Therapeutic Role of Deep Eutectic Solvents Based on Menthol and Saturated Fatty Acids on Wound Healing
- Joana M. SilvaJoana M. Silva3B’s Research Group—Biomaterials, Biodegradable and Biomimetic, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Avepark Barco, Guimarães 4805-017, PortugalICVS/3B’s PT Government Associated Laboratory, Braga/Guimarães 4806-909, PortugalMore by Joana M. Silva,
- Carolina V. PereiraCarolina V. PereiraNutraceuticals and Bioactives Process Technology Laboratory, Instituto de Biologia Experimental e Tecnológica, Oeiras 2780-157, PortugalMore by Carolina V. Pereira,
- Francisca ManoFrancisca ManoLAQV/REQUIMTE, Departamento de Química, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, Caparica 2829-516, PortugalMore by Francisca Mano,
- Eduardo SilvaEduardo Silva3B’s Research Group—Biomaterials, Biodegradable and Biomimetic, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Avepark Barco, Guimarães 4805-017, PortugalICVS/3B’s PT Government Associated Laboratory, Braga/Guimarães 4806-909, PortugalMore by Eduardo Silva,
- Vânia I. B. CastroVânia I. B. Castro3B’s Research Group—Biomaterials, Biodegradable and Biomimetic, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Avepark Barco, Guimarães 4805-017, PortugalICVS/3B’s PT Government Associated Laboratory, Braga/Guimarães 4806-909, PortugalMore by Vânia I. B. Castro,
- Isabel Sá-NogueiraIsabel Sá-NogueiraMicrobial Genetics Laboratory, UCIBIO/REQUIMTE, Departamento de Ciências da Vida, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, Caparica 2829-516, PortugalMore by Isabel Sá-Nogueira,
- Rui L. ReisRui L. Reis3B’s Research Group—Biomaterials, Biodegradable and Biomimetic, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Avepark Barco, Guimarães 4805-017, PortugalICVS/3B’s PT Government Associated Laboratory, Braga/Guimarães 4806-909, PortugalThe Discoveries Centre for Regenerative and Precision Medicine, Headquarters, University of Minho, Avepark Barco, Guimarães 4805-017, PortugalMore by Rui L. Reis,
- Alexandre PaivaAlexandre PaivaLAQV/REQUIMTE, Departamento de Química, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, Caparica 2829-516, PortugalMore by Alexandre Paiva,
- Ana A. MatiasAna A. MatiasNutraceuticals and Bioactives Process Technology Laboratory, Instituto de Biologia Experimental e Tecnológica, Oeiras 2780-157, PortugalInstituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa, Oeiras 2780-157, PortugalMore by Ana A. Matias, and
- Ana Rita C. Duarte*Ana Rita C. Duarte*E-mail: [email protected]3B’s Research Group—Biomaterials, Biodegradable and Biomimetic, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Avepark Barco, Guimarães 4805-017, PortugalICVS/3B’s PT Government Associated Laboratory, Braga/Guimarães 4806-909, PortugalMore by Ana Rita C. Duarte
Abstract
The breakthroughs achieved in green solvents promote the emergence of therapeutic deep eutectic solvents (THEDES), which possess intriguing possible applications in the biomedical field. Herein, the main aim was to unravel the biomedical potential of hydrophobic THEDES based in menthol and saturated fatty acids with different chain lengths (e.g., stearic acid (SA), myristic acid (MA), and lauric acid (LA)). Our comprehensive strategy resulted in the thermophysical characterization of different formulations, which allow one to identify the most suitable molar ratio, as well as the intermolecular interactions behind the successful formation of THEDES. The evaluation of their biological performance was also performed toward bacteria and HaCaT cells. Among the different formulations of THEDES, the one based on menthol and SA establishes stronger hydrogen bonding interactions, being also the most promising formulation because it did not elicit any relevant cytotoxicity, and potentiated wound healing, while presenting antibacterial properties against Staphylococcus epidermis and Staphylococcus aureus strains, some of which were methicillin resistant. This work provides clues on the future use of THEDES based on menthol:SA in wound dressings.
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