Remote Control of Neural Stem Cell Fate Using NIR-Responsive Photoswitching Upconversion Nanoparticle Constructs
- Yixiao ZhangYixiao ZhangDepartment of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, United StatesMore by Yixiao Zhang
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- Lisa M. WieshollerLisa M. WieshollerInstitute of Analytical Chemistry, Chemo- and Biosensors, University of Regensburg, 93040 Regensburg, GermanyMore by Lisa M. Wiesholler
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- Hudifah RabieHudifah RabieDepartment of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, United StatesMore by Hudifah Rabie
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- Pengfei JiangPengfei JiangDepartment of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, United StatesMore by Pengfei Jiang
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- Jinping LaiJinping LaiDepartment of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, United StatesMore by Jinping Lai
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- Thomas HirschThomas HirschInstitute of Analytical Chemistry, Chemo- and Biosensors, University of Regensburg, 93040 Regensburg, GermanyMore by Thomas Hirsch
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- Ki-Bum Lee*Ki-Bum Lee*Email: [email protected]. Tel: +1-732-445-2081. Fax: +1-732-445-5312.Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, United StatesMore by Ki-Bum Lee
Abstract
Light-mediated remote control of stem cell fate, such as proliferation, differentiation, and migration, can bring a significant impact on stem cell biology and regenerative medicine. Current UV/vis-mediated control approaches are limited in terms of nonspecific absorption, poor tissue penetration, and phototoxicity. Upconversion nanoparticle (UCNP)-based near-infrared (NIR)-mediated control systems have gained increasing attention for vast applications with minimal nonspecific absorption, good penetration depth, and minimal phototoxicity from NIR excitations. Specifically, 808 nm NIR-responsive upconversion nanomaterials have shown clear advantages for biomedical applications owing to diminished heating effects and better tissue penetration. Herein, a novel 808 nm NIR-mediated control method for stem cell differentiation has been developed using multishell UCNPs, which are optimized for upconverting 808 nm NIR light to UV emission. The locally generated UV emissions further toggle photoswitching polymer capping ligands to achieve spatiotemporally controlled small-molecule release. More specifically, with 808 nm NIR excitation, stem cell differentiation factors can be released to guide neural stem cell (NSC) differentiation in a highly controlled manner. Given the challenges in stem cell behavior control, the developed 808 nm NIR-responsive UCNP-based approach to control stem cell differentiation can represent a new tool for studying single-molecule roles in stem cell and developmental biology.
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