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Design of a Multifunctional Biomaterial Inspired by Ancient Chinese Medicine for Hair Regeneration in Burned Skin

  • Zhaowenbin Zhang
    Zhaowenbin Zhang
    State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Dingxi Road, Shanghai 200050, People’s Republic of China
    Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, 19 Yuquan Road, Beijing 100049, People’s Republic of China
  • Qiuxia Dai
    Qiuxia Dai
    Department of Plastic Surgery, Shanghai Jiaotong University Affiliated Sixth People’s Hospital, Shanghai 200233, PR China
    More by Qiuxia Dai
  • Yu Zhang
    Yu Zhang
    State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Dingxi Road, Shanghai 200050, People’s Republic of China
    Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, 19 Yuquan Road, Beijing 100049, People’s Republic of China
    More by Yu Zhang
  • Hui Zhuang
    Hui Zhuang
    State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Dingxi Road, Shanghai 200050, People’s Republic of China
    Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, 19 Yuquan Road, Beijing 100049, People’s Republic of China
    More by Hui Zhuang
  • Endian Wang
    Endian Wang
    State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Dingxi Road, Shanghai 200050, People’s Republic of China
    Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, 19 Yuquan Road, Beijing 100049, People’s Republic of China
    More by Endian Wang
  • Qing Xu
    Qing Xu
    State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Dingxi Road, Shanghai 200050, People’s Republic of China
    Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, 19 Yuquan Road, Beijing 100049, People’s Republic of China
    More by Qing Xu
  • Lingling Ma
    Lingling Ma
    State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Dingxi Road, Shanghai 200050, People’s Republic of China
    Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, 19 Yuquan Road, Beijing 100049, People’s Republic of China
    More by Lingling Ma
  • Chengtie Wu
    Chengtie Wu
    State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Dingxi Road, Shanghai 200050, People’s Republic of China
    Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, 19 Yuquan Road, Beijing 100049, People’s Republic of China
    More by Chengtie Wu
  • Zhiguang Huan
    Zhiguang Huan
    State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Dingxi Road, Shanghai 200050, People’s Republic of China
    Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, 19 Yuquan Road, Beijing 100049, People’s Republic of China
  • Feng Guo*
    Feng Guo
    Department of Plastic Surgery, Shanghai Jiaotong University Affiliated Sixth People’s Hospital, Shanghai 200233, PR China
    *Email: [email protected]. Phone: +86 21 64370045.
    More by Feng Guo
  • , and 
  • Jiang Chang*
    Jiang Chang
    State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Dingxi Road, Shanghai 200050, People’s Republic of China
    Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, 19 Yuquan Road, Beijing 100049, People’s Republic of China
    *Email: [email protected]. Phone: +86 21 52412804.
    More by Jiang Chang
Cite this: ACS Appl. Mater. Interfaces 2020, 12, 11, 12489–12499
Publication Date (Web):March 2, 2020
https://doi.org/10.1021/acsami.9b22769
Copyright © 2020 American Chemical Society

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    Abstract

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    In deep burn injuries, the dermis of the skin is often severely damaged, and hair follicles are also lost and lose the potential for regeneration. Therefore, the development of wound dressings that promote hair follicle regeneration has important clinical significance. In this study, inspired by an ancient Chinese medicine prescription, a novel fibrous membrane (P/Qu/Cup; P, PCL; Qu, quercetin; Cup, cuprorivaite, CaCuSi4O10) containing quercetin-copper (Qu-Cu) chelates was fabricated by using quercetin and a highly bioactive bioceramic (CaCuSi4O10) incorporated in PCL/gelatin electrospun fibers. The fibrous membrane can effectively release Qu and Cu ions to induce proliferation, migration, and differentiation of skin and hair follicle related cells, and the Qu, Cu ions, and Si ions released from the composite membrane revealed synergistic activity to stimulate hair follicle regeneration and wound healing. Our study demonstrated that the analysis of the common components in ancient Chinese prescription is an effective approach to design novel bioactive materials for regenerative medicine.

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    The Supporting Information is available free of charge at https://pubs.acs.org/doi/10.1021/acsami.9b22769.

    • Supplementary Experimental Section; supplementary experimental results including XRD analysis, hydrophilic properties, antibacterial properties, cytotoxicity, cell morphology, cell migration rate, and statistical results of in vivo blood vessel formation; analysis of the main components of the four-herb Ancient Chinese herbal formula; and Supporting Information-related literature (PDF)

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