ACS Publications. Most Trusted. Most Cited. Most Read

OR SEARCH CITATIONS

My Activity
Recently Viewed
You have not visited any articles yet, Please visit some articles to see contents here.
Publications
CONTENT TYPES

Figure 1Loading Img
Download Hi-Res ImageDownload to MS-PowerPointCite This:Mol. Pharmaceutics 2016, 13, 11, 3601-3612
RETURN TO ISSUEReviewNEXT

64Cu2+ Ions as PET Probe: An Emerging Paradigm in Molecular Imaging of Cancer

View Author Information
Radiopharmaceuticals Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400 085, India
*E-mail: [email protected] or [email protected]. Phone: +91-22-25590624. Fax: +91-22-25505151.
Cite this: Mol. Pharmaceutics 2016, 13, 11, 3601–3612
Publication Date (Web):October 6, 2016
https://doi.org/10.1021/acs.molpharmaceut.6b00582
Copyright © 2016 American Chemical Society
RIGHTS & PERMISSIONS
Article Views
957
Altmetric
-
Citations
34
LEARN ABOUT THESE METRICS
Read OnlinePDF (7 MB)
Get e-Alerts
SUBJECTS:

Abstract

Abstract Image

Positron emission tomography (PET) imaging has transformed diagnostic nuclear medicine and become an essential strategy in cancer management. With the expected growth of this molecular imaging modality, there is a recognized need for new PET probes to address the clinical challenges in the early diagnosis and staging of various types of cancers. In this endeavor, the prospect of using 64Cu in the form of simple Cu2+ ions as PET probe is not only a cost-effective proposition but also seems poised to broaden the palette of molecular imaging probes in the foreseeable future. The usefulness of 64Cu2+ ions as PET probe is based on the fact that Cu is an essential element that plays an important role in cell proliferation and angiogenesis. Over the past few years, there has been continuous flow of evidences based on studies in animal models on the uptake of 64Cu2+ ions in different types of tumors, including, hepatoma, colorectal cancer, prostate cancer, lung cancer, breast cancer, head and neck cancer, fibrosarcoma, melanoma, glioblastoma, and ovarian cancer. The widespread preclinical success of 64Cu2+ ions as PET probe has recently resulted in translation of this radiotracer to clinical settings for noninvasive imaging and staging of prostate cancer in human patients. In this concise review, we have focused on the latest developments in PET imaging of cancer in preclinical and clinical settings using 64Cu2+ ion as a probe and discussed the challenges and opportunities for future development.

KEYWORDS:

Cited By

This article is cited by 34 publications.

