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Protein-Specific Differential Glycosylation of Immunoglobulins in Serum of Ovarian Cancer Patients

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Department of Chemistry, University of California, Davis, California 95616, United States
Division of Biostatistics, Department of Public Health Sciences, University of California, Davis, California 95616, United States
§ University of California Davis Medical Center, Sacramento, California 95817, United States
Division of Gynecologic Oncology, University of California Davis Medical Center, Sacramento, California 98517, United States
*E-mail: [email protected]. Phone: +31 71 526 6397.
Cite this: J. Proteome Res. 2016, 15, 3, 1002–1010
Publication Date (Web):January 27, 2016
https://doi.org/10.1021/acs.jproteome.5b01071
Copyright © 2016 American Chemical Society

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    Abstract

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    Previous studies indicated that glycans in serum may serve as biomarkers for diagnosis of ovarian cancer; however, it was unclear to which proteins these glycans belong. We hypothesize that protein-specific glycosylation profiles of the glycans may be more informative of ovarian cancer and can provide insight into biological mechanisms underlying glycan aberration in serum of diseased individuals. Serum samples from women diagnosed with epithelial ovarian cancer (EOC, n = 84) and matched healthy controls (n = 84) were obtained from the Gynecologic Oncology Group. Immunoglobulin (IgG, IgA, and IgM) concentrations and glycosylation profiles were quantified using multiple reaction monitoring mass spectrometry. Differential and classification analyses were performed to identify aberrant protein-specific glycopeptides using a training set. All findings were validated in an independent test set. Multiple glycopeptides from immunoglubins IgA, IgG, and IgM were found to be differentially expressed in serum of EOC patients compared with controls. The protein-specific glycosylation profiles showed their potential in the diagnosis of EOC. In particular, IgG-specific glycosylation profiles are the most powerful in discriminating between EOC case and controls. Additional studies of protein- and site-specific glycosylation profiles of immunoglobulins and other proteins will allow further elaboration on the characteristics of biological functionality and causality of the differential glycosylation in ovarian cancer and thus ultimately lead to increased sensitivity and specificity of diagnosis.

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    The Supporting Information is available free of charge on the ACS Publications website at DOI: 10.1021/acs.jproteome.5b01071.

    • Supplementary Figure SF1. Stability of method used. Supplementary Table ST1. Characteristics of the transitions monitored in this study. Supplementary Table ST2. Classification metrics for peptides and glycopeptides from IgG. Supplementary Table ST3. Classification metrics for each peptide/glycopeptide from IgM of which levels were significantly different for EOC in the discovery set. Supplementary Table ST4. Entry order and classification metrics for each peptide/glycopeptide from all three proteins of which levels were significantly different for EOC in the discovery set. Supplementary Table ST5. Entry order and classification metrics for peptides and glycopeptides from all three proteins. (PDF)

    • Supplementary Table ST6. All data and metadata used for this publication. (XLSX)

