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Bioinspired Nanotopography for Combinatory Osseointegration and Antibacterial Therapy
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    Biological and Medical Applications of Materials and Interfaces

    Bioinspired Nanotopography for Combinatory Osseointegration and Antibacterial Therapy
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    • Min-Kyu Lee
      Min-Kyu Lee
      Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, Illinois 60208, United States
      Shirley Ryan AbilityLab, Chicago, Illinois 60611, United States
      Department of Physical Medicine and Rehabilitation, Northwestern University, Chicago, Illinois 60611, United States
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    • Hyun Lee
      Hyun Lee
      Department of Biomedical-Chemical Engineering, The Catholic University of Korea, 43 Jibong-ro, Bucheon-si, Gyeonggi-do 14662, Republic of Korea
      Department of Biotechnology, The Catholic University of Korea, 43 Jibong-ro, Bucheon-si, Gyeonggi-do 14662, Republic of Korea
      More by Hyun Lee
    • Min-Ho Kang
      Min-Ho Kang
      Department of Biomedical-Chemical Engineering, The Catholic University of Korea, 43 Jibong-ro, Bucheon-si, Gyeonggi-do 14662, Republic of Korea
      Department of Biotechnology, The Catholic University of Korea, 43 Jibong-ro, Bucheon-si, Gyeonggi-do 14662, Republic of Korea
      More by Min-Ho Kang
    • Changha Hwang
      Changha Hwang
      Department of Materials Science and Engineering, Seoul National University, Seoul 08826, Republic of Korea
    • Hyoun-Ee Kim
      Hyoun-Ee Kim
      Department of Materials Science and Engineering, Seoul National University, Seoul 08826, Republic of Korea
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    • Martin Oudega
      Martin Oudega
      Shirley Ryan AbilityLab, Chicago, Illinois 60611, United States
      Department of Physical Therapy and Human Movement Sciences, Northwestern University, Chicago, Illinois 60611, United States
      Edward Hines Jr. VA Hospital, Hines, Illinois 60141, United States
      Department of Neuroscience, Northwestern University, Chicago, Illinois 60611, United States
    • Tae-Sik Jang*
      Tae-Sik Jang
      School of Biomedical Convergence Engineering, Pusan National University, Yangsan 50612, Republic of Korea
      *Email: [email protected]. Tel.: +82-51-510-6212.
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    • Hyun-Do Jung*
      Hyun-Do Jung
      Division of Materials Science and Engineering, Hanyang University, Seoul 04763, Republic of Korea
      *Email: [email protected]. Tel.: +82-2-2220-0506
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    ACS Applied Materials & Interfaces

    Cite this: ACS Appl. Mater. Interfaces 2024, 16, 24, 30967–30979
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    https://doi.org/10.1021/acsami.4c06351
    Published June 10, 2024
    Copyright © 2024 American Chemical Society

    Abstract

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    The ongoing global health has highlighted the critical issue of secondary infections, particularly antibiotic-resistant bacterial infections, which have been significant contributors to mortality rates. Orthopedic implants, while essential for trauma and orthopedic surgeries, are particularly susceptible to these infections, leading to severe complications and economic burdens. The traditional use of antibiotics in treating these infections poses further challenges including the risk of developing antibiotic-resistant bacteria. This study introduces a novel approach to combat this issue by developing nanostructured surfaces for orthopedic implants using target ion-induced plasma sputtering. Inspired by the natural design of dragonfly wings, these surfaces aim to prevent bacterial adhesion while promoting preosteoblast activity, offering a dual-function solution to the problems of bacterial infection and implant integration without relying on antibiotics. The in vitro results demonstrate the effectiveness of these bioinspired surfaces in eradicating bacteria and supporting cell proliferation and differentiation, presenting a promising alternative for the development of biomedical implants.

    Copyright © 2024 American Chemical Society

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    The Supporting Information is available free of charge at https://pubs.acs.org/doi/10.1021/acsami.4c06351.

    • Optical images of groups with or without the TIPS process; optimization of TIPS processing time for the achievement of the mechano-bactericidal surface; surface chemistry after sputtering in all groups obtained from XPS analysis; and hydrophilicity of the surfaces analyzed by water contact angle measurement (PDF)

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    ACS Applied Materials & Interfaces

    Cite this: ACS Appl. Mater. Interfaces 2024, 16, 24, 30967–30979
    Click to copy citationCitation copied!
    https://doi.org/10.1021/acsami.4c06351
    Published June 10, 2024
    Copyright © 2024 American Chemical Society

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