Self-Expandable Electrode Based on Chemically Polished Nickel–Titanium Alloy Wire for Treating Endoluminal Tumors Using Bipolar Irreversible ElectroporationClick to copy article linkArticle link copied!
- Song Hee KimSong Hee KimBiomedical Engineering Research Center, Asan Institute for Life Sciences, Asan Medical Center, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Republic of KoreaDepartment of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Republic of KoreaMore by Song Hee Kim
- Jeon Min KangJeon Min KangBiomedical Engineering Research Center, Asan Institute for Life Sciences, Asan Medical Center, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Republic of KoreaMore by Jeon Min Kang
- Yubeen ParkYubeen ParkBiomedical Engineering Research Center, Asan Institute for Life Sciences, Asan Medical Center, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Republic of KoreaMore by Yubeen Park
- Seung JeongSeung JeongDepartment of Biosystems & Biomaterials Science and Engineering, Seoul National University, Seoul 11 08826, Republic of KoreaMore by Seung Jeong
- Yuhyun NaYuhyun NaDepartment of Biomedical-Chemical Engineering, The Catholic University of Korea, Bucheon 14662, Republic of KoreaDepartment of Biotechnology, The Catholic University of Korea, Bucheon 14662, Republic of KoreaMore by Yuhyun Na
- Hyun-Do JungHyun-Do JungDepartment of Biomedical-Chemical Engineering, The Catholic University of Korea, Bucheon 14662, Republic of KoreaDepartment of Biotechnology, The Catholic University of Korea, Bucheon 14662, Republic of KoreaMore by Hyun-Do Jung
- Jinsu AnJinsu AnDepartment of Biomedical Engineering, School of ICT Convergence Engineering, College of Science & Technology, Konkuk University, Chungju-si 22478, Republic of KoreaMore by Jinsu An
- Hyung-Sik KimHyung-Sik KimDepartment of Mechatronics Engineering, School of ICT Convergence Engineering, College of Science & Technology, Konkuk University, Chungju-si 22478, Republic of KoreaMore by Hyung-Sik Kim
- Sang Soo Lee*Sang Soo Lee*Email: [email protected]Biomedical Engineering Research Center, Asan Institute for Life Sciences, Asan Medical Center, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Republic of KoreaDepartment of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Republic of KoreaMore by Sang Soo Lee
- Jung-Hoon Park*Jung-Hoon Park*Email: [email protected]Biomedical Engineering Research Center, Asan Institute for Life Sciences, Asan Medical Center, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Republic of KoreaMore by Jung-Hoon Park
Abstract
The application of irreversible electroporation (IRE) to endoluminal organs is being investigated; however, the current preclinical evidence and optimized electrodes are insufficient for clinical translation. Here, a novel self-expandable electrode (SE) made of chemically polished nickel–titanium (Ni–Ti) alloy wire for endoluminal IRE is developed in this study. Chemically polished heat-treated Ni–Ti alloy wires demonstrate increased electrical conductivity, reduced carbon and oxygen levels, and good mechanical and self-expanding properties. Bipolar IRE using chemically polished Ni–Ti wires successfully induces cancer cell death. IRE-treated potato tissue shows irreversibly and reversibly electroporated areas containing dead cells in an electrical strength-dependent manner. In vivo study using an optimized electric field strength demonstrates that endobiliary IRE using the SE evenly induces well-distributed mucosal injuries in the common bile duct (CBD) with the overexpression of the TUNEL, HSP70, and inflammatory cells without ductal perforation or stricture formation. This study demonstrates the basic concept of the endobiliary IRE procedure, which is technically feasible and safe in a porcine CBD as a novel therapeutic strategy for malignant biliary obstruction. The SE is a promising electrical energy delivery platform for effectively treating endoluminal organs.
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