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    34. Si Liu, Yuting Yu, Yuanyuan Liu, Jiajing Lin, Yang Fu, Liming Cheng, Xin Liu. Revealing the changes of IgG subclass‐specific N ‐glycosylation in colorectal cancer progression by high‐throughput assay. PROTEOMICS – Clinical Applications 2021, 15 (2-3) https://doi.org/10.1002/prca.202000022
    35. Francis Mugeni Wanyama, Véronique Blanchard. Glycomic-Based Biomarkers for Ovarian Cancer: Advances and Challenges. Diagnostics 2021, 11 (4) , 643. https://doi.org/10.3390/diagnostics11040643
    36. Junyan Wang, Chuncui Huang, Jinyu Zhou, Keli Zhao, Yan Li. Causal link between immunoglobulin G glycosylation and cancer: A potential glycobiomarker for early tumor detection. Cellular Immunology 2021, 361 , 104282. https://doi.org/10.1016/j.cellimm.2021.104282
    37. Marija Pezer. Immunoglobulin G Glycosylation in Diseases. 2021, 395-431. https://doi.org/10.1007/978-3-030-76912-3_13
    38. Si Liu, Xin Liu. IgG N-glycans. 2021, 1-47. https://doi.org/10.1016/bs.acc.2021.02.001
    39. Sudarat Onsurathum, Muchena J. Kailemia, Kitti Intuyod, Ornuma Haonon, Chawalit Pairojkul, Raynoo Thanan, Porntip Pinlaor, Carlito B. Lebrilla, Somchai Pinlaor. N-glycosylation profiling of serum immunoglobulin in opisthorchiasis patients. Journal of Proteomics 2021, 230 , 103980. https://doi.org/10.1016/j.jprot.2020.103980
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    41. Yong Zhang, Tianhai Lin, Yang Zhao, Yonghong Mao, Yiran Tao, Yan Huang, Shisheng Wang, Liqiang Hu, Jingqiu Cheng, Hao Yang. Characterization of N-linked intact glycopeptide signatures of plasma IgGs from patients with prostate carcinoma and benign prostatic hyperplasia for diagnosis pre-stratification. The Analyst 2020, 145 (15) , 5353-5362. https://doi.org/10.1039/D0AN00225A
    42. Marta Wieczorek, Elena Ioana Braicu, Leticia Oliveira-Ferrer, Jahid Sehouli, Véronique Blanchard. Immunoglobulin G Subclass-Specific Glycosylation Changes in Primary Epithelial Ovarian Cancer. Frontiers in Immunology 2020, 11 https://doi.org/10.3389/fimmu.2020.00654
    43. Hsiao‐Fan Chen, Ching‐Ya Shiao, Mei‐Yi Wu, Yen‐Chung Lin, Hsi‐Hsien Chen, Wei‐Chiao Chang, Mai‐Szu Wu, Chih‐Chin Kao, I‐Lin Tsai. Quantitative determination of human IgA subclasses and their Fc‐glycosylation patterns in plasma by using a peptide analogue internal standard and ultra‐high‐performance liquid chromatography/triple quadrupole mass spectrometry. Rapid Communications in Mass Spectrometry 2020, 34 (S1) https://doi.org/10.1002/rcm.8606
    44. Oleg Kurtenkov. Profiling of Naturally Occurring Antibodies to the Thomsen-Friedenreich Antigen in Health and Cancer: The Diversity and Clinical Potential. BioMed Research International 2020, 2020 , 1-12. https://doi.org/10.1155/2020/9747040
    45. Noortje de Haan, David Falck, Manfred Wuhrer. Monitoring of immunoglobulin N- and O-glycosylation in health and disease. Glycobiology 2020, 30 (4) , 226-240. https://doi.org/10.1093/glycob/cwz048
    46. Cuiyan Cao, Long Yu, Dongmei Fu, Jingli Yuan, Xinmiao Liang. Absolute quantitation of high abundant Fc-glycopeptides from human serum IgG-1. Analytica Chimica Acta 2020, 1102 , 130-139. https://doi.org/10.1016/j.aca.2019.12.035
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    50. Ting Zhao, Cheng Zhang, Weide Ma, Yun Xiong, Jun Yao, Guoquan Yan, Gang Chen, Haojie Lu. A practical approach to enrich intact tryptic N-glycopeptides through size exclusion chromatography and hydrophilicity (SELIC) using an acrylamide-agarose composite gel system. Analytica Chimica Acta 2019, 1058 , 107-116. https://doi.org/10.1016/j.aca.2019.01.044
