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    Nanopillar Polymer Films as Antibacterial Packaging Materials
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    • Denver P. Linklater
      Denver P. Linklater
      STEM College, School of Science, RMIT University, Melbourne, Victoria 3000, Australia
      More by Denver P. Linklater
      Orcidhttps://orcid.org/0000-0003-1433-3685
    • Soichiro Saita
      Soichiro Saita
      The KAITEKI Institute Inc., 1-1, Marunouchi 1-chome, Chiyoda-ku, Tokyo 100-8251, Japan
      More by Soichiro Saita
    • Takaaki Murata
      Takaaki Murata
      The KAITEKI Institute Inc., 1-1, Marunouchi 1-chome, Chiyoda-ku, Tokyo 100-8251, Japan
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    • Takashi Yanagishita
      Takashi Yanagishita
      Department of Applied Chemistry, School of Engineering, Tokyo Metropolitan University, 1-1 minamiosawa, Hachioji, Tokyo 192-0397, Japan
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      Orcidhttps://orcid.org/0000-0002-6079-9294
    • Chaitali Dekiwadia
      Chaitali Dekiwadia
      STEM College, School of Science, RMIT University, Melbourne, Victoria 3000, Australia
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    • Russell J. Crawford
      Russell J. Crawford
      STEM College, School of Science, RMIT University, Melbourne, Victoria 3000, Australia
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    • Hideki Masuda
      Hideki Masuda
      Department of Applied Chemistry, School of Engineering, Tokyo Metropolitan University, 1-1 minamiosawa, Hachioji, Tokyo 192-0397, Japan
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    • Haruhiko Kusaka
      Haruhiko Kusaka
      The KAITEKI Institute Inc., 1-1, Marunouchi 1-chome, Chiyoda-ku, Tokyo 100-8251, Japan
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    • Elena P. Ivanova*
      Elena P. Ivanova
      STEM College, School of Science, RMIT University, Melbourne, Victoria 3000, Australia
      *Email: [email protected]
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      Orcidhttps://orcid.org/0000-0002-5509-8071
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    ACS Applied Nano Materials

    Cite this: ACS Appl. Nano Mater. 2022, 5, 2, 2578–2591
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    https://doi.org/10.1021/acsanm.1c04251
    Published February 4, 2022
    Copyright © 2022 American Chemical Society
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    Abstract

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    This work presents a comprehensive analytical survey of the antibacterial and antibiofouling properties of sub-100-nanometer scale nanopatterned polymers fabricated using scalable industrial processes that are directly applicable for commercial use. Regular nanopillar arrays of 60 nm height and 60 nm pitch were fabricated on polyethylene terephthalate (PET), polypropylene (PP), acrylic, and nylon polymer films using nanoimprint lithography. Analyses of the influence of material type on antibacterial performance revealed that the nanoscale patterns produced using acrylic and nylon polymers were most suitable as anti-infective nanostructured materials. Further assessment of the influence of the nanopattern geometric parameters on the antibacterial efficacy of acrylic and nylon materials revealed the superlative pattern for inactivating and repelling both Gram-positive and Gram-negative bacteria. Acrylic nanostructured films consisting of nanopillars with a height of 60 nm and pitch of 30 nm, respectively, demonstrated distinctly superior antimicrobial and antibiofouling behavior toward both Gram-negative Pseudomonas aeruginosa and Gram-positive Staphylococcus aureus bacterial species.

    Copyright © 2022 American Chemical Society

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    • SEM images of bacterial cell morphology on nonpatterned (control) polymer films; Characterization of acrylic sample pattern dimensions; Statistical analysis of the bactericidal performance of acrylic nanopatterns; Profile SEM micrographs of patterned nylon surfaces with pillar heights of 30, 120, and 220 nm; Top-view SEM micrographs of bacterial cell morphology on nylon nanopatterned surfaces; FIB-SEM analysis of the biointerface of S. aureus and P. aeruginosa on nylon and PP surfaces with 30 nm pillar height (PDF)

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    This article is cited by 31 publications.

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    ACS Applied Nano Materials

    Cite this: ACS Appl. Nano Mater. 2022, 5, 2, 2578–2591
    Click to copy citationCitation copied!
    https://doi.org/10.1021/acsanm.1c04251
    Published February 4, 2022
    Copyright © 2022 American Chemical Society
    Request reuse permissions

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