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Light-Triggered Release of Bioactive Molecules from DNA Nanostructures

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Download Hi-Res ImageDownload to MS-PowerPointCite This:Nano Lett. 2016, 16, 4, 2781-2785
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    Light-Triggered Release of Bioactive Molecules from DNA Nanostructures
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    † Biomedical Engineering Department, Boston University, Boston, Massachusetts 02215, United States
    ‡ Biology Department, Boston University, Boston, Massachusetts 02215, United States
    *E-mail: [email protected]
    *E-mail: [email protected]
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    Nano Letters

    Cite this: Nano Lett. 2016, 16, 4, 2781–2785
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    https://doi.org/10.1021/acs.nanolett.6b00530
    Published March 3, 2016
    Copyright © 2016 American Chemical Society
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    Abstract

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    Recent innovations in DNA nanofabrication allow the creation of intricately shaped nanostructures ideally suited for many biological applications. To advance the use of DNA nanotechnology for the controlled release of bioactive molecules, we report a general strategy that uses light to liberate encapsulated cargoes from DNA nanostructures with high spatiotemporal precision. Through the incorporation of a custom, photolabile cross-linker, we encapsulated cargoes ranging in size from small molecules to full-sized proteins within DNA nanocages and then released such cargoes upon brief exposure to light. This novel molecular uncaging technique offers a general approach for precisely releasing a large variety of bioactive molecules, allowing investigation into their mechanism of action, or finely tuned delivery with high temporal precision for broad biomedical and materials applications.

    Copyright © 2016 American Chemical Society

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    The Supporting Information is available free of charge on the ACS Publications website at DOI: 10.1021/acs.nanolett.6b00530.

    • Synthetic schemes, synthetic details, bioconjugation details, experimental details of glutamate uncaging, additional TEM images, and DNA sequences. (PDF)

    • Supplemental Video S1: In the presence of DNA nanocages containing glutamate, neurons exhibited an increase in intracellular calcium levels after 1 ms light pulse illumination. (AVI)

    • Supplement Video S2: In the absence of the DNA nanocages, no neurons exhibited a change in calcium levels after 1 ms light pulse illumination. (AVI)

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    Cite this: Nano Lett. 2016, 16, 4, 2781–2785
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    https://doi.org/10.1021/acs.nanolett.6b00530
    Published March 3, 2016
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