  1. Pengju Cai, Dongdong Su, Wenjiang Yang, Zhesheng He, Chunyu Zhang, Hui Liu, Zhibo Liu, Xiangchun Zhang, Liang Gao, Yu Liu, Huaidong Jiang, Fuping Gao, Xueyun Gao. Inherently PET/CT Dual Modality Imaging Lipid Nanocapsules for Early Detection of Orthotopic Lung Tumors. ACS Applied Bio Materials 2020, 3 (1) , 611-621. https://doi.org/10.1021/acsabm.9b00993
  2. Jun Wang, Yi Gou, Zhenlei Zhang, Ping Yu, Jinxu Qi, Qipin Qin, Hongbin Sun, Xiaoyang Wu, Hong Liang, Feng Yang. Developing an Anticancer Copper(II) Multitarget Pro-Drug Based on the His146 Residue in the IB Subdomain of Modified Human Serum Albumin. Molecular Pharmaceutics 2018, 15 (6) , 2180-2193. https://doi.org/10.1021/acs.molpharmaceut.8b00045
  3. Eva J. Ge, Ashley I. Bush, Angela Casini, Paul A. Cobine, Justin R. Cross, Gina M. DeNicola, Q. Ping Dou, Katherine J. Franz, Vishal M. Gohil, Sanjeev Gupta, Stephen G. Kaler, Svetlana Lutsenko, Vivek Mittal, Michael J. Petris, Roman Polishchuk, Martina Ralle, Michael L. Schilsky, Nicholas K. Tonks, Linda T. Vahdat, Linda Van Aelst, Dan Xi, Peng Yuan, Donita C. Brady, Christopher J. Chang. Connecting copper and cancer: from transition metal signalling to metalloplasia. Nature Reviews Cancer 2021, 144 https://doi.org/10.1038/s41568-021-00417-2
  4. Rubel Chakravarty, Sudipta Chakraborty. Production of a broad palette of positron emitting radioisotopes using a low-energy cyclotron: Towards a new success story in cancer imaging?. Applied Radiation and Isotopes 2021, 176 , 109860. https://doi.org/10.1016/j.apradiso.2021.109860
  5. Quguang Li, Ziliang Dong, Meiwan Chen, Liangzhu Feng. Phenolic molecules constructed nanomedicine for innovative cancer treatment. Coordination Chemistry Reviews 2021, 439 , 213912. https://doi.org/10.1016/j.ccr.2021.213912
  6. Juan Pellico, Peter J. Gawne, Rafael T. M. de Rosales. Radiolabelling of nanomaterials for medical imaging and therapy. Chemical Society Reviews 2021, 50 (5) , 3355-3423. https://doi.org/10.1039/D0CS00384K
  7. Nirvik Sen, Rubel Chakravarty, K.K. Singh, Sudipta Chakraborty, K.T. Shenoy. Selective separation of Cu from large excess of Zn using a microfluidic platform. Chemical Engineering and Processing - Process Intensification 2021, 159 , 108215. https://doi.org/10.1016/j.cep.2020.108215
  8. Cristina Bolzati, Adriano Duatti. The emerging value of 64Cu for molecular imaging and therapy. The Quarterly Journal of Nuclear Medicine and Molecular Imaging 2020, 64 (4) https://doi.org/10.23736/S1824-4785.20.03292-6
  9. Amir R. Jalilian, Joao A. Osso Jr, Julia Vera-Araujo, Vijay Kumar, Matthew J. Harris, Bianca Gutfilen, Brigitte Guérin, Hongyu Li, Fedor Zhuravlev, Rubel Chakravarty, Behrouz Alirezapour, Miguel A. Ávila-Rodríguez, Irfan U. Khan, Ibrahim Aljammaz, Thaer Assaad, Gert Luurtsema, Jeff Smith, Adriano Duatti. IAEA contribution to the development of 64Cu radiopharmaceuticals for theranostic applications. The Quarterly Journal of Nuclear Medicine and Molecular Imaging 2020, 64 (4) https://doi.org/10.23736/S1824-4785.20.03302-6
  10. Rubel Chakravarty, Priyalata Shetty, K. V. Vimalnath Nair, Ardhi Rajeswari, K. C. Jagadeesan, Haladhar Dev Sarma, Venkatesh Rangarajan, Rahul Krishnatry, Sudipta Chakraborty. Reactor produced [64Cu]CuCl2 as a PET radiopharmaceutical for cancer imaging: from radiochemistry laboratory to nuclear medicine clinic. Annals of Nuclear Medicine 2020, 34 (12) , 899-910. https://doi.org/10.1007/s12149-020-01522-2
