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Accelerated Engineering of Optimized Functional Composite Hydrogels via High-Throughput Experimentation

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Download Hi-Res ImageDownload to MS-PowerPointCite This:ACS Appl. Mater. Interfaces 2023, 15, 45, 52908-52920
    Applications of Polymer, Composite, and Coating Materials

    Accelerated Engineering of Optimized Functional Composite Hydrogels via High-Throughput Experimentation
    Click to copy article linkArticle link copied!

    • Yang Liu
      Yang Liu
      Grado Department of Industrial and Systems Engineering, Virginia Tech, Blacksburg, Virginia 24061, United States
      Macromolecules Innovation Institute, Virginia Tech, Blacksburg, Virginia 24061, United States
      More by Yang Liu
    • Junru Zhang
      Junru Zhang
      Grado Department of Industrial and Systems Engineering, Virginia Tech, Blacksburg, Virginia 24061, United States
      More by Junru Zhang
    • Yujing Zhang
      Yujing Zhang
      Bradley Department of Electrical and Computer Engineering, Virginia Tech, Blacksburg, Virginia 24061, United States
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    • Hu Young Yoon
      Hu Young Yoon
      Macromolecules Innovation Institute, Virginia Tech, Blacksburg, Virginia 24061, United States
      Department of Sustainable Biomaterials, Virginia Tech, Blacksburg, Virginia 24061, United States
      More by Hu Young Yoon
      Orcidhttps://orcid.org/0000-0001-8841-4758
    • Xiaoting Jia
      Xiaoting Jia
      Bradley Department of Electrical and Computer Engineering, Virginia Tech, Blacksburg, Virginia 24061, United States
      More by Xiaoting Jia
      Orcidhttps://orcid.org/0000-0003-4890-6103
    • Maren Roman
      Maren Roman
      Macromolecules Innovation Institute, Virginia Tech, Blacksburg, Virginia 24061, United States
      Department of Sustainable Biomaterials, Virginia Tech, Blacksburg, Virginia 24061, United States
      More by Maren Roman
      Orcidhttps://orcid.org/0000-0001-6622-8591
    • Blake N. Johnson*
      Blake N. Johnson
      Grado Department of Industrial and Systems Engineering, Virginia Tech, Blacksburg, Virginia 24061, United States
      Macromolecules Innovation Institute, Virginia Tech, Blacksburg, Virginia 24061, United States
      Department of Materials Science and Engineering, Virginia Tech, Blacksburg, Virginia 24061, United States
      Department of Chemical Engineering, Virginia Tech, Blacksburg, Virginia 24061, United States
      *Email: [email protected]. Phone: 540-231-0755. Fax: 540-231-3322.
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      Orcidhttps://orcid.org/0000-0003-4668-2011
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    ACS Applied Materials & Interfaces

    Cite this: ACS Appl. Mater. Interfaces 2023, 15, 45, 52908–52920
    Click to copy citationCitation copied!
    https://doi.org/10.1021/acsami.3c11483
    Published October 31, 2023
    Copyright © 2023 American Chemical Society
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    Abstract

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    The Materials Genome Initiative (MGI) seeks to accelerate the discovery and engineering of advanced materials via high-throughput experimentation (HTE), which is a challenging task, given the common trade-off between design for optimal processability vs performance. Here, we report a HTE method based on automated formulation, synthesis, and multiproperty characterization of bulk soft materials in well plate formats that enables accelerated engineering of functional composite hydrogels with optimized properties for processability and performance. The method facilitates rapid high-throughput screening of hydrogel composition–property relations for multiple properties in well plate formats. The feasibility and utility of the method were demonstrated by application to several functional composite hydrogel systems, including alginate/poly(N-isopropylacrylamide) (PNIPAM) and poly(ethylene glycol) dimethacrylate (PEGDMA)/poly(3,4-ethylenedioxythiophene)-poly(styrenesulfonate) (PEDOT:PSS) hydrogels. The HTE method was leveraged to identify formulations of conductive PEGDMA/PEDOT:PSS composite hydrogels for optimized performance and processability in three-dimensional (3D) printing. This work provides an advance in experimental methods based on automated dispensing, mixing, and sensing for the accelerated engineering of soft functional materials.

    Copyright © 2023 American Chemical Society

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    • Additional description of the fluid-structure interaction model for the dynamic-mode cantilever sensor, photographs of sensors and mixers, results of senor stability testing, additional supporting impedimetric data generated during HTC, and characterization of solution viscosity (PDF)

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    ACS Applied Materials & Interfaces

    Cite this: ACS Appl. Mater. Interfaces 2023, 15, 45, 52908–52920
    Click to copy citationCitation copied!
    https://doi.org/10.1021/acsami.3c11483
    Published October 31, 2023
    Copyright © 2023 American Chemical Society
    Request reuse permissions

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