Development of Zoledronic Acid-Based Nanoassemblies for Bone-Targeted Anticancer Therapy
- Elham HatamiElham HatamiDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, 881 Madison Avenue, Memphis, Tennessee 38163, United StatesMore by Elham Hatami,
- Prashanth Kumar Bhusetty NageshPrashanth Kumar Bhusetty NageshDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, 881 Madison Avenue, Memphis, Tennessee 38163, United StatesMore by Prashanth Kumar Bhusetty Nagesh,
- Pallabita ChowdhuryPallabita ChowdhuryDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, 881 Madison Avenue, Memphis, Tennessee 38163, United StatesMore by Pallabita Chowdhury,
- Stacie ElliotStacie ElliotDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, 881 Madison Avenue, Memphis, Tennessee 38163, United StatesMore by Stacie Elliot,
- Deanna ShieldsDeanna ShieldsDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, 881 Madison Avenue, Memphis, Tennessee 38163, United StatesMore by Deanna Shields,
- Subhash Chand ChauhanSubhash Chand ChauhanDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, 881 Madison Avenue, Memphis, Tennessee 38163, United StatesMore by Subhash Chand Chauhan,
- Meena JaggiMeena JaggiDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, 881 Madison Avenue, Memphis, Tennessee 38163, United StatesMore by Meena Jaggi, and
- Murali Mohan Yallapu*Murali Mohan Yallapu*E-mail: [email protected]. Phone: (901) 448-1536. Fax: (901) 448-3446.Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, 881 Madison Avenue, Memphis, Tennessee 38163, United StatesMore by Murali Mohan Yallapu
Abstract
Bone metastasis occurs in the majority of cancer patients, which hampers quality of life and significantly decreases survival. Aggressive chemotherapy is a traditional treatment regimen that induces severe systemic toxicities. Therefore, bone-directed therapies are highly warranted. We report a novel nanoparticle formulation that is composed of poly(vinylpyrrolidone) and tannic acid core nanoparticles (PVT NPs) that forms self-assembly with zoledronic acid ([email protected] NPs). The construction of [email protected] NPs was confirmed by particle size, zeta potential, transmission electron microscopy, and spectral analyses. An optimized bone-targeted [email protected] NPs formulation showed greater binding and internalization in in vitro with metastasis prostate and breast cancer cells. [email protected] NPs were able to deliver ZA more efficiently to tumor cells, which inhibited proliferation of human prostate and breast cancer cells. In addition, [email protected] NPs were capable of targeting mouse bones and prostate tumor microarray tissues (ex vivo) while sparing all other vital organs. More importantly, [email protected] NPs induce chemo sensitization to docetaxel treatment in cancer cells. Overall, the study results confirm that ZA-based, bone-targeted NPs have great potential for the treatment of bone metastasis in the near future.
Cited By
This article is cited by 1 publications.
- Shijie Wang, Dingyao Gao, Ke Li, Siqin Ye, Qingzhu Liu, Ying Peng, Gaochao Lv, Ling Qiu, Jianguo Lin. Radiopharmacological evaluation of a caspase-3 responsive probe with optimized pharmacokinetics for PET imaging of tumor apoptosis. Organic & Biomolecular Chemistry 2020, 18 (18) , 3512-3521. https://doi.org/10.1039/D0OB00690D