Chrysin Stimulates Subcutaneous Fat Thermogenesis in Mice by Regulating PDGFRα and MicroRNA ExpressionsClick to copy article linkArticle link copied!
- Xin WangXin WangSchool of Food and Biological Engineering, Hefei University of Technology, Hefei, Anhui 230009, ChinaMore by Xin Wang
- Hao CaiHao CaiSchool of Food and Biological Engineering, Hefei University of Technology, Hefei, Anhui 230009, ChinaMore by Hao Cai
- Shanshan ShuiShanshan ShuiSchool of Food and Biological Engineering, Hefei University of Technology, Hefei, Anhui 230009, ChinaMore by Shanshan Shui
- Yan LinYan LinSchool of Food and Biological Engineering, Hefei University of Technology, Hefei, Anhui 230009, ChinaMore by Yan Lin
- Fangbin WangFangbin WangSchool of Food and Biological Engineering, Hefei University of Technology, Hefei, Anhui 230009, ChinaMore by Fangbin Wang
- Lu WangLu WangSchool of Food and Biological Engineering, Hefei University of Technology, Hefei, Anhui 230009, ChinaMore by Lu Wang
- Juan Chen*Juan Chen*Email: [email protected]School of Food and Biological Engineering, Hefei University of Technology, Hefei, Anhui 230009, ChinaMore by Juan Chen
- Jian Liu*Jian Liu*Email: [email protected]School of Food and Biological Engineering, Hefei University of Technology, Hefei, Anhui 230009, ChinaEngineering Research Center of Bioprocess, Ministry of Education, Hefei University of Technology, Hefei 230009, ChinaMore by Jian Liu
Abstract

The activation of adipose tissue browning and thermogenesis provides a new strategy to counter obesity and associated metabolic diseases. Here, a natural flavonoid chrysin is used as the supplement of a high-fat diet (HFD). Dietary chrysin alleviates adiposity and insulin resistance in HFD-fed mice. Meanwhile, dietary chrysin elevates systemic energy expenditure and enhances the uncoupling protein-1 (UCP1) level in subcutaneous adipose tissue (SAT), which is accompanied by the increased thermogenic program, beige preadipocyte number, and angiogenesis in SAT. Dietary chrysin also induces the expression of SAT platelet-derived growth factor receptor α (PDGFRα), which commits adipose progenitor cells to differentiate into beige or white adipocytes in response to various environmental signals. Double immunofluorescent staining for UCP1 and PDGFRα reveals that chrysin elevates the number of UCP1+PDGFRα+ beige progenitors in SAT. Further, chrysin treatment reverses the effects of the specific PDGFRα inhibitor imatinib on browning differentiation of stromal vascular fraction cells from SAT. Finally, chrysin-induced adipocyte browning is correlated with the expressions of microRNAs as PDGFRα inhibitors or thermogenesis suppressors. In conclusion, dietary chrysin promotes subcutaneous adipocyte browning and systematic energy expenditure by regulating PDGFRα and microRNA expressions in HFD-fed mice.
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