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Angiogenic Microspheres for the Treatment of a Thin Endometrium

  • Lanjie Lei
    Lanjie Lei
    Animal Science and Technology College, Beijing University of Agriculture, Beijing 102206, P. R. China
    Key Laboratory of System Bio-medicine of Jiangxi Province, Jiujiang University, Jiujiang, Jiangxi 332000, P. R. China
    More by Lanjie Lei
  • Qizhuang Lv
    Qizhuang Lv
    College of Biology & Pharmacy, Yulin Normal University, Yulin 537000, P. R. China
    More by Qizhuang Lv
  • Yan Jin
    Yan Jin
    Animal Science and Technology College, Beijing University of Agriculture, Beijing 102206, P. R. China
    More by Yan Jin
  • Hong An
    Hong An
    Animal Science and Technology College, Beijing University of Agriculture, Beijing 102206, P. R. China
    More by Hong An
  • Zhe Shi
    Zhe Shi
    Animal Science and Technology College, Beijing University of Agriculture, Beijing 102206, P. R. China
    More by Zhe Shi
  • Ge Hu
    Ge Hu
    Animal Science and Technology College, Beijing University of Agriculture, Beijing 102206, P. R. China
    More by Ge Hu
  • Yuze Yang
    Yuze Yang
    Beijing General Station of Animal Husbandry, Beijing 100101, P. R. China
    More by Yuze Yang
  • Xiangguo Wang*
    Xiangguo Wang
    Animal Science and Technology College, Beijing University of Agriculture, Beijing 102206, P. R. China
    *E-mail: [email protected]
  • , and 
  • Lei Yang*
    Lei Yang
    Key Laboratory of System Bio-medicine of Jiangxi Province, Jiujiang University, Jiujiang, Jiangxi 332000, P. R. China
    Department of Biomedical Engineering, Shenzhen University, Shenzhen 518060, P. R. China
    *E-mail: [email protected]
    More by Lei Yang
Cite this: ACS Biomater. Sci. Eng. 2021, 7, 10, 4914–4920
Publication Date (Web):August 20, 2021
https://doi.org/10.1021/acsbiomaterials.1c00615
Copyright © 2021 American Chemical Society

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    Abstract

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    The poor vascular development of an endometrium is the key cause of a thin endometrium due to the vascular endothelial growth factor (VEGF) decreasing in the glandular epithelium. Hence, inducing angiogenesis is an effective strategy for thin endometrium treatment in clinic. Herein, we developed a novel angiogenic hydrogel microsphere based on methacrylated hyaluronic acid (HAMA) loaded with VEGF for the treatment of a thin endometrium by a microfluidic electrospray technique. The generated HAMA microspheres with uniform size, porous structure, and satisfactory biocompatibility increased the drug-loading ability and controlled the drug-release rate by adjusting the hydrogel concentration. Besides, the HAMA microspheres loaded with VEGF showed satisfactory biocompatibility and promoted blood vessel formation in vitro. More importantly, the combination of HA and VEGF promoted new blood vessels and endometrial regeneration of a thin endometrium in vivo. Therefore, the combination of HA and VEGF would be conducive to the development of a drug-delivery microsphere with excellent biocompatibility and therapeutic effect for thin endometrium treatment and other biomedical applications.

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    The Supporting Information is available free of charge at https://pubs.acs.org/doi/10.1021/acsbiomaterials.1c00615.

    • Synthesis of HAMA; photo-cross-linking of HAMA; vaginal smears via HE staining in different stages of the estrus cycle; SEM in different concentrations of HAMA hydrogel; drug-loading efficiencies in different doses of HAMA microspheres; fluorescent images of after drug release on days 0, 1, 3, and 5; and morphologies of the uteri in the control and model (PDF)

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