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Injectable and Biodegradable pH-Responsive Hydrogels for Localized and Sustained Treatment of Human Fibrosarcoma

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† The Second Affiliated Hospital of Soochow University, 1055 Sanxiang Road, Suzhou, 215004, Jiangsu, China
‡ School for Radiological & Interdisciplinary Sciences (RAD-X), and School of Radiation Medicine and Protection, Soochow University, Suzhou, 215123, Jiangsu, China
§ Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, 199 Renai Road, Suzhou Industrial Park, Suzhou, 215123, Jiangsu, China
*Tel.: 86-512-67784117. E-mail: [email protected] (Q. Dong).
*Tel.: 86-512-65882263. E-mail: [email protected] (Y. Wang).
Cite this: ACS Appl. Mater. Interfaces 2015, 7, 15, 8033–8040
Publication Date (Web):April 2, 2015
https://doi.org/10.1021/acsami.5b00389
Copyright © 2015 American Chemical Society
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Injectable hydrogels are an important class of biomaterials, and they have been widely used for controlled drug release. This study evaluated an injectable hydrogel formed in situ system by the reaction of a polyethylene glycol derivative with α,β-polyaspartylhydrazide for local cancer chemotherapy. This pH-responsive hydrogel was used to realize a sol–gel phase transition, where the gel remained a free-flowing fluid before injection but spontaneously changed into a semisolid hydrogel just after administration. As indicated by scanning electron microscopy images, the hydrogel exhibited a porous three-dimensional microstructure. The prepared hydrogel was biocompatible and biodegradable and could be utilized as a pH-responsive vector for drug delivery. The therapeutic effect of the hydrogel loaded with doxorubicin (DOX) after intratumoral administration in mice with human fibrosarcoma was evaluated. The inhibition of tumor growth was more obvious in the group treated by the DOX-loaded hydrogel, compared to that treated with the free DOX solution. Hence, this hydrogel with good syringeability and high biodegradability, which focuses on local chemotherapy, may enhance the therapeutic effect on human fibrosarcoma.

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Additional information as noted in text, including FT-IR spectra of PAHy, DF-PEG, and hydrogel; storage shear moduli (G′) as a function of angular frequency (ω) for the hydrogels under various pH conditions; in vitro release of DOX from free DOX, the PAHy + DOX mixture, and the DF-PEG + DOX mixture under different pH media. This material is available free of charge via the Internet at http://pubs.acs.org.

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