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Functional Silver Nanoparticle as a Benign Antimicrobial Agent That Eradicates Antibiotic-Resistant Bacteria and Promotes Wound Healing

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† Key Laboratory of Functional Polymer Materials of Ministry of Education, Institute of Polymer Chemistry, Nankai University, Tianjin 300071, China
‡ Department of Chemical Engineering, University of Washington, Seattle, Washington 98195, United States
*Tel +86-22-23501645; Fax +86-22-23505598; e-mail [email protected] (X.Z.).
Cite this: ACS Appl. Mater. Interfaces 2016, 8, 39, 25798–25807
Publication Date (Web):September 13, 2016
https://doi.org/10.1021/acsami.6b09267
Copyright © 2016 American Chemical Society
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Abstract

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With the increased prevalence of antibiotic-resistant bacteria infections, there is a pressed need for innovative antimicrobial agent. Here, we report a benign ε-polylysine/silver nanoparticle nanocomposite (EPL-g[email protected]) with polyvalent and synergistic antibacterial effects. EPL-g[email protected] exhibited good stability in aqueous solution and effective antibacterial activity against both Gram-negative (P. aeruginosa) and Gram-positive (S. aureus) bacteria without emergence of bacterial resistance. Importantly, the nanocomposites eradicated the antibiotic-resistant bacteria without toxicity to mammalian cells. Analysis of the antibacterial mechanism confirmed that the nanocomposites adhered to the bacterial surface, irreversibly disrupted the membrane structure of the bacteria, subsequently penetrated cells, and effectively inhibited protein activity, which ultimately led to bacteria apoptosis. Notably, the nanocomposites modulated the relative level of CD3+ T cells and CD68+ macrophages and effectively promoted infected wound healing in diabetic rats. This work improves our understanding of the antibacterial mechanism of AgNPs-based nanocomposites and offers guidance to activity prediction and rational design of effective antimicrobial nanoparticles.

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The Supporting Information is available free of charge on the ACS Publications website at DOI: 10.1021/acsami.6b09267.

  • Figure S1: 1H NMR spectra of EPL and EPL-g-butyl in D2O; Figure S2: FT-IR spectra of (a) EPL and (b) EPL-g-butyl; Figure S3: diameter distribution of EPL-g[email protected] with different ratios of EPL-g-butyl to silver ion in aqueous solution: (A) 1:4, (B) 1:8, (C) 1:16, (D) 1:32, and (E) 1:64 (PDF)

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