  11. Rubel Chakravarty, Ardhi Rajeswari, Priyalata Shetty, K.C. Jagadeesan, Ramu Ram, Sachin Jadhav, Haladhar Dev Sarma, Ashutosh Dash, Sudipta Chakraborty. A simple and robust method for radiochemical separation of no-carrier-added 64Cu produced in a research reactor for radiopharmaceutical preparation. Applied Radiation and Isotopes 2020, 165 , 109341. https://doi.org/10.1016/j.apradiso.2020.109341
  12. Qiang Wang, Dongli Song, Xiaowei Ma, Xiaodong Wu, Lei Jiang. Preclinical PET imaging study of lung cancer with 64CuCl2. Annals of Nuclear Medicine 2020, 34 (9) , 653-662. https://doi.org/10.1007/s12149-020-01491-6
  13. Dongdong Su, Liang Gao, Fuping Gao, Xiangchun Zhang, Xueyun Gao. Peptide and protein modified metal clusters for cancer diagnostics. Chemical Science 2020, 11 (22) , 5614-5629. https://doi.org/10.1039/D0SC01201G
  14. J.L.T.M. Moret, T.A. Hardens, O. van Batenburg, H.T. Wolterbeek, J.R. van Ommen, A.G. Denkova. 64Cu enrichment using the Szilard-Chalmers effect – The influence of γ-dose. Applied Radiation and Isotopes 2020, 160 , 109135. https://doi.org/10.1016/j.apradiso.2020.109135
  15. Anikó Gaál, Tamás M. Garay, Ildikó Horváth, Domokos Máthé, Dávid Szöllősi, Dániel S. Veres, Jeremiah Mbuotidem, Tibor Kovács, József Tóvári, Ralf Bergmann, Christina Streli, Gergely Szakács, Judith Mihály, Zoltán Varga, Norbert Szoboszlai. Development and In Vivo Application of a Water-Soluble Anticancer Copper Ionophore System Using a Temperature-Sensitive Liposome Formulation. Pharmaceutics 2020, 12 (5) , 466. https://doi.org/10.3390/pharmaceutics12050466
  16. Luca Filippi, Agostino Chiaravalloti, Orazio Schillaci, Roberto Cianni, Oreste Bagni. Theranostic approaches in nuclear medicine: current status and future prospects. Expert Review of Medical Devices 2020, 17 (4) , 331-343. https://doi.org/10.1080/17434440.2020.1741348
  17. Cinzia Imberti, Peter J. Sadler. 150 years of the periodic table: New medicines and diagnostic agents. 2020,,, 3-56. https://doi.org/10.1016/bs.adioch.2019.11.001
  18. Amaury Guillou, Luís M. P. Lima, David Esteban-Gómez, Rita Delgado, Carlos Platas-Iglesias, Véronique Patinec, Raphaël Tripier. endo - versus exo -Cyclic coordination in copper complexes with methylthiazolylcarboxylate tacn derivatives. Dalton Transactions 2019, 48 (24) , 8740-8755. https://doi.org/10.1039/C9DT01366K
  19. Han Feng, Xiaobo Wang, Jian Chen, Jing Cui, Tang Gao, Yongju Gao, Wenbin Zeng. Nuclear Imaging of Glucose Metabolism: Beyond 18 F-FDG. Contrast Media & Molecular Imaging 2019, 2019 , 1-12. https://doi.org/10.1155/2019/7954854
  20. Francis Man, Peter J. Gawne, Rafael T.M. de Rosales. Nuclear imaging of liposomal drug delivery systems: A critical review of radiolabelling methods and applications in nanomedicine. Advanced Drug Delivery Reviews 2019, 143 , 134-160. https://doi.org/10.1016/j.addr.2019.05.012
  21. Theodora J. Stewart. Across the spectrum: integrating multidimensional metal analytics for in situ metallomic imaging. Metallomics 2019, 11 (1) , 29-49. https://doi.org/10.1039/C8MT00235E
  22. Xiaoxi Ling, Cathy S. Cutler, Carolyn J. Anderson. The Radiopharmaceutical Chemistry of the Radioisotopes of Copper. 2019,,, 335-358. https://doi.org/10.1007/978-3-319-98947-1_19
  23. Yeye Zhou, Jihui Li, Xin Xu, Man Zhao, Bin Zhang, Shengming Deng, Yiwei Wu. 64 Cu-based Radiopharmaceuticals in Molecular Imaging. Technology in Cancer Research & Treatment 2019, 18 , 153303381983075. https://doi.org/10.1177/1533033819830758
  24. A. Gopalakrishna, S. V. Suryanarayana, H. Naik, B. K. Nayak, B. J. Patil, S. Devraju, R. R. Upreti, R. Kinhikar, D. D. Deshpande, P. Maletha, Kamaldeep, S. Banerjee, A. Saxena. Production of 99Mo and 64Cu in a mixed field of photons and neutrons in a clinical electron linear accelerator. Journal of Radioanalytical and Nuclear Chemistry 2018, 317 (3) , 1409-1417. https://doi.org/10.1007/s10967-018-6016-9
