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RETURN TO ISSUEPREVBiological and Medic...Biological and Medical Applications of Materials and InterfacesNEXT

Self-Expandable Electrode Based on Chemically Polished Nickel–Titanium Alloy Wire for Treating Endoluminal Tumors Using Bipolar Irreversible Electroporation

  • Song Hee Kim
    Song Hee Kim
    Biomedical Engineering Research Center, Asan Institute for Life Sciences, Asan Medical Center, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Republic of Korea
    Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Republic of Korea
    More by Song Hee Kim
  • Jeon Min Kang
    Jeon Min Kang
    Biomedical Engineering Research Center, Asan Institute for Life Sciences, Asan Medical Center, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Republic of Korea
  • Yubeen Park
    Yubeen Park
    Biomedical Engineering Research Center, Asan Institute for Life Sciences, Asan Medical Center, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Republic of Korea
    More by Yubeen Park
  • Seung Jeong
    Seung Jeong
    Department of Biosystems & Biomaterials Science and Engineering, Seoul National University, Seoul 11 08826, Republic of Korea
    More by Seung Jeong
  • Yuhyun Na
    Yuhyun Na
    Department of Biomedical-Chemical Engineering, The Catholic University of Korea, Bucheon 14662, Republic of Korea
    Department of Biotechnology, The Catholic University of Korea, Bucheon 14662, Republic of Korea
    More by Yuhyun Na
  • Hyun-Do Jung
    Hyun-Do Jung
    Department of Biomedical-Chemical Engineering, The Catholic University of Korea, Bucheon 14662, Republic of Korea
    Department of Biotechnology, The Catholic University of Korea, Bucheon 14662, Republic of Korea
    More by Hyun-Do Jung
  • Jinsu An
    Jinsu An
    Department of Biomedical Engineering, School of ICT Convergence Engineering, College of Science & Technology, Konkuk University, Chungju-si 22478, Republic of Korea
    More by Jinsu An
  • Hyung-Sik Kim
    Hyung-Sik Kim
    Department of Mechatronics Engineering, School of ICT Convergence Engineering, College of Science & Technology, Konkuk University, Chungju-si 22478, Republic of Korea
  • Sang Soo Lee*
    Sang Soo Lee
    Biomedical Engineering Research Center, Asan Institute for Life Sciences, Asan Medical Center, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Republic of Korea
    Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Republic of Korea
    *Email: [email protected]
    More by Sang Soo Lee
  • , and 
  • Jung-Hoon Park*
    Jung-Hoon Park
    Biomedical Engineering Research Center, Asan Institute for Life Sciences, Asan Medical Center, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Republic of Korea
    *Email: [email protected]
Cite this: ACS Appl. Mater. Interfaces 2023, 15, 29, 34475–34487
Publication Date (Web):July 15, 2023
https://doi.org/10.1021/acsami.3c04703
Copyright © 2023 American Chemical Society

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    Abstract

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    The application of irreversible electroporation (IRE) to endoluminal organs is being investigated; however, the current preclinical evidence and optimized electrodes are insufficient for clinical translation. Here, a novel self-expandable electrode (SE) made of chemically polished nickel–titanium (Ni–Ti) alloy wire for endoluminal IRE is developed in this study. Chemically polished heat-treated Ni–Ti alloy wires demonstrate increased electrical conductivity, reduced carbon and oxygen levels, and good mechanical and self-expanding properties. Bipolar IRE using chemically polished Ni–Ti wires successfully induces cancer cell death. IRE-treated potato tissue shows irreversibly and reversibly electroporated areas containing dead cells in an electrical strength-dependent manner. In vivo study using an optimized electric field strength demonstrates that endobiliary IRE using the SE evenly induces well-distributed mucosal injuries in the common bile duct (CBD) with the overexpression of the TUNEL, HSP70, and inflammatory cells without ductal perforation or stricture formation. This study demonstrates the basic concept of the endobiliary IRE procedure, which is technically feasible and safe in a porcine CBD as a novel therapeutic strategy for malignant biliary obstruction. The SE is a promising electrical energy delivery platform for effectively treating endoluminal organs.

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    The Supporting Information is available free of charge at https://pubs.acs.org/doi/10.1021/acsami.3c04703.

    • The following files are available free of charge.

      The quantitative elemental analysis results of the heat-treated and chemically polished wires and scanning electron microscopy (SEM) with energy-dispersive X-ray spectroscopy (EDS) mapping analysis of the heat-treated and chemically polished self-expandable metallic stents; the effect of IRE on the cell viability of the potatoes 3 h after IRE treatment; comparison of the changes in conductivity at different electric field strengths over time; irreversible electroporation (IRE)-induced thermal effects of the self-expandable electrode; the electrical resistance of wires of different lengths and types; effect of IRE on the cell viability of the potatoes; histological findings of the sham control and IRE in the porcine common bile duct (PDF)

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    Cited By

    This article is cited by 1 publications.

    1. Dae Sung Ryu, Ji Won Kim, Hyeonseung Lee, Seong Jin Eo, Song Hee Kim, Jin Hee Noh, Yuri Kim, Seokin Kang, Kun Na, Jung-Hoon Park, Do Hoon Kim. Localized Photodynamic Therapy Using a Chlorin e6-Embedded Silicone-Covered Self-Expandable Metallic Stent as a Palliative Treatment for Malignant Esophageal Strictures. ACS Biomaterials Science & Engineering 2024, 10 (3) , 1869-1879. https://doi.org/10.1021/acsbiomaterials.3c01211