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Download Hi-Res ImageDownload to MS-PowerPointCite This:Mol. Pharmaceutics 2018, 15, 5, 1791-1799
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Iron Oxide Nanoparticles-Based Vaccine Delivery for Cancer Treatment

  • Yi Zhao
    Yi Zhao
    School of Pharmacy, Shanghai Jiao Tong University, No. 800 Dongchuan Road, Shanghai 200240, China
    More by Yi Zhao
    • , 
  • Xiaotian Zhao
    Xiaotian Zhao
    School of Pharmacy, Shanghai Jiao Tong University, No. 800 Dongchuan Road, Shanghai 200240, China
    More by Xiaotian Zhao
    • , 
  • Yuan Cheng
    Yuan Cheng
    School of Pharmacy, Shanghai Jiao Tong University, No. 800 Dongchuan Road, Shanghai 200240, China
    More by Yuan Cheng
    • , 
  • Xiaoshuang Guo
    Xiaoshuang Guo
    School of Pharmacy, Shanghai Jiao Tong University, No. 800 Dongchuan Road, Shanghai 200240, China
    More by Xiaoshuang Guo
    • , and 
  • Weien Yuan*
    Weien Yuan
    School of Pharmacy, Shanghai Jiao Tong University, No. 800 Dongchuan Road, Shanghai 200240, China
    *E-mail: [email protected]
    More by Weien Yuan
    Orcidhttp://orcid.org/0000-0003-4177-7812
Cite this: Mol. Pharmaceutics 2018, 15, 5, 1791–1799
Publication Date (Web):March 23, 2018
https://doi.org/10.1021/acs.molpharmaceut.7b01103
Copyright © 2018 American Chemical Society
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Abstract

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Modern therapeutic cancer vaccines need simple and effective formulations to enhance both humoral and cellular immune responses. Nanoparticles have obtained more and more attention in the development of vaccine delivery platforms. Moreover, nanoparticles-based vaccine delivery platform has high potential for improving the immunogenicity of vaccine. The Food and Drug Administration (FDA) has approved many types of iron oxide nanoparticles for clinical use, such as treating iron deficiency, contrast agents for magnetic resonance imaging (MRI) and drug delivery platforms. In this study, we explored a novel combined use of iron oxide nanoparticles (superparamagnetic Fe3O4 nanoparticles) as a vaccine delivery platform and immune potentiator, and investigated how this formulation affected cytokine expression in macrophages and dendritic cells (DCs) in vitro and tumor growth in vivo. Comparing with soluble OVA alone and iron oxide nanoparticles alone, we found significant differences in immune responses and tumor inhibition induced by OVA formulated with iron oxide nanoparticles. Our iron oxide nanoparticles greatly promoted the activation of immune cells and cytokine production, inducing potent humoral and cellular immune responses. These results suggest that this nanoparticle-based delivery system has strong potential to be utilized as a general platform for cancer vaccines.

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