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A Polysaccharide-Based Antibacterial Coating with Improved Durability for Clear Overlay Appliances

  • Sohyeon Park
    Sohyeon Park
    Department of Chemical and Biomolecular Engineering, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul, Republic of Korea
    More by Sohyeon Park
  • Hyun-hye Kim
    Hyun-hye Kim
    Graduate Student, Department of Dentistry, Graduate School, Kyung Hee University, Seoul, Korea, Republic of Korea
    More by Hyun-hye Kim
  • Seok Bin Yang
    Seok Bin Yang
    Department of Maxillofacial Biomedical Engineering, School of Dentistry, Kyung Hee University, Seoul, Republic of Korea
  • Ji-Hoi Moon
    Ji-Hoi Moon
    Department of Maxillofacial Biomedical Engineering, School of Dentistry, Kyung Hee University, Seoul, Republic of Korea
    Department of Life and Nanopharmaceutical Sciences, Kyung Hee University, Seoul, Republic of Korea
    More by Ji-Hoi Moon
  • Hyo-Won Ahn*
    Hyo-Won Ahn
    Department of Orthodontics, Kyung Hee University School of Dentistry, Seoul, Republic of Korea
    *E-mail: [email protected] (H.-W. Ahn).
    More by Hyo-Won Ahn
  • , and 
  • Jinkee Hong*
    Jinkee Hong
    Department of Chemical and Biomolecular Engineering, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul, Republic of Korea
    *E-mail: [email protected] (J. Hong).
    More by Jinkee Hong
Cite this: ACS Appl. Mater. Interfaces 2018, 10, 21, 17714–17721
Publication Date (Web):May 4, 2018
Copyright © 2018 American Chemical Society

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    Abstract Image

    Clear overlay appliances (COAs) are widely used in orthodontic fields because they offer many advantages, such as cost-effectiveness, good formability, and good optical characteristics. However, it is necessary to frequently replace COAs because the thermoplastic polymers that are used to fabricate COAs have poor abrasion resistance and have a tendency to induce bacterial accumulation. Here, we have developed polysaccharide-based antibacterial multilayer films with enhanced durability, intended for COA applications. First, multilayer films composed of carboxymethylcellulose (CMC) and chitosan (CHI) were fabricated on polyethylene terephthalate glycol-modified (PETG), which was preferred material for COA fabrication, via a layer-by-layer (LbL) technique. Next, chemical cross-linking was introduced within the LbL-assembled multilayer films. The LbL-assembled CMC/CHI film, which was made porous and rough by the cross-linking, formed a superhydrophilic surface to prevent the adhesion of bacteria and exhibited a bacterial reduction ratio of ∼75%. Furthermore, the cross-linking of the multilayer film coated on the PETG also improved the chemical resistance and mechanical stability of the PETG under simulated intraoral conditions with artificial saliva, by increasing the bond strength between the polysaccharide chains. We attempted to accumulate datasets using our experimental design and to develop sophisticated methods to assess nanoscale changes through large-scale measurements.

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    Supporting Information

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    The Supporting Information is available free of charge on the ACS Publications website at DOI: 10.1021/acsami.8b04433.

    • Chemical structure of CMC and chitosan; experimental section; appearance of each film following the stability tests; design of the PETG sheets used for mechanical testing; load–elongation curve; FE-SEM images of cross-linked (CMC/CHI)20-coated PETG before and after thermoforming; pictures of layer-by-layer assembly process using PETG as a substrate and completely coated PETG (PDF)

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