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Chrysin Stimulates Subcutaneous Fat Thermogenesis in Mice by Regulating PDGFRα and MicroRNA Expressions
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    Bioactive Constituents, Metabolites, and Functions

    Chrysin Stimulates Subcutaneous Fat Thermogenesis in Mice by Regulating PDGFRα and MicroRNA Expressions
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    • Xin Wang
      Xin Wang
      School of Food and Biological Engineering, Hefei University of Technology, Hefei, Anhui 230009, China
      More by Xin Wang
    • Hao Cai
      Hao Cai
      School of Food and Biological Engineering, Hefei University of Technology, Hefei, Anhui 230009, China
      More by Hao Cai
    • Shanshan Shui
      Shanshan Shui
      School of Food and Biological Engineering, Hefei University of Technology, Hefei, Anhui 230009, China
    • Yan Lin
      Yan Lin
      School of Food and Biological Engineering, Hefei University of Technology, Hefei, Anhui 230009, China
      More by Yan Lin
    • Fangbin Wang
      Fangbin Wang
      School of Food and Biological Engineering, Hefei University of Technology, Hefei, Anhui 230009, China
      More by Fangbin Wang
    • Lu Wang
      Lu Wang
      School of Food and Biological Engineering, Hefei University of Technology, Hefei, Anhui 230009, China
      More by Lu Wang
    • Juan Chen*
      Juan Chen
      School of Food and Biological Engineering, Hefei University of Technology, Hefei, Anhui 230009, China
      *Email: [email protected]
      More by Juan Chen
    • Jian Liu*
      Jian Liu
      School of Food and Biological Engineering, Hefei University of Technology, Hefei, Anhui 230009, China
      Engineering Research Center of Bioprocess, Ministry of Education, Hefei University of Technology, Hefei 230009, China
      *Email: [email protected]
      More by Jian Liu
    Other Access OptionsSupporting Information (1)

    Journal of Agricultural and Food Chemistry

    Cite this: J. Agric. Food Chem. 2021, 69, 21, 5897–5906
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    https://doi.org/10.1021/acs.jafc.1c01130
    Published May 24, 2021
    Copyright © 2021 American Chemical Society

    Abstract

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    The activation of adipose tissue browning and thermogenesis provides a new strategy to counter obesity and associated metabolic diseases. Here, a natural flavonoid chrysin is used as the supplement of a high-fat diet (HFD). Dietary chrysin alleviates adiposity and insulin resistance in HFD-fed mice. Meanwhile, dietary chrysin elevates systemic energy expenditure and enhances the uncoupling protein-1 (UCP1) level in subcutaneous adipose tissue (SAT), which is accompanied by the increased thermogenic program, beige preadipocyte number, and angiogenesis in SAT. Dietary chrysin also induces the expression of SAT platelet-derived growth factor receptor α (PDGFRα), which commits adipose progenitor cells to differentiate into beige or white adipocytes in response to various environmental signals. Double immunofluorescent staining for UCP1 and PDGFRα reveals that chrysin elevates the number of UCP1+PDGFRα+ beige progenitors in SAT. Further, chrysin treatment reverses the effects of the specific PDGFRα inhibitor imatinib on browning differentiation of stromal vascular fraction cells from SAT. Finally, chrysin-induced adipocyte browning is correlated with the expressions of microRNAs as PDGFRα inhibitors or thermogenesis suppressors. In conclusion, dietary chrysin promotes subcutaneous adipocyte browning and systematic energy expenditure by regulating PDGFRα and microRNA expressions in HFD-fed mice.

    Copyright © 2021 American Chemical Society

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    Supporting Information

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    The Supporting Information is available free of charge at https://pubs.acs.org/doi/10.1021/acs.jafc.1c01130.

    • Dietary chrysin reduced adiposity without affecting energy intake, effects of dietary chrysin on SAT F4/80CD137+ cells and EAT angiogenesis in HFD-fed mice, compositions of the diet used in the experiment, and primer sequences used for real-time PCR (PDF)

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    Journal of Agricultural and Food Chemistry

    Cite this: J. Agric. Food Chem. 2021, 69, 21, 5897–5906
    Click to copy citationCitation copied!
    https://doi.org/10.1021/acs.jafc.1c01130
    Published May 24, 2021
    Copyright © 2021 American Chemical Society

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