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    The APOE ε4 Allele Is Associated with Lower Selenium Levels in the Brain: Implications for Alzheimer’s Disease
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    † The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria 3052, Australia
    ‡ Faculty of Pharmaceutical Sciences, Department of Food and Experimental Nutrition, University of São Paulo, São Paulo 05508-000, Brazil
    § Elemental Bio-imaging Facility, University of Technology Sydney, Ultimo, New South Wales 2007, Australia
    ∥ Department of Anatomical Pathology, Alfred Hospital, Prahran, Victoria 3181, Australia
    ⊥ Collaborative Genomics Group, Centre of Excellence for Alzheimer’s Disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia 6027, Australia
    # Cooperative Research Centre for Mental Health, Carlton, Victoria 3053, Australia
    *Mailing address: The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, 30 Royal Parade, Parkville, Victoria 3052, Australia. Ph: +61 450 633 537. E-mail: [email protected]
    *Mailing address: The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, 30 Royal Parade, Parkville, Victoria 3052, Australia. Ph: +61 450 633 537. E-mail: [email protected]
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    ACS Chemical Neuroscience

    Cite this: ACS Chem. Neurosci. 2017, 8, 7, 1459–1464
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    https://doi.org/10.1021/acschemneuro.7b00014
    Published April 28, 2017
    Copyright © 2017 American Chemical Society
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    The antioxidant activity of selenium, which is mainly conferred by its incorporation into dedicated selenoproteins, has been suggested as a possible neuroprotective approach for mitigating neuronal loss in Alzheimer’s disease. However, there is inconsistent information with respect to selenium levels in the Alzheimer’s disease brain. We examined the concentration and cellular compartmentalization of selenium in the temporal cortex of Alzheimer’s disease and control brain tissue. We found that Alzheimer’s disease was associated with decreased selenium concentration in both soluble (i.e., cytosolic) and insoluble (i.e., plaques and tangles) fractions of brain homogenates. The presence of the APOE ε4 allele correlated with lower total selenium levels in the temporal cortex and a higher concentration of soluble selenium. Additionally, we found that age significantly contributed to lower selenium concentrations in the peripheral membrane-bound and vesicular fractions. Our findings suggest a relevant interaction between APOE ε4 and selenium delivery into brain, and show changes in cellular selenium distribution in the Alzheimer’s disease brain.

    Copyright © 2017 American Chemical Society

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    10. Thahira A, Thirumal Kumar D, Dhanya MS, Rasitha CH, Aswathi Rajan, Pinchulatha K, Harisree PH, Deepthi S, Aiganesh I, Jeyapal V, Dinesh Roy D. Apolipoprotein E Polymorphism And It’s Lifestyle Impact. Journal of Advanced Zoology 2023, 45 (1) https://doi.org/10.17762/jaz.v45i1.2925
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    17. E. A. Turovsky, V. N. Mal’tseva, R. M. Sarimov, A. V. Simakin, S. V. Gudkov, E. Y. Plotnikov. Features of the cytoprotective effect of selenium nanoparticles on primary cortical neurons and astrocytes during oxygen–glucose deprivation and reoxygenation. Scientific Reports 2022, 12 (1) https://doi.org/10.1038/s41598-022-05674-1
    18. Yanhui Zhang, Huiling Gao, Wei Zheng, He Xu. Current understanding of the interactions between metal ions and Apolipoprotein E in Alzheimer’s disease. Neurobiology of Disease 2022, 172 , 105824. https://doi.org/10.1016/j.nbd.2022.105824
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    ACS Chemical Neuroscience

    Cite this: ACS Chem. Neurosci. 2017, 8, 7, 1459–1464
    Click to copy citationCitation copied!
    https://doi.org/10.1021/acschemneuro.7b00014
    Published April 28, 2017
    Copyright © 2017 American Chemical Society
    Request reuse permissions

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