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Characterization of Sulfoxaflor and Its Metabolites on Survival, Growth, Reproduction, Biochemical Markers, and Transcription of Genes of Daphnia magna

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Download Hi-Res ImageDownload to MS-PowerPointCite This:J. Agric. Food Chem. 2023, 71, 16, 6424-6433
    Food Safety and Toxicology

    Characterization of Sulfoxaflor and Its Metabolites on Survival, Growth, Reproduction, Biochemical Markers, and Transcription of Genes of Daphnia magna
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    • Tingting Yuan
      Tingting Yuan
      National Key Laboratory of Green Pesticide, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for R&D of Fine Chemicals of Guizhou University, Guiyang 550025, China
      More by Tingting Yuan
    • Hui Jiao
      Hui Jiao
      National Key Laboratory of Green Pesticide, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for R&D of Fine Chemicals of Guizhou University, Guiyang 550025, China
      More by Hui Jiao
    • Lina Ai
      Lina Ai
      National Key Laboratory of Green Pesticide, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for R&D of Fine Chemicals of Guizhou University, Guiyang 550025, China
      More by Lina Ai
    • Yafang Chen
      Yafang Chen
      National Key Laboratory of Green Pesticide, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for R&D of Fine Chemicals of Guizhou University, Guiyang 550025, China
      More by Yafang Chen
    • Deyu Hu
      Deyu Hu
      National Key Laboratory of Green Pesticide, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for R&D of Fine Chemicals of Guizhou University, Guiyang 550025, China
      More by Deyu Hu
      Orcidhttps://orcid.org/0000-0001-7843-371X
    • Ping Lu*
      Ping Lu
      National Key Laboratory of Green Pesticide, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for R&D of Fine Chemicals of Guizhou University, Guiyang 550025, China
      Huitong Experimental Station of Forest Ecology, Chinese Academy of Sciences, Huitong, Hunan 418300, China
      *Email: [email protected]. Tel: +86-851-88292090. Fax: +86-851-88292090.
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      Orcidhttps://orcid.org/0000-0003-4524-6365
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    Journal of Agricultural and Food Chemistry

    Cite this: J. Agric. Food Chem. 2023, 71, 16, 6424–6433
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    https://doi.org/10.1021/acs.jafc.2c08748
    Published April 18, 2023
    Copyright © 2023 American Chemical Society
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    Abstract

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    Sulfoxaflor is a promising neonicotinoid. However, the negative implications of sulfoxaflor on nontarget aquatic organisms have been rarely studied. In this study, the risks of sulfoxaflor and its main metabolites X11719474 and X11519540 on Daphnia magna were characterized, including acute toxicity, reproduction, swimming behavior, biochemical markers, and gene transcription. Acute toxicity measurements indicated that X11719474 and X11519540 have high toxicity than the parent compound sulfoxaflor. Chronic exposure reduced reproduction and delayed the birth of the firstborn D. magna. Swimming behavior monitoring showed that exposure to three compounds stimulated swimming behavior. The induction of catalase, superoxide dismutase, and acetylcholinesterase activities was observed with oxidative stress, whereas malondialdehyde content was remarkably increased with exposure to sulfoxaflor, X11719474, and X11519540. Moreover, transcriptomics profiles showed that sulfoxaflor, X11719474, and X11519540 induced KEGG pathways related to cellular processes, organismal systems, and metabolisms. The findings present valuable insights into the prospective hazards of these pesticides and emphasize the critical importance of conducting a systematic evaluation of combining antecedents and their metabolites.

    Copyright © 2023 American Chemical Society

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    Supporting Information

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    The Supporting Information is available free of charge at https://pubs.acs.org/doi/10.1021/acs.jafc.2c08748.

