Jiaying Liu, Nour Wattar, Catherine J. Field, Irina Dinu, Deborah Dewey, Jonathan W. Martin. Exposure and dietary sources of bisphenol A (BPA) and BPA-alternatives among mothers in the APrON cohort study. Environment International 2018, 119 , 319-326. https://doi.org/10.1016/j.envint.2018.07.001
  33. Tunga Salthammer, Yinping Zhang, Jinhan Mo, Holger M. Koch, Charles J. Weschler. Erfassung der Humanexposition mit organischen Verbindungen in Innenraumumgebungen. Angewandte Chemie 2018, 130 (38) , 12406-12443. https://doi.org/10.1002/ange.201711023
  34. Tunga Salthammer, Yinping Zhang, Jinhan Mo, Holger M. Koch, Charles J. Weschler. Assessing Human Exposure to Organic Pollutants in the Indoor Environment. Angewandte Chemie International Edition 2018, 57 (38) , 12228-12263. https://doi.org/10.1002/anie.201711023
  35. Cynthia J Hines, Annette L Christianson, Matthew V Jackson, Xiaoyun Ye, Jack R Pretty, James E Arnold, Antonia M Calafat. An Evaluation of the Relationship among Urine, Air, and Hand Measures of Exposure to Bisphenol A (BPA) in US Manufacturing Workers. Annals of Work Exposures and Health 2018, 62 (7) , 840-851. https://doi.org/10.1093/annweh/wxy042
  36. Inae Lee, Sunmi Kim, Ki-Tae Kim, Sungkyoon Kim, Suhyun Park, Hyojin Lee, Yunsun Jeong, Jae-Eun Lim, Hyo-Bang Moon, Kyungho Choi. Bisphenol A exposure through receipt handling and its association with insulin resistance among female cashiers. Environment International 2018, 117 , 268-275. https://doi.org/10.1016/j.envint.2018.05.013
  37. María García-Espiñeira, Lesly Tejeda-Benítez, Jesus Olivero-Verbel. Toxic Effects of Bisphenol A, Propyl Paraben, and Triclosan on Caenorhabditis elegans. International Journal of Environmental Research and Public Health 2018, 15 (4) , 684. https://doi.org/10.3390/ijerph15040684
  38. Miriam Schöpel, Oleksandr Shkura, Jana Seidel, Klaus Kock, Xueyin Zhong, Stefanie Löffek, Iris Helfrich, Hagen Bachmann, Jürgen Scherkenbeck, Christian Herrmann, Raphael Stoll. Allosteric Activation of GDP-Bound Ras Isoforms by Bisphenol Derivative Plasticisers. International Journal of Molecular Sciences 2018, 19 (4) , 1133. https://doi.org/10.3390/ijms19041133
  39. G. Bekö, G. Morrison, C. J. Weschler, H. M. Koch, C. Pälmke, T. Salthammer, T. Schripp, A. Eftekhari, J. Toftum, G. Clausen. Dermal uptake of nicotine from air and clothing: Experimental verification. Indoor Air 2018, 28 (2) , 247-257. https://doi.org/10.1111/ina.12437
  40. Angelos Rigopoulos, Victoria Samanidou, Maria Touraki. Development and Validation of an HPLC-DAD Method for the Simultaneous Extraction and Quantification of Bisphenol-A, 4-Hydroxybenzoic Acid, 4-Hydroxyacetophenone and Hydroquinone in Bacterial Cultures of Lactococcus lactis. Separations 2018, 5 (1) , 12. https://doi.org/10.3390/separations5010012
  41. Chang Yeob Song, Woong Kim, Myung Chan Gye. Current State of Use and the Risks of Bisphenols: A Minireview. Environmental Biology Research 2017, 35 (4) , 581-594. https://doi.org/10.11626/KJEB.2017.35.4.581

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