Enhanced Osseointegration Ability of Poly(lactic acid) via Tantalum Sputtering-Based Plasma Immersion Ion ImplantationClick to copy article linkArticle link copied!
- Cheonil ParkCheonil ParkDepartment of Materials Science and Engineering, Seoul National University, Seoul 08826, KoreaMore by Cheonil Park
- Yun-Jeong SeongYun-Jeong SeongDepartment of Materials Science and Engineering, Seoul National University, Seoul 08826, KoreaMore by Yun-Jeong Seong
- In-Gu KangIn-Gu KangDepartment of Materials Science and Engineering, Seoul National University, Seoul 08826, KoreaMore by In-Gu Kang
- Eun-Ho SongEun-Ho SongDepartment of Materials Science and Engineering, Seoul National University, Seoul 08826, KoreaMore by Eun-Ho Song
- Hyun LeeHyun LeeDepartment of Materials Science and Engineering, Seoul National University, Seoul 08826, KoreaMore by Hyun Lee
- Jinyoung KimJinyoung KimDepartment of Materials Science and Engineering, Seoul National University, Seoul 08826, KoreaMore by Jinyoung Kim
- Hyun-Do JungHyun-Do JungLiquid Processing & Casting Technology R&D Group, Korea Institute of Industrial Technology, Incheon 21999, KoreaMore by Hyun-Do Jung
- Hyoun-Ee KimHyoun-Ee KimDepartment of Materials Science and Engineering, Seoul National University, Seoul 08826, KoreaMore by Hyoun-Ee Kim
- Tae-Sik Jang*Tae-Sik Jang*E-mail: [email protected]Liquid Processing & Casting Technology R&D Group, Korea Institute of Industrial Technology, Incheon 21999, KoreaMore by Tae-Sik Jang
Abstract

Poly(lactic acid) (PLA) is the most utilized biodegradable polymer in orthopedic implant applications because of its ability to replace regenerated bone tissue via continuous degradation over time. However, the poor osteoblast affinity for PLA results in a high risk of early implant failure, and this issue remains one of the most difficult challenges with this technology. In this study, we demonstrate the use of a new technique in which plasma immersion ion implantation (PIII) is combined with a conventional DC magnetron sputtering. This technique, referred to as sputtering-based PIII (S-PIII), makes it possible to produce a tantalum (Ta)-implanted PLA surface within 30 s without any tangible degradation or deformation of the PLA substrate. Compared to a Ta-coated PLA surface, the Ta-implanted PLA showed twice the surface roughness and substantially enhanced adhesion stability in dry and wet conditions. The strong hydrophobic surface properties and biologically relatively inert chemical structure of PLA were ameliorated by Ta S-PIII treatment, which produced a moderate hydrophilic surface and enhanced cell–material interactions. Furthermore, in an in vivo evaluation in a rabbit distal femur implantation model, Ta-implanted PLA demonstrated significantly enhanced osseointegration and osteogenesis compared with bare PLA. These results indicate that the Ta-implanted PLA has great potential for orthopedic implant applications.
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