Palladium Probe Consisting of Naphthalimide and Ethylenediamine for Selective Turn-On Sensing of CO and Cell ImagingClick to copy article linkArticle link copied!
- Anjong Florence TikumAnjong Florence TikumDepartment of Chemistry and Nano Science, Ewha Womans University, Seoul 120-750, KoreaMore by Anjong Florence Tikum
- Wanyoung LimWanyoung LimDepartment of Global Biomedical Engineering, Sungkyunkwan University, Suwon 16419, KoreaMore by Wanyoung Lim
- Maxine Mambo FortibuiMaxine Mambo FortibuiDepartment of Chemistry and Nano Science, Ewha Womans University, Seoul 120-750, KoreaMore by Maxine Mambo Fortibui
- Sohyun LeeSohyun LeeDepartment of Chemistry and Nano Science, Ewha Womans University, Seoul 120-750, KoreaMore by Sohyun Lee
- Sungsu Park*Sungsu Park*Email: [email protected]Department of Global Biomedical Engineering, Sungkyunkwan University, Suwon 16419, KoreaSchool of Mechanical Engineering, Sungkyunkwan University, Suwon 16419, KoreaMore by Sungsu Park
- Jinheung Kim*Jinheung Kim*Email: [email protected]Department of Chemistry and Nano Science, Ewha Womans University, Seoul 120-750, KoreaMore by Jinheung Kim
Abstract
An assay to detect carbon monoxide (CO), one of the gaseous signaling molecules, has been prepared using a new palladium complex probe. The ethylenediamine group linked to the naphthalimide fluorophore coordinates to Pd(II) which intramolecularly quenches the emission. Upon treatment with CO, the absorbance of the turn-on fluorescent sensor changes due to the formation of a complex between Pd(II) and CO at room temperature in a phosphate buffer. As the concentration of CO increases, the probe peak emission intensity at 527 nm gradually increases. Other analyte controls, such as K+, Mg2+, Al3+, Zn2+, Cr3+, Hg2+, Fe3+, alanine, glycine, leucine, lysine, serine, threonine, tyrosine, F–, Cl–, Br–, NO, NO2–, NO3–, HCO3–, CH3COO–, H2O2, •OH, and tBuOO•, exhibit no significant effect on emission intensity. The response time of the probe to CO was quite fast because of the relatively weak coordination of Pd(II) to the pendent ethylenediamine group. The Pd probe is capable of detecting CO in aqueous buffer as well as in living cells with high selectivity and stability, providing a potential real-time indicator for studying CO-involved reactions in biological systems.
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