    51. Jiani Wang, Jianrong Song, Hongli Zheng, Xiangqin Zheng, Hong Dai, Zhensheng Hong, Yanyu Lin. Application of NiFe2O4 nanotubes as catalytically promoted sensing platform for ratiometric electrochemiluminescence analysis of ovarian cancer marker. Sensors and Actuators B: Chemical 2019, 288 , 80-87. https://doi.org/10.1016/j.snb.2019.02.099
    52. Kwang Hoe Kim, Gun Wook Park, Ji Eun Jeong, Eun Sun Ji, Hyun Joo An, Jin Young Kim, Jong Shin Yoo. Parallel reaction monitoring with multiplex immunoprecipitation of N-glycoproteins in human serum for detection of hepatocellular carcinoma. Analytical and Bioanalytical Chemistry 2019, 411 (14) , 3009-3019. https://doi.org/10.1007/s00216-019-01775-5
    53. Hannah J. Lomax-Browne, Claire Robertson, Aristotelis Antonopoulos, Anthony J. C. Leathem, Stuart M. Haslam, Anne Dell, Miriam V. Dwek. Serum IgA1 shows increased levels of α 2,6-linked sialic acid in breast cancer. Interface Focus 2019, 9 (2) , 20180079. https://doi.org/10.1098/rsfs.2018.0079
    54. Kwang Hoe Kim, Soo‐Youn Lee, Heeyoun Hwang, Ju Yeon Lee, Eun Sun Ji, Hyun Joo An, Jin Young Kim, Jong Shin Yoo. Direct Monitoring of Fucosylated Glycopeptides of Alpha‐Fetoprotein in Human Serum for Early Hepatocellular Carcinoma by Liquid Chromatography–Tandem Mass Spectrometry with Immunoprecipitation. PROTEOMICS – Clinical Applications 2018, 12 (6) https://doi.org/10.1002/prca.201800062
    55. Ivan Gudelj, Gordan Lauc, Marija Pezer. Immunoglobulin G glycosylation in aging and diseases. Cellular Immunology 2018, 333 , 65-79. https://doi.org/10.1016/j.cellimm.2018.07.009
    56. Yanyan Qu, Liangliang Sun, Guijie Zhu, Zhenbin Zhang, Elizabeth H. Peuchen, Norman J. Dovichi. Sensitive and fast characterization of site-specific protein glycosylation with capillary electrophoresis coupled to mass spectrometry. Talanta 2018, 179 , 22-27. https://doi.org/10.1016/j.talanta.2017.10.015
    57. Annika Wahl, Erik van den Akker, Lucija Klaric, Jerko Štambuk, Elisa Benedetti, Rosina Plomp, Genadij Razdorov, Irena Trbojević-Akmačić, Joris Deelen, Diana van Heemst, P. Eline Slagboom, Frano Vučković, Harald Grallert, Jan Krumsiek, Konstantin Strauch, Annette Peters, Thomas Meitinger, Caroline Hayward, Manfred Wuhrer, Marian Beekman, Gordan Lauc, Christian Gieger. Genome-Wide Association Study on Immunoglobulin G Glycosylation Patterns. Frontiers in Immunology 2018, 9 https://doi.org/10.3389/fimmu.2018.00277
    58. Qing Kay Li, Punit Shah, Yuan Tian, Yingwei Hu, Richard B. S. Roden, Hui Zhang, Daniel W. Chan. An integrated proteomic and glycoproteomic approach uncovers differences in glycosylation occupancy from benign and malignant epithelial ovarian tumors. Clinical Proteomics 2017, 14 (1) https://doi.org/10.1186/s12014-017-9152-2
    59. Muchena J. Kailemia, Dayoung Park, Carlito B. Lebrilla. Glycans and glycoproteins as specific biomarkers for cancer. Analytical and Bioanalytical Chemistry 2017, 409 (2) , 395-410. https://doi.org/10.1007/s00216-016-9880-6
    60. L. Renee Ruhaak, Yuri E.M. van der Burgt, Christa M. Cobbaert. Prospective applications of ultrahigh resolution proteomics in clinical mass spectrometry. Expert Review of Proteomics 2016, 13 (12) , 1063-1071. https://doi.org/10.1080/14789450.2016.1253477
    61. Irena Trbojević-Akmačić, Marija Vilaj, Gordan Lauc. High-throughput analysis of immunoglobulin G glycosylation. Expert Review of Proteomics 2016, 13 (5) , 523-534. https://doi.org/10.1080/14789450.2016.1174584

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