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Multi-metal, Multi-wavelength Surface-Enhanced Raman Spectroscopy Detection of Neurotransmitters

Cite this: ACS Chem. Neurosci. 2018, 9, 6, 1380–1387
Publication Date (Web):March 30, 2018
Copyright © 2018 American Chemical Society

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    The development of a sensor for the rapid and sensitive detection of neurotransmitters could provide a pathway for the diagnosis of neurological diseases, leading to the discovery of more effective treatment methods. We investigate the use of surface enhanced Raman spectroscopy (SERS) based sensors for the rapid detection of melatonin, serotonin, glutamate, dopamine, GABA, norepinephrine, and epinephrine. Previous studies have demonstrated SERS detection of neurotransmitters; however, there has been no comprehensive study on the effect of the metal used as the SERS substrate or the excitation wavelength used for detection. Here, we present the detection of 7 neurotransmitters using both silver and gold nanoparticles at excitation wavelengths of 532, 633, and 785 nm. Over the range of wavelengths investigated, the SERS enhancement on the silver and gold nanoparticles varies, with an average enhancement factor of 105–106. The maximum SERS enhancement occurs at an excitation wavelength of 785 nm for the gold nanoparticles and at 633 nm for the silver nanoparticles.

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    The Supporting Information is available free of charge on the ACS Publications website at DOI: 10.1021/acschemneuro.8b00020.

    • SEM images, solid spectra, SERS spectra, peak positions of neurotransmitters, Scores on PC1 plotted against scores on PC2 (PDF)

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