  25. Anife Ahmedova, Boyan Todorov, Nikola Burdzhiev, Christine Goze. Copper radiopharmaceuticals for theranostic applications. European Journal of Medicinal Chemistry 2018, 157 , 1406-1425. https://doi.org/10.1016/j.ejmech.2018.08.051
  26. Joanna J. Bartnicka, Philip J. Blower. Insights into Trace Metal Metabolism in Health and Disease from PET: “PET Metallomics”. Journal of Nuclear Medicine 2018, 59 (9) , 1355-1359. https://doi.org/10.2967/jnumed.118.212803
  27. Alessandra Boschi, Petra Martini, Emilija Janevik-Ivanovska, Adriano Duatti. The emerging role of copper-64 radiopharmaceuticals as cancer theranostics. Drug Discovery Today 2018, 23 (8) , 1489-1501. https://doi.org/10.1016/j.drudis.2018.04.002
  28. Feng Yang, Hong Liang. Designing anticancer multitarget metal thiosemicarbazone prodrug based on the nature of binding sites of human serum albumin carrier. Future Medicinal Chemistry 2018, 10 (16) , 1881-1883. https://doi.org/10.4155/fmc-2018-0175
  29. Clément Bailly, Sébastien Gouard, Marie Lacombe, Patricia Remaud-Le Saëc, Benjamin Chalopin, Mickaël Bourgeois, Nicolas Chouin, Raphaël Tripier, Zakaria Halime, Ferid Haddad, Alain Faivre-Chauvet, Françoise Kraeber-Bodéré, Michel Chérel, Caroline Bodet-Milin. Comparison of Immuno-PET of CD138 and PET imaging with 64CuCl2 and 18F-FDG in a preclinical syngeneic model of multiple myeloma. Oncotarget 2018, 9 (10) , 9061-9072. https://doi.org/10.18632/oncotarget.23886
  30. Lei Jiang, Dongli Song, Hao Chen, Ao Zhang, Huoqiang Wang, Zhen Cheng. Pilot Study of 64CuCl2 for PET Imaging of Inflammation. Molecules 2018, 23 (2) , 502. https://doi.org/10.3390/molecules23020502
  31. Ulrich Abram. Innovative PET and SPECT Tracers. 2018,,, 255-279. https://doi.org/10.1007/978-3-319-65924-4_11
  32. Weijun Wei, Emily B. Ehlerding, Xiaoli Lan, Quanyong Luo, Weibo Cai. PET and SPECT imaging of melanoma: the state of the art. European Journal of Nuclear Medicine and Molecular Imaging 2018, 45 (1) , 132-150. https://doi.org/10.1007/s00259-017-3839-5
  33. Monika Paúrová, Tomáš David, Ivana Císařová, Přemysl Lubal, Petr Hermann, Jan Kotek. Optimization of the selectivity and rate of copper radioisotope complexation: formation and dissociation kinetic studies of 1,4,8-trimethylcyclam-based ligands with different coordinating pendant arms. New Journal of Chemistry 2018, 42 (14) , 11908-11929. https://doi.org/10.1039/C8NJ00419F
  34. Rubel Chakravarty, Sudipta Chakraborty, Apurav Guleria, Amit Kunwar, Haladhar Dev Sarma, Ashutosh Dash. Facile One-Pot Synthesis of Intrinsically Radiolabeled 64 Cu-Human Serum Albumin Nanocomposite for Cancer Targeting. ChemistrySelect 2017, 2 (26) , 8043-8051. https://doi.org/10.1002/slct.201701237

Pair your accounts.

Export articles to Mendeley

Get article recommendations from ACS based on references in your Mendeley library.

Pair your accounts.

Export articles to Mendeley

Get article recommendations from ACS based on references in your Mendeley library.

You’ve supercharged your research process with ACS and Mendeley!

STEP 1:
Click to create an ACS ID

Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

MENDELEY PAIRING EXPIRED
Your Mendeley pairing has expired. Please reconnect

This website uses cookies to improve your user experience. By continuing to use the site, you are accepting our use of cookies. Read the ACS privacy policy.

CONTINUE