Bioinspired Nanotopography for Combinatory Osseointegration and Antibacterial TherapyClick to copy article linkArticle link copied!
- Min-Kyu LeeMin-Kyu LeeQuerrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, Illinois 60208, United StatesShirley Ryan AbilityLab, Chicago, Illinois 60611, United StatesDepartment of Physical Medicine and Rehabilitation, Northwestern University, Chicago, Illinois 60611, United StatesMore by Min-Kyu Lee
- Hyun LeeHyun LeeDepartment of Biomedical-Chemical Engineering, The Catholic University of Korea, 43 Jibong-ro, Bucheon-si, Gyeonggi-do 14662, Republic of KoreaDepartment of Biotechnology, The Catholic University of Korea, 43 Jibong-ro, Bucheon-si, Gyeonggi-do 14662, Republic of KoreaMore by Hyun Lee
- Min-Ho KangMin-Ho KangDepartment of Biomedical-Chemical Engineering, The Catholic University of Korea, 43 Jibong-ro, Bucheon-si, Gyeonggi-do 14662, Republic of KoreaDepartment of Biotechnology, The Catholic University of Korea, 43 Jibong-ro, Bucheon-si, Gyeonggi-do 14662, Republic of KoreaMore by Min-Ho Kang
- Changha HwangChangha HwangDepartment of Materials Science and Engineering, Seoul National University, Seoul 08826, Republic of KoreaMore by Changha Hwang
- Hyoun-Ee KimHyoun-Ee KimDepartment of Materials Science and Engineering, Seoul National University, Seoul 08826, Republic of KoreaMore by Hyoun-Ee Kim
- Martin OudegaMartin OudegaShirley Ryan AbilityLab, Chicago, Illinois 60611, United StatesDepartment of Physical Therapy and Human Movement Sciences, Northwestern University, Chicago, Illinois 60611, United StatesEdward Hines Jr. VA Hospital, Hines, Illinois 60141, United StatesDepartment of Neuroscience, Northwestern University, Chicago, Illinois 60611, United StatesMore by Martin Oudega
- Tae-Sik Jang*Tae-Sik Jang*Email: [email protected]. Tel.: +82-51-510-6212.School of Biomedical Convergence Engineering, Pusan National University, Yangsan 50612, Republic of KoreaMore by Tae-Sik Jang
- Hyun-Do Jung*Hyun-Do Jung*Email: [email protected]. Tel.: +82-2-2220-0506Division of Materials Science and Engineering, Hanyang University, Seoul 04763, Republic of KoreaMore by Hyun-Do Jung
Abstract
The ongoing global health has highlighted the critical issue of secondary infections, particularly antibiotic-resistant bacterial infections, which have been significant contributors to mortality rates. Orthopedic implants, while essential for trauma and orthopedic surgeries, are particularly susceptible to these infections, leading to severe complications and economic burdens. The traditional use of antibiotics in treating these infections poses further challenges including the risk of developing antibiotic-resistant bacteria. This study introduces a novel approach to combat this issue by developing nanostructured surfaces for orthopedic implants using target ion-induced plasma sputtering. Inspired by the natural design of dragonfly wings, these surfaces aim to prevent bacterial adhesion while promoting preosteoblast activity, offering a dual-function solution to the problems of bacterial infection and implant integration without relying on antibiotics. The in vitro results demonstrate the effectiveness of these bioinspired surfaces in eradicating bacteria and supporting cell proliferation and differentiation, presenting a promising alternative for the development of biomedical implants.
Cited By
This article has not yet been cited by other publications.
Article Views
Altmetric
Citations
Article Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.
Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.
The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated.