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Enhanced Osseointegration Ability of Poly(lactic acid) via Tantalum Sputtering-Based Plasma Immersion Ion Implantation

  • Cheonil Park
    Cheonil Park
    Department of Materials Science and Engineering, Seoul National University, Seoul 08826, Korea
    More by Cheonil Park
  • Yun-Jeong Seong
    Yun-Jeong Seong
    Department of Materials Science and Engineering, Seoul National University, Seoul 08826, Korea
  • In-Gu Kang
    In-Gu Kang
    Department of Materials Science and Engineering, Seoul National University, Seoul 08826, Korea
    More by In-Gu Kang
  • Eun-Ho Song
    Eun-Ho Song
    Department of Materials Science and Engineering, Seoul National University, Seoul 08826, Korea
    More by Eun-Ho Song
  • Hyun Lee
    Hyun Lee
    Department of Materials Science and Engineering, Seoul National University, Seoul 08826, Korea
    More by Hyun Lee
  • Jinyoung Kim
    Jinyoung Kim
    Department of Materials Science and Engineering, Seoul National University, Seoul 08826, Korea
    More by Jinyoung Kim
  • Hyun-Do Jung
    Hyun-Do Jung
    Liquid Processing & Casting Technology R&D Group, Korea Institute of Industrial Technology, Incheon 21999, Korea
    More by Hyun-Do Jung
  • Hyoun-Ee Kim
    Hyoun-Ee Kim
    Department of Materials Science and Engineering, Seoul National University, Seoul 08826, Korea
    More by Hyoun-Ee Kim
  • , and 
  • Tae-Sik Jang*
    Tae-Sik Jang
    Liquid Processing & Casting Technology R&D Group, Korea Institute of Industrial Technology, Incheon 21999, Korea
    *E-mail: [email protected]
    More by Tae-Sik Jang
Cite this: ACS Appl. Mater. Interfaces 2019, 11, 11, 10492–10504
Publication Date (Web):February 25, 2019
https://doi.org/10.1021/acsami.8b21363
Copyright © 2019 American Chemical Society

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    Abstract

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    Poly(lactic acid) (PLA) is the most utilized biodegradable polymer in orthopedic implant applications because of its ability to replace regenerated bone tissue via continuous degradation over time. However, the poor osteoblast affinity for PLA results in a high risk of early implant failure, and this issue remains one of the most difficult challenges with this technology. In this study, we demonstrate the use of a new technique in which plasma immersion ion implantation (PIII) is combined with a conventional DC magnetron sputtering. This technique, referred to as sputtering-based PIII (S-PIII), makes it possible to produce a tantalum (Ta)-implanted PLA surface within 30 s without any tangible degradation or deformation of the PLA substrate. Compared to a Ta-coated PLA surface, the Ta-implanted PLA showed twice the surface roughness and substantially enhanced adhesion stability in dry and wet conditions. The strong hydrophobic surface properties and biologically relatively inert chemical structure of PLA were ameliorated by Ta S-PIII treatment, which produced a moderate hydrophilic surface and enhanced cell–material interactions. Furthermore, in an in vivo evaluation in a rabbit distal femur implantation model, Ta-implanted PLA demonstrated significantly enhanced osseointegration and osteogenesis compared with bare PLA. These results indicate that the Ta-implanted PLA has great potential for orthopedic implant applications.

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    The Supporting Information is available free of charge on the ACS Publications website at DOI: 10.1021/acsami.8b21363.

    • Schematic representation of the S-PIII technique onto the PLA substrate using a conventional DC magnetron sputter gun and a metal back-plate placed behind the PLA substrate; surface morphologies of samples with different substrate bias voltages (0, −1000, and −2000 V) and processing times (10, 30, 180, and 300 s) for the S-PIII process; EDS mapping images of Ta-coated and Ta-implanted PLA samples after immersion in 0.9% NaCl solution for 1, 3, and 7 days; high-resolution cross-sectional FE-SEM image of the surface of a Ta-coated PLA sample deposited by Ta sputtering for 3 min; FE-SEM image of bare and Ta-implanted PLA surfaces and EDS mapping after immersion in PBS up to 8 weeks; CLSM image of GFP attached on the surfaces of bare, Ta-coated, and Ta-implanted PLA; FE-SEM images of cells attached on the surfaces of bare, Ta-coated, and Ta-implanted PLA after 1, 3, and 6 days of culturing; implantation procedure for in vivo animal tests; size reduction rates of implants in a rabbit femur after 4 and 8 weeks of surgery (PDF)

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