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Classics in Chemical Neuroscience: Haloperidol

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Chemical Neurobiology Laboratory, Center for Genomic Medicine, Chemical Biology Program, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, United States
§ Centro de Investigaciones Biológicas-CSIC, Madrid 28040, Spain
*M.W.T. E-mail: [email protected]
*S.J.H. E-mail: [email protected]
Cite this: ACS Chem. Neurosci. 2017, 8, 3, 444–453
Publication Date (Web):February 7, 2017
https://doi.org/10.1021/acschemneuro.7b00018
Copyright © 2017 American Chemical Society

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    Abstract

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    The discovery of haloperidol catalyzed a breakthrough in our understanding of the biochemical basis of schizophrenia, improved the treatment of psychosis, and facilitated deinstitutionalization. In doing so, it solidified the role for chemical neuroscience as a means to elucidate the molecular underpinnings of complex neuropsychiatric disorders. In this Review, we will cover aspects of haloperidol’s synthesis, manufacturing, metabolism, pharmacology, approved and off-label indications, and adverse effects. We will also convey the fascinating history of this classic molecule and the influence that it has had on the evolution of neuropsychopharmacology and neuroscience.

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