    • Results of acute exposure of SFX (a) and its metabolites X540 (b) and X474 (c) to D. magna for 24 and 48 h (Figure S1); acute exposure results of SFX + X474 (1:1) (a), SFX + X540 (1:1) (b), X540 + X474 (1:1) (c), and SFX + X540 + X474 (1:1) (d) on D. magna for 48 h (Figure S2); Body length. (Comparison of differences between different groups on the same date) (Figure S3); the number of differential genes between groups (Figure S4); expressions of genes in D. magna were randomly selected in transcriptomic sequencing and real-time quantitative PCR (Figure S5); sequences of primers for the genes tested in D. magna (Table S1); LC50 values and correlation coefficient of SFX, X540, and X474 in D. magna (Table S2); the combined toxic modes of SFX, X540, and X474 at a 1:1, 1:1:1 toxic unit ratio as assessed by three classic methods: toxic unit (TU), additive index (AI), and mixed toxicity index (MTI) (Table S3); the significantly downregulated pathways at CK vs SFX, CK vs X540, CK vs X474, SFX vs X540, SFX vs X474, and X540 vs X474 for D. magna (Table S4); synthesis and structural identification of X11519540 and X11719474 (Document S1); the TU method, AI, and MTI method (Document S2); Lotka’s formula (Document S3) (PDF)

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    This article is cited by 7 publications.

    1. Peiling Han, Xuehua Li, Jingyuan Yang, Yuxuan Zhang, Jingwen Chen. Advancing Toxicity Predictions: A Review on in Vitro to in Vivo Extrapolation in Next-Generation Risk Assessment. Environment & Health 2024, 2 (7) , 499-513. https://doi.org/10.1021/envhealth.4c00043
    2. Zhi-Cong He, Tao Zhang, Xin-Fang Lu, Rui Li, Wei Peng, Qiong Mei, Qi-Zhao Wang, Fei Ding. Assessing the nicotinic acetylcholine receptor-mediated enantioselective neurotoxicity of a neonicotinoid-like pollutant, chiral sulfoxaflor: Insight from the two asymmetric centers. Journal of Hazardous Materials 2025, 494 , 138468. https://doi.org/10.1016/j.jhazmat.2025.138468
    3. J. P. Giesy, K. R. Solomon, J. R. Purdy, V. J. Kramer. Weight of evidence assessment of effects of sulfoxaflor on aquatic invertebrates: sulfoxaflor environmental science review part II. Journal of Toxicology and Environmental Health, Part B 2025, 28 (5) , 293-321. https://doi.org/10.1080/10937404.2025.2478965
    4. Yun-Xiu Zhao, Yue Shen, Li-Wen Chen, Jing Li, Ju Yang. Neonicotinoid insecticide sulfoxaflor in the environment: a critical review of environmental fate, degradation mechanism, and toxic effects. Environmental Science: Processes & Impacts 2025, 27 (4) , 818-832. https://doi.org/10.1039/D4EM00798K
    5. Chenglong Dong, Liqiang Wang, Nikolai Barulin, Juan José Alava, Shaoquan Liu, Dongmei Xiong. Maternal Daphnia magna exposure to the antidepressant sertraline causes molting disorder, multi-generational reproductive and serotonergic dysfunction. Aquatic Toxicology 2025, 278 , 107161. https://doi.org/10.1016/j.aquatox.2024.107161
    6. Yafang Chen, Xiang Yu, Shaoqin Chen, Ping Lu. Stereoselective toxicity: Investigating the adverse effects of benzovindiflupyr on Xenopus laevis tadpoles. Journal of Hazardous Materials 2024, 480 , 135789. https://doi.org/10.1016/j.jhazmat.2024.135789
    7. Paulina Łukaszewicz, Przemysław Siudak, Klaudia Kropidłowska, Magda Caban, Łukasz P. Haliński. Unicellular cyanobacteria degrade sulfoxaflor to its amide metabolite of potentially higher aquatic toxicity. Chemosphere 2023, 337 , 139440. https://doi.org/10.1016/j.chemosphere.2023.139440
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    Journal of Agricultural and Food Chemistry

    Cite this: J. Agric. Food Chem. 2023, 71, 16, 6424–6433
    Click to copy citationCitation copied!
    https://doi.org/10.1021/acs.jafc.2c08748
    Published April 18, 2023
    Copyright © 2023 American Chemical Society
    Request reuse permissions

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