Phosphorescence Kinetics of Singlet Oxygen Produced by Photosensitization in Spherical Nanoparticles. Part I. Theory
- Andrej HovanAndrej HovanDepartment of Biophysics, Faculty of Science, P. J. Šafárik University, Jesenná 5, 041 54 Košice, Slovak RepublicMore by Andrej Hovan
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- Shubhashis DattaShubhashis DattaCenter for Interdisciplinary Biosciences, Technology and Innovation Park, P. J. Šafárik University, Jesenná 5, 041 54 Košice, Slovak RepublicMore by Shubhashis Datta
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- Sergei G. KruglikSergei G. KruglikLaboratoire Jean Perrin, Sorbonne Universités, UPMC Univ. Paris 6, CNRS UMR 8237, 4 Place Jussieu, 75005 Paris, FranceMore by Sergei G. Kruglik
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- Daniel JancuraDaniel JancuraDepartment of Biophysics, Faculty of Science and Center for Interdisciplinary Biosciences, Technology and Innovation Park, P. J. Šafárik University, Jesenná 5, 041 54 Košice, Slovak RepublicMore by Daniel Jancura
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- Pavol MiskovskyPavol MiskovskyDepartment of Biophysics, Faculty of Science and Center for Interdisciplinary Biosciences, Technology and Innovation Park, P. J. Šafárik University, Jesenná 5, 041 54 Košice, Slovak RepublicMore by Pavol Miskovsky
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- Gregor Bánó*Gregor Bánó*E-mail: [email protected]. Phone: +421 55 2342253.Department of Biophysics, Faculty of Science and Center for Interdisciplinary Biosciences, Technology and Innovation Park, P. J. Šafárik University, Jesenná 5, 041 54 Košice, Slovak RepublicMore by Gregor Bánó
Abstract
The singlet oxygen produced by energy transfer between an excited photosensitizer (pts) and ground-state oxygen molecules plays a key role in photodynamic therapy. Different nanocarrier systems are extensively studied to promote targeted pts delivery in a host body. The phosphorescence kinetics of the singlet oxygen produced by the short laser pulse photosensitization of pts inside nanoparticles is influenced by singlet oxygen diffusion from the particles to the surrounding medium. Two theoretical models are presented in this work: a more complex numerical one and a simple analytical one. Both the models predict the time course of singlet oxygen concentration inside and outside of the spherical particles following short-pulse excitation of pts. On the basis of the comparison of the numerical and analytical results, a semiempirical analytical formula is derived to calculate the characteristic diffusion time of singlet oxygen from the nanoparticles to the surrounding solvent. The phosphorescence intensity of singlet oxygen produced in pts-loaded nanocarrier systems can be calculated as a linear combination of the two concentrations (inside and outside the particles), taking the different phosphorescence emission rate constants into account.
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