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Diterpenoids from the Roots of Euphorbia fischeriana with Inhibitory Effects on Nitric Oxide Production

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College of Pharmacy, Chungbuk National University, Cheongju 28644, Korea
Department of Biosystems and Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Korea
§ Western Seoul Center, Korea Basic Science Institute, Seoul 03759, Korea
Beamline Department, Pohang Accelerator Laboratory/POSTECH, Pohang 37673, Korea
*Tel (B. Y. Hwang): +82-43-261-2814. Fax: +82-43-268-2732. E-mail: [email protected]
Cite this: J. Nat. Prod. 2016, 79, 1, 126–131
Publication Date (Web):December 24, 2015
https://doi.org/10.1021/acs.jnatprod.5b00789
Copyright © 2015 The American Chemical Society and American Society of Pharmacognosy
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Abstract

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Bioactivity-guided isolation of a methanolic extract of Euphorbia fischeriana led to the isolation of four new abietane-type diterpenoids, fischeriolides A–D (14), together with 11 known diterpenoids. Their structures were elucidated based on the interpretation of 1D and 2D NMR spectroscopic and HRESIMS data. The absolute configuration of compound 3 was determined by single-crystal X-ray diffraction analysis and electronic circular dichroism methods. Compounds 59 exhibited inhibitory effects on LPS-induced nitric oxide production in RAW 264.7 macrophages with IC50 values in the range 4.9–12.6 μM.

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The Supporting Information is available free of charge on the ACS Publications website at DOI: 10.1021/acs.jnatprod.5b00789.

  • 1D NMR, 2D NMR, and HRESIMS of compounds 14 (PDF)

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